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Aliases for ICAM1 Gene

Aliases for ICAM1 Gene

  • Intercellular Adhesion Molecule 1 2 3
  • Major Group Rhinovirus Receptor 3 4
  • ICAM-1 3 4
  • Intercellular Adhesion Molecule 1 (CD54), Human Rhinovirus Receptor 3
  • Cell Surface Glycoprotein P3.58 3
  • Human Rhinovirus Receptor 2
  • CD54 Antigen 4
  • P3.58 3
  • CD54 3
  • BB2 3

External Ids for ICAM1 Gene

Summaries for ICAM1 Gene

Entrez Gene Summary for ICAM1 Gene

  • This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM1 Gene

ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include folliculotropic mycosis fungoides and lupus erythematosus tumidus. Among its related pathways are Class I MHC mediated antigen processing and presentation and Integrin Pathway. GO annotations related to this gene include receptor activity and integrin binding. An important paralog of this gene is ICAM2.

UniProtKB/Swiss-Prot for ICAM1 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Gene Wiki entry for ICAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM1 Gene

Genomics for ICAM1 Gene

Genomic Location for ICAM1 Gene

Start:
10,270,835 bp from pter
End:
10,286,615 bp from pter
Size:
15,781 bases
Orientation:
Plus strand

Genomic View for ICAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM1 Gene

Proteins for ICAM1 Gene

  • Protein details for ICAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05362-ICAM1_HUMAN
    Recommended name:
    Intercellular adhesion molecule 1
    Protein Accession:
    P05362
    Secondary Accessions:
    • B2R6M3
    • Q5NKV7
    • Q96B50

    Protein attributes for ICAM1 Gene

    Size:
    532 amino acids
    Molecular mass:
    57825 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.

    Three dimensional structures from OCA and Proteopedia for ICAM1 Gene

neXtProt entry for ICAM1 Gene

Proteomics data for ICAM1 Gene at MOPED

Post-translational modifications for ICAM1 Gene

  • Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ile60, Asn130, Asn145, Asn183, Asn202, Asn267, Asn296, Asn385, and Asn406

Other Protein References for ICAM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ICAM1 Gene

Domains for ICAM1 Gene

Gene Families for ICAM1 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

UniProtKB/Swiss-Prot:

ICAM1_HUMAN
Domain:
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.:
    • P05362
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.:
    • P05362
genes like me logo Genes that share domains with ICAM1: view

Function for ICAM1 Gene

Molecular function for ICAM1 Gene

GENATLAS Biochemistry: adhesion molecule,intercellular 1,ligand for LFA1 (CD11A/CD18),expressed on vascular endothelium and leukocytes,up-regulated by cytokines,inhibiting interleukin 4 production by naive T cells,also interacting with ezrin VIL2 and ICAM2 in microvillar projections under phosphatidylinositol-4,5 biphosphate regulation,human rhinovirus receptor with some allele(s) predisposing to cerebral malaria,also contributing to multiple sclerosis susceptibility
UniProtKB/Swiss-Prot Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Gene Ontology (GO) - Molecular Function for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity TAS 2538243
GO:0004888 transmembrane signaling receptor activity TAS 2538243
GO:0005178 integrin binding IPI 1448173
GO:0005515 protein binding IPI 12716892
genes like me logo Genes that share ontologies with ICAM1: view
genes like me logo Genes that share phenotypes with ICAM1: view

Animal Models for ICAM1 Gene

MGI Knock Outs for ICAM1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ICAM1 Gene

Localization for ICAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICAM1 Gene COMPARTMENTS Subcellular localization image for ICAM1 gene
Compartment Confidence
extracellular 4
plasma membrane 4
cytoskeleton 3
nucleus 3
cytosol 1
endoplasmic reticulum 1
endosome 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2538243
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ICAM1: view

Pathways for ICAM1 Gene

genes like me logo Genes that share pathways with ICAM1: view

Gene Ontology (GO) - Biological Process for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001666 response to hypoxia --
GO:0001910 regulation of leukocyte mediated cytotoxicity TAS 16038038
GO:0001975 response to amphetamine IEA --
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
genes like me logo Genes that share ontologies with ICAM1: view

Compounds for ICAM1 Gene

(5) Tocris Compounds for ICAM1 Gene

Compound Action Cas Number
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation [151988-33-9]
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor [154303-05-6]
Heparin sodium salt Anticoagulant [9041-08-1]
RGDS peptide Integrin binding sequence; inhibits integrin receptor function [91037-65-9]
Thiolutin Bacterial RNA polymerase inhibitor [87-11-6]

(1) HMDB Compounds for ICAM1 Gene

Compound Synonyms Cas Number PubMed IDs
Simvastatin
  • (+)-Simvastatin
79902-63-9

(2) Drugbank Compounds for ICAM1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Hyaluronan
  • Hyaluronate
9067-32-7 target
Natalizumab
  • Anti-alpha4 integrin
189261-10-7 target

(132) Novoseek inferred chemical compound relationships for ICAM1 Gene

Compound -log(P) Hits PubMed IDs
rantes 64.9 95
pdtc 58.2 30
slex 56.8 24
enlimomab 54.1 3
sele 53.7 7
genes like me logo Genes that share compounds with ICAM1: view

Transcripts for ICAM1 Gene

Unigene Clusters for ICAM1 Gene

Intercellular adhesion molecule 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ICAM1 Gene

GeneLoc Exon Structure for
ICAM1
ECgene alternative splicing isoforms for
ICAM1

Expression for ICAM1 Gene

mRNA expression in normal human tissues for ICAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICAM1 Gene

This gene is overexpressed in Lung (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ICAM1 Gene

SOURCE GeneReport for Unigene cluster for ICAM1 Gene Hs.643447

genes like me logo Genes that share expressions with ICAM1: view

Orthologs for ICAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICAM1 36
  • 98.5 (n)
  • 96.99 (a)
ICAM1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ICAM1 36
  • 68.91 (n)
  • 56.72 (a)
ICAM1 37
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICAM1 36
  • 72.96 (n)
  • 62.23 (a)
ICAM1 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Icam1 36
  • 64.77 (n)
  • 54.81 (a)
Icam1 16
Icam1 37
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 29 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 34 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Icam1 36
  • 63.46 (n)
  • 53.44 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 23 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
Species with no ortholog for ICAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM1 Gene

ENSEMBL:
Gene Tree for ICAM1 (if available)
TreeFam:
Gene Tree for ICAM1 (if available)

Paralogs for ICAM1 Gene

Paralogs for ICAM1 Gene

Selected SIMAP similar genes for ICAM1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ICAM1 Gene

genes like me logo Genes that share paralogs with ICAM1: view

Variants for ICAM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM1 Gene

P05362-ICAM1_HUMAN
Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [MIM:611162]

Sequence variations from dbSNP and Humsavar for ICAM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs5490 -- 10,271,151(+) ACCTC(A/C)GCCTC utr-variant-5-prime
rs5491 other, -, - 10,274,864(+) GCCCA(A/T)GTTGT reference, missense
rs5492 - 10,283,614(+) GAGAA(C/G)GAGCT missense, reference
rs5493 -- 10,284,118(+) GACRG(G/T)CTGTT reference, synonymous-codon
rs5494 -- 10,284,241(+) GAGGA(C/T)GAGGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ICAM1 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
nsv911033 CNV Gain 21882294
nsv911034 CNV Gain 21882294
dgv3726n71 CNV Loss 21882294

Relevant External Links for ICAM1 Gene

HapMap Linkage Disequilibrium report
ICAM1
Human Gene Mutation Database (HGMD)
ICAM1

Disorders for ICAM1 Gene

(1) OMIM Diseases for ICAM1 Gene (147840)

(95) Novoseek inferred disease relationships for ICAM1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 82.7 142
necrosis 81.6 129
atherosclerosis 70.2 94
tumors 68.8 270
malaria cerebral 60.2 15

Relevant External Links for ICAM1

Genetic Association Database (GAD)
ICAM1
Human Genome Epidemiology (HuGE) Navigator
ICAM1
genes like me logo Genes that share disorders with ICAM1: view

No data available for UniProtKB/Swiss-Prot for ICAM1 Gene

Publications for ICAM1 Gene

  1. Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster. (PMID: 7525451) Vora D.K. … Cottingham R.W. (Genomics 1994) 3 4 23
  2. A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya. (PMID: 9259284) Fernandez-Reyes D. … Newbold C.I. (Hum. Mol. Genet. 1997) 3 4 23
  3. Polymorphism at codon 469 of the intercellular adhesion molecule-1 locus is associated with protection against severe gastrointestinal complications in Henoch-SchAPnlein purpura. (PMID: 11361181) Amoli M.M. … Gonzalez-Gay M.A. (J. Rheumatol. 2001) 3 23 49
  4. Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status. (PMID: 11726228) Braun C. … Folwaczny C. (Clin. Immunol. 2001) 3 23 49
  5. Cross-sectional study on cytokine polymorphisms, cytokine production after T-cell stimulation and clinical parameters in a random sample of a German population. (PMID: 11354638) Nieters A. … Becker N. (Hum. Genet. 2001) 3 23 49

Products for ICAM1 Gene

  • Addgene plasmids for ICAM1

Sources for ICAM1 Gene

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