Aliases for FREM2 Gene
External Ids for FREM2 Gene
Previous GeneCards Identifiers for FREM2 Gene
This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]
GeneCards Summary for FREM2 Gene
FREM2 (FRAS1 Related Extracellular Matrix Protein 2) is a Protein Coding gene. Diseases associated with FREM2 include Fraser Syndrome 2 and Fraser Syndrome 1. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is FREM3.
UniProtKB/Swiss-Prot for FREM2 Gene
Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.