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Aliases for ID2 Gene

Aliases for ID2 Gene

  • Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein 2 3
  • Class B Basic Helix-Loop-Helix Protein 26 3 4
  • Inhibitor Of Differentiation 2 3 4
  • Cell Growth-Inhibiting Gene 8 2 3
  • BHLHb26 3 4
  • DNA-Binding Protein Inhibitor ID-2 3
  • DNA-Binding Protein Inhibitor ID2 3
  • Helix-Loop-Helix Protein ID2 3
  • Inhibitor Of DNA Binding 2 4
  • GIG8 3
  • ID2A 3
  • ID2H 3

External Ids for ID2 Gene

Previous GeneCards Identifiers for ID2 Gene

  • GC02P008605
  • GC02P008873
  • GC02P008843
  • GC02P008818

Summaries for ID2 Gene

Entrez Gene Summary for ID2 Gene

  • The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

GeneCards Summary for ID2 Gene

ID2 (Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein) is a Protein Coding gene. Diseases associated with ID2 include congenital hydronephrosis and diamond-blackfan anemia. Among its related pathways are Hippo signaling pathway and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include protein dimerization activity and ion channel binding. An important paralog of this gene is ID3.

UniProtKB/Swiss-Prot for ID2 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Gene Wiki entry for ID2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ID2 Gene

Genomics for ID2 Gene

Regulatory Elements for ID2 Gene

Genomic Location for ID2 Gene

Start:
8,678,845 bp from pter
End:
8,684,453 bp from pter
Size:
5,609 bases
Orientation:
Plus strand

Genomic View for ID2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID2 Gene

Proteins for ID2 Gene

  • Protein details for ID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02363-ID2_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-2
    Protein Accession:
    Q02363
    Secondary Accessions:

    Protein attributes for ID2 Gene

    Size:
    134 amino acids
    Molecular mass:
    14917 Da
    Quaternary structure:
    • Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5 (By similarity). Interacts with NR0B2. Interacts with CLOCK and ARNTL/BMAL1.

    Three dimensional structures from OCA and Proteopedia for ID2 Gene

neXtProt entry for ID2 Gene

Proteomics data for ID2 Gene at MOPED

Post-translational modifications for ID2 Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for ID2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ID2 Gene

Domains for ID2 Gene

Gene Families for ID2 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for ID2 Gene

Graphical View of Domain Structure for InterPro Entry

Q02363

UniProtKB/Swiss-Prot:

ID2_HUMAN :
  • Q02363
Domain:
  • The bHLH domain is essential for its repressor activity towards the CLOCK-ARNTL/BMAL1 heterodimer.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ID2: view

Function for ID2 Gene

Molecular function for ID2 Gene

GENATLAS Biochemistry: inhibitor of DNA binding 2,putative transcription regulator,expressed during early development,inhibiting transcription factors of the basic helix loop helix family
UniProtKB/Swiss-Prot Function: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Gene Ontology (GO) - Molecular Function for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10915743
GO:0044325 ion channel binding IPI 16311606
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ID2: view
genes like me logo Genes that share phenotypes with ID2: view

Animal Models for ID2 Gene

MGI Knock Outs for ID2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ID2 Gene

Localization for ID2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ID2 Gene COMPARTMENTS Subcellular localization image for ID2 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA 16311606
GO:0005654 nucleoplasm IDA --
GO:0005737 colocalizes_with cytoplasm IDA 16311606
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with ID2: view

Pathways for ID2 Gene

genes like me logo Genes that share pathways with ID2: view

Gene Ontology (GO) - Biological Process for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001656 metanephros development IEA --
GO:0001779 natural killer cell differentiation IEA --
GO:0002521 leukocyte differentiation --
GO:0003149 membranous septum morphogenesis IEA --
genes like me logo Genes that share ontologies with ID2: view

Compounds for ID2 Gene

(9) Novoseek inferred chemical compound relationships for ID2 Gene

Compound -log(P) Hits PubMed IDs
vegf 21.4 6
phosphatidylinositol 11.1 1
bromodeoxyuridine 9.61 1
oligonucleotide 9.04 1
retinoic acid 8.53 4
genes like me logo Genes that share compounds with ID2: view

Transcripts for ID2 Gene

mRNA/cDNA for ID2 Gene

Unigene Clusters for ID2 Gene

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ID2 Gene

No ASD Table

Relevant External Links for ID2 Gene

GeneLoc Exon Structure for
ID2
ECgene alternative splicing isoforms for
ID2

Expression for ID2 Gene

mRNA expression in normal human tissues for ID2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ID2 Gene

This gene is overexpressed in Artery - Tibial (6.6) and Liver (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ID2 Gene

SOURCE GeneReport for Unigene cluster for ID2 Gene Hs.180919

mRNA Expression by UniProt/SwissProt for ID2 Gene

Q02363-ID2_HUMAN
Tissue specificity: Highly expressed in early fetal tissues, including those of the central nervous system
genes like me logo Genes that share expressions with ID2: view

Orthologs for ID2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ID2 35
  • 99.54 (n)
  • 100 (a)
ID2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ID2 35
  • 94.53 (n)
  • 98.51 (a)
ID2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Id2 35
  • 95.02 (n)
  • 98.51 (a)
Id2 16
Id2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ID2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ID2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Id2 35
  • 94.03 (n)
  • 97.76 (a)
chicken
(Gallus gallus)
Aves ID2 35
  • 86.32 (n)
  • 94.03 (a)
ID2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ID2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia id2 35
tropical clawed frog
(Silurana tropicalis)
Amphibia id2 35
  • 79.13 (n)
  • 83.97 (a)
MGC75823 35
zebrafish
(Danio rerio)
Actinopterygii id2 35
id2a 35
  • 77.61 (n)
  • 82.44 (a)
id2a 36
  • 78 (a)
OneToMany
id2b 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta emc 36
  • 7 (a)
OneToMany
Species with no ortholog for ID2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID2 Gene

ENSEMBL:
Gene Tree for ID2 (if available)
TreeFam:
Gene Tree for ID2 (if available)

Paralogs for ID2 Gene

Paralogs for ID2 Gene

Selected SIMAP similar genes for ID2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ID2 Gene

genes like me logo Genes that share paralogs with ID2: view

Variants for ID2 Gene

Sequence variations from dbSNP and Humsavar for ID2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1802549 -- 8,683,960(+) ATGGG(A/G)AGCGA utr-variant-3-prime
rs1802550 -- 8,683,965(+) GAGCG(A/G)AAACG utr-variant-3-prime
rs3900795 -- 8,684,857(-) GTACA(A/G)CCTCT downstream-variant-500B
rs4487066 -- 8,684,861(+) GCTGT(A/G)CAGAA downstream-variant-500B
rs6724553 -- 8,684,554(+) ACACA(C/T)ATTGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ID2 Gene

Variant ID Type Subtype PubMed ID
nsv873614 CNV Loss 21882294
nsv873615 CNV Loss 21882294
nsv873616 CNV Loss 21882294

Relevant External Links for ID2 Gene

HapMap Linkage Disequilibrium report
ID2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ID2 Gene

Disorders for ID2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ID2 Gene including...

Search for ID2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ID2 Gene

(15) Novoseek inferred disease relationships for ID2 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 56.4 11
ewings sarcoma 41.7 10
tumors 38.2 37
cancer 12.2 6
lymphoma 10.4 4

Relevant External Links for ID2

Genetic Association Database (GAD)
ID2
Human Genome Epidemiology (HuGE) Navigator
ID2
genes like me logo Genes that share disorders with ID2: view

No data available for UniProtKB/Swiss-Prot for ID2 Gene

Publications for ID2 Gene

  1. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PMID: 8294468) Hara E. … Oda K. (J. Biol. Chem. 1994) 2 3 4
  2. The helix-loop-helix protein Id2 is expressed differentially and induced by myc in T-cell lymphomas. (PMID: 18085637) Cotta C.V. … Rassidakis G.Z. (Cancer 2008) 3 23
  3. RFX1 mediates the serum-induced immediate early response of Id2 gene expression. (PMID: 17630394) Wang K.R. … Yokota Y. (J. Biol. Chem. 2007) 3 23
  4. Interleukin-1 beta-induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells. (PMID: 17631285) Zhu X. … Chen Y.E. (Cardiovasc. Res. 2007) 3 23
  5. Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone. (PMID: 19010462) Weigent D.A. (Cell. Immunol. 2009) 3 23

Products for ID2 Gene

Sources for ID2 Gene

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