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Aliases for HTR2C Gene

Aliases for HTR2C Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled 2 3
  • 5-Hydroxytryptamine Receptor 1C 3 4
  • 5-HTR2C 3 4
  • 5-HT1C 3 4
  • 5-HT2C 3 4
  • HTR1C 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 2C 2
  • Serotonin 5-HT-1C Receptor 3
  • Serotonin 5-HT-2C Receptor 3
  • Serotonin Receptor 2C 4
  • 5-HT-1C 4
  • 5-HT-2C 4
  • 5HTR2C 3

External Ids for HTR2C Gene

Previous HGNC Symbols for HTR2C Gene

  • HTR1C

Previous GeneCards Identifiers for HTR2C Gene

  • GC0XP108837
  • GC0XP110943
  • GC0XP111854
  • GC0XP112582
  • GC0XP113641
  • GC0XP113818
  • GC0XP103403

Summaries for HTR2C Gene

Entrez Gene Summary for HTR2C Gene

  • This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for HTR2C Gene

HTR2C (5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR2C include htr2c-related altered drug metabolism and premature ejaculation. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and serotonin receptor activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for HTR2C Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Tocris Summary for HTR2C Gene

  • Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation, thermoregulation, penile erection and anxiety.

Gene Wiki entry for HTR2C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR2C Gene

Genomics for HTR2C Gene

Regulatory Elements for HTR2C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HTR2C Gene

Chromosome:
X
Start:
114,584,078 bp from pter
End:
114,910,061 bp from pter
Size:
325,984 bases
Orientation:
Plus strand

Genomic View for HTR2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR2C Gene

Proteins for HTR2C Gene

  • Protein details for HTR2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28335-5HT2C_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 2C
    Protein Accession:
    P28335
    Secondary Accessions:
    • B1AMW4
    • Q5VUF8
    • Q9NP28

    Protein attributes for HTR2C Gene

    Size:
    458 amino acids
    Molecular mass:
    51821 Da
    Quaternary structure:
    • Interacts with MPDZ. Interacts with ARRB2.

    Alternative splice isoforms for HTR2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR2C Gene

Proteomics data for HTR2C Gene at MOPED

Post-translational modifications for HTR2C Gene

Other Protein References for HTR2C Gene

Antibody Products

No data available for DME Specific Peptides for HTR2C Gene

Domains & Families for HTR2C Gene

Graphical View of Domain Structure for InterPro Entry

P28335

UniProtKB/Swiss-Prot:

5HT2C_HUMAN :
  • The PDZ domain-binding motif is involved in the interaction with MPDZ.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The PDZ domain-binding motif is involved in the interaction with MPDZ.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR2C: view

Function for HTR2C Gene

Molecular function for HTR2C Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 2C with two alternatively spliced forms,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Gene Ontology (GO) - Molecular Function for HTR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001587 Gq/11-coupled serotonin receptor activity IDA 18703043
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IDA 7582481
GO:0008144 drug binding IDA 12970106
GO:0051378 serotonin binding IDA 7582481
genes like me logo Genes that share ontologies with HTR2C: view
genes like me logo Genes that share phenotypes with HTR2C: view

Animal Models for HTR2C Gene

MGI Knock Outs for HTR2C:

Animal Model Products

miRNA for HTR2C Gene

miRTarBase miRNAs that target HTR2C

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR2C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HTR2C Gene

Localization for HTR2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR2C Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR2C Gene COMPARTMENTS Subcellular localization image for HTR2C gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HTR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 18703043
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR2C: view

Pathways & Interactions for HTR2C Gene

genes like me logo Genes that share pathways with HTR2C: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HTR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response ISS --
GO:0006182 cGMP biosynthetic process IDA 12970106
GO:0006874 cellular calcium ion homeostasis IDA 19057895
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA 12970106
genes like me logo Genes that share ontologies with HTR2C: view

No data available for SIGNOR curated interactions for HTR2C Gene

Drugs & Compounds for HTR2C Gene

(160) Drugs for HTR2C Gene - From: NovoSeek, DrugBank, IUPHAR, DGIdb, HMDB, PharmGKB, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Agomelatine Approved, Investigational Pharma Antagonist, agonist, Target, antagonist MT1/MT2 / 5-HT2C agonist 0
Olanzapine Approved, Investigational Pharma Antagonist, agonist, Target, antagonist 369
Aripiprazole Approved, Investigational Pharma Antagonist, agonist, Target, antagonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 331
Ziprasidone Approved Pharma Antagonist, agonist, Target, antagonist 139
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication 108

(30) Additional Compounds for HTR2C Gene - From: IUPHAR, Tocris, NovoSeek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
<i>m</i>-CPP
Partial agonist, Agonist
5-HT
Inhibition, Inhibitor
alpha-methyl-5-HT
Full agonist, Agonist
AMI-193
Antagonist
DOB
Full agonist, Agonist
genes like me logo Genes that share compounds with HTR2C: view

Drug Products

Transcripts for HTR2C Gene

mRNA/cDNA for HTR2C Gene

Unigene Clusters for HTR2C Gene

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR2C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR2C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2: -

Relevant External Links for HTR2C Gene

GeneLoc Exon Structure for
HTR2C
ECgene alternative splicing isoforms for
HTR2C

Expression for HTR2C Gene

mRNA expression in normal human tissues for HTR2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR2C Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x16.9), Brain - Putamen (basal ganglia) (x10.0), Brain - Caudate (basal ganglia) (x8.7), and Brain - Hypothalamus (x7.5).

Protein differential expression in normal tissues from HIPED for HTR2C Gene

This gene is overexpressed in Plasma (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR2C Gene



SOURCE GeneReport for Unigene cluster for HTR2C Gene Hs.149037

mRNA Expression by UniProt/SwissProt for HTR2C Gene

P28335-5HT2C_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expression patterns with HTR2C: view

Protein tissue co-expression partners for HTR2C Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for HTR2C Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR2C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR2C 35
  • 90.62 (n)
  • 92.96 (a)
dog
(Canis familiaris)
Mammalia HTR2C 35
  • 90.47 (n)
  • 94.76 (a)
HTR2C 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr2c 35
  • 86.29 (n)
  • 90.59 (a)
Htr2c 16
Htr2c 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR2C 35
  • 99.71 (n)
  • 99.78 (a)
HTR2C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr2c 35
  • 86.65 (n)
  • 90.81 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR2C 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR2C 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR2C 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii htr2cl1 36
  • 47 (a)
OneToMany
htr2cl2 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta 5-HT2 37
  • 44 (a)
5-HT1A 36
  • 13 (a)
ManyToMany
5-HT1B 36
  • 17 (a)
ManyToMany
5-HT2 36
  • 15 (a)
ManyToMany
CG42796 36
  • 15 (a)
ManyToMany
TyrR 36
  • 17 (a)
ManyToMany
TyrRII 36
  • 19 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT2A 35
  • 49.74 (n)
  • 40.32 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 41 (a)
sca-1 37
  • 31 (a)
ser-1 37
  • 31 (a)
ser-1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for HTR2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HTR2C Gene

ENSEMBL:
Gene Tree for HTR2C (if available)
TreeFam:
Gene Tree for HTR2C (if available)

Paralogs for HTR2C Gene

Paralogs for HTR2C Gene

genes like me logo Genes that share paralogs with HTR2C: view

Variants for HTR2C Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HTR2C Gene

P28335-5HT2C_HUMAN
Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for Ser

Sequence variations from dbSNP and Humsavar for HTR2C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs498177 -- 114,590,222(-) TTTTT(C/T)CAAGT intron-variant
rs498207 -- 114,583,649(-) CATTC(C/T)TCCAA upstream-variant-2KB
rs518147 -- 114,584,109(-) TCCTC(C/G)GCAAG utr-variant-5-prime
rs521018 -- 114,583,441(-) AGACA(A/C/G/T)CTTGA upstream-variant-2KB
rs539748 -- 114,586,876(-) GCACC(A/G)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR2C Gene

Variant ID Type Subtype PubMed ID
dgv523n21 CNV Loss 19592680
esv33994 CNV Gain+Loss 17666407
dgv524n21 CNV Gain 19592680
nsv527347 CNV Gain 19592680
nsv7044 CNV Loss 18451855
nsv507990 CNV Insertion 20534489
nsv425061 CNV Loss 16902084
esv270001 CNV Insertion 20981092
esv2740401 CNV Deletion 23290073
esv1117381 CNV Deletion 17803354
esv1501559 CNV Insertion 17803354
esv2660156 CNV Deletion 23128226

Variation tolerance for HTR2C Gene

Residual Variation Intolerance Score: 62.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR2C Gene

HapMap Linkage Disequilibrium report
HTR2C
Human Gene Mutation Database (HGMD)
HTR2C

Disorders for HTR2C Gene

MalaCards: The human disease database

(23) MalaCards diseases for HTR2C Gene - From: GeneTests, DISEASES, NovoSeek, and GeneCards

- elite association
Search HTR2C in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR2C

Genetic Association Database (GAD)
HTR2C
Human Genome Epidemiology (HuGE) Navigator
HTR2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR2C
genes like me logo Genes that share disorders with HTR2C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR2C Gene

Publications for HTR2C Gene

  1. The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes. (PMID: 16679816) Horishita T. … Shigematsu A. (Pharmacology 2006) 23 25 26 67
  2. The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. (PMID: 15105221) Ogata J. … Ueta Y. (Anesth. Analg. 2004) 23 25 26 67
  3. The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. (PMID: 14728084) Stahl S.M. … Shayegan D.K. (J Clin Psychiatry 2003) 23 25 26 67
  4. An investigation of the 5-HT2C receptor gene as a migraine candidate gene. (PMID: 12555241) Johnson M.P. … Griffiths L.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 23 25 26 67
  5. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. (PMID: 18308814) Shahid M. … Wong E.H. (J. Psychopharmacol. (Oxford) 2009) 23 25 67

Products for HTR2C Gene

Sources for HTR2C Gene

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