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Aliases for IFI16 Gene

Aliases for IFI16 Gene

  • Interferon Gamma Inducible Protein 16 2 3
  • Interferon-Inducible Myeloid Differentiation Transcriptional Activator 3 4
  • Interferon, Gamma-Inducible Protein 16 3 5
  • IFNGIP1 3 4
  • Interferon-Gamma Induced Protein IFI 16 3
  • PYHIN2 3
  • Ifi-16 4

External Ids for IFI16 Gene

Previous GeneCards Identifiers for IFI16 Gene

  • GC01P156771
  • GC01P154702
  • GC01P155747
  • GC01P156196
  • GC01P155782
  • GC01P157236
  • GC01P130336

Summaries for IFI16 Gene

Entrez Gene Summary for IFI16 Gene

  • This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

GeneCards Summary for IFI16 Gene

IFI16 (Interferon Gamma Inducible Protein 16) is a Protein Coding gene. Diseases associated with IFI16 include herpes simplex and diffuse cutaneous systemic sclerosis. Among its related pathways are Immune System and Id Signaling Pathway. GO annotations related to this gene include poly(A) RNA binding and transcription factor binding. An important paralog of this gene is PYHIN1.

UniProtKB/Swiss-Prot for IFI16 Gene

  • Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposis sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Gene Wiki entry for IFI16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFI16 Gene

Genomics for IFI16 Gene

Regulatory Elements for IFI16 Gene

Promoters for IFI16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IFI16 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFI16 Gene

Chromosome:
1
Start:
158,999,968 bp from pter
End:
159,055,155 bp from pter
Size:
55,188 bases
Orientation:
Plus strand

Genomic View for IFI16 Gene

Genes around IFI16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFI16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFI16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFI16 Gene

Proteins for IFI16 Gene

  • Protein details for IFI16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16666-IF16_HUMAN
    Recommended name:
    Gamma-interferon-inducible protein 16
    Protein Accession:
    Q16666
    Secondary Accessions:
    • B4DJT8
    • H3BLV7
    • Q59GX0
    • Q5T3W7
    • Q5T3W8
    • Q5T3X0
    • Q5T3X1
    • Q5T3X2
    • Q8N9E5
    • Q8NEQ7
    • Q96AJ5
    • Q9UH78

    Protein attributes for IFI16 Gene

    Size:
    785 amino acids
    Molecular mass:
    88256 Da
    Quaternary structure:
    • Forms homooligomers; isoform 2 can self-associate or associate with isoform 1 or isoform 3. Interacts with TMEM173, AIM2, PYCARD and CASP1. Interacts with BRCA1, TP53, E2F1, RB1 and SP1. Interacts with MTA1.
    SequenceCaution:
    • Sequence=AAF20997.1; Type=Frameshift; Positions=776; Evidence={ECO:0000305}; Sequence=AAF20997.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAC04462.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAD92226.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG58950.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IFI16 Gene

    Alternative splice isoforms for IFI16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFI16 Gene

Proteomics data for IFI16 Gene at MOPED

Post-translational modifications for IFI16 Gene

  • Isoform 3 seems to show a minor degree of complex carbohydrate addition.
  • Lysine acetylation in the multipartite nuclear localization signal (NLS) regulates the subcellular location. In vitro can be acetylated by p300/EP300 coupled to cytoplasmic localization.
  • Phosphorylated on Ser and Thr.
  • Ubiquitinated by human herpes simplex virus 1 (HHV-1) ICP0 protein; leading to degradation by the proteasome.
  • Ubiquitination at Lys 128, Lys 143, Lys 190, Lys 614, and Lys 743
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IFI16 (IFI16)
  • Cloud-Clone Corp. Antibodies for IFI16

No data available for DME Specific Peptides for IFI16 Gene

Domains & Families for IFI16 Gene

Protein Domains for IFI16 Gene

Graphical View of Domain Structure for InterPro Entry

Q16666

UniProtKB/Swiss-Prot:

IF16_HUMAN :
  • The HIN-20 domains mediates dsDNA binding via electrostatic interactions.
  • Belongs to the HIN-200 family.
Domain:
  • The HIN-20 domains mediates dsDNA binding via electrostatic interactions.
  • Contains 2 HIN-200 domains.
  • Contains 1 pyrin domain.
Family:
  • Belongs to the HIN-200 family.
genes like me logo Genes that share domains with IFI16: view

Function for IFI16 Gene

Molecular function for IFI16 Gene

GENATLAS Biochemistry:
nuclear protein,constitutively expressed in lymphocytes,interferon alpha or gamma inducible in myeloid cells (clone IFI-6-16)
UniProtKB/Swiss-Prot Function:
Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposis sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
UniProtKB/Swiss-Prot Induction:
Strongly induced by IFNG/IFN-gamma and, to a lesser extent, by alpha interferon. In HL-60 cells, maximum induction by IFNG/IFN-gamma occurs within 12 hours whereas, for IFN-alpha, only 10-fold induction was observed after 36 hours. Induced in vitro by dimethylsulfoxide, retinoic acid and 1,25 dihydroxyvitamin D3. Induced in monocytes by IFN-alpha and viral dsDNA. Induced by glucose restriction.

Gene Ontology (GO) - Molecular Function for IFI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 24413532
genes like me logo Genes that share ontologies with IFI16: view
genes like me logo Genes that share phenotypes with IFI16: view

Animal Model Products

CRISPR Products

miRNA for IFI16 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFI16 Gene

Localization for IFI16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFI16 Gene

Nucleus. Cytoplasm. Note=Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Localizes in the nucleus during human herpes simplex virus 1 (HHV-1) infection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFI16 Gene COMPARTMENTS Subcellular localization image for IFI16 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for IFI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IFI16: view

Pathways & Interactions for IFI16 Gene

genes like me logo Genes that share pathways with IFI16: view

Gene Ontology (GO) - Biological Process for IFI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production TAS 22046441
GO:0006351 transcription, DNA-templated IEA --
GO:0008283 cell proliferation NAS 9766636
GO:0030097 hemopoiesis NAS 9766636
GO:0030099 myeloid cell differentiation NAS 7536752
genes like me logo Genes that share ontologies with IFI16: view

No data available for SIGNOR curated interactions for IFI16 Gene

Drugs & Compounds for IFI16 Gene

(1) Drugs for IFI16 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for IFI16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFI16: view

Transcripts for IFI16 Gene

Unigene Clusters for IFI16 Gene

Interferon, gamma-inducible protein 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFI16 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c ^
SP1:
SP2: -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7: -
SP8: - - - -
SP9: -
SP10:
SP11: - - -
SP12:

ExUns: 15a · 15b · 15c ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:

Relevant External Links for IFI16 Gene

GeneLoc Exon Structure for
IFI16
ECgene alternative splicing isoforms for
IFI16

Expression for IFI16 Gene

mRNA expression in normal human tissues for IFI16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFI16 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for IFI16 Gene

This gene is overexpressed in Lymph node (12.9) and Peripheral blood mononuclear cells (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFI16 Gene



SOURCE GeneReport for Unigene cluster for IFI16 Gene Hs.380250

mRNA Expression by UniProt/SwissProt for IFI16 Gene

Q16666-IF16_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level).
genes like me logo Genes that share expression patterns with IFI16: view

Protein tissue co-expression partners for IFI16 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for IFI16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFI16 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Pydc4 35
  • 65.77 (n)
  • 57.14 (a)
Pyhin1 16
BC094916 36
  • 37 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia IFI16 35
  • 99.27 (n)
  • 98.35 (a)
IFI16 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mnda 35
  • 65.29 (n)
  • 47.55 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 31 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 21 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
OneToMany
Species with no ortholog for IFI16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFI16 Gene

ENSEMBL:
Gene Tree for IFI16 (if available)
TreeFam:
Gene Tree for IFI16 (if available)

Paralogs for IFI16 Gene

Paralogs for IFI16 Gene

(3) SIMAP similar genes for IFI16 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with IFI16: view

Variants for IFI16 Gene

Sequence variations from dbSNP and Humsavar for IFI16 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1057018 - 159,015,913(+) AAGTG(C/G)ATGCT reference, missense
rs866484 - 159,016,687(-) AAGAA(C/G)TGTTG intron-variant, reference, missense
rs11585341 - 159,018,283(+) TCCAA(A/G)AACGC reference, missense
rs1057027 - 159,032,587(+) AACAG(A/C)GTCAG reference, missense
rs1057028 - 159,032,599(+) TTCCA(A/T)ATCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IFI16 Gene

Variant ID Type Subtype PubMed ID
nsv3176 CNV Loss 18451855
nsv872486 CNV Loss 21882294
esv32912 CNV Loss 17666407
nsv506961 CNV Insertion 20534489
esv33390 CNV Gain 17666407
esv33763 CNV Loss 17666407
esv2718684 CNV Deletion 23290073
esv6708 CNV Loss 19470904
esv21466 CNV Gain+Loss 19812545
nsv825019 CNV Loss 20364138
nsv825032 CNV Loss 20364138
esv2718696 CNV Deletion 23290073

Variation tolerance for IFI16 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFI16 Gene

HapMap Linkage Disequilibrium report
IFI16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFI16 Gene

Disorders for IFI16 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IFI16 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
limited scleroderma
  • crest syndrome
- elite association - COSMIC cancer census association via MalaCards
Search IFI16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IFI16

Genetic Association Database (GAD)
IFI16
Human Genome Epidemiology (HuGE) Navigator
IFI16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFI16
genes like me logo Genes that share disorders with IFI16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFI16 Gene

Publications for IFI16 Gene

  1. Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization. (PMID: 7959953) Trapani J.A. … Browne K.A. (Immunogenetics 1994) 2 3 4 23 67
  2. A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. (PMID: 1526658) Trapani J.A. … Dupont B. (Immunogenetics 1992) 2 3 23
  3. In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16. (PMID: 19553003) Mazibrada J. … Landolfo S. (Cancer Lett. 2010) 3 23
  4. Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene. (PMID: 20052289) Song L.L. … Choubey D. (PLoS ONE 2010) 3 23
  5. Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma. (PMID: 20214740) Yu F. … Li J. (Liver Int. 2010) 3 23

Products for IFI16 Gene

Sources for IFI16 Gene

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