Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ABCB5 Gene

Aliases for ABCB5 Gene

  • ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 2 3
  • P-Glycoprotein ABCB5 2 3 4
  • ATP-Binding Cassette Protein 2 3
  • ABCB5 P-Gp 3 4
  • ATP-Binding Cassette Sub-Family B Member 5 3
  • EC 3.6.3.44 63
  • ABCB5alpha 3
  • ABCB5beta 3
  • EST422562 3
  • EC 3.6.3 63

External Ids for ABCB5 Gene

Previous GeneCards Identifiers for ABCB5 Gene

  • GC07U990157
  • GC07P020328
  • GC07P020431
  • GC07P020412
  • GC07P020460
  • GC07P020653
  • GC07P020544

Summaries for ABCB5 Gene

Entrez Gene Summary for ABCB5 Gene

  • ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ABCB5 Gene

ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and ABC-family proteins mediated transport. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances and efflux transmembrane transporter activity. An important paralog of this gene is ABCB11.

UniProtKB/Swiss-Prot for ABCB5 Gene

  • Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.

Tocris Summary for ABCB5 Gene

  • P-glycoprotein (ABCB1, MDR1) is a well-characterized human ABC transporter that was the first ABC transporter implicated in multidrug resistance. Normal physiological expression of P-glycoprotein has been found to prevent uptake of some lipophilic drugs into the brain and other key organs. P-glycoprotein is frequently overexpressed in cancer cells resulting in drugs being pumped out of the cells faster than they can enter. This causes a lower concentration of the drug in the cell and reduces the effectiveness of the drugs in killing cancer cells. Drugs that are affected by classical multidrug resistance include the vinca alkaloids (vinblastine and vincristine), the anthracyclines (doxorubicin and daunorubicin), the RNA transcription inhibitor actinomycin D and the microtubule-stabilizing drug taxol.

Gene Wiki entry for ABCB5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCB5 Gene

Genomics for ABCB5 Gene

Regulatory Elements for ABCB5 Gene

Genomic Location for ABCB5 Gene

Start:
20,615,207 bp from pter
End:
20,777,038 bp from pter
Size:
161,832 bases
Orientation:
Plus strand

Genomic View for ABCB5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCB5 Gene

Proteins for ABCB5 Gene

  • Protein details for ABCB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3G0-ABCB5_HUMAN
    Recommended name:
    ATP-binding cassette sub-family B member 5
    Protein Accession:
    Q2M3G0
    Secondary Accessions:
    • A4D131
    • A7BKA4
    • B5MD19
    • B7WPL1
    • F8QQP8
    • F8QQP9
    • J3KQ04
    • Q2M3I5
    • Q5I5Q7
    • Q5I5Q8
    • Q6KG50
    • Q6XFQ5
    • Q8IXA1

    Protein attributes for ABCB5 Gene

    Size:
    1257 amino acids
    Molecular mass:
    138641 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Acts as a marker of stem-like cells (CSC) in a number of malignancies (PubMed:24934811). Associated with clinical drug resistance, tumor progression and disease recurrence in malignant melanoma and acute leukemias. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. ABCB5-expressing cells selectively survive when exposed to dacarbazine drug, the reference treatment of metastatic melanoma, vemurafenib and other various chemotherapeutic drugs, suggesting that anti-melanoma chemotherapy participates to the chemoresistance acquisition by selecting tumor cell subpopulations expressing ABCB5 (PubMed:22784549, PubMed:22044138, PubMed:22675422, PubMed:23770371, PubMed:24934811). Present in melanoma-initiating cells that acts as an enhancer of tumor growth by promoting CSC maintenance and tumor growth by controlling IL-1beta (IL1B) secretion to maintain slow-cycling, chemoresistant cells through an IL-1beta (IL1B)/IL8/CXCR1 cytokine signaling circuit (PubMed:24934811).
    SequenceCaution:
    • Sequence=AAN76500.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ03033.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCB5 Gene

Proteomics data for ABCB5 Gene at MOPED

Selected DME Specific Peptides for ABCB5 Gene

Post-translational modifications for ABCB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABCB5 Gene

Domains for ABCB5 Gene

Gene Families for ABCB5 Gene

HGNC:
  • ABCB :ATP binding cassette transporters / subfamily B
IUPHAR :

Protein Domains for ABCB5 Gene

Graphical View of Domain Structure for InterPro Entry

Q2M3G0

UniProtKB/Swiss-Prot:

ABCB5_HUMAN :
  • Q2M3G0
Domain:
  • Contains 2 ABC transmembrane type-1 domains.
  • Contains 2 ABC transporter domains.
Family:
  • Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
genes like me logo Genes that share domains with ABCB5: view

Function for ABCB5 Gene

Molecular function for ABCB5 Gene

GENATLAS Biochemistry: ATP binding cassette superfamily,subfamily B (MDR/TAP),member 5,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.

Enzyme Numbers (IUBMB) for ABCB5 Gene

Gene Ontology (GO) - Molecular Function for ABCB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0015562 efflux transmembrane transporter activity IDA 12960149
GO:0016887 ATPase activity --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA --
genes like me logo Genes that share ontologies with ABCB5: view
genes like me logo Genes that share phenotypes with ABCB5: view

Animal Model Products

CRISPR Products

miRNA for ABCB5 Gene

miRTarBase miRNAs that target ABCB5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ABCB5 Gene

Localization for ABCB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCB5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCB5 Gene COMPARTMENTS Subcellular localization image for ABCB5 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ABCB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 12960149
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ABCB5: view

Pathways for ABCB5 Gene

genes like me logo Genes that share pathways with ABCB5: view

Pathways by source for ABCB5 Gene

1 KEGG pathway for ABCB5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ABCB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IBA --
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IBA --
GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent IBA --
GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I IBA --
GO:0006200 obsolete ATP catabolic process --
genes like me logo Genes that share ontologies with ABCB5: view

Compounds for ABCB5 Gene

(5) Tocris Compounds for ABCB5 Gene

Compound Action Cas Number
Fumitremorgin C Inhibitor of BCRP-mediated multidrug resistance [118974-02-0]
Ko 143 Potent and selective BCRP inhibitor [461054-93-3]
Probenecid MRP inhibitor [57-66-9]
PSC 833 Inhibitor of P-gp-mediated MDR [121584-18-7]
Reversan Selective MRP1 and P-gp inhibitor [313397-13-6]
genes like me logo Genes that share compounds with ABCB5: view

Transcripts for ABCB5 Gene

Unigene Clusters for ABCB5 Gene

ATP-binding cassette, sub-family B (MDR/TAP), member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ABCB5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCB5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -
SP2: -
SP3: -

Relevant External Links for ABCB5 Gene

GeneLoc Exon Structure for
ABCB5
ECgene alternative splicing isoforms for
ABCB5

Expression for ABCB5 Gene

mRNA expression in normal human tissues for ABCB5 Gene

mRNA differential expression in normal tissues according to GTEx for ABCB5 Gene

This gene is overexpressed in Breast - Mammary Tissue (11.4), Adipose - Subcutaneous (7.8), Cervix - Ectocervix (6.6), and Adipose - Visceral (Omentum) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ABCB5 Gene

SOURCE GeneReport for Unigene cluster for ABCB5 Gene Hs.404102

mRNA Expression by UniProt/SwissProt for ABCB5 Gene

Q2M3G0-ABCB5_HUMAN
Tissue specificity: Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.
genes like me logo Genes that share expressions with ABCB5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ABCB5 Gene

Orthologs for ABCB5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCB5 35
  • 98.75 (n)
  • 98.33 (a)
ABCB5 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABCB5 36
  • 88 (a)
OneToOne
LOC536724 35
  • 89.84 (n)
  • 87.67 (a)
dog
(Canis familiaris)
Mammalia ABCB5 35
  • 89.18 (n)
  • 86.98 (a)
ABCB5 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcb5 35
  • 82.32 (n)
  • 78.23 (a)
Abcb5 16
Abcb5 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcb5 35
  • 81.34 (n)
  • 78.31 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485969 35
  • 64.56 (n)
  • 61.2 (a)
zebrafish
(Danio rerio)
Actinopterygii abcb5 36
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10226 36
  • 36 (a)
ManyToMany
Mdr49 36
  • 39 (a)
ManyToMany
Mdr50 36
  • 38 (a)
ManyToMany
Mdr65 36
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pgp-10 36
  • 28 (a)
ManyToMany
pgp-11 36
  • 30 (a)
ManyToMany
pgp-12 36
  • 34 (a)
ManyToMany
pgp-13 36
  • 33 (a)
ManyToMany
pgp-14 36
  • 34 (a)
ManyToMany
pgp-3 36
  • 37 (a)
ManyToMany
pgp-5 36
  • 35 (a)
ManyToMany
pgp-6 36
  • 36 (a)
ManyToMany
pgp-7 36
  • 36 (a)
ManyToMany
pgp-8 36
  • 34 (a)
ManyToMany
pgp-9 36
  • 41 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE6 36
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PGP13 35
  • 49.33 (n)
  • 39.43 (a)
rice
(Oryza sativa)
Liliopsida Os.41637 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
Species with no ortholog for ABCB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCB5 Gene

ENSEMBL:
Gene Tree for ABCB5 (if available)
TreeFam:
Gene Tree for ABCB5 (if available)

Paralogs for ABCB5 Gene

Paralogs for ABCB5 Gene

Selected SIMAP similar genes for ABCB5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ABCB5: view

Variants for ABCB5 Gene

Sequence variations from dbSNP and Humsavar for ABCB5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs740292 -- 20,754,442(+) ttcag(C/T)tatca intron-variant
rs756885 -- 20,647,287(+) TAATC(A/G)AAAGT intron-variant, upstream-variant-2KB
rs916737 -- 20,649,797(+) CTCTT(A/C)ATTTA intron-variant
rs916738 -- 20,649,872(+) TATTA(C/T)TACAC intron-variant
rs916739 -- 20,664,514(+) TTTTT(A/G)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCB5 Gene

Variant ID Type Subtype PubMed ID
esv2663031 CNV Deletion 23128226
esv2734105 CNV Deletion 23290073
nsv522999 CNV Loss 19592680
esv2734107 CNV Deletion 23290073
esv2306944 CNV Deletion 18987734
esv2734108 CNV Deletion 23290073
esv2551418 CNV Deletion 19546169
nsv522599 CNV Loss 19592680
nsv511370 CNV Loss 21212237
nsv5651 CNV Loss 18451855
nsv517268 CNV Loss 19592680
esv1003420 CNV Deletion 20482838
esv2654247 CNV Deletion 19546169
nsv511951 CNV Loss 21212237
esv2340535 CNV Deletion 18987734
nsv514408 CNV Loss 21397061
esv2734109 CNV Deletion 23290073
dgv1187e199 CNV Deletion 23128226
nsv499219 CNV Loss 21111241
esv29258 CNV Loss 19812545
esv2474858 CNV Loss 19546169
nsv524866 CNV Loss 19592680
esv2668344 CNV Deletion 23128226
nsv887837 CNV Loss 21882294

Relevant External Links for ABCB5 Gene

HapMap Linkage Disequilibrium report
ABCB5
Human Gene Mutation Database (HGMD)
ABCB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCB5 Gene

Disorders for ABCB5 Gene

(1) University of Copenhagen DISEASES for ABCB5 Gene

Relevant External Links for ABCB5

Genetic Association Database (GAD)
ABCB5
Human Genome Epidemiology (HuGE) Navigator
ABCB5
genes like me logo Genes that share disorders with ABCB5: view

No data available for UniProtKB/Swiss-Prot for ABCB5 Gene

Publications for ABCB5 Gene

  1. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. (PMID: 12960149) Frank N.Y. … Frank M.H. (J. Biol. Chem. 2003) 2 3 4
  2. Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. (PMID: 15205344) Huang Y. … Sadee W. (Cancer Res. 2004) 3 4
  3. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. (PMID: 8894702) Allikmets R. … Dean M. (Hum. Mol. Genet. 1996) 2 3
  4. ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. (PMID: 21652540) Wilson B.J. … Frank N.Y. (Cancer Res. 2011) 3 4
  5. Expression of ABCB5 gene in hematological malignances and its significance. (PMID: 22044138) Yang M. … Xiong D. (Leuk. Lymphoma 2012) 3 4

Products for ABCB5 Gene

Sources for ABCB5 Gene

Back to Top

Content