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Aliases for IFI35 Gene

Aliases for IFI35 Gene

  • Interferon Induced Protein 35 2 3 5
  • Interferon-Induced Protein 35 2 3
  • IFP 35 3 4
  • Ifi-35 3 4
  • IFP35 3 4

External Ids for IFI35 Gene

Previous GeneCards Identifiers for IFI35 Gene

  • GC17M062367
  • GC17P043320
  • GC17P041067
  • GC17P041532
  • GC17P041533
  • GC17P038412
  • GC17P041158
  • GC17P036924

Summaries for IFI35 Gene

GeneCards Summary for IFI35 Gene

IFI35 (Interferon Induced Protein 35) is a Protein Coding gene. Diseases associated with IFI35 include Stomatitis and Lymphocytic Choriomeningitis. Among its related pathways are Immune System and Immune response IFN alpha/beta signaling pathway. An important paralog of this gene is NMI.

UniProtKB/Swiss-Prot for IFI35 Gene

  • Not yet known.

Gene Wiki entry for IFI35 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI35 Gene

Genomics for IFI35 Gene

Regulatory Elements for IFI35 Gene

Enhancers for IFI35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFI35 on UCSC Golden Path with GeneCards custom track

Promoters for IFI35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IFI35 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFI35 Gene

43,006,725 bp from pter
43,014,459 bp from pter
7,735 bases
Plus strand

Genomic View for IFI35 Gene

Genes around IFI35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI35 Gene

Proteins for IFI35 Gene

  • Protein details for IFI35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon-induced 35 kDa protein
    Protein Accession:
    Secondary Accessions:
    • C9JGX1
    • Q92984
    • Q99537
    • Q9BV98

    Protein attributes for IFI35 Gene

    286 amino acids
    Molecular mass:
    31546 Da
    Quaternary structure:
    • Homodimer. Also interacts with B-ATF.
    • Sequence=AAB61703.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for IFI35 Gene


neXtProt entry for IFI35 Gene

Proteomics data for IFI35 Gene at MOPED

Post-translational modifications for IFI35 Gene

  • Ubiquitination at Lys 221
  • Modification sites at PhosphoSitePlus

Other Protein References for IFI35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFI35 Gene

Domains & Families for IFI35 Gene

Protein Domains for IFI35 Gene


Suggested Antigen Peptide Sequences for IFI35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NMI family.
  • Belongs to the NMI family.
genes like me logo Genes that share domains with IFI35: view

No data available for Gene Families for IFI35 Gene

Function for IFI35 Gene

Molecular function for IFI35 Gene

GENATLAS Biochemistry:
interferon-induced leucine zipper protein IFI35,may be the same as APRF
UniProtKB/Swiss-Prot Function:
Not yet known.
UniProtKB/Swiss-Prot Induction:
By interferon gamma.
genes like me logo Genes that share phenotypes with IFI35: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFI35 Gene

Localization for IFI35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI35 Gene

Nucleus. Note=Nuclear following IFN treatment.

Subcellular locations from

Jensen Localization Image for IFI35 Gene COMPARTMENTS Subcellular localization image for IFI35 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for IFI35 Gene

Pathways & Interactions for IFI35 Gene

genes like me logo Genes that share pathways with IFI35: view

Pathways by source for IFI35 Gene

Gene Ontology (GO) - Biological Process for IFI35 Gene


No data available for SIGNOR curated interactions for IFI35 Gene

Drugs & Compounds for IFI35 Gene

(1) Drugs for IFI35 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IFI35: view

Transcripts for IFI35 Gene

Unigene Clusters for IFI35 Gene

Interferon-induced protein 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFI35 Gene

No ASD Table

Relevant External Links for IFI35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFI35 Gene

mRNA expression in normal human tissues for IFI35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFI35 Gene

This gene is overexpressed in Monocytes (12.4) and Lymph node (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFI35 Gene

SOURCE GeneReport for Unigene cluster for IFI35 Gene Hs.632258

mRNA Expression by UniProt/SwissProt for IFI35 Gene

Tissue specificity: In a wide range of cell types, including fibroblasts, macrophages, and epithelial cells.
genes like me logo Genes that share expression patterns with IFI35: view

Protein tissue co-expression partners for IFI35 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for IFI35 Gene

Orthologs for IFI35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IFI35 35
  • 80.97 (n)
  • 74.71 (a)
IFI35 36
  • 75 (a)
(Canis familiaris)
Mammalia IFI35 35
  • 79 (n)
  • 74.73 (a)
IFI35 36
  • 73 (a)
(Mus musculus)
Mammalia Ifi35 35
  • 78.32 (n)
  • 72.03 (a)
Ifi35 16
Ifi35 36
  • 72 (a)
(Pan troglodytes)
Mammalia IFI35 35
  • 98.84 (n)
  • 98.25 (a)
IFI35 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ifi35 35
  • 78.9 (n)
  • 72.73 (a)
(Monodelphis domestica)
Mammalia IFI35 36
  • 58 (a)
(Gallus gallus)
Aves IFI35 35
  • 53.06 (n)
  • 40.44 (a)
IFI35 36
  • 35 (a)
(Anolis carolinensis)
Reptilia IFI35 36
  • 29 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ifi35 35
  • 48.96 (n)
  • 38.1 (a)
(Danio rerio)
Actinopterygii ifi35 35
  • 49.25 (n)
  • 37.45 (a)
ifi35 36
  • 25 (a)
Species with no ortholog for IFI35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI35 Gene

Gene Tree for IFI35 (if available)
Gene Tree for IFI35 (if available)

Paralogs for IFI35 Gene

Paralogs for IFI35 Gene

genes like me logo Genes that share paralogs with IFI35: view

Variants for IFI35 Gene

Sequence variations from dbSNP and Humsavar for IFI35 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs588703 - 43,013,476(-) GGACA(C/T)CTAGG reference, missense
rs13229 -- 43,013,861(+) GTGAA(A/C/T)GGGGA reference, synonymous-codon
rs443759 -- 43,013,717(-) GCACC(A/G)TAATC intron-variant
rs691144 -- 43,011,632(-) agccc(A/G)tctga intron-variant
rs692119 -- 43,005,370(-) gaggc(A/G)gtgaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IFI35 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv483009 CNV Gain 15286789
nsv457742 CNV Loss 19166990
esv2672913 CNV Deletion 23128226
esv2672649 CNV Deletion 23128226
esv2662750 CNV Deletion 23128226

Variation tolerance for IFI35 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IFI35 Gene

Disorders for IFI35 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IFI35 Gene - From: GeneCards

Disorder Aliases PubMed IDs
lymphocytic choriomeningitis
  • lcm
- elite association - COSMIC cancer census association via MalaCards
Search IFI35 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFI35

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IFI35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFI35 Gene

Publications for IFI35 Gene

  1. IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution. (PMID: 8288566) Bange F.-C. … Boettger E.C. (J. Biol. Chem. 1994) 3 4 23 67
  2. The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. (PMID: 17197158) Zhang L. … He F. (Cell. Signal. 2007) 3 23
  3. Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells. (PMID: 11911807) Chen J. … Naumovski L. (J. Interferon Cytokine Res. 2002) 3 23
  4. Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. (PMID: 10779520) Zhou X. … Omary M.B. (J. Biol. Chem. 2000) 3 23
  5. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PMID: 8938427) Smith T.M. … King M.-C. (Genome Res. 1996) 3 23

Products for IFI35 Gene

Sources for IFI35 Gene