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Aliases for HYAL1 Gene

Aliases for HYAL1 Gene

  • Hyaluronoglucosaminidase 1 2 3
  • Lung Carcinoma Protein 1 3 4
  • EC 4 63
  • HYAL-1 3 4
  • LuCa-1 3 4
  • LUCA1 3 4
  • Hyaluronoglucosaminidase-1 4
  • Tumor Suppressor LUCA-1 3
  • Plasma Hyaluronidase 3
  • Hyaluronidase-1 3
  • MPS9 3
  • NAT6 3

External Ids for HYAL1 Gene

Previous GeneCards Identifiers for HYAL1 Gene

  • GC03P049646
  • GC03P049807
  • GC03M050191
  • GC03M050296
  • GC03M050312
  • GC03M050339

Summaries for HYAL1 Gene

Entrez Gene Summary for HYAL1 Gene

  • This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HYAL1 Gene

HYAL1 (Hyaluronoglucosaminidase 1) is a Protein Coding gene. Diseases associated with HYAL1 include mucopolysaccharidosis type ix and mucolipidoses. Among its related pathways are Disease and Lysosome. GO annotations related to this gene include transcription factor binding and hyalurononglucosaminidase activity. An important paralog of this gene is HYAL3.

UniProtKB/Swiss-Prot for HYAL1 Gene

  • May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

Gene Wiki entry for HYAL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYAL1 Gene

Genomics for HYAL1 Gene

Regulatory Elements for HYAL1 Gene

Transcription factor binding sites by QIAGEN in the HYAL1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HYAL1 Gene

50,299,889 bp from pter
50,312,381 bp from pter
12,493 bases
Minus strand

Genomic View for HYAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HYAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYAL1 Gene

Proteins for HYAL1 Gene

  • Protein details for HYAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6FH23
    • Q6PIZ6
    • Q7KYU2
    • Q7LE34
    • Q8NFK5
    • Q8NFK6
    • Q8NFK7
    • Q8NFK8
    • Q8NFK9
    • Q93013
    • Q9UKD5
    • Q9UNI8

    Protein attributes for HYAL1 Gene

    435 amino acids
    Molecular mass:
    48368 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH25774.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HYAL1 Gene

    Alternative splice isoforms for HYAL1 Gene

neXtProt entry for HYAL1 Gene

Proteomics data for HYAL1 Gene at MOPED

Selected DME Specific Peptides for HYAL1 Gene

Post-translational modifications for HYAL1 Gene

  • Glycosylation at Asn99, Asn216, and Asn350
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for HYAL1 Gene

Suggested Antigen Peptide Sequences for HYAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EGF-like domain.
  • Belongs to the glycosyl hydrolase 56 family.
  • Contains 1 EGF-like domain.
  • Belongs to the glycosyl hydrolase 56 family.
genes like me logo Genes that share domains with HYAL1: view

No data available for Gene Families for HYAL1 Gene

Function for HYAL1 Gene

Molecular function for HYAL1 Gene

GENATLAS Biochemistry:
hyaluroglucosaminidase 1,plasma,expressed in embryonic kidney and somatic tissues,paralog to SPAM1,involved in glycosaminoglycan catabolism,also involved in cell migration during embryonic development,clustered with HYAL2 and HYAL3
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is about 3.8.;
UniProtKB/Swiss-Prot CatalyticActivity:
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate
UniProtKB/Swiss-Prot Function:
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

Enzyme Numbers (IUBMB) for HYAL1 Gene

Gene Ontology (GO) - Molecular Function for HYAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 NOT virus receptor activity IDA 11296287
GO:0004415 NOT hyalurononglucosaminidase activity IDA 12084718
GO:0008134 transcription factor binding IDA 18718911
GO:0050501 hyaluronan synthase activity IDA 21829529
genes like me logo Genes that share ontologies with HYAL1: view
genes like me logo Genes that share phenotypes with HYAL1: view

Animal Models for HYAL1 Gene

MGI Knock Outs for HYAL1:

Animal Model Products

miRNA for HYAL1 Gene

miRTarBase miRNAs that target HYAL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HYAL1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for HYAL1 Gene

Localization for HYAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYAL1 Gene

Secreted. Lysosome.

Subcellular locations from

Jensen Localization Image for HYAL1 Gene COMPARTMENTS Subcellular localization image for HYAL1 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
cytosol 3
endosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HYAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 17170110
GO:0005737 cytoplasm IDA 21829529
GO:0005764 lysosome IDA 16600643
GO:0031410 cytoplasmic vesicle IDA 18390475
GO:0036117 hyaluranon cable IDA 16900089
genes like me logo Genes that share ontologies with HYAL1: view

Pathways for HYAL1 Gene

genes like me logo Genes that share pathways with HYAL1: view

Interacting Proteins for HYAL1 Gene

Gene Ontology (GO) - Biological Process for HYAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species IDA 20554532
GO:0005975 carbohydrate metabolic process TAS --
GO:0006954 inflammatory response IDA 18390475
GO:0009615 response to virus IDA 11296287
GO:0010634 positive regulation of epithelial cell migration IDA 21829529
genes like me logo Genes that share ontologies with HYAL1: view

Drugs for HYAL1 Gene

(3) HMDB Compounds for HYAL1 Gene

Compound Synonyms Cas Number PubMed IDs
  • 2-Acetamido-2-deoxy-a-D-allopyranose
N-Acetylgalactosamine 4-sulphate
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulfate)
  • Dihydrogen oxide

(3) Novoseek inferred chemical compound relationships for HYAL1 Gene

Compound -log(P) Hits PubMed IDs
hyaluronic acid 60.6 4
chondroitin sulfate 46 1
bupivacaine 27.5 1
genes like me logo Genes that share compounds with HYAL1: view

Transcripts for HYAL1 Gene

Unigene Clusters for HYAL1 Gene

Hyaluronoglucosaminidase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HYAL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6: - - - -

Relevant External Links for HYAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYAL1 Gene

mRNA expression in normal human tissues for HYAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HYAL1 Gene

This gene is overexpressed in Liver (12.9), Spleen (6.8), Heart - Left Ventricle (4.8), and Kidney - Cortex (4.3).

Protein differential expression in normal tissues for HYAL1 Gene

This gene is overexpressed in Urine (62.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HYAL1 Gene

SOURCE GeneReport for Unigene cluster for HYAL1 Gene Hs.75619

mRNA Expression by UniProt/SwissProt for HYAL1 Gene

Tissue specificity: Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
genes like me logo Genes that share expressions with HYAL1: view

Expression partners for HYAL1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for HYAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HYAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia HYAL1 35
  • 86.71 (n)
  • 82.03 (a)
HYAL1 36
  • 68 (a)
(Mus musculus)
Mammalia Hyal1 35
  • 80.68 (n)
  • 73.67 (a)
Hyal1 16
Hyal1 36
  • 69 (a)
(Pan troglodytes)
Mammalia HYAL1 35
  • 99.69 (n)
  • 99.31 (a)
HYAL1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hyal1 35
  • 80.22 (n)
  • 74.6 (a)
(Bos Taurus)
Mammalia -- 36
  • 67 (a)
HYAL1 36
  • 77 (a)
(Monodelphis domestica)
Mammalia HYAL1 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia HYAL1 36
  • 50 (a)
(Gallus gallus)
Aves HYAL1 35
  • 61.56 (n)
  • 52.59 (a)
HYAL1 36
  • 49 (a)
(Anolis carolinensis)
Reptilia HYAL1 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hyal1 35
  • 55.94 (n)
  • 48.02 (a)
(Danio rerio)
Actinopterygii LOC100535290 35
  • 53.48 (n)
  • 47.66 (a)
CU694224.2 36
  • 46 (a)
HYAL1 (1 of 2) 36
  • 43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11072 35
(Caenorhabditis elegans)
Secernentea T22C8.2 37
  • 31 (a)
chhy-1 35
  • 41.19 (n)
  • 34.01 (a)
chhy-1 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for HYAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYAL1 Gene

Gene Tree for HYAL1 (if available)
Gene Tree for HYAL1 (if available)

Paralogs for HYAL1 Gene

Paralogs for HYAL1 Gene

(5) SIMAP similar genes for HYAL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HYAL1: view

Variants for HYAL1 Gene

Sequence variations from dbSNP and Humsavar for HYAL1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs878328 -- 50,302,109(-) GCCGG(C/T)GCTGC missense, reference, nc-transcript-variant
rs4311206 -- 50,301,884(-) aagct(C/G)tgcct intron-variant
rs4688680 -- 50,309,818(-) ggcct(C/G)tgtgc intron-variant
rs4688734 -- 50,310,067(-) aacat(A/C/G/T)atttt intron-variant
rs6790431 -- 50,313,046(+) ctttt(C/T)ttttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HYAL1 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv523560 CNV Loss 19592680
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897
nsv3813 CNV Loss 18451855
esv2665476 CNV Deletion 23128226
dgv5133n71 CNV Loss 21882294
esv2671943 CNV Deletion 23128226
esv29569 CNV Loss 19812545
esv1266548 CNV Deletion 17803354

Relevant External Links for HYAL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYAL1 Gene

Disorders for HYAL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HYAL1 Gene in MalaCards »

(3) Diseases for HYAL1 Gene

(1) OMIM Diseases for HYAL1 Gene (607071)


  • Mucopolysaccharidosis 9 (MPS9) [MIM:601492]: A lysosomal storage disease characterized by high hyaluronan concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. {ECO:0000269 PubMed:10339581}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for HYAL1 Gene

(8) Novoseek inferred disease relationships for HYAL1 Gene

Disease -log(P) Hits PubMed IDs
mucopolysaccharidosis 64.3 2
bladder cancer 47.4 6
tumors 33.6 18
bladder tumors 33 1
prostate cancer 32.8 5

Relevant External Links for HYAL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HYAL1: view

No data available for Genatlas for HYAL1 Gene

Publications for HYAL1 Gene

  1. Purification, cloning, and expression of human plasma hyaluronidase. (PMID: 9223416) Frost G.I. … Stern R. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. Purification and microsequencing of hyaluronidase isozymes from human urine. (PMID: 9409739) CsA^ka A.B. … CsA^ka T.B. (FEBS Lett. 1997) 2 3 23
  3. Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. (PMID: 10339581) Triggs-Raine B. … Natowicz M.R. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  4. HYAL1(LUCA-1), a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA. (PMID: 10702795) Frost G.I. … Stern R. (Oncogene 2000) 3 4 23
  5. Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis. (PMID: 17503783) Chao K.L. … Herzberg O. (Biochemistry 2007) 3 4 23

Products for HYAL1 Gene

Sources for HYAL1 Gene

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