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Aliases for IFI27 Gene

Aliases for IFI27 Gene

  • Interferon, Alpha-Inducible Protein 27 2 3
  • Interferon Alpha-Induced 11.5 KDa Protein 3 4
  • Interferon-Stimulated Gene 12a Protein 3 4
  • ISG12(A) 3 4
  • P27 3 4
  • 2310061N23Rik 3
  • FAM14D 3
  • ISG12A 3
  • ISG12 3

External Ids for IFI27 Gene

Previous GeneCards Identifiers for IFI27 Gene

  • GC14P092084
  • GC14P088393
  • GC14P092567
  • GC14P093646
  • GC14P094577
  • GC14P074756

Summaries for IFI27 Gene

GeneCards Summary for IFI27 Gene

IFI27 (Interferon, Alpha-Inducible Protein 27) is a Protein Coding gene. Diseases associated with IFI27 include laryngeal carcinoma and familial breast cancer. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include RNA polymerase II activating transcription factor binding and lamin binding. An important paralog of this gene is IFI27L2.

UniProtKB/Swiss-Prot for IFI27 Gene

  • Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9.

Gene Wiki entry for IFI27 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI27 Gene

Genomics for IFI27 Gene

Regulatory Elements for IFI27 Gene

Genomic Location for IFI27 Gene

Chromosome:
14
Start:
94,104,836 bp from pter
End:
94,116,699 bp from pter
Size:
11,864 bases
Orientation:
Plus strand

Genomic View for IFI27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFI27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI27 Gene

Proteins for IFI27 Gene

  • Protein details for IFI27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40305-IFI27_HUMAN
    Recommended name:
    Interferon alpha-inducible protein 27, mitochondrial
    Protein Accession:
    P40305
    Secondary Accessions:
    • Q53YA6
    • Q6IEC1
    • Q96BK3

    Protein attributes for IFI27 Gene

    Size:
    119 amino acids
    Molecular mass:
    11268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFI27 Gene

Proteomics data for IFI27 Gene at MOPED

Post-translational modifications for IFI27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFI27 Gene

Domains & Families for IFI27 Gene

Protein Domains for IFI27 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P40305

UniProtKB/Swiss-Prot:

IFI27_HUMAN :
  • Belongs to the IFI6/IFI27 family.
Family:
  • Belongs to the IFI6/IFI27 family.
genes like me logo Genes that share domains with IFI27: view

No data available for Gene Families for IFI27 Gene

Function for IFI27 Gene

Molecular function for IFI27 Gene

GENATLAS Biochemistry:
interferon alpha-inducible protein,27kDa (clone IFI27K),overexpressed in breast carcinoma
UniProtKB/Swiss-Prot Function:
Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9.
UniProtKB/Swiss-Prot Induction:
Up-regulated by interferons.

Gene Ontology (GO) - Molecular Function for IFI27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI 22427340
GO:0003674 molecular_function ND --
GO:0005521 lamin binding IDA 22427340
genes like me logo Genes that share ontologies with IFI27: view

Phenotypes for IFI27 Gene

GenomeRNAi human phenotypes for IFI27:
genes like me logo Genes that share phenotypes with IFI27: view

Animal Model Products

miRNA for IFI27 Gene

miRTarBase miRNAs that target IFI27

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFI27

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IFI27 Gene

Localization for IFI27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI27 Gene

Mitochondrion. Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFI27 Gene COMPARTMENTS Subcellular localization image for IFI27 gene
Compartment Confidence
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for IFI27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IDA 22427340
GO:0005739 mitochondrion IDA 18330707
GO:0005741 mitochondrial outer membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFI27: view

Pathways & Interactions for IFI27 Gene

genes like me logo Genes that share pathways with IFI27: view

Pathways by source for IFI27 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for IFI27 Gene

Selected Interacting proteins: P40305-IFI27_HUMAN for IFI27 Gene via I2D

Gene Ontology (GO) - Biological Process for IFI27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IGI 22427340
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 18330707
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0046825 regulation of protein export from nucleus IGI 22427340
GO:0060337 type I interferon signaling pathway TAS --
genes like me logo Genes that share ontologies with IFI27: view

No data available for SIGNOR curated interactions for IFI27 Gene

Drugs & Compounds for IFI27 Gene

(40) Drugs for IFI27 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Cytarabine Approved, Investigational Pharma 995
Dexamethasone Approved, Investigational Pharma Agonist 1806
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1525
Estradiol Approved, Investigational Pharma Sex hormone 1057

(32) Additional Compounds for IFI27 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15-deoxy-delta-12,14-prostaglandin j2
87893-55-8
adpribose
Betacarotene
butyrate
CHI 2
genes like me logo Genes that share compounds with IFI27: view

Transcripts for IFI27 Gene

Unigene Clusters for IFI27 Gene

Interferon, alpha-inducible protein 27:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFI27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI27 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8:

Relevant External Links for IFI27 Gene

GeneLoc Exon Structure for
IFI27
ECgene alternative splicing isoforms for
IFI27

Expression for IFI27 Gene

mRNA expression in normal human tissues for IFI27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFI27 Gene

This gene is overexpressed in Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for IFI27 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFI27 Gene



SOURCE GeneReport for Unigene cluster for IFI27 Gene Hs.532634

genes like me logo Genes that share expression patterns with IFI27: view

Protein tissue co-expression partners for IFI27 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IFI27 Gene

Orthologs for IFI27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFI27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFI27 35
  • 98.6 (n)
  • 97.48 (a)
IFI27 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifi27l1 16
Ifi27l2a 36
  • 59 (a)
ManyToMany
Ifi27l2b 36
  • 19 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia IFI27 36
  • 26 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFI27L2 36
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-188i13.10 36
  • 38 (a)
ManyToMany
si:dkey-188i13.11 36
  • 41 (a)
ManyToMany
si:dkey-188i13.6 36
  • 30 (a)
ManyToMany
si:dkey-188i13.7 36
  • 30 (a)
ManyToMany
si:dkey-188i13.9 36
  • 31 (a)
ManyToMany
zgc:123068 36
  • 42 (a)
ManyToMany
zgc:152791 36
  • 49 (a)
ManyToMany
Species with no ortholog for IFI27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFI27 Gene

ENSEMBL:
Gene Tree for IFI27 (if available)
TreeFam:
Gene Tree for IFI27 (if available)

Paralogs for IFI27 Gene

Paralogs for IFI27 Gene

genes like me logo Genes that share paralogs with IFI27: view

Variants for IFI27 Gene

Sequence variations from dbSNP and Humsavar for IFI27 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_028066 -

Structural Variations from Database of Genomic Variants (DGV) for IFI27 Gene

Variant ID Type Subtype PubMed ID
esv34067 CNV Loss 18971310

Variation tolerance for IFI27 Gene

Residual Variation Intolerance Score: 70.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFI27 Gene

HapMap Linkage Disequilibrium report
IFI27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI27 Gene

Disorders for IFI27 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IFI27 Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
laryngeal carcinoma
  • cancer of larynx
familial breast cancer
  • breast cancer, familial
esophageal cancer
  • esophageal cancer, somatic
- elite association
Search IFI27 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFI27

Genetic Association Database (GAD)
IFI27
Human Genome Epidemiology (HuGE) Navigator
IFI27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFI27
genes like me logo Genes that share disorders with IFI27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFI27 Gene

Publications for IFI27 Gene

  1. Identification of a new interferon-alpha-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma. (PMID: 8358738) Rasmussen U.B. … Basset P. (Cancer Res. 1993) 2 23 67
  2. CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. (PMID: 19790197) Firestein R. … Ogino S. (Int. J. Cancer 2010) 23 67
  3. Hepatitis B virus X protein overcomes the growth-inhibitory potential of retinoic acid by downregulating retinoic acid receptor-beta2 expression via DNA methylation. (PMID: 19828754) Jung J.K. … Jang K.L. (J. Gen. Virol. 2010) 23 67
  4. Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function. (PMID: 20088798) Gandhi A.K. … Schafer P. (Curr Cancer Drug Targets 2010) 23 67
  5. p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. (PMID: 20194624) Belletti B. … Baldassarre G. (Mol. Cell. Biol. 2010) 23 67

Products for IFI27 Gene

Sources for IFI27 Gene

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