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Aliases for HTR6 Gene

Aliases for HTR6 Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 6, G Protein-Coupled 2 3
  • Serotonin Receptor 6 3 4
  • 5-HT6 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 6 2
  • 5-Hydroxytryptamine Receptor 6 3
  • 5-HT6R 3
  • 5-HT-6 4

External Ids for HTR6 Gene

Previous GeneCards Identifiers for HTR6 Gene

  • GC01P019551
  • GC01P019016
  • GC01P019137
  • GC01P019461
  • GC01P019737
  • GC01P019864
  • GC01P019991
  • GC01P018237

Summaries for HTR6 Gene

Entrez Gene Summary for HTR6 Gene

  • This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

GeneCards Summary for HTR6 Gene

HTR6 (5-Hydroxytryptamine (Serotonin) Receptor 6, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR6 include schizophrenia. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include serotonin receptor activity and histamine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for HTR6 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).

Tocris Summary for HTR6 Gene

  • Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and they have a role in spatial learning and memory. The human 5-HT6 receptor gene has been localized to chromosome 1 (1p35-36).

Gene Wiki entry for HTR6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR6 Gene

Genomics for HTR6 Gene

Regulatory Elements for HTR6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HTR6 Gene

19,665,287 bp from pter
19,680,966 bp from pter
15,680 bases
Plus strand

Genomic View for HTR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR6 Gene

Proteins for HTR6 Gene

  • Protein details for HTR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 6
    Protein Accession:
    Secondary Accessions:
    • Q13640
    • Q5TGZ1

    Protein attributes for HTR6 Gene

    440 amino acids
    Molecular mass:
    46954 Da
    Quaternary structure:
    • Interacts with MTOR, RPTOR and NF1 (PubMed:23027611). Interacts with CDK5 (By similarity).

neXtProt entry for HTR6 Gene

Proteomics data for HTR6 Gene at MOPED

Post-translational modifications for HTR6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR6 Gene

Domains for HTR6 Gene

Protein Domains for HTR6 Gene

Suggested Antigen Peptide Sequences for HTR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR6: view

Function for HTR6 Gene

Molecular function for HTR6 Gene

GENATLAS Biochemistry:
5-hydroxytrhyptamine (serotonin) receptor,subtype 6,prominently expressed in the caudal nucleus,G protein coupled receptor superfamily,activating adenylate cyclase
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).

Gene Ontology (GO) - Molecular Function for HTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004969 histamine receptor activity TAS 8522988
GO:0004993 serotonin receptor activity IEA --
GO:0005515 protein binding IPI 17189269
genes like me logo Genes that share ontologies with HTR6: view
genes like me logo Genes that share phenotypes with HTR6: view

Animal Models for HTR6 Gene

MGI Knock Outs for HTR6:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for HTR6 Gene

Localization for HTR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HTR6 Gene COMPARTMENTS Subcellular localization image for HTR6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8522988
GO:0005929 cilium IEA --
GO:0016021 integral component of membrane --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with HTR6: view

Pathways for HTR6 Gene

genes like me logo Genes that share pathways with HTR6: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA --
GO:0007210 serotonin receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS 8522988
GO:0007420 brain development --
genes like me logo Genes that share ontologies with HTR6: view

Drugs for HTR6 Gene

(19) Drugbank Compounds for HTR6 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Abilify
129722-12-9 60795 Target antagonist approved, investigational
  • 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
132539-06-1 Target antagonist approved, investigational
  • 1-[2-[4-[5-chloro-1-(4-Fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one
106516-24-9 60149 Target antagonist approved, withdrawn
  • 10,11-dihydro-5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,D)cycloheptene
50-48-6 2160 Target antagonist approved
  • 2-Chloro-11-(1-piperazinyl)dibenz(b,F)(1,4)oxazepine
14028-44-5 2170 Target antagonist approved

(5) Tocris Compounds for HTR6 Gene

Compound Action Cas Number
EMD 386088 hydrochloride Potent 5-HT6 agonist [1171123-46-8]
EMDT oxalate Selective 5-HT6 agonist [263744-72-5]
SB 258585 hydrochloride Potent, selective 5-HT6 antagonist [1216468-02-8]
SB 399885 hydrochloride Potent and selective 5-HT6 antagonist [402713-81-9]
WAY 208466 dihydrochloride Selective 5-HT6 agonist [1207064-61-6]

(39) ApexBio Compounds for HTR6 Gene

Compound Action Cas Number
Asenapine Inhibits adrenergic receptor/5-HT receptor [85650-56-2]
Bilobalide Neuroprotective agent [33570-04-6]
Blonanserin Atypical antipsychotic [132810-10-7]
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker [17321-77-6]
Dapoxetine HCl Selective serotonin reuptake inhibitor [129938-20-1]
Desvenlafaxine [93413-62-8]
Desvenlafaxine Succinate [386750-22-7]
Duloxetine HCl [136434-34-9]
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor [219861-08-2]
Fenspiride HCl [5053-8-7]
Fluoxetine HCl Serotonin reuptake inhibitor,selective [56296-78-7]
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant [61718-82-9]
Ketanserin [74050-98-9]
Lorcaserin HCl [846589-98-8]
Lu AE58054 Hydrochloride 5-HT(6)R antagonist [467458-02-2]
LY310762 [192927-92-7]
Milnacipran HCl [101152-94-7]
Mosapride Citrate 5-HT receptor agonist [112885-42-4]
Naratriptan [143388-64-1]
Olanzapine [132539-06-1]
Ondansetron [99614-02-5]
Palonosetron HCl [135729-62-3]
Pizotifen Malate [5189-11-7]
Risperidone SR-2A inhibitor [106266-06-2]
Rizatriptan Benzoate [145202-66-0]
SB271046 [209481-20-9]
SB742457 5-HT6 receptor antagonist,highly selective and high affinity [607742-69-8]
SEA0400 Specific inhibitor of Na+/Ca2+ exchange [223104-29-8]
Sertraline HCl [79559-97-0]
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant [30123-17-2]
Trazodone HCl Antidepressant [25332-39-2]
Tropisetron [105826-92-4]
Urapidil HCl [64887-14-5]
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor [99300-78-4]
Vortioxetine 5-HT receptors antagonist [508233-74-7]
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic [960203-27-4]
VUF 10166 [155584-74-0]
Ziprasidone HCl Serotonin and dopamine receptor antagonist [122883-93-6]
Zolmitriptan [139264-17-8]

(4) HMDB Compounds for HTR6 Gene

Compound Synonyms Cas Number PubMed IDs
  • Abilify
  • Ondansetron
  • Sertindol [inn-spanish]
  • Ziprasidone mesylate trihydrate

(52) IUPHAR Ligand for HTR6 Gene

Ligand Type Action Affinity Pubmed IDs
cyproheptadine Antagonist Antagonist 10.2
methiothepin Antagonist Antagonist 9.4
zotepine Antagonist Antagonist 9.2
olanzapine Antagonist Antagonist 9.2
SL65.0155 Agonist Partial agonist 9.2
SB399885 Antagonist Antagonist 9
[125I]SB258585 Antagonist Antagonist 9
SB 271046 Antagonist Antagonist 8.9
E-6801 Agonist Partial agonist 8.7
[3H]LSD Agonist Full agonist 8.7
WAY-181187 Agonist Agonist 8.7
ergotamine Agonist Full agonist 8.6
SB357134 Antagonist Antagonist 8.5
LSD Agonist Full agonist 8.4
Ro 63-0563 Antagonist Antagonist 8.4
[3H]Ro 63-0563 Antagonist Antagonist 8.3
loxapine Antagonist Antagonist 8.2
perphenazine Antagonist Antagonist 8.1
ICI 169369 Antagonist Antagonist 8
Ro 04-6790 Antagonist Antagonist 7.9
risperidone Antagonist Antagonist 7.8
EMDT Agonist Full agonist 7.8
fluphenazine Antagonist Antagonist 7.7
thioridazine Antagonist Antagonist 7.7
MPDT Antagonist Antagonist 7.7
fluperlapine Antagonist Inverse agonist 7.5
metergoline Antagonist Antagonist 7.4
ritanserin Antagonist Antagonist 7.4
mianserin Antagonist Antagonist 7.3
amoxapine Antagonist Antagonist 7.3
lisuride Agonist Partial agonist 7.2
amitriptyline Antagonist Antagonist 7.2
dimethyltryptamine Agonist Full agonist 7.2
iloperidone Antagonist Antagonist 7.2
5-MeOT Agonist Full agonist 6.8
methysergide Antagonist Antagonist 6.8
clozapine Antagonist Antagonist 6.7
duloxetine Antagonist Antagonist 6.4
TFMPP Agonist Full agonist 6.4
bromocriptine Agonist Partial agonist 6.2
RU 24969 Agonist Full agonist 6.2
5-CT Agonist Full agonist 6.1
tiospirone Antagonist Antagonist 6
xanomeline Agonist Full agonist 5.9
BRL-15572 Agonist Partial agonist 5.9
GR-127935 Agonist Partial agonist 5.8
mesulergine Antagonist Antagonist 5.7
donitriptan Agonist Partial agonist 5.6
sumatriptan Antagonist Antagonist 5.6
5-HT Inhibitor Inhibition 2.2
chlorpromazine Channel blocker None
[3H]5-CT Agonist Agonist

(9) Novoseek inferred chemical compound relationships for HTR6 Gene

Compound -log(P) Hits PubMed IDs
iloperidone 78.3 2
5-carboxamidotryptamine 66.1 1
5-hydroxytryptamine 64.6 4
risperidone 50.4 2
clozapine 46.4 7
genes like me logo Genes that share compounds with HTR6: view

Compound Products

Transcripts for HTR6 Gene

mRNA/cDNA for HTR6 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR6 Gene

5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR6 Gene

No ASD Table

Relevant External Links for HTR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTR6 Gene

mRNA expression in normal human tissues for HTR6 Gene

mRNA differential expression in normal tissues according to GTEx for HTR6 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (11.9), Brain - Putamen (basal ganglia) (10.9), Brain - Caudate (basal ganglia) (8.7), and Brain - Cortex (4.7).

SOURCE GeneReport for Unigene cluster for HTR6 Gene Hs.22180

mRNA Expression by UniProt/SwissProt for HTR6 Gene

Tissue specificity: Expressed in several human brain regions, most prominently in the caudate nucleus
genes like me logo Genes that share expressions with HTR6: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for HTR6 Gene

Orthologs for HTR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HTR6 35
  • 89.7 (n)
  • 89.77 (a)
HTR6 36
  • 90 (a)
(Canis familiaris)
Mammalia HTR6 35
  • 89.19 (n)
  • 89.65 (a)
HTR6 36
  • 90 (a)
(Mus musculus)
Mammalia Htr6 35
  • 86.45 (n)
  • 87.67 (a)
Htr6 16
Htr6 36
  • 88 (a)
(Pan troglodytes)
Mammalia HTR6 35
  • 98.94 (n)
  • 99.32 (a)
HTR6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Htr6 35
  • 88.32 (n)
  • 92.02 (a)
(Monodelphis domestica)
Mammalia HTR6 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia HTR6 36
  • 50 (a)
(Gallus gallus)
Aves HTR6 35
  • 69.85 (n)
  • 64.06 (a)
HTR6 36
  • 61 (a)
(Anolis carolinensis)
Reptilia HTR6 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia htr6 35
  • 68.41 (n)
  • 66.33 (a)
(Danio rerio)
Actinopterygii LOC568269 35
  • 65.32 (n)
  • 65.42 (a)
htr6 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6989 37
  • 33 (a)
DopR 37
  • 37 (a)
(Caenorhabditis elegans)
Secernentea ser-5 36
  • 22 (a)
ser-6 36
  • 20 (a)
Species with no ortholog for HTR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR6 Gene

Gene Tree for HTR6 (if available)
Gene Tree for HTR6 (if available)

Paralogs for HTR6 Gene

Paralogs for HTR6 Gene

(8) SIMAP similar genes for HTR6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR6: view

Variants for HTR6 Gene

Sequence variations from dbSNP and Humsavar for HTR6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6321 -- 19,679,341(+) CGGCC(A/G)CATCC synonymous-codon, reference
rs6322 -- 19,679,296(+) GCCGC(C/T)GTCAA reference, synonymous-codon
rs1320982 -- 19,677,450(-) AGGAA(A/G)AGGAG intron-variant
rs1805054 -- 19,666,020(+) CTGTA(C/T)GGGCG reference, synonymous-codon
rs1883563 -- 19,680,091(+) AGTTA(C/T)TTAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTR6 Gene

Variant ID Type Subtype PubMed ID
nsv508991 CNV Insertion 20534489
dgv187n71 CNV Loss 21882294

Relevant External Links for HTR6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR6 Gene

Disorders for HTR6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HTR6 Gene in MalaCards »

(1) Disease for HTR6 Gene

(4) Novoseek inferred disease relationships for HTR6 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 48.3 13
alzheimers disease 25.1 6
mood disorders 22.4 1
bipolar disorder 10.2 1

Relevant External Links for HTR6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HTR6: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HTR6 Gene

Publications for HTR6 Gene

  1. Cloning, characterization, and chromosomal localization of a human 5- HT6 serotonin receptor. (PMID: 8522988) Kohen R. … Hamblin M.W. (J. Neurochem. 1996) 2 3 4 25
  2. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. (PMID: 11163544) Masellis M. … Kennedy J.L. (Schizophr. Res. 2001) 3 23 48
  3. Serotonin 6 receptor polymorphism in schizophrenia: frequency, age at onset and cognitive function. (PMID: 11287786) Chiu H.J. … Liu W.C. (Neuropsychobiology 2001) 3 23 48
  4. Serotonergic genes and personality traits in the Korean population. (PMID: 14698468) Ham B.J. … Lee M.S. (Neurosci. Lett. 2004) 3 23 48
  5. Risperidone-related weight gain: genetic and nongenetic predictors. (PMID: 16633140) Lane H.Y. … Chang W.H. (J Clin Psychopharmacol 2006) 3 23 48

Products for HTR6 Gene

Sources for HTR6 Gene

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