Aliases for IRF8 Gene
External Ids for IRF8 Gene
Previous HGNC Symbols for IRF8 Gene
Previous GeneCards Identifiers for IRF8 Gene
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRF8 Gene
IRF8 (Interferon Regulatory Factor 8) is a Protein Coding gene. Diseases associated with IRF8 include Immunodeficiency 32A, Mycobacteriosis, Autosomal Dominant and Immunodeficiency 32B, Monocyte And Dendritic Cell Deficiency, Autosomal Recessive. Among its related pathways are NF-kappaB Signaling and Immune System. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and regulatory region DNA binding. An important paralog of this gene is IRF3.
UniProtKB/Swiss-Prot for IRF8 Gene
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).