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Aliases for HTR2B Gene

Aliases for HTR2B Gene

  • 5-Hydroxytryptamine Receptor 2B 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 2B, G Protein-Coupled 2 3 5
  • Serotonin Receptor 2B 3 4
  • 5-HT-2B 3 4
  • 5-HT2B 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 2B 2
  • 5-Hydroxytryptamine Receptor 2B Variant B 3
  • 5-Hydroxytryptamine 2B Receptor 3
  • 5-HT 2B Receptor 3
  • 5-HT(2B) 3

External Ids for HTR2B Gene

Previous GeneCards Identifiers for HTR2B Gene

  • GC02M230030
  • GC02M230704
  • GC02M231936
  • GC02M232175
  • GC02M231798
  • GC02M231681
  • GC02M223815

Summaries for HTR2B Gene

Entrez Gene Summary for HTR2B Gene

  • This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

GeneCards Summary for HTR2B Gene

HTR2B (5-Hydroxytryptamine Receptor 2B) is a Protein Coding gene. Diseases associated with HTR2B include ocular hypotension and heart valve disease. Among its related pathways are Calcium signaling pathway and Signaling in Gap Junctions. GO annotations related to this gene include G-protein coupled receptor activity and drug binding. An important paralog of this gene is HTR2C.

UniProtKB/Swiss-Prot for HTR2B Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.

Tocris Summary for HTR2B Gene

  • Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with limited distribution in the brain. 5-HT2B overexpression leads to ventricular hypertrophy.

Gene Wiki entry for HTR2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR2B Gene

Genomics for HTR2B Gene

Regulatory Elements for HTR2B Gene

Enhancers for HTR2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HTR2B on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR2B Gene

Chromosome:
2
Start:
231,108,230 bp from pter
End:
231,125,778 bp from pter
Size:
17,549 bases
Orientation:
Minus strand

Genomic View for HTR2B Gene

Genes around HTR2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR2B Gene

Proteins for HTR2B Gene

  • Protein details for HTR2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41595-5HT2B_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 2B
    Protein Accession:
    P41595
    Secondary Accessions:
    • B2R9D5
    • Q53TI1
    • Q62221
    • Q6P523

    Protein attributes for HTR2B Gene

    Size:
    481 amino acids
    Molecular mass:
    54298 Da
    Quaternary structure:
    • Interacts with MPDZ.

    Three dimensional structures from OCA and Proteopedia for HTR2B Gene

neXtProt entry for HTR2B Gene

Proteomics data for HTR2B Gene at MOPED

Post-translational modifications for HTR2B Gene

  • Glycosylation at Asn 30
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR2B Gene

Domains & Families for HTR2B Gene

Graphical View of Domain Structure for InterPro Entry

P41595

UniProtKB/Swiss-Prot:

5HT2B_HUMAN :
  • Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR2B: view

Function for HTR2B Gene

Molecular function for HTR2B Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 2B,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.

Gene Ontology (GO) - Molecular Function for HTR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with HTR2B: view
genes like me logo Genes that share phenotypes with HTR2B: view

Animal Models for HTR2B Gene

MGI Knock Outs for HTR2B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HTR2B Gene

Localization for HTR2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR2B Gene

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR2B Gene COMPARTMENTS Subcellular localization image for HTR2B gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HTR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with HTR2B: view

Pathways & Interactions for HTR2B Gene

genes like me logo Genes that share pathways with HTR2B: view

Gene Ontology (GO) - Biological Process for HTR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration ISS --
GO:0001819 positive regulation of cytokine production IDA 19023134
GO:0001938 positive regulation of endothelial cell proliferation IEA,IMP 19308295
GO:0003007 heart morphogenesis IEA,ISS --
GO:0003300 cardiac muscle hypertrophy IEA,ISS --
genes like me logo Genes that share ontologies with HTR2B: view

No data available for SIGNOR curated interactions for HTR2B Gene

Drugs & Compounds for HTR2B Gene

(124) Drugs for HTR2B Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Apomorphine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 34
Bromocriptine Approved, Investigational Pharma Antagonist, agonist, Target 29
Cabergoline Approved Pharma Antagonist, agonist, Target 45
Lisuride Approved Pharma Antagonist, agonist, Target, antagonist 5
Methysergide Approved Pharma Antagonist, antagonist, Target 0

(25) Additional Compounds for HTR2B Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-norfenfluramine
Full agonist, Agonist
<i>m</i>-CPP
Antagonist
5-HT
Full agonist, Agonist
alpha-methyl-5-HT
Full agonist, Agonist
AMI-193
Antagonist

(5) Tocris Compounds for HTR2B Gene

Compound Action Cas Number
alpha-Methyl-5-hydroxytryptamine maleate 5-HT2B agonist 97469-12-0
BW 723C86 hydrochloride 5-HT2B agonist 160521-72-2
m-CPP hydrochloride 5-HT2B/2C receptor agonist 13078-15-4
SB 200646 hydrochloride 5-HT2C/2B antagonist 143797-62-0
SDZ SER 082 fumarate Selective 5-HT2B/2C antagonist 1417343-80-6

(2) ApexBio Compounds for HTR2B Gene

Compound Action Cas Number
PRX-08066 Maleic acid 5-HT2B receptor antagonist,potent and selective 866206-55-5
RS 127445 5-HT2B receptor antagonist,high affinity 199864-87-4
genes like me logo Genes that share compounds with HTR2B: view

Transcripts for HTR2B Gene

mRNA/cDNA for HTR2B Gene

Unigene Clusters for HTR2B Gene

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTR2B Gene

No ASD Table

Relevant External Links for HTR2B Gene

GeneLoc Exon Structure for
HTR2B
ECgene alternative splicing isoforms for
HTR2B

Expression for HTR2B Gene

mRNA expression in normal human tissues for HTR2B Gene

mRNA differential expression in normal tissues according to GTEx for HTR2B Gene

This gene is overexpressed in Adrenal Gland (x6.9), Uterus (x6.3), Esophagus - Muscularis (x5.9), and Colon - Sigmoid (x4.0).

SOURCE GeneReport for Unigene cluster for HTR2B Gene Hs.421649

mRNA Expression by UniProt/SwissProt for HTR2B Gene

P41595-5HT2B_HUMAN
Tissue specificity: Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
genes like me logo Genes that share expression patterns with HTR2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HTR2B Gene

Orthologs for HTR2B Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR2B 35
  • 90.28 (n)
  • 88.96 (a)
5HTR2B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR2B 35
  • 89.55 (n)
  • 87.32 (a)
5HT2B 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr2b 35
  • 82.74 (n)
  • 81.63 (a)
Htr2b 16
Htr2b 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR2B 35
  • 99.31 (n)
  • 99.58 (a)
HTR2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr2b 35
  • 82.67 (n)
  • 80.17 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR2B 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR2B 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR2B 35
  • 73.88 (n)
  • 79.53 (a)
gga-mir-6558 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR2B 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr2b 35
  • 67.92 (n)
  • 70.59 (a)
zebrafish
(Danio rerio)
Actinopterygii htr2b 35
  • 63.73 (n)
  • 64.76 (a)
htr2b 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT2 37
  • 39 (a)
5-HT2 36
  • 15 (a)
ManyToMany
CG42796 36
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ser-1 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for HTR2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR2B Gene

ENSEMBL:
Gene Tree for HTR2B (if available)
TreeFam:
Gene Tree for HTR2B (if available)

Paralogs for HTR2B Gene

Paralogs for HTR2B Gene

(13) SIMAP similar genes for HTR2B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HTR2B: view

Variants for HTR2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HTR2B Gene

P41595-5HT2B_HUMAN
A variation at a single nucleotide base, which results in an erroneous stop codon and affects Gln-20, triggers non-sense mediated RNA decay, such that no HTR2B-receptor protein is expressed. It is associated with impulsive behavior and co-segregates with disorders characterized by impulsivity. However, the presence of this variant is not in itself sufficient to cause impulsive behavior: male sex, testosterone level, alcohol and stress exposure are other factors playing important roles.

Sequence variations from dbSNP and Humsavar for HTR2B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_055907 -
VAR_064574 -
VAR_064575 -
VAR_064576 -

Structural Variations from Database of Genomic Variants (DGV) for HTR2B Gene

Variant ID Type Subtype PubMed ID
nsv525474 CNV Loss 19592680
nsv524208 CNV Gain 19592680
esv271896 CNV Insertion 20981092
nsv875957 CNV Gain 21882294

Variation tolerance for HTR2B Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR2B Gene

HapMap Linkage Disequilibrium report
HTR2B
Human Gene Mutation Database (HGMD)
HTR2B

Disorders for HTR2B Gene

MalaCards: The human disease database

(9) MalaCards diseases for HTR2B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ocular hypotension
  • hypotony of eye
heart valve disease
  • valvular heart disease
hypoactive sexual desire disorder
  • lack or loss of sexual desire
chronic pulmonary heart disease
urethral intrinsic sphincter deficiency
  • intrinsic sphincter deficiency [isd]
- elite association - COSMIC cancer census association via MalaCards
Search HTR2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR2B

Genetic Association Database (GAD)
HTR2B
Human Genome Epidemiology (HuGE) Navigator
HTR2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR2B
genes like me logo Genes that share disorders with HTR2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR2B Gene

Publications for HTR2B Gene

  1. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. (PMID: 18703043) Cussac D. … Rauly-Lestienne I. (Eur. J. Pharmacol. 2008) 3 23 25 26
  2. Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. (PMID: 12970106) Schaerlinger B. … Maroteaux L. (Br. J. Pharmacol. 2003) 3 23 25 26
  3. Cloning and functional characterization of the human 5-HT2B serotonin receptor. (PMID: 8143856) Schmuck K. … Luebbert H. (FEBS Lett. 1994) 2 3 4 67
  4. Activation of meningeal 5-HT2B receptors: an early step in the generation of migraine headache? (PMID: 8743744) Schmuck K. … Lubbert H. (Eur. J. Neurosci. 1996) 23 25 26
  5. Serotonin-2 receptor agonists as novel ocular hypotensive agents and their cellular and molecular mechanisms of action. (PMID: 20426763) Sharif N.A. (Curr Drug Targets 2010) 25 26

Products for HTR2B Gene

Sources for HTR2B Gene

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