Aliases for ID2 Gene
External Ids for ID2 Gene
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
GeneCards Summary for ID2 Gene
ID2 (Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein) is a Protein Coding gene. Diseases associated with ID2 include congenital hydronephrosis and diamond-blackfan anemia. Among its related pathways are Hippo signaling pathway and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include protein dimerization activity and ion channel binding. An important paralog of this gene is ID3.
UniProtKB/Swiss-Prot for ID2 Gene
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.