Aliases for HTN3 Gene
Aliases for HTN3 Gene
External Ids for HTN3 Gene
- HGNC: 5284
- Entrez Gene: 3347
- Ensembl: ENSG00000205649
- OMIM: 142702
- UniProtKB: P15516
Previous GeneCards Identifiers for HTN3 Gene
- GC04P070804
- GC04P070942
- GC04P071144
- GC04P071209
- GC04P071074
- GC04P066691
- GC04P070894
Summaries for HTN3 Gene
-
This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]
GeneCards Summary for HTN3 Gene
HTN3 (Histatin 3) is a Protein Coding gene. Diseases associated with HTN3 include Oral Candidiasis and Candida Glabrata. Among its related pathways are Innate Immune System and Defensins. An important paralog of this gene is HTN1.
UniProtKB/Swiss-Prot for HTN3 Gene
-
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTN3 Gene
Genomics for HTN3 Gene
GeneHancer (GH) Regulatory Elements for HTN3 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04I070028 | Promoter | 0.5 | EPDnew | 550.8 | +0.0 | 27 | 0.1 | HTN3 GC04P070037 | ||
GH04I069995 | Promoter | 0.5 | EPDnew | 0.3 | -32.5 | -32466 | 0.1 | STATH HTN3 |
Regulatory Element Products
Genomic Locations for HTN3 Gene
- chr4:70,028,413-70,036,538
- (GRCh38/hg38)
- Size:
- 8,126 bases
- Orientation:
- Plus strand
- chr4:70,894,130-70,902,255
- (GRCh37/hg19)
Genomic View for HTN3 Gene
- Cytogenetic band:
-
- 4q13.3 by Ensembl
- 4q13.3 by Entrez Gene
- 4q13.3 by HGNC


RefSeq DNA sequence for HTN3 Gene
Proteins for HTN3 Gene
-
Protein details for HTN3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15516-HIS3_HUMAN
- Recommended name:
- Histatin-3
- Protein Accession:
- P15516
- Q16243
- Q502Z1
Protein attributes for HTN3 Gene
- Size:
- 51 amino acids
- Molecular mass:
- 6149 Da
- Quaternary structure:
-
- His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and SSA2 proteins.
- Miscellaneous:
-
- The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.
Protein Expression for HTN3 Gene
Post-translational modifications for HTN3 Gene
- 24 proteolytic products are found in saliva.
Other Protein References for HTN3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HTN3
-
Cloud-Clone Corp. Antibodies for HTN3
- antibodies-online: Search results for 4 available HTN3 Antibodies ranked by validation data
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Protein Products
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- antibodies-online: Search results for 3 available HTN3 Proteins ranked by validation data
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-
ProSci Proteins for HTN3
Assay Products
-
Cloud-Clone Corp. Assay Kits for HTN3
No data available for DME Specific Peptides for HTN3 Gene
Domains & Families for HTN3 Gene
Gene Families for HTN3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
- Transporters
Protein Domains for HTN3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HTN3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P15516- Family:
-
- Belongs to the histatin/statherin family.
Function for HTN3 Gene
Molecular function for HTN3 Gene
- GENATLAS Biochemistry:
- histatin 3
- UniProtKB/Swiss-Prot Function:
- Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 23499434 |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for HTN3 Gene
- GenomeRNAi human phenotypes for HTN3:
Animal Model Products
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-
-
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CRISPR Products
-
OriGene CRISPR knockouts for HTN3
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for HTN3 Gene
- miRTarBase miRNAs that target HTN3
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HTN3 gene related products
- orf clones - Search results for available HTN3 gene related products
- Applied Biological Materials Clones for HTN3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HTN3
-
ViGene Biosciences adenoviral particle packaged cDNA for HTN3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HTN3 gene
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTN3 Gene
Localization for HTN3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HTN3 Gene
- Secreted. Note=Secreted by serous acinar and demilune cells.
- Vesicles (1)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
Pathways & Interactions for HTN3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Salivary secretion | ||
3 | Defensins |
Pathways by source for HTN3 Gene
3 Reactome pathways for HTN3 Gene
1 KEGG pathway for HTN3 Gene
Interacting Proteins for HTN3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0019730 | antimicrobial humoral response | TAS | -- |
GO:0031214 | biomineral tissue development | IEA | -- |
GO:0031640 | killing of cells of other organism | IEA | -- |
GO:0042742 | defense response to bacterium | IEA,NAS | 3286634 |
GO:0050832 | defense response to fungus | IEA | -- |
No data available for SIGNOR curated interactions for HTN3 Gene
Transcripts for HTN3 Gene
mRNA/cDNA for HTN3 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (1728) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HTN3
- genomics-online: gRNA clones - Search results for available HTN3 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for HTN3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HTN3 gene related products
- orf clones - Search results for available HTN3 gene related products
- Applied Biological Materials Clones for HTN3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HTN3 Gene
mRNA differential expression in normal tissues according to GTEx for HTN3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTN3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HTN3 Gene:
HTN3SOURCE GeneReport for Unigene cluster for HTN3 Gene:
Hs.654442Evidence on tissue expression from TISSUES for HTN3 Gene
- Muscle(4.4)
- Saliva(4.4)
- Thyroid gland(4.3)
- Nervous system(3.2)
Primer Products
-
OriGene qPCR primer pairs for HTN3
- genomics-online: primer clones - Search results for available HTN3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTN3 Gene
Orthologs for HTN3 Gene
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | HTN3 33 34 |
|
- Species where no ortholog for HTN3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HTN3 Gene
(1) SIMAP similar genes for HTN3 Gene using alignment to 1 proteins:
Variants for HTN3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for HTN3 Gene
- HIS3_HUMAN-P15516
- There are two alleles of HTN3, HIS2(1) (shown here) and HIS2(2) that codes for the variant histatin-3-2 found primarily and in high frequencies in black populations.
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1136511 | pathogenic, HIS2*1/HIS2*2 POLYMORPHISM | 70,033,186(+) | G/A | coding_sequence_variant, missense_variant | |
rs17147990 | pathogenic, HIS2*1/HIS2*2 POLYMORPHISM | 70,033,205(+) | T/A | coding_sequence_variant, stop_gained | |
rs1000049861 | -- | 70,030,743(+) | G/T | initiator_codon_variant, missense_variant | |
rs1000103488 | -- | 70,030,487(+) | C/T | intron_variant | |
rs10007523 | -- | 70,029,260(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1012495 | CNV | gain | 25217958 |
nsv594642 | CNV | loss | 21841781 |
Additional Variant Information for HTN3 Gene
Disorders for HTN3 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
oral candidiasis |
|
|
candida glabrata |
|
|
candidiasis |
|
|
hypertropia |
|
|
cerebral creatine deficiency syndrome 3 |
|
|
Additional Disease Information for HTN3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HTN3 Gene
Publications for HTN3 Gene
- Polymorphism of salivary histatin gene and periodontal disease in the Japanese population. (PMID: 19753800) Fujigaki Y … Wang PL (Journal of the International Academy of Periodontology 2009) 3 22 44 58
- A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. (PMID: 15272024) Castagnola M … Messana I (The Journal of biological chemistry 2004) 3 4 22 58
- Zinc and copper bind to unique sites of histatin 5. (PMID: 11226423) Grogan J … Oppenheim FG (FEBS letters 2001) 3 4 22 58
- Candidacidal activity of recombinant human salivary histatin-5 and variants. (PMID: 8945538) Tsai H … Bobek LA (Infection and immunity 1996) 3 4 22 58
- Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. (PMID: 8336540) Sabatini LM … Azen EA (Molecular biology and evolution 1993) 3 4 22 58
Products for HTN3 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 4 available HTN3 Antibodies ranked by validation data
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Sources for HTN3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (14) ProtoNet
- (15) Blocks
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- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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- (60) TGDB
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- (64) ProSpec
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
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- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
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- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew