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Aliases for HTR1D Gene

Aliases for HTR1D Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled 2 3
  • Serotonin 1D Alpha Receptor 3 4
  • Serotonin Receptor 1D 3 4
  • 5-HT-1D-Alpha 3 4
  • 5-HT-1D 3 4
  • 5-HT1D 3 4
  • HTR1DA 3 4
  • HTRL 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1D 2
  • 5-Hydroxytryptamine Receptor 1D 3
  • HT1DA 3
  • RDC4 3

External Ids for HTR1D Gene

Previous HGNC Symbols for HTR1D Gene

  • HTRL

Previous GeneCards Identifiers for HTR1D Gene

  • GC01M023088
  • GC01M022554
  • GC01M022664
  • GC01M022987
  • GC01M023263
  • GC01M023389
  • GC01M023517
  • GC01M021762

Summaries for HTR1D Gene

GeneCards Summary for HTR1D Gene

HTR1D (5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR1D include migraine and schizophrenia. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include serotonin receptor activity and serotonin binding. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR1D Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

Tocris Summary for HTR1D Gene

  • Serotonin 5-HT1D receptors, previously known as 5-HT1Dalpha receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in anxiety, depression, and other neuropsychiatric disorders. The human 5-HT1D receptor gene has been localized to chromosome 1 (1p34.3-36.3).

Gene Wiki entry for HTR1D Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1D Gene

Genomics for HTR1D Gene

Regulatory Elements for HTR1D Gene

Genomic Location for HTR1D Gene

Start:
23,191,895 bp from pter
End:
23,194,729 bp from pter
Size:
2,835 bases
Orientation:
Minus strand

Genomic View for HTR1D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1D Gene

Proteins for HTR1D Gene

  • Protein details for HTR1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28221-5HT1D_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1D
    Protein Accession:
    P28221
    Secondary Accessions:

    Protein attributes for HTR1D Gene

    Size:
    377 amino acids
    Molecular mass:
    41907 Da
    Quaternary structure:
    • Homodimer. Heterodimer with HTR1B.

neXtProt entry for HTR1D Gene

Proteomics data for HTR1D Gene at MOPED

Post-translational modifications for HTR1D Gene

  • Glycosylation at Asn5, Asn17, and Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR1D Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HTR1D Gene

Domains for HTR1D Gene

Gene Families for HTR1D Gene

HGNC:
  • HTRGP :GPCR / Class A : 5-HT (serotonin) receptors, GPCR only
  • HTR :5-HT (serotonin) receptors
IUPHAR :

Suggested Antigen Peptide Sequences for HTR1D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28221

UniProtKB/Swiss-Prot:

5HT1D_HUMAN :
  • P28221
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1D: view

Function for HTR1D Gene

Molecular function for HTR1D Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 1.D,alpha,expressed in brain cortex,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

Gene Ontology (GO) - Molecular Function for HTR1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IMP 1652050
GO:0051378 serotonin binding IEA --
genes like me logo Genes that share ontologies with HTR1D: view

Phenotypes for HTR1D Gene

MGI mutant phenotypes for HTR1D:
inferred from 1 alleles
GenomeRNAi human phenotypes for HTR1D:
genes like me logo Genes that share phenotypes with HTR1D: view

Animal Models for HTR1D Gene

MGI Knock Outs for HTR1D:

Animal Model Products

miRNA for HTR1D Gene

miRTarBase miRNAs that target HTR1D

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HTR1D Gene

Localization for HTR1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1D Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR1D Gene COMPARTMENTS Subcellular localization image for HTR1D gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 1652050
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR1D: view

Pathways for HTR1D Gene

genes like me logo Genes that share pathways with HTR1D: view

Pathways by source for HTR1D Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for HTR1D Gene

Selected Interacting proteins: P28221-5HT1D_HUMAN for HTR1D Gene via I2D

Gene Ontology (GO) - Biological Process for HTR1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1565658
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 1652050
GO:0007210 serotonin receptor signaling pathway TAS 1565658
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with HTR1D: view

Compounds for HTR1D Gene

(5) Tocris Compounds for HTR1D Gene

Compound Action Cas Number
BRL 15572 hydrochloride Selective h5-HT1D antagonist [1173022-77-9]
GR 127935 hydrochloride Potent, selective 5-HT1B/1D antagonist [148642-42-6]
L-694,247 5-HT1D agonist [137403-12-4]
LY 310762 hydrochloride 5-HT1D-preferring antagonist [192927-92-7]
PNU 142633 Highly selective 5-HT1D agonist [187665-65-2]

(3) ApexBio Compounds for HTR1D Gene

Compound Action Cas Number
Almotriptan Malate 5-HT1B/1D-receptor agonist [181183-52-8]
BRL-15572 5-HT1D receptor antagonist [193611-72-2]
Eletriptan HBr [177834-92-3]

(2) HMDB Compounds for HTR1D Gene

Compound Synonyms Cas Number PubMed IDs
Serotonin
  • 3-(2-Aminoethyl)-1H-indol-5-ol
50-67-9
Sumatriptan
  • Imigran
103628-46-2

(24) Drugbank Compounds for HTR1D Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Almotriptan
181183-52-8 target agonist
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist
Bromocriptine
  • Bromergocryptine
25614-03-3 target agonist
Cabergoline
  • Cabergolina [Spanish]
81409-90-7 target agonist

(82) IUPHAR Ligand for HTR1D Gene

Ligand Type Action Affinity Pubmed IDs
5-HT-moduline Allosteric regulator Negative 12
asenapine Antagonist Antagonist 9.8
S33084 Antagonist Antagonist 9.6
alniditan Agonist Full agonist 9.4
[3H]8-OH-DPAT Agonist Full agonist 9.4
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
L-694,247 Agonist Full agonist 9.3
zotepine Antagonist Antagonist 9.2
olanzapine Antagonist Antagonist 9.2
SL65.0155 Agonist Partial agonist 9.2
[3H]eletriptan Agonist Full agonist 9.1
(+)-lysergic acid Agonist Full agonist 9
[3H]5-HT Agonist Full agonist 9
[3H]alniditan Agonist Full agonist 8.92
terguride Antagonist Antagonist 8.9
quetiapine Antagonist Antagonist 8.7
7-methoxy-1-naphthylpiperazine Agonist Full agonist 8.6
SB 649915 Antagonist Antagonist 8.6
[3H]GR 125,743 Antagonist Antagonist 8.6
roxindole Antagonist Antagonist 8.6
m-CPP Agonist Partial agonist 8.5
rauwolscine Antagonist Antagonist 8.4
[3H]sumatriptan Agonist Full agonist 8.2
ocaperidone Agonist Full agonist 8
SB 272183 Antagonist Antagonist 8
1-naphthylpiperazine Agonist Full agonist 8
bufotenine Antagonist Antagonist 8
SB 277011-A Antagonist Antagonist 8
fluspirilene Antagonist Antagonist 7.9
ziprasidone Antagonist Antagonist 7.8
risperidone Antagonist Antagonist 7.8
EMDT Agonist Full agonist 7.8
CP-122288 Agonist Full agonist 7.7
MPDT Antagonist Antagonist 7.7
naratriptan Agonist Full agonist 7.6
(+)-WAY 100135 Antagonist Antagonist 7.6
9-OH-risperidone Antagonist Antagonist 7.5
aripiprazole Antagonist Antagonist 7.5
metergoline Antagonist Antagonist 7.4
lysergol Agonist Full agonist 7.4
eletriptan Agonist Full agonist 7.4
ritanserin Antagonist Antagonist 7.4
yohimbine Antagonist Antagonist 7.3
L-772,405 Agonist Full agonist 7.2
lisuride Agonist Partial agonist 7.2
tryptamine Agonist Full agonist 7.2
dimethyltryptamine Agonist Full agonist 7.2
dihydroergotamine Agonist Full agonist 7.1
cyanopindolol Antagonist Antagonist 7.1
sertindole Antagonist Antagonist 6.9
oxymetazoline Agonist Full agonist 6.8
methysergide Antagonist Antagonist 6.8
5-MeOT Agonist Full agonist 6.8
cabergoline Agonist Full agonist 6.7
clozapine Antagonist Antagonist 6.7
spiperone Antagonist Antagonist 6.7
zolmitriptan Agonist Full agonist 6.6
SB 714786 Antagonist Antagonist 6.5
pergolide Agonist Full agonist 6.5
rizatriptan Agonist Full agonist 6.4
TFMPP Agonist Full agonist 6.4
2-methyl-5-HT Agonist Full agonist 6.4
SB 216641 Agonist Partial agonist 6.3
ketanserin Inhibitor Inhibition 6.3
LY344864 Agonist Full agonist 6.3
bromocriptine Agonist Partial agonist 6.2
RU 24969 Agonist Full agonist 6.2
5-CT Agonist Full agonist 6.1
haloperidol Antagonist Antagonist 6.1
xanomeline Agonist Full agonist 5.9
BRL-15572 Agonist Partial agonist 5.9
GR-127935 Agonist Partial agonist 5.8
dipropyl-5-CT Agonist Full agonist 5.8
alpha-methyl-5-HT Agonist Full agonist 5.8
SB 224289 Antagonist Antagonist 5.7
donitriptan Agonist Partial agonist 5.6
sumatriptan Antagonist Antagonist 5.6
CGS-12066 Agonist Full agonist 5.6
pipamperone Antagonist Antagonist 5.6
5-HT Inhibitor Inhibition 2.2
[3H]5-CT Agonist Agonist

(34) Novoseek inferred chemical compound relationships for HTR1D Gene

Compound -log(P) Hits PubMed IDs
sumatriptan 90.6 14
ly 344864 89.2 3
gr 127935 87.4 3
5-carboxamidotryptamine 87.1 3
methiothepin 83.4 3
genes like me logo Genes that share compounds with HTR1D: view

Transcripts for HTR1D Gene

mRNA/cDNA for HTR1D Gene

(10) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1D Gene

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR1D

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1D Gene

No ASD Table

Relevant External Links for HTR1D Gene

GeneLoc Exon Structure for
HTR1D
ECgene alternative splicing isoforms for
HTR1D

Expression for HTR1D Gene

mRNA expression in normal human tissues for HTR1D Gene

mRNA differential expression in normal tissues according to GTEx for HTR1D Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (15.1), Brain - Putamen (basal ganglia) (9.9), Brain - Caudate (basal ganglia) (8.2), and Small Intestine - Terminal Ileum (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HTR1D Gene

SOURCE GeneReport for Unigene cluster for HTR1D Gene Hs.121482

mRNA Expression by UniProt/SwissProt for HTR1D Gene

P28221-5HT1D_HUMAN
Tissue specificity: Detected in brain neocortex and caudate nucleus (at protein level).
genes like me logo Genes that share expressions with HTR1D: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for HTR1D Gene

Orthologs for HTR1D Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR1D 35
  • 88.33 (n)
  • 90.45 (a)
HTR1D 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR1D 35
  • 87.18 (n)
  • 88.06 (a)
HTR1D 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr1d 35
  • 85.38 (n)
  • 90.91 (a)
Htr1d 16
Htr1d 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR1D 35
  • 99.38 (n)
  • 99.47 (a)
HTR1D 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr1d 35
  • 85.65 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR1D 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR1D 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR1D 35
  • 71.62 (n)
  • 79.84 (a)
HTR1D 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR1D 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1d 35
  • 67.24 (n)
  • 77.01 (a)
zebrafish
(Danio rerio)
Actinopterygii htr1bd 35
  • 69.3 (n)
  • 71.27 (a)
htr1bd 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 41 (a)
5-HT1B 37
  • 37 (a)
5-HT7 37
  • 37 (a)
CG7431 37
  • 38 (a)
DopR2 37
  • 45 (a)
Oct-TyrR 35
  • 56.58 (n)
  • 45.39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRTYR 35
  • 56.04 (n)
  • 44.93 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 37 (a)
tyra-3 35
  • 47.07 (n)
  • 41.55 (a)
Species with no ortholog for HTR1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1D Gene

ENSEMBL:
Gene Tree for HTR1D (if available)
TreeFam:
Gene Tree for HTR1D (if available)

Paralogs for HTR1D Gene

Paralogs for HTR1D Gene

Selected SIMAP similar genes for HTR1D Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HTR1D Gene

genes like me logo Genes that share paralogs with HTR1D: view

Variants for HTR1D Gene

Sequence variations from dbSNP and Humsavar for HTR1D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6299 - 23,193,426(-) GCACT(C/T)GCACT reference, missense
rs6300 -- 23,193,140(-) TTTAA(C/T)GAAGA synonymous-codon, reference
rs604030 -- 23,191,734(+) CATCA(C/T)GCTAT downstream-variant-500B
rs605367 -- 23,192,031(+) TGCGG(C/T)GGGTG utr-variant-3-prime
rs623988 -- 23,192,984(-) TCATG(A/G)TATCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTR1D Gene

Variant ID Type Subtype PubMed ID
nsv834424 CNV Loss 17160897

Relevant External Links for HTR1D Gene

HapMap Linkage Disequilibrium report
HTR1D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1D Gene

Disorders for HTR1D Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HTR1D Gene in MalaCards »

(2) Diseases for HTR1D Gene including...

(1) University of Copenhagen DISEASES for HTR1D Gene

(4) Novoseek inferred disease relationships for HTR1D Gene

Disease -log(P) Hits PubMed IDs
migraine 67.3 12
schizophrenia 14.7 1
genetic susceptibility 1.85 1
inflammation 0 2

Relevant External Links for HTR1D

Genetic Association Database (GAD)
HTR1D
Human Genome Epidemiology (HuGE) Navigator
HTR1D
genes like me logo Genes that share disorders with HTR1D: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for HTR1D Gene

Publications for HTR1D Gene

  1. Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. (PMID: 1565658) Weinshank R.L. … Hartig P.R. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  2. The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects. (PMID: 17099886) Li J. … Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 23 48
  3. Primary structure and functional characterization of a human 5-HT1D- type serotonin receptor. (PMID: 1652050) Hamblin M.W. … Metcalf M.A. (Mol. Pharmacol. 1991) 3 4
  4. Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. (PMID: 1662665) Libert F. … Mattei M.G. (Genomics 1991) 2 3
  5. Selective amplification and cloning of four new members of the G protein-coupled receptor family. (PMID: 2541503) Libert F. … Vassart G. (Science 1989) 2 3

Products for HTR1D Gene

Sources for HTR1D Gene

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