Aliases for RSPO2 Gene
External Ids for RSPO2 Gene
Previous GeneCards Identifiers for RSPO2 Gene
This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for RSPO2 Gene
RSPO2 (R-Spondin 2) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and Regulation of FZD by ubiquitination. GO annotations related to this gene include receptor binding and G-protein coupled receptor binding. An important paralog of this gene is RSPO3.
UniProtKB/Swiss-Prot for RSPO2 Gene
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.