Aliases for NDST1 Gene
External Ids for NDST1 Gene
Previous HGNC Symbols for NDST1 Gene
Previous GeneCards Identifiers for NDST1 Gene
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for NDST1 Gene
NDST1 (N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1) is a Protein Coding gene. Diseases associated with NDST1 include mental retardation, autosomal recessive 46 and autosomal recessive non-syndromic intellectual disability. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include deacetylase activity and [heparan sulfate]-glucosamine N-sulfotransferase activity. An important paralog of this gene is NDST4.
UniProtKB/Swiss-Prot for NDST1 Gene
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.