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Aliases for HSPE1 Gene

Aliases for HSPE1 Gene

  • Heat Shock 10kDa Protein 1 2 3
  • Chaperonin 10 2 3 4
  • HSP10 3 4 6
  • Heat Shock 10kD Protein 1 (Chaperonin 10) 2 3
  • Early Pregnancy Factor 2 3
  • Early-Pregnancy Factor 3 4
  • 10 KDa Chaperonin 3 4
  • CPN10 3 4
  • EPF 3 4
  • 10 KDa Heat Shock Protein, Mitochondrial 3
  • GROES 3

External Ids for HSPE1 Gene

Previous GeneCards Identifiers for HSPE1 Gene

  • GC02P196563
  • GC02P197078
  • GC02P198328
  • GC02P198567
  • GC02P198190
  • GC02P198073
  • GC02P190217

Summaries for HSPE1 Gene

Entrez Gene Summary for HSPE1 Gene

  • This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]

GeneCards Summary for HSPE1 Gene

HSPE1 (Heat Shock 10kDa Protein 1) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding and chaperone binding.

UniProtKB/Swiss-Prot for HSPE1 Gene

  • Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter

Gene Wiki entry for HSPE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPE1 Gene

Genomics for HSPE1 Gene

Regulatory Elements for HSPE1 Gene

Genomic Location for HSPE1 Gene

197,499,994 bp from pter
197,503,463 bp from pter
3,470 bases
Plus strand

Genomic View for HSPE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPE1 Gene

Proteins for HSPE1 Gene

  • Protein details for HSPE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    10 kDa heat shock protein, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • O95421
    • Q04984
    • Q53X54
    • Q9UDH0

    Protein attributes for HSPE1 Gene

    102 amino acids
    Molecular mass:
    10932 Da
    Quaternary structure:
    • Homohexamer

neXtProt entry for HSPE1 Gene

Proteomics data for HSPE1 Gene at MOPED

Post-translational modifications for HSPE1 Gene

  • Ubiquitination at Lys8, Lys28, Lys40, and Lys86
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPE1 Gene

Domains for HSPE1 Gene

Gene Families for HSPE1 Gene

  • CHAP :Heat Shock Proteins / Chaperonins

Protein Domains for HSPE1 Gene

Suggested Antigen Peptide Sequences for HSPE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P61604
  • Belongs to the GroES chaperonin family.
genes like me logo Genes that share domains with HSPE1: view

Function for HSPE1 Gene

Molecular function for HSPE1 Gene

UniProtKB/Swiss-Prot Function: Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UniProtKB/Swiss-Prot Induction: By stress

Gene Ontology (GO) - Molecular Function for HSPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18319262
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0051082 unfolded protein binding NAS 12483302
GO:0051087 chaperone binding ISS --
genes like me logo Genes that share ontologies with HSPE1: view

Phenotypes for HSPE1 Gene

GenomeRNAi human phenotypes for HSPE1:
genes like me logo Genes that share phenotypes with HSPE1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSPE1 Gene

Localization for HSPE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPE1 Gene

Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for HSPE1 Gene COMPARTMENTS Subcellular localization image for HSPE1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HSPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion ISS --
GO:0005759 mitochondrial matrix IEA --
GO:0016020 membrane IDA 16210410
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HSPE1: view

Pathways for HSPE1 Gene

SuperPathways for HSPE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006457 protein folding IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process NAS 10205158
GO:0006950 response to stress --
GO:0006986 response to unfolded protein TAS 7698325
genes like me logo Genes that share ontologies with HSPE1: view

No data available for Pathways by source for HSPE1 Gene

Compounds for HSPE1 Gene

(23) Novoseek inferred chemical compound relationships for HSPE1 Gene

Compound -log(P) Hits PubMed IDs
amp-pnp 54.2 3
8-azido-atp 52.4 3
atp 51.8 38
mgatp 46.1 4
malate 43.9 2
genes like me logo Genes that share compounds with HSPE1: view

Transcripts for HSPE1 Gene

Unigene Clusters for HSPE1 Gene

Heat shock 10kDa protein 1 (chaperonin 10):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -

Relevant External Links for HSPE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPE1 Gene

mRNA expression in normal human tissues for HSPE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPE1 Gene

This gene is overexpressed in Liver (4.2) and Adrenal Gland (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPE1 Gene

SOURCE GeneReport for Unigene cluster for HSPE1 Gene Hs.1197

genes like me logo Genes that share expressions with HSPE1: view

No data available for mRNA Expression by UniProt/SwissProt for HSPE1 Gene

Orthologs for HSPE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPE1 36
  • 100 (a)
(Bos Taurus)
Mammalia HSPE1 35
  • 93.14 (n)
  • 100 (a)
HSPE1 36
  • 100 (a)
(Canis familiaris)
Mammalia HSPE1 35
  • 92.81 (n)
  • 100 (a)
HSPE1 36
  • 99 (a)
(Mus musculus)
Mammalia Hspe1 35
  • 90.52 (n)
  • 96.08 (a)
Hspe1 16
Hspe1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia HSPE1 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia HSPE1 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Hspe1 35
  • 89.54 (n)
  • 98.04 (a)
(Gallus gallus)
Aves HSPE1 36
  • 57 (a)
(Anolis carolinensis)
Reptilia HSPE1 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspe1 35
  • 78.1 (n)
  • 87.25 (a)
Str.10777 35
(Danio rerio)
Actinopterygii hspe1 35
  • 70.71 (n)
  • 82.83 (a)
hspe1 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11267 36
  • 52 (a)
CG9920 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea Y22D7AL.10 35
  • 60.94 (n)
  • 62.63 (a)
Y22D7AL.10 36
  • 57 (a)
Y22D7AL.10 37
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL235W 35
  • 45.49 (n)
  • 47.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSP10 35
  • 50 (n)
  • 45.83 (a)
HSP10 36
  • 42 (a)
HSP10 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E09307g 35
  • 50.51 (n)
  • 44.44 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CPN10 35
  • 53.62 (n)
  • 53.26 (a)
(Oryza sativa)
Liliopsida Os07g0641700 35
  • 52.98 (n)
  • 50.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04334 35
  • 50.84 (n)
  • 44.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hsp10 35
  • 48.94 (n)
  • 43.62 (a)
Species with no ortholog for HSPE1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPE1 Gene

Gene Tree for HSPE1 (if available)
Gene Tree for HSPE1 (if available)

Paralogs for HSPE1 Gene

Selected SIMAP similar genes for HSPE1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSPE1: view

No data available for Paralogs for HSPE1 Gene

Variants for HSPE1 Gene

Relevant External Links for HSPE1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HSPE1 Gene

Disorders for HSPE1 Gene

(23) Novoseek inferred disease relationships for HSPE1 Gene

Disease -log(P) Hits PubMed IDs
shock 56.2 31
abortion threatened 55.8 1
abortion missed 44.5 1
tuberculosis 43.1 29
miscarriage recurrent 41.9 3

Relevant External Links for HSPE1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HSPE1: view

No data available for UniProtKB/Swiss-Prot for HSPE1 Gene

Publications for HSPE1 Gene

  1. Identification and cloning of human chaperonin 10 homologue. (PMID: 7914093) Monzini N. … Modena D. (Biochim. Biophys. Acta 1994) 2 3 4 23
  2. Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10. (PMID: 7916212) Chen J.J. … Androphy E.J. (Biochim. Biophys. Acta 1994) 3 4 23
  3. Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10. (PMID: 7698325) Legname G. … Modena D. (FEBS Lett. 1995) 2 3 23
  4. The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10. (PMID: 7912672) Cavanagh A.C. … Morton H. (Eur. J. Biochem. 1994) 3 4 23
  5. Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. (PMID: 12483302) Hansen J.J. … Gregersen N. (Hum. Genet. 2003) 3 4 23

Products for HSPE1 Gene

Sources for HSPE1 Gene

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