Aliases for TNC Gene
External Ids for TNC Gene
Previous Symbols for TNC Gene
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
GeneCards Summary for TNC Gene
TNC (Tenascin C) is a Protein Coding gene. Diseases associated with TNC include deafness, autosomal dominant 56 and juvenile pilocytic astrocytoma. Among its related pathways are PI3K-Akt signaling pathway and ERK Signaling. GO annotations related to this gene include syndecan binding. An important paralog of this gene is FGA.
UniProtKB/Swiss-Prot for TNC Gene
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6