Aliases for HTN3 Gene
Aliases for HTN3 Gene
External Ids for HTN3 Gene
- HGNC: 5284
- Entrez Gene: 3347
- Ensembl: ENSG00000205649
- OMIM: 142702
- UniProtKB: P15516
Previous GeneCards Identifiers for HTN3 Gene
- GC04P070804
- GC04P070942
- GC04P071144
- GC04P071209
- GC04P071074
- GC04P066691
- GC04P070894
Summaries for HTN3 Gene
-
This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]
GeneCards Summary for HTN3 Gene
HTN3 (Histatin 3) is a Protein Coding gene. Diseases associated with HTN3 include Candida Glabrata and Oral Candidiasis. Among its related pathways are Salivary secretion. An important paralog of this gene is HTN1.
UniProtKB/Swiss-Prot for HTN3 Gene
-
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTN3 Gene
Genomics for HTN3 Gene
Regulatory Elements for HTN3 Gene
- Transcription factor binding sites by QIAGEN in the HTN3 gene promoter:
Regulatory Element Products
Genomic Location for HTN3 Gene
- Chromosome:
- 4
- Start:
- 70,028,413 bp from pter
- End:
- 70,036,538 bp from pter
- Size:
- 8,126 bases
- Orientation:
- Plus strand
Genomic View for HTN3 Gene
Genes around HTN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by Ensembl
- 4q13 by Entrez Gene
- 4q13 by HGNC
HTN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HTN3 Gene
Proteins for HTN3 Gene
-
Protein details for HTN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15516-HIS3_HUMAN
- Recommended name:
- Histatin-3
- Protein Accession:
- P15516
- Q16243
- Q502Z1
Protein attributes for HTN3 Gene
- Size:
- 51 amino acids
- Molecular mass:
- 6149 Da
- Quaternary structure:
-
- His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and SSA2 proteins.
- Miscellaneous:
-
- The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.
Protein Expression for HTN3 Gene
Post-translational modifications for HTN3 Gene
- 24 proteolytic products are found in saliva.
Other Protein References for HTN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HTN3
-
Cloud-Clone Corp. Antibodies for HTN3
- antibodies-online Antibodies for HTN3: See all 4
- Search GeneTex for Antibodies for HTN3
-
Santa Cruz Biotechnology (SCBT) Antibodies for HTN3
Protein Products
-
OriGene Purified Proteins for HTN3
- Search Origene for MassSpec and Protein Over-expression Lysates for HTN3
- Origene Custom Protein Services for HTN3
-
Cloud-Clone Corp. Proteins for HTN3
- Search GeneTex for Proteins for HTN3
- Abcam proteins for Histatin-3
No data available for DME Specific Peptides for HTN3 Gene
Domains & Families for HTN3 Gene
Gene Families for HTN3 Gene
Protein Domains for HTN3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HTN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P15516- Family:
-
- Belongs to the histatin/statherin family.
Function for HTN3 Gene
Molecular function for HTN3 Gene
- GENATLAS Biochemistry:
- histatin 3
- UniProtKB/Swiss-Prot Function:
- Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
Phenotypes for HTN3 Gene
- GenomeRNAi human phenotypes for HTN3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HTN3 gene
- Search ViGene Biosciences for HTN3
CRISPR Products
-
OriGene CRISPR knockouts for HTN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTN3
- GenScript: Design CRISPR guide RNA sequences for HTN3
miRNA for HTN3 Gene
- miRTarBase miRNAs that target HTN3
miRNA Products
- Search ViGene Biosciences for HTN3
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for HTN3
- Browse OriGene Inhibitory RNA Products For HTN3
- Search ViGene Biosciences for HTN3
Clone Products
- OriGene clones in human for HTN3
- OriGene ORF clones in human for HTN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HTN3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HTN3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HTN3 gene
- Search ViGene Biosciences for HTN3
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTN3 Gene
Localization for HTN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HTN3 Gene
- Secreted. Note=Secreted by serous acinar and demilune cells.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 2 |
No data available for Gene Ontology (GO) - Cellular Components for HTN3 Gene
Pathways & Interactions for HTN3 Gene
More details on SuperPathways for HTN3| Superpath | Contained pathways | |
|---|---|---|
| 1 | Salivary secretion |
Pathways by source for HTN3 Gene
1 KEGG pathway for HTN3 Gene
Interacting Proteins for HTN3 Gene
Selected Interacting proteins:
P15516-HIS3_HUMAN
ENSP00000432561
for HTN3 Gene via
MINT
STRING
UniProtKB
I2D
| Symbol | External ID(s) | Details |
|---|---|---|
| MUC7 | ||
| -- |
|
|
| RGPB (XENO) |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031640 | killing of cells of other organism | IEA | -- |
| GO:0042742 | defense response to bacterium | IEA,NAS | 3286634 |
No data available for SIGNOR curated interactions for HTN3 Gene
Transcripts for HTN3 Gene
mRNA/cDNA for HTN3 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (1728) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HTN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTN3
- GenScript: Design CRISPR guide RNA sequences for HTN3
miRNA Products
- Search ViGene Biosciences for HTN3
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for HTN3
- Browse OriGene Inhibitory RNA Products For HTN3
- Search ViGene Biosciences for HTN3
Clone Products
- OriGene clones in human for HTN3
- OriGene ORF clones in human for HTN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HTN3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HTN3 Gene
mRNA differential expression in normal tissues according to GTEx for HTN3 Gene
This gene is overexpressed in Pituitary (x40.1), Minor Salivary Gland (x4.4), and Muscle - Skeletal (x4.3).
This gene is overexpressed in Saliva (56.2) and Salivary gland (12.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HTN3 Gene
SOURCE GeneReport for Unigene cluster for HTN3 Gene Hs.654442
Primer Products
-
OriGene qPCR primer pairs for HTN3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HTN3 Gene
Orthologs for HTN3 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HTN3 35 |
|
||
| HTN3 36 |
|
OneToOne |
- Species with no ortholog for HTN3:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HTN3 Gene
(1) SIMAP similar genes for HTN3 Gene using alignment to 1 proteins:
Variants for HTN3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for HTN3 Gene
- HIS3_HUMAN-P15516
- There are two alleles of HTN3, HIS2(1) (shown here) and HIS2(2) that codes for the variant histatin-3-2 found primarily and in high frequencies in black populations.
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1136511 | - | 70,033,186(+) | ACATC(A/G)AGGCT | reference, missense | |
| rs800756 | -- | 70,031,790(+) | ATTAA(C/T)TATAG | intron-variant | |
| rs1136515 | -- | 70,033,236(+) | AATCA(C/T)GGGGC | utr-variant-3-prime | |
| rs776845 | -- | 70,026,469(+) | TCAGT(A/T)AGCTA | upstream-variant-2KB | |
| rs776846 | -- | 70,026,783(+) | AACAG(G/T)TATCT | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5628n71 | CNV | Loss | 21882294 |
| dgv5629n71 | CNV | Loss | 21882294 |
| nsv879460 | CNV | Gain | 21882294 |
| dgv5630n71 | CNV | Loss | 21882294 |
| nsv879463 | CNV | Loss | 21882294 |
Residual Variation Intolerance Score:
71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.82;
67.05% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HTN3 Gene
- Human Gene Mutation Database (HGMD)
- HTN3
Disorders for HTN3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| candida glabrata |
|
|
| oral candidiasis |
|
|
| candidiasis |
|
|
| hypertropia |
|
|
| cerebral creatine deficiency syndrome 3 |
|
|
Search HTN3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HTN3
No data available for UniProtKB/Swiss-Prot and Genatlas for HTN3 Gene
Publications for HTN3 Gene
- A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. (PMID: 15272024) Castagnola M. … Messana I. (J. Biol. Chem. 2004) 3 4 23 67
- Cooperation of salivary protein histatin 3 with heat shock cognate protein 70 relative to the G1/S transition in human gingival fibroblasts. (PMID: 19321452) Imamura Y. … Wang P.L. (J. Biol. Chem. 2009) 3 23
- Polymorphism of salivary histatin gene and periodontal disease in the Japanese population. (PMID: 19753800) Fujigaki Y. … Wang P.L. (J Int Acad Periodontol 2009) 3 23
- Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania. (PMID: 18230684) Luque-Ortega J.R. … Rivas L. (FASEB J. 2008) 3 23
- Metal-binding and nuclease activity of an antimicrobial peptide analogue of the salivary histatin 5. (PMID: 17176059) Melino S. … Petruzzelli R. (Biochemistry 2006) 3 23
Products for HTN3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Selection and Detection Kits
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- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HTN3
- Search Origene for MassSpec and Protein Over-expression Lysates for HTN3
- Origene Custom Protein Services for HTN3
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for HTN3
- Browse OriGene Inhibitory RNA Products For HTN3
- OriGene qPCR primer pairs for HTN3
- OriGene CRISPR knockouts for HTN3
- OriGene clones in human for HTN3
- OriGene ORF clones in human for HTN3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for HTN3
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- GenScript: Design CRISPR guide RNA sequences for HTN3
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- Novus Biologicals Antibodies for HTN3
- Novus Biologicals proteins and lysates for HTN3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for HTN3
- Cloud-Clone Corp. Proteins for HTN3
- Cloud-Clone Corp Assay Kits for HTN3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for HTN3: See all 4
- antibodies-online Kits for HTN3: See all 21
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for HTN3
- Search GeneTex for Proteins for HTN3
- ViGene Biosciences adenoviral particle packaged cDNA for HTN3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HTN3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HTN3 gene
- Search ViGene Biosciences for HTN3
- Search ViGene Biosciences for HTN3
- Search ViGene Biosciences for HTN3
- Search ViGene Biosciences for HTN3
- Santa Cruz Biotechnology (SCBT) Antibodies for HTN3
- Search Santa Cruz Biotechnology (SCBT) for HTN3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HTN3
Sources for HTN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
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- (128) RVIS
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- (130) diseasecard
- (131) NIH Rare Diseases
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- (136) Genetics Home Reference
- (137) MeSH
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- (149) ENCODE
- (150) ProSci
- (151) Horizon