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Aliases for HTR3A Gene

Aliases for HTR3A Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 3A, Ionotropic 2 3
  • Serotonin-Gated Ion Channel Receptor 3 4
  • 5-Hydroxytryptamine Receptor 3 3 4
  • Serotonin Receptor 3A 3 4
  • 5-HT3-A 3 4
  • 5-HT-3 3 4
  • 5-HT3A 3 4
  • 5-HT3R 3 4
  • 5HT3R 3 4
  • HTR3 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 3A 2
  • 5HT3 Serotonin Receptor 3

External Ids for HTR3A Gene

Previous HGNC Symbols for HTR3A Gene

  • HTR3

Previous GeneCards Identifiers for HTR3A Gene

  • GC11P116198
  • GC11P115357
  • GC11P113879
  • GC11P113383
  • GC11P113351
  • GC11P109774

Summaries for HTR3A Gene

Entrez Gene Summary for HTR3A Gene

  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR3A Gene

HTR3A (5-Hydroxytryptamine (Serotonin) Receptor 3A, Ionotropic) is a Protein Coding gene. Diseases associated with HTR3A include irritable bowel syndrome and serotonin syndrome. Among its related pathways are CREB Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include receptor activity and extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3D.

UniProtKB/Swiss-Prot for HTR3A Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3A Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3A Gene

Genomics for HTR3A Gene

Regulatory Elements for HTR3A Gene

Genomic Location for HTR3A Gene

Chromosome:
11
Start:
113,974,881 bp from pter
End:
113,990,313 bp from pter
Size:
15,433 bases
Orientation:
Plus strand

Genomic View for HTR3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3A Gene

Proteins for HTR3A Gene

  • Protein details for HTR3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46098-5HT3A_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3A
    Protein Accession:
    P46098
    Secondary Accessions:
    • B4DSY6
    • G5E986
    • O60854
    • Q7KZM7
    • Q99918
    • Q9BSZ9

    Protein attributes for HTR3A Gene

    Size:
    478 amino acids
    Molecular mass:
    55280 Da
    Quaternary structure:
    • Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.
    Miscellaneous:
    • The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers

    Alternative splice isoforms for HTR3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR3A Gene

Proteomics data for HTR3A Gene at MOPED

Post-translational modifications for HTR3A Gene

  • Glycosylation at Asn 28, Asn 104, Asn 170, and Asn 186
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR3A Gene

No data available for DME Specific Peptides for HTR3A Gene

Domains & Families for HTR3A Gene

Gene Families for HTR3A Gene

Graphical View of Domain Structure for InterPro Entry

P46098

UniProtKB/Swiss-Prot:

5HT3A_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily.
genes like me logo Genes that share domains with HTR3A: view

Function for HTR3A Gene

Molecular function for HTR3A Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 3a,coexpressed with HTR3B in the amygdala,caudate and hyppocampus,also expressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Gene Ontology (GO) - Molecular Function for HTR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9950429
GO:0004889 NOT contributes_to acetylcholine-activated cation-selective channel activity IBA --
GO:0004993 serotonin receptor activity IDA 7565620
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0005232 serotonin-activated cation-selective channel activity IEA --
genes like me logo Genes that share ontologies with HTR3A: view
genes like me logo Genes that share phenotypes with HTR3A: view

Animal Models for HTR3A Gene

MGI Knock Outs for HTR3A:

Animal Model Products

miRNA for HTR3A Gene

miRTarBase miRNAs that target HTR3A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR3A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HTR3A Gene

Localization for HTR3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3A Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR3A Gene COMPARTMENTS Subcellular localization image for HTR3A gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HTR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7565620
GO:0005892 NOT acetylcholine-gated channel complex IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with HTR3A: view

Pathways & Interactions for HTR3A Gene

genes like me logo Genes that share pathways with HTR3A: view

Pathways by source for HTR3A Gene

1 Qiagen pathway for HTR3A Gene
1 BioSystems pathway for HTR3A Gene
1 KEGG pathway for HTR3A Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for HTR3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 7565620
GO:0006811 ion transport --
GO:0006812 cation transport --
GO:0007210 serotonin receptor signaling pathway IDA 7565620
GO:0007268 synaptic transmission TAS 7565620
genes like me logo Genes that share ontologies with HTR3A: view

No data available for SIGNOR curated interactions for HTR3A Gene

Drugs & Compounds for HTR3A Gene

(141) Drugs for HTR3A Gene - From: DGIdb, NovoSeek, DrugBank, HMDB, ApexBio, FDA Approved Drugs, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alosetron Approved, Withdrawn Pharma antagonist, Target 5
Dolasetron Approved Pharma antagonist, Target 7
Granisetron Approved, Investigational Pharma antagonist, Target 69
Mirtazapine Approved Pharma antagonist, Target 74
Ondansetron Approved Pharma agonist, Target, antagonist 268

(47) Additional Compounds for HTR3A Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Methyl-5-hydroxytryptamine hydrochloride
845861-49-6
Dexfenfluramine hydrochloride
3239-45-0
m-Chlorophenylbiguanide hydrochloride
2113-05-5
N-Methylquipazine dimaleate
171205-17-7
Quipazine dimaleate
150323-78-7
genes like me logo Genes that share compounds with HTR3A: view

Transcripts for HTR3A Gene

Unigene Clusters for HTR3A Gene

5-hydroxytryptamine (serotonin) receptor 3A, ionotropic:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR3A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for HTR3A Gene

GeneLoc Exon Structure for
HTR3A
ECgene alternative splicing isoforms for
HTR3A

Expression for HTR3A Gene

mRNA expression in normal human tissues for HTR3A Gene

mRNA differential expression in normal tissues according to GTEx for HTR3A Gene

This gene is overexpressed in Minor Salivary Gland (x14.4), Pancreas (x4.8), and Brain - Caudate (basal ganglia) (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR3A Gene



SOURCE GeneReport for Unigene cluster for HTR3A Gene Hs.413899

mRNA Expression by UniProt/SwissProt for HTR3A Gene

P46098-5HT3A_HUMAN
Tissue specificity: Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.
genes like me logo Genes that share expression patterns with HTR3A: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for HTR3A Gene

Orthologs for HTR3A Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR3A 35
  • 87.17 (n)
  • 87.24 (a)
HTR3A 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR3A 35
  • 87.94 (n)
  • 88.08 (a)
HTR3A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr3a 35
  • 83.92 (n)
  • 86.62 (a)
Htr3a 16
Htr3a 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR3A 35
  • 98.97 (n)
  • 98.76 (a)
HTR3A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr3a 35
  • 83.84 (n)
  • 86.24 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR3A 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR3A 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR3A 35
  • 73.85 (n)
  • 73.33 (a)
HTR3A 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR3A 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC571641 35
  • 67.79 (n)
  • 68.54 (a)
htr3a 36
  • 73 (a)
OneToMany
htr3a 36
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acr-17 37
  • 29 (a)
acr-18 37
  • 22 (a)
acr-22 37
  • 28 (a)
C04C3.2 37
  • 27 (a)
Y57G11C.2 37
  • 27 (a)
Species with no ortholog for HTR3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HTR3A Gene

ENSEMBL:
Gene Tree for HTR3A (if available)
TreeFam:
Gene Tree for HTR3A (if available)

Paralogs for HTR3A Gene

Paralogs for HTR3A Gene

genes like me logo Genes that share paralogs with HTR3A: view

Variants for HTR3A Gene

Sequence variations from dbSNP and Humsavar for HTR3A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8236 -- 113,990,122(+) TGCTT(C/T)TCTTT utr-variant-3-prime, nc-transcript-variant
rs897686 -- 113,985,208(-) AACTC(A/G)TAAAG intron-variant
rs897687 -- 113,985,089(-) AACTC(C/T)TGTTG intron-variant
rs909411 -- 113,983,560(-) ATATA(C/T)GCACA intron-variant
rs909412 -- 113,983,843(-) GAATC(A/G)CAAAT intron-variant

Variation tolerance for HTR3A Gene

Residual Variation Intolerance Score: 18.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR3A Gene

HapMap Linkage Disequilibrium report
HTR3A
Human Gene Mutation Database (HGMD)
HTR3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HTR3A Gene

Disorders for HTR3A Gene

MalaCards: The human disease database

(34) MalaCards diseases for HTR3A Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
irritable bowel syndrome
  • irritable colon
serotonin syndrome
  • serotonergic syndrome
motion sickness
  • travel sickness
myofascial pain syndrome
  • myofascial pain dysfunction syndrome
dyspepsia
  • dyspepsia, indigestion nos
- elite association
Search HTR3A in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR3A

Genetic Association Database (GAD)
HTR3A
Human Genome Epidemiology (HuGE) Navigator
HTR3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR3A
genes like me logo Genes that share disorders with HTR3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3A Gene

Publications for HTR3A Gene

  1. Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. (PMID: 17587360) Kast R.E. … Foley K.F. (Eur J Cancer Care (Engl) 2007) 23 25 26 67
  2. Pharmacology, pharmacogenetics, and clinical efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. (PMID: 17093363) Ho K.Y. … Gan T.J. (Curr Opin Anaesthesiol 2006) 23 25 26 67
  3. Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjects. (PMID: 15102873) Stoltz R. … Parisi S. (J Clin Pharmacol 2004) 23 25 26 67
  4. Efficacy, safety and pharmacokinetics of palonosetron in patients receiving highly emetogenic cisplatin-based chemotherapy: a dose-ranging clinical study. (PMID: 14760130) Eisenberg P. … Macciocchi A. (Ann. Oncol. 2004) 23 25 26 67
  5. The pharmacological properties of the novel selective 5-HT3 receptor antagonist, alosetron, and its effects on normal and perturbed small intestinal transit in the fasted rat. (PMID: 10354345) Clayton N.M. … Humphrey P.P. (Neurogastroenterol. Motil. 1999) 23 25 26 67

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