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Aliases for HTR2C Gene

Aliases for HTR2C Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled 2 3
  • 5-Hydroxytryptamine Receptor 1C 3 4
  • 5-HTR2C 3 4
  • 5-HT1C 3 4
  • 5-HT2C 3 4
  • HTR1C 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 2C 2
  • 5-Hydroxytryptamine Receptor 2C 3
  • Serotonin 5-HT-1C Receptor 3
  • Serotonin 5-HT-2C Receptor 3
  • Serotonin Receptor 2C 4
  • 5-HT-1C 4
  • 5-HT-2C 4
  • 5HTR2C 3

External Ids for HTR2C Gene

Previous Symbols for HTR2C Gene

  • HTR1C

Summaries for HTR2C Gene

Entrez Gene Summary for HTR2C Gene

  • This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for HTR2C Gene

HTR2C (5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR2C include cyclothymic disorder and premature ejaculation. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include drug binding and serotonin binding. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for HTR2C Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Tocris Summary for HTR2C Gene

  • Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation, thermoregulation, penile erections and anxiety. The human 5-HT2C receptor gene has been localized to chromosome X (Xq24).

Gene Wiki entry for HTR2C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR2C Gene

Genomics for HTR2C Gene

Genomic Location for HTR2C Gene

Start:
114,584,078 bp from pter
End:
114,910,061 bp from pter
Size:
325,984 bases
Orientation:
Plus strand

Genomic View for HTR2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR2C Gene

Regulatory Elements for HTR2C Gene

Proteins for HTR2C Gene

  • Protein details for HTR2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28335-5HT2C_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 2C
    Protein Accession:
    P28335
    Secondary Accessions:
    • B1AMW4
    • Q5VUF8
    • Q9NP28

    Protein attributes for HTR2C Gene

    Size:
    458 amino acids
    Molecular mass:
    51821 Da
    Quaternary structure:
    • Interacts with MPDZ. Interacts with ARRB2.

    Alternative splice isoforms for HTR2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR2C Gene

Proteomics data for HTR2C Gene at MOPED

Post-translational modifications for HTR2C Gene

Other Protein References for HTR2C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR2C Gene

Domains for HTR2C Gene

Gene Families for HTR2C Gene

HGNC:
  • HTR :5-HT (serotonin) receptors
  • HTRGP :GPCR / Class A : 5-HT (serotonin) receptors, GPCR only
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P28335

UniProtKB/Swiss-Prot:

5HT2C_HUMAN
Domain:
  • The PDZ domain-binding motif is involved in the interaction with MPDZ.:
    • P28335
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P28335
genes like me logo Genes that share domains with HTR2C: view

Function for HTR2C Gene

Molecular function for HTR2C Gene

GENATLAS Biochemistry: 5-hydroxytryptamine (serotonin) receptor,subtype 2C with two alternatively spliced forms,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle
UniProtKB/Swiss-Prot Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

Gene Ontology (GO) - Molecular Function for HTR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001587 Gq/11-coupled serotonin receptor activity IDA 18703043
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IDA 7582481
GO:0008144 drug binding IDA 12970106
GO:0051378 serotonin binding IDA 15831837
genes like me logo Genes that share ontologies with HTR2C: view
genes like me logo Genes that share phenotypes with HTR2C: view

Animal Models for HTR2C Gene

MGI Knock Outs for HTR2C:

miRNA for HTR2C Gene

miRTarBase miRNAs that target HTR2C

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HTR2C Gene

Localization for HTR2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR2C Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR2C Gene COMPARTMENTS Subcellular localization image for HTR2C gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for HTR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 18703043
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR2C: view

Pathways for HTR2C Gene

genes like me logo Genes that share pathways with HTR2C: view

Gene Ontology (GO) - Biological Process for HTR2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response ISS --
GO:0006182 cGMP biosynthetic process IDA 12970106
GO:0006874 cellular calcium ion homeostasis IDA 19057895
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA 12970106
genes like me logo Genes that share ontologies with HTR2C: view

Compounds for HTR2C Gene

(7) ApexBio Compounds for HTR2C Gene

Compound Action Cas Number
Adoprazine 5-HT1A receptor agonist properties. [222551-17-9]
Granisetron HCl 5-HT3 receptor antagonist [107007-99-8]
SB 271046 hydrochloride potent, selective and orally active 5-HT6 receptor antagonist [209481-24-3]
SEA0400 specific Na+/Ca2+ exchange (NCX) inhibitor [223104-29-8]
Vilazodone combined SSRI and 5-HT1A receptor partial agonist [163521-12-8]
Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor [508233-74-7]
WAY-100635 maleate salt potent and selective 5-hydroxytryptamine1A antagonist [634908-75-1]

(5) Tocris Compounds for HTR2C Gene

Compound Action Cas Number
CP 809101 hydrochloride Potent and selective 5-HT2C agonist [1215721-40-6]
Ro 60-0175 fumarate Potent, selective 5-HT2C agonist [169675-09-6]
RS 102221 hydrochloride Selective 5-HT2C antagonist [187397-18-8]
SB 206553 hydrochloride Potent, selective 5-HT2C/5-HT2B antagonist. Orally active [158942-04-2]
SB 242084 Selective 5-HT2C antagonist; brain penetrant [181632-25-7]

(3) HMDB Compounds for HTR2C Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Olanzapine
  • Lanzac
132539-06-1
Quetiapine
  • Quetiapine fumarate
111974-69-7

(38) Drugbank Compounds for HTR2C Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3,4-Methylenedioxymethamphetamine
  • Ecstasy
42542-10-9 target agonist
Agomelatine
  • S-20098
138112-76-2 target
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist
Asenapine
65576-45-6 target antagonist

(94) IUPHAR Ligand for HTR2C Gene

Ligand Type Action Affinity Pubmed IDs
S33084 Antagonist Antagonist 9.6
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
zotepine Antagonist Antagonist 9.2
olanzapine Antagonist Antagonist 9.2
SL65.0155 Agonist Partial agonist 9.2
SB 228357 Antagonist Antagonist 9.1
SB 242084 Antagonist Antagonist 9
SB 243213 Antagonist Antagonist 9
YM348 Agonist Full agonist 9
FR260010 Antagonist Antagonist 9
(+)-LSD Agonist Full agonist 9
DOB Agonist Full agonist 8.9
terguride Antagonist Antagonist 8.9
[3H]mesulergine Antagonist Inverse agonist 8.7
SB 221284 Antagonist Antagonist 8.7
[3H]LSD Agonist Full agonist 8.7
ergotamine Agonist Full agonist 8.6
DOI Agonist Full agonist 8.6
roxindole Antagonist Antagonist 8.6
m-CPP Agonist Partial agonist 8.5
AL-37350A Agonist Full agonist 8.5
LSD Agonist Full agonist 8.4
(R)-DOI Agonist Full agonist 8.4
RS-102221 Antagonist Antagonist 8.4
S 16924 Agonist Partial agonist 8.4
methylergonovine Agonist Full agonist 8.3
Ro 60-0175 Agonist Full agonist 8.2
VER-3323 Agonist Full agonist 8.2
[125I]DOI None None 8.2
loxapine Antagonist Antagonist 8.2
lorcaserin Agonist Full agonist 8.1
(+)-DOI Agonist Full agonist 8.1
org 37684 Agonist Full agonist 8.1
SDZ SER-082 Antagonist Antagonist 8.1
perphenazine Antagonist Antagonist 8.1
WAY-163909 Agonist Full agonist 8
SB 206553 Antagonist Antagonist 7.9
ziprasidone Antagonist Antagonist 7.8
org 12962 Agonist Full agonist 7.8
risperidone Antagonist Antagonist 7.8
SB 215505 Antagonist Antagonist 7.7
MDL-100,907 Antagonist Antagonist 7.7
EGIS-7625 Antagonist Antagonist 7.7
thioridazine Antagonist Antagonist 7.7
quinpirole Agonist Full agonist 7.7
aripiprazole Antagonist Antagonist 7.5
ritanserin Antagonist Antagonist 7.4
metergoline Antagonist Antagonist 7.4
sarpogrelate Antagonist Antagonist 7.4
mianserin Antagonist Antagonist 7.3
quipazine Agonist Full agonist 7.3
lisuride Agonist Partial agonist 7.2
tryptamine Agonist Full agonist 7.2
trifluoperazine Antagonist Antagonist 7.2
BW723C86 Agonist Full agonist 7.1
LY334362 Antagonist Antagonist 7
MK-212 Agonist Full agonist 7
5-MeO-DMT Agonist Full agonist 7
sertindole Antagonist Antagonist 6.9
methysergide Antagonist Antagonist 6.8
5-MeOT Agonist Full agonist 6.8
oxymetazoline Agonist Full agonist 6.8
clozapine Antagonist Antagonist 6.7
spiperone Antagonist Antagonist 6.7
cabergoline Agonist Full agonist 6.7
MDL-11,939 Antagonist Antagonist 6.6
trazodone Antagonist Antagonist 6.6
pergolide Agonist Full agonist 6.5
TFMPP Agonist Full agonist 6.4
duloxetine Antagonist Antagonist 6.4
cyamemazine Antagonist Antagonist 6.3
ketanserin Inhibitor Inhibition 6.3
SB 216641 Agonist Partial agonist 6.3
RS-127445 Antagonist Antagonist 6.3
LY344864 Agonist Full agonist 6.3
RU 24969 Agonist Full agonist 6.2
agomelatine Antagonist Antagonist 6.2
bromocriptine Agonist Partial agonist 6.2
5-CT Agonist Full agonist 6.1
tiospirone Antagonist Antagonist 6
xanomeline Agonist Full agonist 5.9
BRL-15572 Agonist Partial agonist 5.9
alpha-methyl-5-HT Agonist Full agonist 5.8
GR-127935 Agonist Partial agonist 5.8
AMI-193 Antagonist Antagonist 5.8
mesulergine Antagonist Antagonist 5.7
SB 224289 Antagonist Antagonist 5.7
CGS-12066 Agonist Full agonist 5.6
SB 204741 Antagonist Antagonist 5.6
AC-90179 Antagonist Inverse agonist 5.5
apomorphine Activator Activation 5.1
5-HT Inhibitor Inhibition 2.2
chlorpromazine Channel blocker None

(52) Novoseek inferred chemical compound relationships for HTR2C Gene

Compound -log(P) Hits PubMed IDs
agomelatine 84.8 10
mesulergine 83 4
5-hydroxytryptamine 79.3 38
m-chlorophenylpiperazine 74.6 7
maoa 73.4 8

(5) PharmGKB related drug/compound annotations for HTR2C Gene

Drug/compound Annotation
antipsychotics CA
clozapine CA
escitalopram CA
olanzapine CA
risperidone CA
genes like me logo Genes that share compounds with HTR2C: view

Transcripts for HTR2C Gene

mRNA/cDNA for HTR2C Gene

Unigene Clusters for HTR2C Gene

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTR2C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2: -

Relevant External Links for HTR2C Gene

GeneLoc Exon Structure for
HTR2C
ECgene alternative splicing isoforms for
HTR2C

Expression for HTR2C Gene

mRNA expression in normal human tissues for HTR2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR2C Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (16.9), Brain - Putamen (basal ganglia) (10.0), Brain - Caudate (basal ganglia) (8.7), and Brain - Hypothalamus (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTR2C Gene

SOURCE GeneReport for Unigene cluster for HTR2C Gene Hs.149037

mRNA Expression by UniProt/SwissProt for HTR2C Gene

P28335-5HT2C_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expressions with HTR2C: view

Orthologs for HTR2C Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR2C 35
  • 99.71 (n)
  • 99.78 (a)
HTR2C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HTR2C 35
  • 90.62 (n)
  • 92.96 (a)
dog
(Canis familiaris)
Mammalia HTR2C 35
  • 90.47 (n)
  • 94.76 (a)
HTR2C 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr2c 35
  • 86.29 (n)
  • 90.59 (a)
Htr2c 16
Htr2c 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HTR2C 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr2c 35
  • 86.65 (n)
  • 90.81 (a)
chicken
(Gallus gallus)
Aves HTR2C 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR2C 36
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii htr2cl1 36
  • 47 (a)
OneToMany
htr2cl2 36
  • 53 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT2A 35
  • 49.74 (n)
  • 40.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 36
  • 13 (a)
ManyToMany
5-HT1B 36
  • 17 (a)
ManyToMany
5-HT2 36
  • 15 (a)
ManyToMany
CG42796 36
  • 15 (a)
ManyToMany
TyrR 36
  • 17 (a)
ManyToMany
TyrRII 36
  • 19 (a)
ManyToMany
5-HT2 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea ser-1 36
  • 19 (a)
OneToMany
sca-1 37
  • 31 (a)
ser-1 37
  • 31 (a)
M03F4.3 37
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for HTR2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HTR2C Gene

ENSEMBL:
Gene Tree for HTR2C (if available)
TreeFam:
Gene Tree for HTR2C (if available)

Paralogs for HTR2C Gene

Paralogs for HTR2C Gene

genes like me logo Genes that share paralogs with HTR2C: view

Variants for HTR2C Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HTR2C Gene

P28335-5HT2C_HUMAN
Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for Ser

Sequence variations from dbSNP and Humsavar for HTR2C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6318 Benign, - 114,731,326(+) GCAAT(C/G)TGATA missense, reference
rs498177 -- 114,590,222(-) TTTTT(C/T)CAAGT intron-variant
rs498207 -- 114,583,649(-) CATTC(C/T)TCCAA upstream-variant-2KB
rs521018 -- 114,583,441(-) AGACA(A/C/G/T)CTTGA upstream-variant-2KB
rs538680 -- 114,587,028(-) TTGGA(C/T)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR2C Gene

Variant ID Type Subtype PubMed ID
dgv523n21 CNV Loss 19592680
esv33994 CNV Gain+Loss 17666407
dgv524n21 CNV Gain 19592680
nsv527347 CNV Gain 19592680
nsv7044 CNV Loss 18451855
nsv507990 CNV Insertion 20534489
nsv425061 CNV Loss 16902084
esv270001 CNV Insertion 20981092
esv2740401 CNV Deletion 23290073
esv1117381 CNV Deletion 17803354
esv1501559 CNV Insertion 17803354
esv2660156 CNV Deletion 23128226

Relevant External Links for HTR2C Gene

HapMap Linkage Disequilibrium report
HTR2C
Human Gene Mutation Database (HGMD)
HTR2C
Locus Specific Mutation Databases (LSDB)
HTR2C

Disorders for HTR2C Gene

(3) University of Copenhagen DISEASES for HTR2C Gene

(19) Novoseek inferred disease relationships for HTR2C Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 65.6 23
bipolar disorder 55.8 7
major depression 55.1 8
psychiatric disorder 37.8 14
attention-deficit hyperactivity disorder 37.5 2

Relevant External Links for HTR2C

Genetic Association Database (GAD)
HTR2C
Human Genome Epidemiology (HuGE) Navigator
HTR2C
genes like me logo Genes that share disorders with HTR2C: view

No data available for UniProtKB/Swiss-Prot for HTR2C Gene

Publications for HTR2C Gene

  1. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). (PMID: 7557992) Lappalainen J. … Goldman D. (Genomics 1995) 3 4 23
  2. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. (PMID: 11526472) Lerer B. … Mendlewicz J. (Mol. Psychiatry 2001) 3 23 48
  3. Positive association between panic disorder and polymorphism of the serotonin 2A receptor gene. (PMID: 12759158) Inada Y. … Sakai T. (Psychiatry Res 2003) 3 23 48
  4. Depression in Alzheimer's disease: the effect of serotonin receptor gene variation. (PMID: 12707936) Holmes C. … Lovestone S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23 48
  5. A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. (PMID: 15048662) Pooley E.C. … Harrison P.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 23 48

Products for HTR2C Gene

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