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Aliases for IDE Gene

Aliases for IDE Gene

  • Insulin-Degrading Enzyme 2 3
  • Abeta-Degrading Protease 3 4
  • Insulin Protease 3 4
  • EC 3.4.24.56 4 64
  • Insulinase 3 4
  • INSULYSIN 3 4
  • Insulysin 2
  • EC 3.4.24 64

External Ids for IDE Gene

Summaries for IDE Gene

Entrez Gene Summary for IDE Gene

  • This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

GeneCards Summary for IDE Gene

IDE (Insulin-Degrading Enzyme) is a Protein Coding gene. Diseases associated with IDE include alzheimer disease. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Alzheimers disease. GO annotations related to this gene include protein homodimerization activity and ATPase activity. An important paralog of this gene is NRD1.

UniProtKB/Swiss-Prot for IDE Gene

  • Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

Gene Wiki entry for IDE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IDE Gene

Genomics for IDE Gene

Genomic Location for IDE Gene

Start:
92,451,684 bp from pter
End:
92,574,095 bp from pter
Size:
122,412 bases
Orientation:
Minus strand

Genomic View for IDE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IDE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IDE Gene

Regulatory Elements for IDE Gene

Proteins for IDE Gene

  • Protein details for IDE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14735-IDE_HUMAN
    Recommended name:
    Insulin-degrading enzyme
    Protein Accession:
    P14735
    Secondary Accessions:
    • B2R721
    • B7ZAU2
    • D3DR35
    • Q5T5N2

    Protein attributes for IDE Gene

    Size:
    1019 amino acids
    Molecular mass:
    117968 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus.
    Miscellaneous:
    • ATP-binding induces a conformation change

    Three dimensional structures from OCA and Proteopedia for IDE Gene

    Alternative splice isoforms for IDE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IDE Gene

Proteomics data for IDE Gene at MOPED

Post-translational modifications for IDE Gene

  • The N-terminus is blocked
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys192, Lys308, Lys884, Lys929, Lys938, and Lys1018

Other Protein References for IDE Gene

Domains for IDE Gene

UniProtKB/Swiss-Prot:

IDE_HUMAN
Domain:
  • The SlyX motif may be involved in the non-conventional secretion of the protein.:
    • P14735
Family:
  • Belongs to the peptidase M16 family.:
    • P14735
genes like me logo Genes that share domains with IDE: view

No data available for Gene Families for IDE Gene

Function for IDE Gene

Molecular function for IDE Gene

GENATLAS Biochemistry: insulin degrading enzyme,cytosolic metalloproteinase (110kDa)
UniProtKB/Swiss-Prot CatalyticActivity: Degradation of insulin, glucagon and other polypeptides. No action on proteins.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by small peptides (By similarity). Activated by ATP and GTP, and to a lesser extent by CTP, TTP and PPPi. Inhibited by bacitracin. Inhibited by S-nitrosylation and oxidation agents.
UniProtKB/Swiss-Prot Function: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

Enzyme Numbers (IUBMB) for IDE Gene

Gene Ontology (GO) - Molecular Function for IDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IEA --
GO:0001948 glycoprotein binding IPI 17055432
GO:0003824 catalytic activity --
GO:0004222 metalloendopeptidase activity IDA 17051221
GO:0005102 receptor binding IPI 20178365
genes like me logo Genes that share ontologies with IDE: view
genes like me logo Genes that share phenotypes with IDE: view

miRNA for IDE Gene

miRTarBase miRNAs that target IDE

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for IDE Gene

Localization for IDE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IDE Gene

Cytoplasm. Cell membrane. Secreted. Note=Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IDE Gene COMPARTMENTS Subcellular localization image for IDE gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
peroxisome 5
plasma membrane 5
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for IDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9830016
GO:0005634 NOT nucleus IDA 18226493
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 15285718
genes like me logo Genes that share ontologies with IDE: view

Pathways for IDE Gene

genes like me logo Genes that share pathways with IDE: view

Pathways by source for IDE Gene

1 Qiagen pathway for IDE Gene
1 BioSystems pathway for IDE Gene
1 KEGG pathway for IDE Gene

Gene Ontology (GO) - Biological Process for IDE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006508 proteolysis IDA 20082125
GO:0008286 insulin receptor signaling pathway NAS 3059494
GO:0008340 determination of adult lifespan IDA 18448515
GO:0010815 bradykinin catabolic process IDA 17613531
genes like me logo Genes that share ontologies with IDE: view

Compounds for IDE Gene

(1) HMDB Compounds for IDE Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6

(3) Drugbank Compounds for IDE Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Bacitracin
1405-87-4 target inhibitor
Insulin Regular
11061-68-0 target
Insulin, porcine
9004-14-2 target

(25) Novoseek inferred chemical compound relationships for IDE Gene

Compound -log(P) Hits PubMed IDs
thermolysin 59.2 4
chymostatin 53.7 2
1,10-phenanthroline 48.2 5
zinc 46.7 17
thimet 46.5 1
genes like me logo Genes that share compounds with IDE: view

Transcripts for IDE Gene

Unigene Clusters for IDE Gene

Insulin-degrading enzyme:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IDE Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: - -
SP2: -
SP3:

ExUns: 27 ^ 28 ^ 29a · 29b
SP1:
SP2:
SP3:

Relevant External Links for IDE Gene

GeneLoc Exon Structure for
IDE
ECgene alternative splicing isoforms for
IDE

Expression for IDE Gene

mRNA expression in normal human tissues for IDE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IDE Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IDE Gene

SOURCE GeneReport for Unigene cluster for IDE Gene Hs.500546

genes like me logo Genes that share expressions with IDE: view

Orthologs for IDE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IDE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IDE 36
  • 99.8 (n)
  • 99.9 (a)
IDE 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IDE 36
  • 94.41 (n)
  • 98.82 (a)
IDE 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IDE 36
  • 94.24 (n)
  • 97.55 (a)
IDE 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ide 36
  • 89.01 (n)
  • 95.09 (a)
Ide 16
Ide 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IDE 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IDE 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ide 36
  • 89.7 (n)
  • 95.49 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 92 (a)
OneToMany
-- 37
  • 98 (a)
OneToMany
IDE 36
  • 82.7 (n)
  • 92.64 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 88 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ide 36
  • 78.88 (n)
  • 91.68 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.5554 36
ide 36
  • 76.48 (n)
  • 89.26 (a)
ide 37
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010351 36
  • 53.65 (n)
  • 46.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ide 36
  • 52.85 (n)
  • 47.08 (a)
Ide 37
  • 46 (a)
OneToOne
Ide 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea C02G6.1 37
  • 38 (a)
OneToMany
C02G6.2 37
  • 40 (a)
OneToMany
C28F5.4 37
  • 37 (a)
OneToMany
F44E7.4 36
  • 49.98 (n)
  • 43.5 (a)
F44E7.4 37
  • 38 (a)
OneToMany
Y70C5C.1 37
  • 39 (a)
OneToMany
C02G6.1 38
  • 38 (a)
Y70C5C.1 38
  • 33 (a)
C02G6.2 38
  • 41 (a)
C28F5.4 38
  • 47 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER053C 36
  • 47.3 (n)
  • 38.45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE23 36
  • 49.2 (n)
  • 39.98 (a)
STE23 37
  • 37 (a)
OneToMany
STE23 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05105g 36
  • 49.37 (n)
  • 40.56 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G41790 36
  • 49.34 (n)
  • 39.32 (a)
rice
(Oryza sativa)
Liliopsida Os07g0570300 36
  • 49.48 (n)
  • 40.58 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00481 36
  • 49.14 (n)
  • 42.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug138 36
  • 47.94 (n)
  • 38.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
OneToMany
-- 37
  • 55 (a)
OneToMany
Species with no ortholog for IDE:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IDE Gene

ENSEMBL:
Gene Tree for IDE (if available)
TreeFam:
Gene Tree for IDE (if available)

Paralogs for IDE Gene

Paralogs for IDE Gene

Selected SIMAP similar genes for IDE Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for IDE Gene

genes like me logo Genes that share paralogs with IDE: view

Variants for IDE Gene

Sequence variations from dbSNP and Humsavar for IDE Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs489517 -- 92,459,747(+) ACATT(A/C)ATATA intron-variant
rs509954 -- 92,458,686(+) tagta(A/G)agacg intron-variant
rs520711 -- 92,460,888(+) CAGAC(A/T)GGAGT intron-variant
rs538469 -- 92,465,636(+) CATCA(A/G)AGTCT intron-variant
rs544537 -- 92,469,061(+) TGGCT(A/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IDE Gene

Variant ID Type Subtype PubMed ID
nsv508600 CNV Loss 20534489
nsv895894 CNV Loss 21882294
nsv895895 CNV Gain 21882294

Relevant External Links for IDE Gene

HapMap Linkage Disequilibrium report
IDE
Human Gene Mutation Database (HGMD)
IDE

Disorders for IDE Gene

(1) MalaCards Diseases for IDE Gene

Search for IDE Gene in MalaCards »

(1) University of Copenhagen DISEASES for IDE Gene

(18) Novoseek inferred disease relationships for IDE Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 78.8 63
senile plaques 67.5 6
late onset alzheimer disease 61.9 1
amyloid deposition 49.7 4
neurodegeneration 40.1 1

Relevant External Links for IDE

Genetic Association Database (GAD)
IDE
Human Genome Epidemiology (HuGE) Navigator
IDE
genes like me logo Genes that share disorders with IDE: view

No data available for UniProtKB/Swiss-Prot for IDE Gene

Publications for IDE Gene

  1. Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. (PMID: 2293021) Affholter J.A. … Roth R.A. (Mol. Endocrinol. 1990) 2 3 4 23
  2. Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. (PMID: 12765971) Karamohamed S. … Herbert A. (Diabetes 2003) 3 23 49
  3. Genetic variation in a haplotype block spanning IDE influences Alzheimer disease. (PMID: 14517947) Prince J.A. … Brookes A.J. (Hum. Mutat. 2003) 3 23 49
  4. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. (PMID: 15024728) Ertekin-Taner N. … Younkin S.G. (Hum. Mutat. 2004) 3 23 49
  5. Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease. (PMID: 15088150) Blomqvist M.E. … Prince J.A. (Neurogenetics 2004) 3 23 49

Products for IDE Gene

Sources for IDE Gene

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