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Aliases for HTR1A Gene

Aliases for HTR1A Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled 2 3
  • ADRB2RL1 3 4 6
  • ADRBRL1 3 4
  • 5-HT-1A 3 4
  • 5-HT1A 3 4
  • PFMCD 3 6
  • G-21 3 4
  • Guanine Nucleotide-Binding Regulatory Protein-Coupled Receptor 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 1A 2
  • 5-Hydroxytryptamine Receptor 1A 3
  • Serotonin Receptor 1A 4
  • 5-HT1a Receptor 3
  • 5HT1a 3

External Ids for HTR1A Gene

Previous HGNC Symbols for HTR1A Gene

  • ADRB2RL1
  • ADRBRL1

Previous GeneCards Identifiers for HTR1A Gene

  • GC05M063417
  • GC05M064794
  • GC05M063226
  • GC05M063272
  • GC05M063292
  • GC05M060210

Summaries for HTR1A Gene

Entrez Gene Summary for HTR1A Gene

  • This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

GeneCards Summary for HTR1A Gene

HTR1A (5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR1A include periodic fever, menstrual cycle dependent and agoraphobia. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR1A Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Tocris Summary for HTR1A Gene

  • The serotonin 5-HT1A receptor was the first 5-HT receptor to be fully sequenced and the human gene encoding this receptor has been localized on chromosome 5 (5q11.2-q13). 5-HT1A receptor binding sites are located primarily in limbic brain areas, notably the hypothalamus, lateral septum, cortical areas and the mesencephalic raphe nuclei. 5-HT1A receptor ligands with agonist activity possess antianxiety, antidepressant, antiaggressive, and perhaps anticraving, anticataleptic, antiemetic, and neuroprotective properties.

Gene Wiki entry for HTR1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1A Gene

Genomics for HTR1A Gene

Regulatory Elements for HTR1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HTR1A Gene

Start:
63,960,048 bp from pter
End:
63,962,507 bp from pter
Size:
2,460 bases
Orientation:
Minus strand

Genomic View for HTR1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1A Gene

Proteins for HTR1A Gene

  • Protein details for HTR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08908-5HT1A_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1A
    Protein Accession:
    P08908
    Secondary Accessions:
    • Q6LAE7

    Protein attributes for HTR1A Gene

    Size:
    422 amino acids
    Molecular mass:
    46107 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with GPER1.

neXtProt entry for HTR1A Gene

Proteomics data for HTR1A Gene at MOPED

Post-translational modifications for HTR1A Gene

  • Ubiquitination at Lys334
  • Glycosylation at Asn10, Asn11, and Asn24
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HTR1A (5-HT(1A))

No data available for DME Specific Peptides for HTR1A Gene

Domains for HTR1A Gene

Gene Families for HTR1A Gene

HGNC:
  • HTRGP :GPCR / Class A : 5-HT (serotonin) receptors, GPCR only
  • HTR :5-HT (serotonin) receptors
IUPHAR :

Suggested Antigen Peptide Sequences for HTR1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08908

UniProtKB/Swiss-Prot:

5HT1A_HUMAN :
  • P08908
Family:
  • Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
genes like me logo Genes that share domains with HTR1A: view

Function for HTR1A Gene

Molecular function for HTR1A Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype IA,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Gene Ontology (GO) - Molecular Function for HTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IMP 22957663
GO:0005515 protein binding IPI 22035699
genes like me logo Genes that share ontologies with HTR1A: view
genes like me logo Genes that share phenotypes with HTR1A: view

Animal Models for HTR1A Gene

MGI Knock Outs for HTR1A:

Animal Model Products

miRNA for HTR1A Gene

miRTarBase miRNAs that target HTR1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HTR1A Gene

Localization for HTR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR1A Gene COMPARTMENTS Subcellular localization image for HTR1A gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for HTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 22957663
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR1A: view

Pathways for HTR1A Gene

genes like me logo Genes that share pathways with HTR1A: view

Pathways by source for HTR1A Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for HTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response ISS --
GO:0007186 G-protein coupled receptor signaling pathway IMP 22957663
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA 8393041
GO:0007210 serotonin receptor signaling pathway ISS --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with HTR1A: view

Compounds for HTR1A Gene

Compound Products

(5) Tocris Compounds for HTR1A Gene

Compound Action Cas Number
(R)-(+)-8-Hydroxy-DPAT hydrobromide Selective 5-HT1A agonist. Enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529) [78095-19-9]
(S)-WAY 100135 dihydrochloride Potent, selective 5-HT1A antagonist [149007-54-5]
RU 24969 hemisuccinate 5-HT1B/1A agonist [66611-27-6]
S 14506 hydrochloride Highly potent 5-HT1A agonist; displays unique binding mechanism [286369-38-8]
WAY 100635 maleate Potent, 5-HT1A silent antagonist. Also D4 agonist [634908-75-1]

(7) ApexBio Compounds for HTR1A Gene

Compound Action Cas Number
BMY 7378 5-HT1A partial agonist and α1D adrenoceptor antagonist [21102-95-4]
Buspirone HCl [33386-08-2]
Flopropione [2295-58-1]
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor [367514-88-3]
Sumatriptan Succinate 5-HT1 receptor agonist [103628-48-4]
Vilazodone Hydrochloride Combined SSRI and 5-HT1A receptor partial agonist [163521-08-2]
WAY-100635 Maleate 5-HT1A receptor agonist [1092679-51-0]

(6) HMDB Compounds for HTR1A Gene

Compound Synonyms Cas Number PubMed IDs
Aripiprazole
  • Abilify
129722-12-9
Propranolol
  • Dociton
525-66-6
Quetiapine
  • Quetiapine fumarate
111974-69-7
Serotonin
  • 3-(2-Aminoethyl)-1H-indol-5-ol
50-67-9
Sertraline
  • (+)-Sertraline
79617-96-2

(46) Drugbank Compounds for HTR1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acepromazine
  • 10-(3-dimethylaminopropyl)phenothiazin-3-yl methyl ketone
61-00-7 target antagonist
Alprenolol
  • Alfeprol [Russian]
13655-52-2 target antagonist
Alverine
  • Alverina [inn-spanish]
150-59-4 target antagonist
Amitriptyline
  • Amitriprolidine
50-48-6 target unknown
Apomorphine
  • Apomorfin
41372-20-7 target agonist

(110) IUPHAR Ligand for HTR1A Gene

Ligand Type Action Affinity Pubmed IDs
S-14671 Agonist Full agonist 10.5
LY293284 Agonist Full agonist 10.1
[3H]NAD 299 Antagonist Antagonist 9.8
asenapine Antagonist Antagonist 9.8
Rec 15/3079 Antagonist Antagonist 9.7
U92016A Agonist Full agonist 9.7
S-14506 Agonist Full agonist 9.7
[3H]WAY100635 Antagonist Antagonist 9.5
8-OH-DPAT Agonist Full agonist 9.4
repinotan Antagonist Antagonist 9.4
[3H]8-OH-DPAT Agonist Full agonist 9.4
NAN 190 Antagonist Antagonist 9.4
methiothepin Antagonist Antagonist 9.4
L-694,247 Agonist Full agonist 9.3
(+)-flesinoxan Agonist Full agonist 9.3
WAY-100635 Antagonist Antagonist 9.2
S-15535 Agonist Partial agonist 9.2
NAD 299 Antagonist Antagonist 9.2
zotepine Antagonist Antagonist 9.2
SL65.0155 Agonist Partial agonist 9.2
olanzapine Antagonist Antagonist 9.2
LY 165,163 Agonist Full agonist 8.9
[3H]F13640 Agonist Full agonist 8.9
terguride Antagonist Antagonist 8.9
spiroxatrine Agonist Full agonist 8.8
ipsapirone Agonist Partial agonist 8.8
FG-5893 Agonist Full agonist 8.7
quetiapine Antagonist Antagonist 8.7
roxindole Antagonist Antagonist 8.6
SB 649915 Antagonist Antagonist 8.6
(R)-UH 301 Agonist Partial agonist 8.6
7-methoxy-1-naphthylpiperazine Agonist Full agonist 8.6
F15599 Agonist Full agonist 8.6
nafadotride Antagonist Antagonist 8.5
(+)-butaclamol Antagonist Antagonist 8.5
LSD Agonist Full agonist 8.4
S 16924 Agonist Partial agonist 8.4
[3H]p-MPPF Antagonist Antagonist 8.4
p-MPPI Antagonist Antagonist 8.4
tandospirone Agonist Full agonist 8.2
SDZ-216525 Antagonist Antagonist 8.2
(-)-tertatolol Antagonist Antagonist 8.2
pindolol Antagonist Antagonist 8.1
zalospirone Agonist Full agonist 8.1
SB 272183 Antagonist Antagonist 8
WAY-100135 Antagonist Antagonist 8
ocaperidone Agonist Full agonist 8
1-naphthylpiperazine Agonist Full agonist 8
buspirone Agonist Partial agonist 8
BMY-7378 Agonist Partial agonist 8
raclopride Antagonist Antagonist 8
(S)-UH 301 Antagonist Antagonist 7.9
fluspirilene Antagonist Antagonist 7.9
ziprasidone Antagonist Antagonist 7.8
LY334370 Agonist Full agonist 7.8
EMDT Agonist Full agonist 7.8
risperidone Antagonist Antagonist 7.8
thioridazine Antagonist Antagonist 7.7
MPDT Antagonist Antagonist 7.7
naratriptan Agonist Full agonist 7.6
RS-30199 Allosteric regulator Positive 7.6
aripiprazole Antagonist Antagonist 7.5
(-)-propranolol Antagonist Antagonist 7.5
(S)-flurocarazolol Antagonist Antagonist 7.5
9-OH-risperidone Antagonist Antagonist 7.5
pizotifen Antagonist Antagonist 7.4
eletriptan Agonist Full agonist 7.4
ritanserin Antagonist Antagonist 7.4
yohimbine Antagonist Antagonist 7.3
GR 125,743 Antagonist Antagonist 7.3
lisuride Agonist Partial agonist 7.2
L-772,405 Agonist Full agonist 7.2
BMY-14802 Agonist Full agonist 7.2
iloperidone Antagonist Antagonist 7.2
sertindole Antagonist Antagonist 6.9
piribedil Agonist Partial agonist 6.9
fluparoxan Agonist Partial agonist 6.8
GR 218,231 Antagonist Antagonist 6.8
spiperone Antagonist Antagonist 6.7
cabergoline Agonist Full agonist 6.7
clozapine Antagonist Antagonist 6.7
zolmitriptan Agonist Full agonist 6.6
pergolide Agonist Full agonist 6.5
SB 714786 Antagonist Antagonist 6.5
(R)-flurocarazolol Antagonist Antagonist 6.5
rizatriptan Agonist Full agonist 6.4
LY344864 Agonist Full agonist 6.3
cyamemazine Antagonist Antagonist 6.3
SB 216641 Agonist Partial agonist 6.3
ketanserin Inhibitor Inhibition 6.3
RU 24969 Agonist Full agonist 6.2
bromocriptine Agonist Partial agonist 6.2
pimozide Antagonist Antagonist 6.2
5-CT Agonist Full agonist 6.1
CP 93129 Agonist Full agonist 6.1
haloperidol Antagonist Antagonist 6.1
tiospirone Antagonist Antagonist 6
BRL-15572 Agonist Partial agonist 5.9
xanomeline Agonist Full agonist 5.9
[3H]S-15535 Agonist Partial agonist 5.9
GR-127935 Agonist Partial agonist 5.8
(-)-quinpirole Agonist Full agonist 5.8
donitriptan Agonist Partial agonist 5.6
sumatriptan Antagonist Antagonist 5.6
pipamperone Antagonist Antagonist 5.6
apomorphine Activator Activation 5.1
5-HT Inhibitor Inhibition 2.2
chlorpromazine Channel blocker None
[11C]WAY100635 Antagonist Antagonist
p-[18F]MPPF None None

(127) Novoseek inferred chemical compound relationships for HTR1A Gene

Compound -log(P) Hits PubMed IDs
buspirone 91.8 121
ipsapirone 91.1 55
flesinoxan 89.1 43
8-hydroxy-2-(di-n-propylamino)tetralin 88.1 45
way 100635 86.6 24

(7) PharmGKB related drug/compound annotations for HTR1A Gene

genes like me logo Genes that share compounds with HTR1A: view

Transcripts for HTR1A Gene

mRNA/cDNA for HTR1A Gene

(7) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1A Gene

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1A Gene

No ASD Table

Relevant External Links for HTR1A Gene

GeneLoc Exon Structure for
HTR1A
ECgene alternative splicing isoforms for
HTR1A

Expression for HTR1A Gene

mRNA expression in normal human tissues for HTR1A Gene

mRNA differential expression in normal tissues according to GTEx for HTR1A Gene

This gene is overexpressed in Brain - Hippocampus (13.8), Brain - Frontal Cortex (BA9) (9.7), Brain - Cortex (8.9), Brain - Anterior cingulate cortex (BA24) (7.2), and Brain - Amygdala (4.4).

Protein differential expression in normal tissues for HTR1A Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTR1A Gene

SOURCE GeneReport for Unigene cluster for HTR1A Gene Hs.247940

mRNA Expression by UniProt/SwissProt for HTR1A Gene

P08908-5HT1A_HUMAN
Tissue specificity: Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
genes like me logo Genes that share expressions with HTR1A: view

Expression partners for HTR1A Gene

In Situ Assay Products

Orthologs for HTR1A Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR1A 35
  • 88.31 (n)
  • 91.71 (a)
5HTR1A 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR1A 35
  • 89.1 (n)
  • 91.71 (a)
HTR1A 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr1a 35
  • 85.59 (n)
  • 88.36 (a)
Htr1a 16
Htr1a 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR1A 35
  • 99.68 (n)
  • 99.29 (a)
HTR1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr1a 35
  • 85.47 (n)
  • 89.81 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HTR1A 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR1A 35
  • 77.64 (n)
  • 83.17 (a)
HTR1A 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1a 35
  • 70.29 (n)
  • 77.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia htr1a-A 35
zebrafish
(Danio rerio)
Actinopterygii htr1aa 35
  • 71.33 (n)
  • 79.39 (a)
htr1ab 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 47 (a)
5-HT1B 37
  • 49 (a)
5-HT7 37
  • 39 (a)
CG7431 37
  • 42 (a)
DopR2 37
  • 45 (a)
5-HT1A 35
  • 58.61 (n)
  • 49.82 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT1A 35
  • 56.36 (n)
  • 47.58 (a)
worm
(Caenorhabditis elegans)
Secernentea F14D12.6 37
  • 30 (a)
ser-4 35
  • 47.53 (n)
  • 42.86 (a)
Species with no ortholog for HTR1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1A Gene

ENSEMBL:
Gene Tree for HTR1A (if available)
TreeFam:
Gene Tree for HTR1A (if available)

Paralogs for HTR1A Gene

Paralogs for HTR1A Gene

Selected SIMAP similar genes for HTR1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HTR1A: view

Variants for HTR1A Gene

Sequence variations from dbSNP and Humsavar for HTR1A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6294 -- 63,961,426(-) CAGGT(A/G)CTCAA synonymous-codon, reference
rs6295 -- 63,962,738(-) AAAAA(C/G)GAAGA upstream-variant-2KB
rs878567 -- 63,960,164(-) CCCAG(C/T)AATTG utr-variant-3-prime
rs968554 -- 63,964,063(+) ATCCA(C/G)TTGGG upstream-variant-2KB
rs1799920 - 63,961,656(-) AGACC(A/C/G)GCGGC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for HTR1A Gene

Variant ID Type Subtype PubMed ID
nsv4860 CNV Insertion 18451855

Relevant External Links for HTR1A Gene

HapMap Linkage Disequilibrium report
HTR1A
Human Gene Mutation Database (HGMD)
HTR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1A Gene

Disorders for HTR1A Gene

(1) OMIM Diseases for HTR1A Gene (109760)

UniProtKB/Swiss-Prot

5HT1A_HUMAN
  • Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. {ECO:0000269 PubMed:21990073}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(83) Novoseek inferred disease relationships for HTR1A Gene

Disease -log(P) Hits PubMed IDs
major depression 67.4 56
mood disorders 64.5 15
anxiety disorders 56.2 13
schizophrenia 56.1 49
catalepsy 55.5 11

Relevant External Links for HTR1A

Genetic Association Database (GAD)
HTR1A
Human Genome Epidemiology (HuGE) Navigator
HTR1A
genes like me logo Genes that share disorders with HTR1A: view

No data available for Genatlas for HTR1A Gene

Publications for HTR1A Gene

  1. Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5- hydroxytryptamine. (PMID: 8393041) Aune T.M. … Kelley K.A. (J. Immunol. 1993) 3 4 23
  2. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. (PMID: 11163544) Masellis M. … Kennedy J.L. (Schizophr. Res. 2001) 3 23 48
  3. Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia. (PMID: 14984628) Rothe C. … Lesch K.P. (Int. J. Neuropsychopharmacol. 2004) 3 23 48
  4. The effects of a 5-hydroxytryptamine 1A receptor gene polymorphism on the clinical response to fluvoxamine in depressed patients. (PMID: 15148501) Suzuki Y. … Someya T. (Pharmacogenomics J. 2004) 3 23 48
  5. Investigation of serotonin-related genes in antidepressant response. (PMID: 15052272) Peters E.J. … Hamilton S.P. (Mol. Psychiatry 2004) 3 23 48

Products for HTR1A Gene

  • Addgene plasmids for HTR1A

Sources for HTR1A Gene

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