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Aliases for IDH3A Gene

Aliases for IDH3A Gene

  • Isocitrate Dehydrogenase 3 (NAD+) Alpha 2 3
  • EC 1.1.1.41 4 63
  • NAD(H)-Specific Isocitrate Dehydrogenase Alpha Subunit 2
  • Isocitrate Dehydrogenase [NAD] Subunit Alpha 2
  • Isocitrate Dehydrogenase (NAD+) Alpha Chain 2
  • Isocitric Dehydrogenase Subunit Alpha 4
  • NAD(+)-Specific ICDH Subunit Alpha 4
  • Isocitric Dehydrogenase 2
  • NAD+-Specific ICDH 2
  • Mitochondrial 2
  • H-IDH Alpha 2
  • EC 1.1.1 63

External Ids for IDH3A Gene

Previous GeneCards Identifiers for IDH3A Gene

  • GC15P074520
  • GC15P071531
  • GC15P076017
  • GC15P076157
  • GC15P076228
  • GC15P078441
  • GC15P055199
  • GC15P078423

Summaries for IDH3A Gene

Entrez Gene Summary for IDH3A Gene

  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]

GeneCards Summary for IDH3A Gene

IDH3A (Isocitrate Dehydrogenase 3 (NAD+) Alpha) is a Protein Coding gene. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include magnesium ion binding and isocitrate dehydrogenase (NAD+) activity.

Gene Wiki entry for IDH3A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDH3A Gene

Genomics for IDH3A Gene

Regulatory Elements for IDH3A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IDH3A Gene

Start:
78,131,498 bp from pter
End:
78,171,949 bp from pter
Size:
40,452 bases
Orientation:
Plus strand

Genomic View for IDH3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IDH3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDH3A Gene

Proteins for IDH3A Gene

  • Protein details for IDH3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50213-IDH3A_HUMAN
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Protein Accession:
    P50213
    Secondary Accessions:
    • D3DW83
    • Q9H3X0

    Protein attributes for IDH3A Gene

    Size:
    366 amino acids
    Molecular mass:
    39592 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.;
    Quaternary structure:
    • Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.

    Alternative splice isoforms for IDH3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDH3A Gene

Proteomics data for IDH3A Gene at MOPED

Post-translational modifications for IDH3A Gene

  • Ubiquitination at Lys58, Lys77, and Lys100
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for IDH3A Gene

Graphical View of Domain Structure for InterPro Entry

P50213

UniProtKB/Swiss-Prot:

IDH3A_HUMAN :
  • P50213
Family:
  • Belongs to the isocitrate and isopropylmalate dehydrogenases family.
genes like me logo Genes that share domains with IDH3A: view

No data available for Gene Families for IDH3A Gene

Function for IDH3A Gene

Molecular function for IDH3A Gene

GENATLAS Biochemistry:
isocitrate dehydrogenase 3,alpha subunit,NADH dependent,mitochondrial matrix,catalyzing the third step of citric acid cycle
UniProtKB/Swiss-Prot CatalyticActivity:
Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH

Enzyme Numbers (IUBMB) for IDH3A Gene

Gene Ontology (GO) - Molecular Function for IDH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004449 isocitrate dehydrogenase (NAD+) activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
GO:0051287 NAD binding IEA --
genes like me logo Genes that share ontologies with IDH3A: view

Animal Model Products

miRNA for IDH3A Gene

miRTarBase miRNAs that target IDH3A

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IDH3A Gene

Localization for IDH3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDH3A Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IDH3A Gene COMPARTMENTS Subcellular localization image for IDH3A gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IDH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with IDH3A: view

Pathways for IDH3A Gene

genes like me logo Genes that share pathways with IDH3A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IDH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 8833160
GO:0006099 tricarboxylic acid cycle TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with IDH3A: view

Compounds for IDH3A Gene

(7) HMDB Compounds for IDH3A Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
124-38-9
Isocitric acid
  • 1-Hydroxy-1,2,3-propanetricarboxylate
320-77-4
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9

(1) Drugbank Compounds for IDH3A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with IDH3A: view

Transcripts for IDH3A Gene

Unigene Clusters for IDH3A Gene

Isocitrate dehydrogenase 3 (NAD+) alpha:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IDH3A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IDH3A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - -
SP12: - - - - - - -
SP13:
SP14: - - - -
SP15: - - - - -
SP16: - - - - - - - -
SP17: - - - - - -
SP18: - - -
SP19: - - -
SP20:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for IDH3A Gene

GeneLoc Exon Structure for
IDH3A
ECgene alternative splicing isoforms for
IDH3A

Expression for IDH3A Gene

mRNA expression in normal human tissues for IDH3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IDH3A Gene

This gene is overexpressed in Heart - Left Ventricle (4.1).

Protein differential expression in normal tissues for IDH3A Gene

This gene is overexpressed in Brain (8.6) and Nasal epithelium (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IDH3A Gene

SOURCE GeneReport for Unigene cluster for IDH3A Gene Hs.591110

genes like me logo Genes that share expressions with IDH3A: view

Expression partners for IDH3A Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IDH3A Gene

Orthologs for IDH3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDH3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IDH3A 35
  • 92.53 (n)
  • 96.99 (a)
IDH3A 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IDH3A 35
  • 91.07 (n)
  • 97.54 (a)
IDH3A 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Idh3a 35
  • 89.34 (n)
  • 97.54 (a)
Idh3a 16
Idh3a 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IDH3A 35
  • 99.64 (n)
  • 99.45 (a)
IDH3A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Idh3a 35
  • 88.98 (n)
  • 97.27 (a)
oppossum
(Monodelphis domestica)
Mammalia IDH3A 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IDH3A 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves IDH3A 35
  • 80.9 (n)
  • 91.18 (a)
IDH3A 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IDH3A 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia idh3a 35
  • 76.5 (n)
  • 86.07 (a)
MGC76128 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15952 35
zebrafish
(Danio rerio)
Actinopterygii idh3a 35
  • 75.78 (n)
  • 85.36 (a)
zgc56380 35
idh3a 36
  • 85 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9912 35
fruit fly
(Drosophila melanogaster)
Insecta CG12233 37
  • 71 (a)
CG3483 37
  • 39 (a)
l(1)G0156 35
  • 64.6 (n)
  • 71.3 (a)
CG32026 36
  • 30 (a)
OneToMany
CG3483 36
  • 35 (a)
OneToMany
l(1)G0156 36
  • 68 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002728 35
  • 63.81 (n)
  • 71.01 (a)
worm
(Caenorhabditis elegans)
Secernentea F43G9.1 37
  • 65 (a)
idha-1 35
  • 63.57 (n)
  • 71.22 (a)
idha-1 36
  • 69 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR137C 35
  • 53.92 (n)
  • 56.93 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03125g 35
  • 55.59 (n)
  • 58.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IDH2 35
  • 54.48 (n)
  • 56.5 (a)
IDH2 36
  • 52 (a)
OneToOne
IDH2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons IDH-V 35
  • 58.24 (n)
  • 56.25 (a)
soybean
(Glycine max)
eudicotyledons Gma.7251 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6781 35
barley
(Hordeum vulgare)
Liliopsida Hv.620 35
rice
(Oryza sativa)
Liliopsida Os.207 35
Os01g0276100 35
  • 58.91 (n)
  • 58.81 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.24979 35
corn
(Zea mays)
Liliopsida Zm.3035 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8758 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07697 35
  • 58.28 (n)
  • 63.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes idh2 35
  • 58.23 (n)
  • 62.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 73 (a)
OneToOne
Species with no ortholog for IDH3A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for IDH3A Gene

ENSEMBL:
Gene Tree for IDH3A (if available)
TreeFam:
Gene Tree for IDH3A (if available)

Paralogs for IDH3A Gene

genes like me logo Genes that share paralogs with IDH3A: view

No data available for Paralogs for IDH3A Gene

Variants for IDH3A Gene

Sequence variations from dbSNP and Humsavar for IDH3A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1982241 -- 78,160,380(+) TTTTT(C/T)CCCCC intron-variant
rs1982242 -- 78,160,530(+) tctgt(C/T)gccca intron-variant
rs2044097 -- 78,159,557(+) AAGAA(A/G)TAAGT intron-variant
rs2044098 -- 78,159,572(+) AGGTG(G/T)TAGCT intron-variant
rs2304825 -- 78,166,455(-) ACCCT(A/G)TTCAA intron-variant

Relevant External Links for IDH3A Gene

HapMap Linkage Disequilibrium report
IDH3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IDH3A Gene

Disorders for IDH3A Gene

Relevant External Links for IDH3A

Genetic Association Database (GAD)
IDH3A
Human Genome Epidemiology (HuGE) Navigator
IDH3A

No disorders were found for IDH3A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for IDH3A Gene

Publications for IDH3A Gene

  1. Characterization of a cDNA clone for human NAD(+)-specific isocitrate dehydrogenase alpha-subunit and structural comparison with its isoenzymes from different species. (PMID: 7755589) Kim Y.O. … Huh T.L. (Biochem. J. 1995) 3 4 23
  2. Assignment of the human mitochondrial NAD+ -specific isocitrate dehydrogenase alpha subunit (IDH3A) gene to 15q25.1-->q25.2by in situ hybridization. (PMID: 8833160) Huh T.L. … Inazawa J. (Genomics 1996) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for IDH3A Gene

Sources for IDH3A Gene

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