Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ID3 Gene

Aliases for ID3 Gene

  • Inhibitor Of DNA Binding 3, HLH Protein 2 3 5
  • Inhibitor Of Differentiation 3 2 3 4
  • Inhibitor Of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein 2 3
  • Class B Basic Helix-Loop-Helix Protein 25 3 4
  • ID-Like Protein Inhibitor HLH 1R21 3 4
  • Helix-Loop-Helix Protein HEIR-1 3 4
  • BHLHb25 3 4
  • DNA-Binding Protein Inhibitor ID-3 3
  • Inhibitor Of DNA Binding 3 4
  • HEIR-1 3
  • HEIR1 4
  • 1R21 4

External Ids for ID3 Gene

Previous GeneCards Identifiers for ID3 Gene

  • GC01M023442
  • GC01M022955
  • GC01M023353
  • GC01M023629
  • GC01M023756
  • GC01M023884
  • GC01M022134

Summaries for ID3 Gene

Entrez Gene Summary for ID3 Gene

  • The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

GeneCards Summary for ID3 Gene

ID3 (Inhibitor Of DNA Binding 3, HLH Protein) is a Protein Coding gene. Diseases associated with ID3 include Fibrodysplasia Ossificans Progressiva. Among its related pathways are Circadian rythm related genes and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is ID4.

UniProtKB/Swiss-Prot for ID3 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

Gene Wiki entry for ID3 Gene

Additional gene information for ID3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ID3 Gene

Genomics for ID3 Gene

GeneHancer (GH) Regulatory Elements for ID3 Gene

Promoters and enhancers for ID3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I023553 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.8 +0.6 573 12.2 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ID3 GC01M023559 GC01M023560 LOC105376859 PIR53087 SRSF10 LINC01355 RPL11 MDS2 E2F2
GH01I023521 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 +31.1 31110 13.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 E2F2 GC01P023526 SRSF10 LINC01355 ASAP3 ID3 ZNF436 KDM1A ELOA TCEA3
GH01I023589 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -36.5 -36522 14.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A IRF4 ZNF766 ZNF143 FOS PIR62098 SRSF10 LINC01355 E2F2 ELOA HNRNPR PNRC2 ID3 ZNF436 RPL11
GH01I023634 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -75.5 -75507 1.8 HDGF ARNT ARID4B SIN3A ZNF2 IRF4 ZNF121 GLIS2 ZNF213 ZNF143 MDS2 ID3 GC01P023610 LOC729856
GH01I023637 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.7 -78.0 -77952 0.8 ATF1 ARID4B ZNF2 IRF4 ARID2 ZNF143 ATF7 RUNX3 DEK NCOA1 MDS2 ID3 GC01P023610 LOC729856
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ID3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ID3 gene promoter:

Genomic Locations for ID3 Gene

Genomic Locations for ID3 Gene
chr1:23,557,918-23,559,794
(GRCh38/hg38)
Size:
1,877 bases
Orientation:
Minus strand
chr1:23,884,409-23,886,322
(GRCh37/hg19)

Genomic View for ID3 Gene

Genes around ID3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ID3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ID3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID3 Gene

Proteins for ID3 Gene

  • Protein details for ID3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02535-ID3_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-3
    Protein Accession:
    Q02535
    Secondary Accessions:
    • A8K1T8
    • O75641

    Protein attributes for ID3 Gene

    Size:
    119 amino acids
    Molecular mass:
    12999 Da
    Quaternary structure:
    • Homodimer, and heterodimer with other HLH proteins. Interacts with COPS5 and COPS7A. Interacts with IFI204. Interacts with GATA4 and NKX2-5. Interacts with ANKRD2; both proteins cooperate in myoblast differentiation (By similarity). Interacts with CLOCK and ARNTL/BMAL1.
    SequenceCaution:
    • Sequence=CAA47360.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ID3 Gene

neXtProt entry for ID3 Gene

Post-translational modifications for ID3 Gene

Other Protein References for ID3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ID3 Gene

Domains & Families for ID3 Gene

Gene Families for ID3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ID3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ID3: view

No data available for UniProtKB/Swiss-Prot for ID3 Gene

Function for ID3 Gene

Molecular function for ID3 Gene

GENATLAS Biochemistry:
inhibitor of DNA binding 3,mouse ld-3 related,expressed during early development and in adult tissues,inhibing transcription factors of the basic helix loop helix family, required for neurogenesis and angiogenesis
UniProtKB/Swiss-Prot Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
UniProtKB/Swiss-Prot Induction:
By phorbol 12-myristate 13-acetate (PMA).

Phenotypes From GWAS Catalog for ID3 Gene

Gene Ontology (GO) - Molecular Function for ID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity IEA --
GO:0003714 transcription corepressor activity TAS 8437843
GO:0005515 protein binding IPI 20861012
GO:0008134 transcription factor binding IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with ID3: view
genes like me logo Genes that share phenotypes with ID3: view

Animal Models for ID3 Gene

MGI Knock Outs for ID3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ID3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ID3 Gene

Localization for ID3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID3 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ID3 gene
Compartment Confidence
nucleus 5
extracellular 3
cytoskeleton 3
mitochondrion 2
cytosol 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IC --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ID3: view

Pathways & Interactions for ID3 Gene

genes like me logo Genes that share pathways with ID3: view

Pathways by source for ID3 Gene

SIGNOR curated interactions for ID3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ID3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001656 metanephros development IEA --
GO:0006275 regulation of DNA replication IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ID3: view

Drugs & Compounds for ID3 Gene

(3) Drugs for ID3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Creatine Approved, Investigational Nutra 139

(1) Additional Compounds for ID3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ID3: view

Transcripts for ID3 Gene

mRNA/cDNA for ID3 Gene

Unigene Clusters for ID3 Gene

Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ID3

Alternative Splicing Database (ASD) splice patterns (SP) for ID3 Gene

No ASD Table

Relevant External Links for ID3 Gene

GeneLoc Exon Structure for
ID3
ECgene alternative splicing isoforms for
ID3

Expression for ID3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ID3 Gene

Protein differential expression in normal tissues from HIPED for ID3 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ID3 Gene



Protein tissue co-expression partners for ID3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ID3 Gene:

ID3

SOURCE GeneReport for Unigene cluster for ID3 Gene:

Hs.76884

mRNA Expression by UniProt/SwissProt for ID3 Gene:

Q02535-ID3_HUMAN
Tissue specificity: Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.

Evidence on tissue expression from TISSUES for ID3 Gene

  • Skin(4.8)
  • Nervous system(4.8)
  • Blood(4.3)
  • Thyroid gland(2.8)
  • Lung(2.6)
  • Muscle(2.5)
  • Eye(2.3)
  • Heart(2.3)
  • Intestine(2)
  • Kidney(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ID3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ID3 Gene

Orthologs for ID3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ID3 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia ID3 33 34
  • 92.16 (n)
cow
(Bos Taurus)
Mammalia ID3 33 34
  • 91.6 (n)
mouse
(Mus musculus)
Mammalia Id3 33 16 34
  • 88.52 (n)
rat
(Rattus norvegicus)
Mammalia Id3 33
  • 87.96 (n)
oppossum
(Monodelphis domestica)
Mammalia ID3 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ID3 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ID3 33 34
  • 69.49 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia id3 33
  • 64.04 (n)
zebrafish
(Danio rerio)
Actinopterygii id3 33 34
  • 60.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta emc 34
  • 5 (a)
OneToMany
Species where no ortholog for ID3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID3 Gene

ENSEMBL:
Gene Tree for ID3 (if available)
TreeFam:
Gene Tree for ID3 (if available)

Paralogs for ID3 Gene

Paralogs for ID3 Gene

(3) SIMAP similar genes for ID3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ID3: view

Variants for ID3 Gene

Sequence variations from dbSNP and Humsavar for ID3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000046510 -- 23,560,623(-) C/T upstream_transcript_variant
rs1000949440 -- 23,557,873(-) G/A downstream_transcript_variant
rs1001053944 -- 23,557,477(-) T/C downstream_transcript_variant
rs1001103507 -- 23,561,649(-) C/A upstream_transcript_variant
rs1001497265 -- 23,559,821(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ID3 Gene

Variant ID Type Subtype PubMed ID
nsv834435 CNV loss 17160897

Variation tolerance for ID3 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.13; 61.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ID3 Gene

Human Gene Mutation Database (HGMD)
ID3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ID3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ID3 Gene

Disorders for ID3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ID3 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
fibrodysplasia ossificans progressiva
  • fop
- elite association - COSMIC cancer census association via MalaCards
Search ID3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ID3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ID3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ID3 Gene

Publications for ID3 Gene

  1. Structural organisation and chromosomal mapping of the human Id-3 gene. (PMID: 7828896) Deed RW … Norton JD (Gene 1994) 3 4 22 58
  2. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. (PMID: 1628620) Ellmeier W … Weith A (The EMBO journal 1992) 2 3 4 58
  3. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. (PMID: 20861012) Ward SM … Duffield GE (The Journal of biological chemistry 2010) 3 4 58
  4. Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans. (PMID: 20185798) Doran AC … McNamara CA (Circulation research 2010) 3 44 58
  5. UVB upregulates the bax promoter in immortalized human keratinocytes via ROS induction of Id3. (PMID: 19054058) Trabosh VA … Rosenthal DS (Experimental dermatology 2009) 3 22 58

Products for ID3 Gene

Sources for ID3 Gene

Content
Loading form....