Aliases for IDH3B Gene
External Ids for IDH3B Gene
Previous GeneCards Identifiers for IDH3B Gene
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for IDH3B Gene
IDH3B (Isocitrate Dehydrogenase 3 (NAD+) Beta) is a Protein Coding gene. Diseases associated with IDH3B include idh3b-related retinitis pigmentosa and retinitis pigmentosa 46. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include magnesium ion binding and NAD binding. An important paralog of this gene is IDH3G.