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HTN3 Gene(Protein Coding)

Histatin 3

GCID:
GC04P070028
GIFtS:
44
Genes Participants
UDN Logo

Aliases for HTN3 Gene

Aliases for HTN3 Gene

  • Histatin 3 2 3 5
  • Basic Histidine-Rich Protein 3 4
  • Histidine-Rich Protein 3 3 4
  • HIS2 3 4
  • HST 3 4
  • PB 3 4
  • Histatin-3 3
  • Histatin-4 3
  • Histatin-5 3
  • Histatin-6 3
  • Histatin-7 3
  • Histatin-8 3
  • Histatin-9 3
  • HTN2 3
  • HTN5 3

External Ids for HTN3 Gene

Previous GeneCards Identifiers for HTN3 Gene

  • GC04P070804
  • GC04P070942
  • GC04P071144
  • GC04P071209
  • GC04P071074
  • GC04P066691
  • GC04P070894

Summaries for HTN3 Gene

Entrez Gene Summary for HTN3 Gene

  • This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]

GeneCards Summary for HTN3 Gene

HTN3 (Histatin 3) is a Protein Coding gene. Diseases associated with HTN3 include Oral Candidiasis and Candida Glabrata. Among its related pathways are Innate Immune System and Defensins. An important paralog of this gene is HTN1.

UniProtKB/Swiss-Prot for HTN3 Gene

  • Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.

Gene Wiki entry for HTN3 Gene

Additional gene information for HTN3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTN3 Gene

Genomics for HTN3 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for HTN3 Gene

Promoters and enhancers for HTN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I070028 Promoter 0.5 EPDnew 550.8 +0.0 27 0.1 HTN3 GC04P070037
GH04I069995 Promoter 0.5 EPDnew 0.3 -32.5 -32466 0.1 STATH HTN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HTN3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HTN3 gene promoter:

Genomic Locations for HTN3 Gene

Genomic Locations for HTN3 Gene
chr4:70,028,413-70,036,538
(GRCh38/hg38)
Size:
8,126 bases
Orientation:
Plus strand
chr4:70,894,130-70,902,255
(GRCh37/hg19)

Genomic View for HTN3 Gene

Genes around HTN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTN3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HTN3 Gene

Proteins for HTN3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15516-HIS3_HUMAN
    Recommended name:
    Histatin-3
    Protein Accession:
    P15516
    Secondary Accessions:
    • Q16243
    • Q502Z1

    Protein attributes for HTN3 Gene

    Size:
    51 amino acids
    Molecular mass:
    6149 Da
    Quaternary structure:
    • His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and SSA2 proteins.
    Miscellaneous:
    • The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.

neXtProt entry for HTN3 Gene

Protein Expression for HTN3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HTN3 Gene

Other Protein References for HTN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTN3 Gene

Domains & Families for HTN3 Gene

Gene Families for HTN3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Transporters

Protein Domains for HTN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HTN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15516

UniProtKB/Swiss-Prot:

HIS3_HUMAN :
  • Belongs to the histatin/statherin family.
Family:
  • Belongs to the histatin/statherin family.
genes like me logo Genes that share domains with HTN3: view

Function for HTN3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for HTN3 Gene

GENATLAS Biochemistry:
histatin 3
UniProtKB/Swiss-Prot Function:
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.

Gene Ontology (GO) - Molecular Function for HTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23499434
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HTN3: view

Phenotypes for HTN3 Gene

GenomeRNAi human phenotypes for HTN3:
genes like me logo Genes that share phenotypes with HTN3: view

Animal Model Products

CRISPR Products

miRNA for HTN3 Gene

miRTarBase miRNAs that target HTN3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTN3 Gene

Localization for HTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTN3 Gene

Secreted. Note=Secreted by serous acinar and demilune cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTN3 gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with HTN3: view

Pathways & Interactions for HTN3 Gene

genes like me logo Genes that share pathways with HTN3: view

Pathways by source for HTN3 Gene

3 Reactome pathways for HTN3 Gene
1 KEGG pathway for HTN3 Gene

Interacting Proteins for HTN3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000432561%0d%0a9606.ENSP00000246896%0d%0a9606.ENSP00000227378%0d%0a9606.ENSP00000302021%0d%0a
Selected Interacting proteins: ENSP00000432561 P15516-HIS3_HUMAN for HTN3 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for HTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019730 antimicrobial humoral response TAS --
GO:0031214 biomineral tissue development IEA --
GO:0031640 killing of cells of other organism IEA --
GO:0042742 defense response to bacterium IEA,NAS 3286634
GO:0050832 defense response to fungus IEA --
genes like me logo Genes that share ontologies with HTN3: view

No data available for SIGNOR curated interactions for HTN3 Gene

Drugs & Compounds for HTN3 Gene

Products:

  1. Drug

(13) Drugs for HTN3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for HTN3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HTN3: view

Transcripts for HTN3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for HTN3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1728) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTN3 Gene

Histatin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTN3 Gene

No ASD Table

Relevant External Links for HTN3 Gene

GeneLoc Exon Structure for
HTN3
ECgene alternative splicing isoforms for
HTN3

Expression for HTN3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTN3 Gene

mRNA expression in normal human tissues for HTN3 Gene
mRNA expression by GTEx for HTN3 GenemRNA expression by BioGPS for HTN3 Gene

mRNA differential expression in normal tissues according to GTEx for HTN3 Gene

This gene is overexpressed in Pituitary (x40.1), Minor Salivary Gland (x4.4), and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for HTN3 Gene

This gene is overexpressed in Saliva (56.2) and Salivary gland (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTN3 Gene



Protein tissue co-expression partners for HTN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HTN3 Gene:

HTN3

SOURCE GeneReport for Unigene cluster for HTN3 Gene:

Hs.654442

Evidence on tissue expression from TISSUES for HTN3 Gene

  • Muscle(4.4)
  • Saliva(4.4)
  • Thyroid gland(4.3)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with HTN3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTN3 Gene

Orthologs for HTN3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HTN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HTN3 33 34
  • 99.35 (n)
Species where no ortholog for HTN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HTN3 Gene

ENSEMBL:
Gene Tree for HTN3 (if available)
TreeFam:
Gene Tree for HTN3 (if available)

Paralogs for HTN3 Gene

Paralogs for HTN3 Gene

(1) SIMAP similar genes for HTN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTN3: view

Variants for HTN3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HTN3 Gene

HIS3_HUMAN-P15516
There are two alleles of HTN3, HIS2(1) (shown here) and HIS2(2) that codes for the variant histatin-3-2 found primarily and in high frequencies in black populations.

Sequence variations from dbSNP and Humsavar for HTN3 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1136511 pathogenic, HIS2*1/HIS2*2 POLYMORPHISM 70,033,186(+) G/A coding_sequence_variant, missense_variant
rs17147990 pathogenic, HIS2*1/HIS2*2 POLYMORPHISM 70,033,205(+) T/A coding_sequence_variant, stop_gained
rs1000049861 -- 70,030,743(+) G/T initiator_codon_variant, missense_variant
rs1000103488 -- 70,030,487(+) C/T intron_variant
rs10007523 -- 70,029,260(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HTN3 Gene

Variant ID Type Subtype PubMed ID
nsv1012495 CNV gain 25217958
nsv594642 CNV loss 21841781

Variation tolerance for HTN3 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HTN3 Gene

Human Gene Mutation Database (HGMD)
HTN3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTN3

Disorders for HTN3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for HTN3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
oral candidiasis
  • candidiasis of mouth
candida glabrata
candidiasis
  • disseminated candidiasis
hypertropia
cerebral creatine deficiency syndrome 3
  • ccds3
- elite association - COSMIC cancer census association via MalaCards
Search HTN3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HTN3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HTN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTN3 Gene

Publications for HTN3 Gene

  1. Polymorphism of salivary histatin gene and periodontal disease in the Japanese population. (PMID: 19753800) Fujigaki Y … Wang PL (Journal of the International Academy of Periodontology 2009) 3 22 44 58
  2. A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. (PMID: 15272024) Castagnola M … Messana I (The Journal of biological chemistry 2004) 3 4 22 58
  3. Zinc and copper bind to unique sites of histatin 5. (PMID: 11226423) Grogan J … Oppenheim FG (FEBS letters 2001) 3 4 22 58
  4. Candidacidal activity of recombinant human salivary histatin-5 and variants. (PMID: 8945538) Tsai H … Bobek LA (Infection and immunity 1996) 3 4 22 58
  5. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. (PMID: 8336540) Sabatini LM … Azen EA (Molecular biology and evolution 1993) 3 4 22 58

Products for HTN3 Gene

Sources for HTN3 Gene

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