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Aliases for ID4 Gene

Aliases for ID4 Gene

  • Inhibitor Of DNA Binding 4, HLH Protein 2 3 5
  • Inhibitor Of Differentiation 4 2 3 4
  • Inhibitor Of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein 2 3
  • Class B Basic Helix-Loop-Helix Protein 27 3 4
  • BHLHb27 3 4
  • DNA-Binding Protein Inhibitor ID-4 3
  • Inhibitor Of DNA Binding 4 4
  • IDB4 3

External Ids for ID4 Gene

Previous GeneCards Identifiers for ID4 Gene

  • GC06P019895
  • GC06P019945
  • GC06P019782

Summaries for ID4 Gene

Entrez Gene Summary for ID4 Gene

  • This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis. [provided by RefSeq, Aug 2017]

GeneCards Summary for ID4 Gene

ID4 (Inhibitor Of DNA Binding 4, HLH Protein) is a Protein Coding gene. Diseases associated with ID4 include Mesomelic Dysplasia, Savarirayan Type and Aplastic Anemia. Among its related pathways are Circadian rythm related genes and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and RNA polymerase II transcription factor binding. An important paralog of this gene is ID2.

UniProtKB/Swiss-Prot for ID4 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).

Gene Wiki entry for ID4 Gene

Additional gene information for ID4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ID4 Gene

Genomics for ID4 Gene

GeneHancer (GH) Regulatory Elements for ID4 Gene

Promoters and enhancers for ID4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I019836 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 555.2 +0.7 688 3.2 FOXA2 SIN3A GLI4 ZNF2 GLIS2 ZNF213 SP3 ZNF610 GLIS1 ZNF624 ID4 LOC100506885 GC06M019417 GC06M019801
GH06I019802 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 18 -32.8 -32766 3.3 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF213 LOC100506885 ID4 CDKAL1 PIR47063 GC06M019684 GC06M019417 GC06M019801
GH06I019811 Enhancer 0.8 ENCODE 12.1 -25.7 -25690 1.2 CTCF ELF3 SOX13 FOXA2 ZNF792 SAP130 ARID4B ZNF384 CEBPG DNMT3B LOC100506885 ID4 LOC105374963 GC06M019417 GC06M019801
GH06I019812 Enhancer 0.5 ENCODE 12.1 -24.7 -24665 0.2 CTCF HNF1A SMC3 RUNX3 RAD21 LOC100506885 ID4 LOC105374963 GC06M019417 GC06M019801
GH06I019415 Enhancer 0.5 ENCODE 12 -420.4 -420435 3.4 GATA3 JUND FOSL2 FOS ID4 PIR52560 PIR51845 GC06M019416 LOC100506885 GC06M019417
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ID4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ID4 gene promoter:

Genomic Locations for ID4 Gene

Genomic Locations for ID4 Gene
chr6:19,837,370-19,842,200
(GRCh38/hg38)
Size:
4,831 bases
Orientation:
Plus strand
chr6:19,837,617-19,840,915
(GRCh37/hg19)

Genomic View for ID4 Gene

Genes around ID4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ID4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ID4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID4 Gene

Proteins for ID4 Gene

  • Protein details for ID4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47928-ID4_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-4
    Protein Accession:
    P47928
    Secondary Accessions:
    • Q13005

    Protein attributes for ID4 Gene

    Size:
    161 amino acids
    Molecular mass:
    16622 Da
    Quaternary structure:
    • Heterodimer with other HLH proteins.

neXtProt entry for ID4 Gene

Post-translational modifications for ID4 Gene

No Post-translational modifications

Other Protein References for ID4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ID4 Gene

Domains & Families for ID4 Gene

Gene Families for ID4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ID4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ID4: view

No data available for UniProtKB/Swiss-Prot for ID4 Gene

Function for ID4 Gene

Molecular function for ID4 Gene

GENATLAS Biochemistry:
inhibitor of DNA binding 4,mouse Id-4 related,antagonist of MyoD activity or creatine kinase enhancer,mainly expressed in thyroid,brain and fetal tissue and in some nervous system tumor cell lines
UniProtKB/Swiss-Prot Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).

Phenotypes From GWAS Catalog for ID4 Gene

Gene Ontology (GO) - Molecular Function for ID4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IEA --
GO:0003714 transcription corepressor activity TAS 7665172
GO:0005515 protein binding IPI 17474147
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ID4: view
genes like me logo Genes that share phenotypes with ID4: view

Animal Models for ID4 Gene

MGI Knock Outs for ID4:

miRNA for ID4 Gene

miRTarBase miRNAs that target ID4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ID4 Gene

Localization for ID4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID4 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ID4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ID4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ID4: view

Pathways & Interactions for ID4 Gene

genes like me logo Genes that share pathways with ID4: view

Pathways by source for ID4 Gene

Gene Ontology (GO) - Biological Process for ID4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 7665172
genes like me logo Genes that share ontologies with ID4: view

No data available for SIGNOR curated interactions for ID4 Gene

Drugs & Compounds for ID4 Gene

No Compound Related Data Available

Transcripts for ID4 Gene

mRNA/cDNA for ID4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(358) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ID4 Gene

Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ID4 Gene

No ASD Table

Relevant External Links for ID4 Gene

GeneLoc Exon Structure for
ID4
ECgene alternative splicing isoforms for
ID4

Expression for ID4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ID4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ID4 Gene

This gene is overexpressed in Artery - Coronary (x4.7).

Protein differential expression in normal tissues from HIPED for ID4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ID4 Gene



Protein tissue co-expression partners for ID4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ID4 Gene:

ID4

SOURCE GeneReport for Unigene cluster for ID4 Gene:

Hs.519601

Evidence on tissue expression from TISSUES for ID4 Gene

  • Nervous system(4.4)
  • Lung(3.7)
  • Thyroid gland(2.6)
genes like me logo Genes that share expression patterns with ID4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ID4 Gene

Orthologs for ID4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Id4 33 16 34
  • 93.17 (n)
rat
(Rattus norvegicus)
Mammalia Id4 33
  • 92.96 (n)
oppossum
(Monodelphis domestica)
Mammalia ID4 34
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ID4 34
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ID4 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ID4 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ID1 34
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ID4 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia id4 33
  • 73.08 (n)
Str.5460 33
African clawed frog
(Xenopus laevis)
Amphibia idb4-prov 33
zebrafish
(Danio rerio)
Actinopterygii id4 33 34
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta emc 34
  • 7 (a)
OneToMany
Species where no ortholog for ID4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID4 Gene

ENSEMBL:
Gene Tree for ID4 (if available)
TreeFam:
Gene Tree for ID4 (if available)

Paralogs for ID4 Gene

Paralogs for ID4 Gene

(3) SIMAP similar genes for ID4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ID4: view

Variants for ID4 Gene

Sequence variations from dbSNP and Humsavar for ID4 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001068749 -- 19,838,758(+) C/T intron_variant
rs1001213342 -- 19,839,827(+) T/C 3_prime_UTR_variant
rs1001762212 -- 19,835,500(+) C/T upstream_transcript_variant
rs1002166679 -- 19,839,948(+) TTTT/TT 3_prime_UTR_variant
rs1002616573 -- 19,839,228(+) C/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ID4 Gene

Variant ID Type Subtype PubMed ID
esv23665 CNV loss 19812545
nsv601089 CNV loss 21841781
nsv601090 CNV loss 21841781
nsv819869 CNV gain 19587683

Variation tolerance for ID4 Gene

Gene Damage Index Score: 0.78; 16.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ID4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ID4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ID4 Gene

Disorders for ID4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ID4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mesomelic dysplasia, savarirayan type
  • mesomelic dysplasia with absent fibulas and triangular tibias
aplastic anemia
  • aplastic anemia, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search ID4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ID4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ID4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ID4 Gene

Publications for ID4 Gene

  1. Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. (PMID: 7665172) Pagliuca A … Lania L (Genomics 1995) 2 3 4 22 58
  2. cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. (PMID: 9872455) Rigolet M … Junien C (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 22 58
  3. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber MJ … Krauss RM (PloS one 2010) 3 44 58
  4. [Preliminary study on difference of Id4 gene methylation in various types of myelodysplastic syndromes]. (PMID: 19549375) Zhao Y … Yu L (Zhongguo shi yan xue ye xue za zhi 2009) 3 22 58
  5. [Preliminary study on Id4 as a reporter for all patients before relapse]. (PMID: 18928580) Zhao Y … Yu L (Zhongguo shi yan xue ye xue za zhi 2008) 3 22 58

Products for ID4 Gene

Sources for ID4 Gene

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