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Aliases for HTR2B Gene

Aliases for HTR2B Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 2B, G Protein-Coupled 2 3
  • Serotonin Receptor 2B 3 4
  • 5-HT-2B 3 4
  • 5-HT2B 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 2B 2
  • 5-Hydroxytryptamine Receptor 2B Variant B 3
  • 5-Hydroxytryptamine 2B Receptor 3
  • 5-Hydroxytryptamine Receptor 2B 3
  • 5-HT 2B Receptor 3
  • 5-HT(2B) 3

External Ids for HTR2B Gene

Previous GeneCards Identifiers for HTR2B Gene

  • GC02M230030
  • GC02M230704
  • GC02M231936
  • GC02M232175
  • GC02M231798
  • GC02M231681
  • GC02M223815

Summaries for HTR2B Gene

Entrez Gene Summary for HTR2B Gene

  • This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

GeneCards Summary for HTR2B Gene

HTR2B (5-Hydroxytryptamine (Serotonin) Receptor 2B, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR2B include heart valve disease and ocular hypotension. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include drug binding and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for HTR2B Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.

Tocris Summary for HTR2B Gene

  • Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with little limited distribution in the brain. The functions of 5-HT2B receptors include regulation of differentiation and proliferation of the embryonic and adult heart, gastrointestinal contraction and endothelium-dependent relaxation. Furthermore, 5-HT2B receptor knockout mice exhibit gross heart defects and 5-HT2B overexpression leads to ventricular hypertrophy. The human 5-HT2B receptor gene has been localized to chromosome 2 (2q36.3-q37.1).

Gene Wiki entry for HTR2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR2B Gene

Genomics for HTR2B Gene

Regulatory Elements for HTR2B Gene

Genomic Location for HTR2B Gene

Start:
231,108,230 bp from pter
End:
231,125,213 bp from pter
Size:
16,984 bases
Orientation:
Minus strand

Genomic View for HTR2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR2B Gene

Proteins for HTR2B Gene

  • Protein details for HTR2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41595-5HT2B_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 2B
    Protein Accession:
    P41595
    Secondary Accessions:
    • B2R9D5
    • Q53TI1
    • Q62221
    • Q6P523

    Protein attributes for HTR2B Gene

    Size:
    481 amino acids
    Molecular mass:
    54298 Da
    Quaternary structure:
    • Interacts with MPDZ.

    Three dimensional structures from OCA and Proteopedia for HTR2B Gene

neXtProt entry for HTR2B Gene

Proteomics data for HTR2B Gene at MOPED

Post-translational modifications for HTR2B Gene

  • Glycosylation at Asn30
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HTR2B Gene

Domains for HTR2B Gene

Graphical View of Domain Structure for InterPro Entry

P41595

UniProtKB/Swiss-Prot:

5HT2B_HUMAN :
  • Ligands are bound in a hydrophobic pocket formed by the transmembrane helices
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • Ligands are bound in a hydrophobic pocket formed by the transmembrane helices
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR2B: view

Function for HTR2B Gene

Molecular function for HTR2B Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 2B,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.

Gene Ontology (GO) - Molecular Function for HTR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IMP 15625277
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IDA 15862800
GO:0005096 GTPase activator activity ISS --
GO:0008144 drug binding IDA 12970106
genes like me logo Genes that share ontologies with HTR2B: view
genes like me logo Genes that share phenotypes with HTR2B: view

Animal Models for HTR2B Gene

MGI Knock Outs for HTR2B:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for HTR2B Gene

Localization for HTR2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR2B Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR2B Gene COMPARTMENTS Subcellular localization image for HTR2B gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15925089
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with HTR2B: view

Pathways for HTR2B Gene

genes like me logo Genes that share pathways with HTR2B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Neurotransmitter Receptors in human,mouse,rat
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for HTR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration ISS --
GO:0001819 positive regulation of cytokine production IDA 19023134
GO:0001938 positive regulation of endothelial cell proliferation IMP 19308295
GO:0002031 G-protein coupled receptor internalization IEA --
GO:0003007 heart morphogenesis ISS --
genes like me logo Genes that share ontologies with HTR2B: view

Drugs for HTR2B Gene

(29) Drugbank Compounds for HTR2B Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Apomorphine
  • (-)-10,11-Dihydroxyaporphine
41372-20-7 6005 Target agonist approved, investigational
Bromocriptine
  • (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman
25614-03-3 31101 Target agonist approved, investigational
Eletriptan
  • Eletriptanum
143322-58-1 77993 Target agonist approved, investigational
Olanzapine
  • 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
132539-06-1 Target antagonist approved, investigational
Pramipexole
  • (-)-Pramipexole
104632-26-0 Target unknown approved, investigational

(5) Tocris Compounds for HTR2B Gene

Compound Action Cas Number
alpha-Methyl-5-hydroxytryptamine maleate 5-HT2B agonist [97469-12-0]
BW 723C86 hydrochloride 5-HT2B agonist [160521-72-2]
LY 266097 hydrochloride Selective 5-HT2B receptor antagonist [172895-39-5]
RS 127445 hydrochloride Selective, high affinity 5-HT2B antagonist [199864-86-3]
SB 204741 Potent, selective 5-HT2B antagonist [152239-46-8]

(2) ApexBio Compounds for HTR2B Gene

Compound Action Cas Number
PRX-08066 Maleic acid 5-HT2B receptor antagonist,potent and selective [866206-55-5]
RS 127445 5-HT2B receptor antagonist,high affinity [199864-87-4]

(19) HMDB Compounds for HTR2B Gene

Compound Synonyms Cas Number PubMed IDs
Apomorphine
  • Apomorfin
41372-20-7
Bromocriptine
  • Bromergocryptine
25614-03-3
Cabergoline
  • Cabergolina [Spanish]
81409-90-7
Calcium
  • Ca
7440-70-2
Chlorprothixene
  • alpha-Chlorprothixene
113-59-7

(90) IUPHAR Ligand for HTR2B Gene

Ligand Type Action Affinity Pubmed IDs
piboserod Antagonist Antagonist 10.4
S33084 Antagonist Antagonist 9.6
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
SL65.0155 Agonist Partial agonist 9.2
SB 228357 Antagonist Antagonist 9.1
LY53857 Antagonist Antagonist 9.1
SB 242084 Antagonist Antagonist 9
SB 243213 Antagonist Antagonist 9
(+)-LSD Agonist Full agonist 9
terguride Antagonist Antagonist 8.9
DOB Agonist Full agonist 8.9
spiroxatrine Agonist Full agonist 8.8
[3H]LSD Agonist Full agonist 8.7
[3H]mesulergine Antagonist Inverse agonist 8.7
SB 221284 Antagonist Antagonist 8.7
roxindole Antagonist Antagonist 8.6
ergotamine Agonist Full agonist 8.6
DOI Agonist Full agonist 8.6
fluoxetine Inhibitor Inhibition 8.5
m-CPP Agonist Partial agonist 8.5
AL-37350A Agonist Full agonist 8.5
tegaserod Agonist Partial agonist 8.4
S 16924 Agonist Partial agonist 8.4
(R)-DOI Agonist Full agonist 8.4
RS-102221 Antagonist Antagonist 8.4
rauwolscine Antagonist Antagonist 8.4
[3H]rauwolscine Antagonist Antagonist 8.4
methylergonovine Agonist Full agonist 8.3
Ro 60-0175 Agonist Full agonist 8.2
VER-3323 Agonist Full agonist 8.2
[125I]DOI None None 8.2
pindolol Antagonist Antagonist 8.1
lorcaserin Agonist Full agonist 8.1
(+)-DOI Agonist Full agonist 8.1
org 37684 Agonist Full agonist 8.1
SDZ SER-082 Antagonist Antagonist 8.1
SB 277011-A Antagonist Antagonist 8
1-naphthylpiperazine Agonist Full agonist 8
(+)-norfenfluramine Agonist Full agonist 8
SB 206553 Antagonist Antagonist 7.9
org 12962 Agonist Full agonist 7.8
quinpirole Agonist Full agonist 7.7
SB 215505 Antagonist Antagonist 7.7
MDL-100,907 Antagonist Antagonist 7.7
EGIS-7625 Antagonist Antagonist 7.7
metergoline Antagonist Antagonist 7.4
ritanserin Antagonist Antagonist 7.4
sarpogrelate Antagonist Antagonist 7.4
mianserin Antagonist Antagonist 7.3
yohimbine Antagonist Antagonist 7.3
quipazine Agonist Full agonist 7.3
(plusmn)-norfenfluramine Agonist Full agonist 7.3
(-)-norfenfluramine Agonist Full agonist 7.3
lisuride Agonist Partial agonist 7.2
tryptamine Agonist Full agonist 7.2
BW723C86 Agonist Full agonist 7.1
MK-212 Agonist Full agonist 7
piribedil Agonist Partial agonist 6.9
methysergide Antagonist Antagonist 6.8
clozapine Antagonist Antagonist 6.7
spiperone Antagonist Antagonist 6.7
cabergoline Agonist Full agonist 6.7
MDL-11,939 Antagonist Antagonist 6.6
trazodone Antagonist Antagonist 6.6
pergolide Agonist Full agonist 6.5
TFMPP Agonist Full agonist 6.4
ketanserin Inhibitor Inhibition 6.3
LY344864 Agonist Full agonist 6.3
SB 216641 Agonist Partial agonist 6.3
RS-127445 Antagonist Antagonist 6.3
bromocriptine Agonist Partial agonist 6.2
RU 24969 Agonist Full agonist 6.2
agomelatine Antagonist Antagonist 6.2
L-741,626 Antagonist Antagonist 6.2
haloperidol Antagonist Antagonist 6.1
5-CT Agonist Full agonist 6.1
xanomeline Agonist Full agonist 5.9
BRL-15572 Agonist Partial agonist 5.9
alpha-methyl-5-HT Agonist Full agonist 5.8
GR-127935 Agonist Partial agonist 5.8
AMI-193 Antagonist Antagonist 5.8
mesulergine Antagonist Antagonist 5.7
SB 224289 Antagonist Antagonist 5.7
CGS-12066 Agonist Full agonist 5.6
SB 204741 Antagonist Antagonist 5.6
norfluoxetine Antagonist Antagonist 5.3
melatonin Antagonist Antagonist 5.2
apomorphine Activator Activation 5.1
5-HT Inhibitor Inhibition 2.2

(21) Novoseek inferred chemical compound relationships for HTR2B Gene

Compound -log(P) Hits PubMed IDs
sb204741 93.7 3
rs102221 83.6 1
m-chlorophenylpiperazine 79.7 3
5-hydroxytryptamine 76.3 14
agomelatine 69.2 2
genes like me logo Genes that share compounds with HTR2B: view

Transcripts for HTR2B Gene

mRNA/cDNA for HTR2B Gene

Unigene Clusters for HTR2B Gene

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR2B Gene

No ASD Table

Relevant External Links for HTR2B Gene

GeneLoc Exon Structure for
HTR2B
ECgene alternative splicing isoforms for
HTR2B

Expression for HTR2B Gene

mRNA expression in normal human tissues for HTR2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR2B Gene

This gene is overexpressed in Adrenal Gland (6.9), Uterus (6.3), Esophagus - Muscularis (5.9), and Colon - Sigmoid (4.0).

SOURCE GeneReport for Unigene cluster for HTR2B Gene Hs.421649

mRNA Expression by UniProt/SwissProt for HTR2B Gene

P41595-5HT2B_HUMAN
Tissue specificity: Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
genes like me logo Genes that share expressions with HTR2B: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for HTR2B Gene

Orthologs for HTR2B Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR2B 35
  • 90.28 (n)
  • 88.96 (a)
5HTR2B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR2B 35
  • 89.55 (n)
  • 87.32 (a)
5HT2B 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr2b 35
  • 82.74 (n)
  • 81.63 (a)
Htr2b 16
Htr2b 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR2B 35
  • 99.31 (n)
  • 99.58 (a)
HTR2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr2b 35
  • 82.67 (n)
  • 80.17 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR2B 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR2B 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR2B 35
  • 73.88 (n)
  • 79.53 (a)
gga-mir-6558 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR2B 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr2b 35
  • 67.92 (n)
  • 70.59 (a)
zebrafish
(Danio rerio)
Actinopterygii htr2b 35
  • 63.73 (n)
  • 64.76 (a)
htr2b 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT2 37
  • 39 (a)
5-HT2 36
  • 15 (a)
ManyToMany
CG42796 36
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ser-1 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for HTR2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR2B Gene

ENSEMBL:
Gene Tree for HTR2B (if available)
TreeFam:
Gene Tree for HTR2B (if available)

Paralogs for HTR2B Gene

Paralogs for HTR2B Gene

(13) SIMAP similar genes for HTR2B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HTR2B: view

Variants for HTR2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HTR2B Gene

P41595-5HT2B_HUMAN
A variation at a single nucleotide base, which results in an erroneous stop codon and affects Gln-20, triggers non-sense mediated RNA decay, such that no HTR2B-receptor protein is expressed. It is associated with impulsive behavior and co-segregates with disorders characterized by impulsivity. However, the presence of this variant is not in itself sufficient to cause impulsive behavior: male sex, testosterone level, alcohol and stress exposure are other factors playing important roles

Sequence variations from dbSNP and Humsavar for HTR2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_055907 -
VAR_064574 -
VAR_064575 -
VAR_064576 -

Structural Variations from Database of Genomic Variants (DGV) for HTR2B Gene

Variant ID Type Subtype PubMed ID
nsv525474 CNV Loss 19592680
nsv524208 CNV Gain 19592680
esv271896 CNV Insertion 20981092
nsv875957 CNV Gain 21882294

Relevant External Links for HTR2B Gene

HapMap Linkage Disequilibrium report
HTR2B
Human Gene Mutation Database (HGMD)
HTR2B

Disorders for HTR2B Gene

(2) Novoseek inferred disease relationships for HTR2B Gene

Disease -log(P) Hits PubMed IDs
migraine 18.6 3
tumors 0 1

Relevant External Links for HTR2B

Genetic Association Database (GAD)
HTR2B
Human Genome Epidemiology (HuGE) Navigator
HTR2B
genes like me logo Genes that share disorders with HTR2B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HTR2B Gene

Publications for HTR2B Gene

  1. Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. (PMID: 12970106) Schaerlinger B. … Maroteaux L. (Br. J. Pharmacol. 2003) 3 4 23 25 26
  2. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. (PMID: 18703043) Cussac D. … Rauly-Lestienne I. (Eur. J. Pharmacol. 2008) 3 4 23 25 26
  3. The human serotonin 5-HT2B receptor: pharmacological link between 5- HT2 and 5-HT1D receptors. (PMID: 7926008) Choi D.S. … Maroteaux L. (FEBS Lett. 1994) 3 4 23
  4. 5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells. (PMID: 8882600) Ullmer C. … LA1bbert H. (Br. J. Pharmacol. 1996) 3 4 23
  5. Cloning and functional characterization of the human 5-HT2B serotonin receptor. (PMID: 8143856) Schmuck K. … Luebbert H. (FEBS Lett. 1994) 2 3 4

Products for HTR2B Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
    • Neurotransmitter Receptors in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HTR2B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HTR2B
    • Block miRNA regulation of HTR2B using miScript Target Protectors

    Sources for HTR2B Gene

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