Aliases for HTN3 Gene
Aliases for HTN3 Gene
External Ids for HTN3 Gene
- HGNC: 5284
- Entrez Gene: 3347
- Ensembl: ENSG00000205649
- OMIM: 142702
- UniProtKB: P15516
Previous GeneCards Identifiers for HTN3 Gene
- GC04P070804
- GC04P070942
- GC04P071144
- GC04P071209
- GC04P071074
- GC04P066691
- GC04P070894
Summaries for HTN3 Gene
-
This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]
GeneCards Summary for HTN3 Gene
HTN3 (Histatin 3) is a Protein Coding gene. Diseases associated with HTN3 include Candidiasis and Candida Glabrata. Among its related pathways are Defensins and Innate Immune System. An important paralog of this gene is HTN1.
UniProtKB/Swiss-Prot for HTN3 Gene
-
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTN3 Gene
Genomics for HTN3 Gene
Regulatory Elements for HTN3 Gene
- Transcription factor binding sites by QIAGEN in the HTN3 gene promoter:
Regulatory Element Products
Genomic Location for HTN3 Gene
- Chromosome:
- 4
- Start:
- 70,028,413 bp from pter
- End:
- 70,036,538 bp from pter
- Size:
- 8,126 bases
- Orientation:
- Plus strand
Genomic View for HTN3 Gene
Genes around HTN3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by Ensembl
- 4q13.3 by Entrez Gene
- 4q13.3 by HGNC
HTN3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HTN3 Gene
Proteins for HTN3 Gene
-
Protein details for HTN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15516-HIS3_HUMAN
- Recommended name:
- Histatin-3
- Protein Accession:
- P15516
- Q16243
- Q502Z1
Protein attributes for HTN3 Gene
- Size:
- 51 amino acids
- Molecular mass:
- 6149 Da
- Quaternary structure:
-
- His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and SSA2 proteins.
- Miscellaneous:
-
- The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.
Protein Expression for HTN3 Gene
Post-translational modifications for HTN3 Gene
- 24 proteolytic products are found in saliva.
Other Protein References for HTN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HTN3
- antibodies-online Antibodies for HTN3: See all 4
- Search GeneTex for Antibodies for HTN3
Protein Products
-
OriGene Purified Proteins for HTN3
- Search Origene for MassSpec and Protein Over-expression Lysates for HTN3
- Origene Custom Protein Services for HTN3
- Search GeneTex for Proteins for HTN3
-
ProSci Proteins for HTN3
-
Abcam proteins for HTN3
Assay Products
- antibodies-online Kits for HTN3: See all 21
No data available for DME Specific Peptides for HTN3 Gene
Domains & Families for HTN3 Gene
Gene Families for HTN3 Gene
Protein Domains for HTN3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HTN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P15516- Family:
-
- Belongs to the histatin/statherin family.
Function for HTN3 Gene
Molecular function for HTN3 Gene
- GENATLAS Biochemistry:
- histatin 3
- UniProtKB/Swiss-Prot Function:
- Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 23499434 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for HTN3 Gene
- GenomeRNAi human phenotypes for HTN3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HTN3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HTN3 gene
- Search ViGene Biosciences for HTN3
CRISPR Products
-
OriGene CRISPR knockouts for HTN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTN3
- GenScript: Design CRISPR guide RNA sequences for HTN3
miRNA for HTN3 Gene
- miRTarBase miRNAs that target HTN3
miRNA Products
- Search ViGene Biosciences for HTN3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HTN3
- Browse OriGene Inhibitory RNA Products For HTN3
- Search ViGene Biosciences for HTN3
Clone Products
- Sino Biological Human cDNA Clone for HTN3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HTN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTN3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for HTN3
-
ViGene Biosciences adenoviral particle packaged cDNA for HTN3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HTN3 gene
- Search ViGene Biosciences for HTN3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTN3 Gene
Localization for HTN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HTN3 Gene
- Secreted. Note=Secreted by serous acinar and demilune cells.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 2 |
| cytoskeleton | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IEA | -- |
Pathways & Interactions for HTN3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Salivary secretion | ||
| 3 | Defensins | ||
Pathways by source for HTN3 Gene
3 Reactome pathways for HTN3 Gene
1 KEGG pathway for HTN3 Gene
Interacting Proteins for HTN3 Gene
Selected Interacting proteins:
P15516-HIS3_HUMAN
ENSP00000432561
for HTN3 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019730 | antimicrobial humoral response | TAS | -- |
| GO:0031214 | biomineral tissue development | IEA | -- |
| GO:0031640 | killing of cells of other organism | IEA | -- |
| GO:0042742 | defense response to bacterium | NAS,IEA | 3286634 |
| GO:0050832 | defense response to fungus | IEA | -- |
No data available for SIGNOR curated interactions for HTN3 Gene
Transcripts for HTN3 Gene
mRNA/cDNA for HTN3 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (1728) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HTN3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTN3
- GenScript: Design CRISPR guide RNA sequences for HTN3
miRNA Products
- Search ViGene Biosciences for HTN3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HTN3
- Browse OriGene Inhibitory RNA Products For HTN3
- Search ViGene Biosciences for HTN3
Clone Products
- Sino Biological Human cDNA Clone for HTN3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HTN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTN3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for HTN3 Gene
mRNA differential expression in normal tissues according to GTEx for HTN3 Gene
This gene is overexpressed in Pituitary (x40.1), Minor Salivary Gland (x4.4), and Muscle - Skeletal (x4.3).
This gene is overexpressed in Saliva (56.2) and Salivary gland (12.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTN3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HTN3 Gene:
HTN3SOURCE GeneReport for Unigene cluster for HTN3 Gene:
Hs.654442Evidence on tissue expression from TISSUES for HTN3 Gene
- Muscle(4.4)
- Saliva(4.4)
- Thyroid gland(4.3)
- Nervous system(3.2)
Primer Products
-
OriGene qPCR primer pairs for HTN3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTN3 Gene
Orthologs for HTN3 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HTN3 34 35 |
|
- Species where no ortholog for HTN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HTN3 Gene
(1) SIMAP similar genes for HTN3 Gene using alignment to 1 proteins:
Variants for HTN3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for HTN3 Gene
- HIS3_HUMAN-P15516
- There are two alleles of HTN3, HIS2(1) (shown here) and HIS2(2) that codes for the variant histatin-3-2 found primarily and in high frequencies in black populations.
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1136511 | Pathogenic | 70,033,186(+) | ACATC(A/G)AGGCT | reference, missense | |
| rs17147990 | Pathogenic | 70,033,205(+) | AATTA(A/T)CTGTA | reference, stop-gained | |
| rs1000049861 | -- | 70,030,743(+) | ACTAT(G/T)AAGTT | reference, missense | |
| rs1000103488 | -- | 70,030,487(+) | ATTAG(C/T)TTGTC | intron-variant | |
| rs1001055432 | -- | 70,029,645(+) | TTCCA(C/G)TGGAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1012495 | CNV | gain | 25217958 |
| nsv594642 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.82;
67.05% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HTN3 Gene
Disorders for HTN3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| candidiasis |
|
|
| candida glabrata |
|
|
| oral candidiasis |
|
|
| hypertropia |
|
|
| cerebral creatine deficiency syndrome 3 |
|
|
Search HTN3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HTN3
No data available for UniProtKB/Swiss-Prot and Genatlas for HTN3 Gene
Publications for HTN3 Gene
- Polymorphism of salivary histatin gene and periodontal disease in the Japanese population. (PMID: 19753800) Fujigaki Y. … Wang P.L. (J Int Acad Periodontol 2009) 3 22 46 64
- A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. (PMID: 15272024) Castagnola M. … Messana I. (J. Biol. Chem. 2004) 3 4 22 64
- Zinc and copper bind to unique sites of histatin 5. (PMID: 11226423) Grogan J. … Oppenheim F.G. (FEBS Lett. 2001) 3 4 22 64
- Candidacidal activity of recombinant human salivary histatin-5 and variants. (PMID: 8945538) Tsai H. … Bobek L.A. (Infect. Immun. 1996) 3 4 22 64
- Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. (PMID: 8336540) Chen Z.W. (Mol. Biol. Evol. 1993) 3 4 22 64
Products for HTN3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
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- Custom Antibody Services
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- OriGene Purified Proteins for HTN3
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- OriGene qPCR primer pairs for HTN3
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HTN3 in any vector
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- Novus Biologicals Antibodies for HTN3
- Novus Biologicals proteins and lysates for HTN3
- Novus Biologicals
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- Abcam proteins for HTN3
- Find your target
- Search knockout validated antibodies
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for HTN3: See all 4
- antibodies-online Kits for HTN3: See all 21
- Search antibodies-online for proteins
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- Search for HTN3 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for HTN3
- Horizon Cell Lines for HTN3
- Cyagen custom Knockout/knockin (KOKI) mouse models for HTN3
- VectorBuilder custom plasmid, inducible vectors for HTN3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTN3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HTN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (141) ENCODE
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- (146) Cyagen
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- (148) SNPedia
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer