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Aliases for TNC Gene

Aliases for TNC Gene

  • Tenascin C 2 3 5
  • Glioma-Associated-Extracellular Matrix Antigen 3 4
  • Deafness, Autosomal Dominant 56 2 3
  • Hexabrachion (Tenascin) 2 3
  • Myotendinous Antigen 3 4
  • Neuronectin 3 4
  • GP 150-225 3 4
  • Cytotactin 3 4
  • GMEM 3 4
  • TN-C 3 4
  • HXB 3 4
  • TN 3 4
  • JI 3 4
  • Hexabrachion (Tenascin C, Cytotactin) 2
  • Tenascin-C Additional Domain 1 3
  • Tenascin-C Isoform 14/AD1/16 3
  • Hexabrachion 4
  • Tenascin-C 4
  • 150-225 3
  • DFNA56 3
  • GP 3

External Ids for TNC Gene

Previous HGNC Symbols for TNC Gene

  • HXB
  • DFNA56

Previous GeneCards Identifiers for TNC Gene

  • GC09M108581
  • GC09M109514
  • GC09M111236
  • GC09M113158
  • GC09M113135
  • GC09M114862
  • GC09M116822
  • GC09M117782
  • GC09M087387

Summaries for TNC Gene

Entrez Gene Summary for TNC Gene

  • This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

GeneCards Summary for TNC Gene

TNC (Tenascin C) is a Protein Coding gene. Diseases associated with TNC include Deafness, Autosomal Dominant 56 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are ERK Signaling and Phospholipase-C Pathway. GO annotations related to this gene include syndecan binding. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot for TNC Gene

  • Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

Gene Wiki entry for TNC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNC Gene

Genomics for TNC Gene

Regulatory Elements for TNC Gene

Enhancers for TNC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNC on UCSC Golden Path with GeneCards custom track

Promoters for TNC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNC on UCSC Golden Path with GeneCards custom track

Genomic Location for TNC Gene

Chromosome:
9
Start:
115,019,575 bp from pter
End:
115,118,257 bp from pter
Size:
98,683 bases
Orientation:
Minus strand

Genomic View for TNC Gene

Genes around TNC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNC Gene

Proteins for TNC Gene

  • Protein details for TNC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24821-TENA_HUMAN
    Recommended name:
    Tenascin
    Protein Accession:
    P24821
    Secondary Accessions:
    • C9IYT7
    • C9J575
    • C9J6D9
    • C9J848
    • Q14583
    • Q15567
    • Q5T7S3

    Protein attributes for TNC Gene

    Size:
    2201 amino acids
    Molecular mass:
    240853 Da
    Quaternary structure:
    • Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.

    Three dimensional structures from OCA and Proteopedia for TNC Gene

    Alternative splice isoforms for TNC Gene

neXtProt entry for TNC Gene

Proteomics data for TNC Gene at MOPED

Post-translational modifications for TNC Gene

  • Glycosylation at Asn 38, Asn 166, Asn 184, Asn 327, Asn 788, Asn 1018, Asn 1034, Asn 1079, Asn 1093, Asn 1119, Asn 1184, Asn 1210, Asn 1261, Asn 1275, Asn 1301, Asn 1366, Asn 1392, Asn 1445, Asn 1455, Asn 1485, Asn 1534, Asn 1809, and Asn 2162
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TNC (TNC)

No data available for DME Specific Peptides for TNC Gene

Domains & Families for TNC Gene

Suggested Antigen Peptide Sequences for TNC Gene

Graphical View of Domain Structure for InterPro Entry

P24821

UniProtKB/Swiss-Prot:

TENA_HUMAN :
  • Contains 15 EGF-like domains.
  • Belongs to the tenascin family.
Domain:
  • Contains 15 EGF-like domains.
  • Contains 1 fibrinogen C-terminal domain.
  • Contains 15 fibronectin type-III domains.
Family:
  • Belongs to the tenascin family.
genes like me logo Genes that share domains with TNC: view

Function for TNC Gene

Molecular function for TNC Gene

UniProtKB/Swiss-Prot Function:
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
UniProtKB/Swiss-Prot Induction:
By TGFB1.
genes like me logo Genes that share phenotypes with TNC: view

Human Phenotype Ontology for TNC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNC Gene

MGI Knock Outs for TNC:

Animal Model Products

miRNA for TNC Gene

miRTarBase miRNAs that target TNC

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TNC Gene

Localization for TNC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNC Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNC Gene COMPARTMENTS Subcellular localization image for TNC gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
cytoskeleton 2
cytosol 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TNC Gene

Pathways & Interactions for TNC Gene

genes like me logo Genes that share pathways with TNC: view

Gene Ontology (GO) - Biological Process for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion IEA --
GO:0007528 neuromuscular junction development IEA --
GO:0009612 response to mechanical stimulus IEA --
genes like me logo Genes that share ontologies with TNC: view

No data available for SIGNOR curated interactions for TNC Gene

Drugs & Compounds for TNC Gene

(15) Drugs for TNC Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NEURADIAB Pharma 0

(27) Additional Compounds for TNC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNC: view

Transcripts for TNC Gene

Unigene Clusters for TNC Gene

Tenascin C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ·
SP1: -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7:
SP8: -
SP9: - - - - - - - -

ExUns: 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TNC Gene

GeneLoc Exon Structure for
TNC
ECgene alternative splicing isoforms for
TNC

Expression for TNC Gene

mRNA expression in normal human tissues for TNC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNC Gene

This gene is overexpressed in Artery - Tibial (x11.4) and Colon - Sigmoid (x5.9).

Protein differential expression in normal tissues from HIPED for TNC Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (43.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNC Gene



SOURCE GeneReport for Unigene cluster for TNC Gene Hs.143250

genes like me logo Genes that share expression patterns with TNC: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TNC Gene

Orthologs for TNC Gene

This gene was present in the common ancestor of animals.

Orthologs for TNC Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TNC 35
  • 87.52 (n)
  • 88.05 (a)
TNC 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnc 35
  • 74.06 (n)
  • 71.98 (a)
Tnc 16
Tnc 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNC 35
  • 99.21 (n)
  • 99.18 (a)
TNC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnc 35
  • 73.97 (n)
  • 71.65 (a)
cow
(Bos Taurus)
Mammalia TNC 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNC 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNC 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNC 35
  • 62.98 (n)
  • 57.8 (a)
TNC 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNC 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15574 35
tnc 35
  • 58.62 (n)
  • 54.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24480 35
zebrafish
(Danio rerio)
Actinopterygii LOC100149028 35
  • 54.7 (n)
  • 47.76 (a)
tenc 35
CABZ01048373.1 36
  • 45 (a)
OneToMany
tnc 36
  • 55 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4969 35
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00180.10 37
  • 31 (a)
BG:DS00180.14 37
  • 28 (a)
CG1791 37
  • 40 (a)
CG30280 37
  • 39 (a)
CG30281 37
  • 39 (a)
CG5550 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for TNC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNC Gene

ENSEMBL:
Gene Tree for TNC (if available)
TreeFam:
Gene Tree for TNC (if available)

Paralogs for TNC Gene

Paralogs for TNC Gene

Pseudogenes.org Pseudogenes for TNC Gene

genes like me logo Genes that share paralogs with TNC: view

Variants for TNC Gene

Sequence variations from dbSNP and Humsavar for TNC Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs13321 - 115,030,304(-) AGGCT(C/G)AGGCG reference, missense
rs2274750 - 115,040,992(-) TCATC(A/G)CCATG reference, missense
rs1757095 - 115,086,115(+) GACCC(C/T)GGCCA reference, missense
rs3827816 - 115,085,918(-) AATGC(A/G)TCTCG reference, missense
rs1061494 - 115,084,301(+) GCTCC(C/T)GGATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TNC Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
nsv7434 OTHER Inversion 18451855
nsv831696 CNV Gain 17160897
nsv519131 CNV Loss 19592680
esv3825 CNV Deletion 18987735
esv2738965 CNV Deletion 23290073
esv21967 CNV Gain 19812545
nsv893768 CNV Gain 21882294
esv2422541 CNV Deletion 19546169
esv2738966 CNV Deletion 23290073
esv2738967 CNV Deletion 23290073
esv1008522 CNV Deletion 20482838
esv1713245 CNV Deletion 17803354
nsv831697 CNV Loss 17160897

Variation tolerance for TNC Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.84; 98.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNC Gene

Human Gene Mutation Database (HGMD)
TNC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNC Gene

Disorders for TNC Gene

MalaCards: The human disease database

(33) MalaCards diseases for TNC Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal dominant 56
  • deafness, autosomal dominant, 56
autosomal dominant non-syndromic sensorineural deafness type dfna
  • autosomal dominant isolated neurosensory deafness type dfna
bullous keratopathy
acute myocarditis
cryptogenic organizing pneumonia
  • boop
- elite association - COSMIC cancer census association via MalaCards
Search TNC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TENA_HUMAN
  • Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with post-lingual onset. {ECO:0000269 PubMed:23936043}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TNC

Genetic Association Database (GAD)
TNC
Human Genome Epidemiology (HuGE) Navigator
TNC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNC
genes like me logo Genes that share disorders with TNC: view

No data available for Genatlas for TNC Gene

Publications for TNC Gene

  1. Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. (PMID: 1707164) Siri A. … Zardi L. (Nucleic Acids Res. 1991) 2 3 4 23 67
  2. Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. (PMID: 23936043) Zhao Y. … Wang Q. (PLoS ONE 2013) 2 3
  3. Tenascin-C is induced in cerebral vasospasm after subarachnoid hemorrhage in rats and humans: a pilot study. (PMID: 19589197) Suzuki H. … Taki W. (Neurol. Res. 2010) 3 23
  4. Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading. (PMID: 19748582) Ambort D. … Sterchi E.E. (Matrix Biol. 2010) 3 23
  5. Tenascin-C is a novel RBPJkappa-induced target gene for Notch signaling in gliomas. (PMID: 19147558) Sivasankaran B. … Boulay J.L. (Cancer Res. 2009) 3 23

Products for TNC Gene

Sources for TNC Gene

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