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Aliases for BIRC5 Gene

Aliases for BIRC5 Gene

  • Baculoviral IAP Repeat Containing 5 2 3
  • Apoptosis Inhibitor 4 2 3 4
  • API4 3 4 6
  • Apoptosis Inhibitor Survivin 3 4
  • Survivin Variant 3 Alpha 2 3
  • Baculoviral IAP Repeat-Containing Protein 5 3
  • Baculoviral IAP Repeat-Containing 5 2
  • EPR-1 3
  • IAP4 4

External Ids for BIRC5 Gene

Previous HGNC Symbols for BIRC5 Gene

  • API4

Previous GeneCards Identifiers for BIRC5 Gene

  • GC17M076124
  • GC17P079197
  • GC17P076671
  • GC17P076808
  • GC17P076809
  • GC17P073722
  • GC17P076210
  • GC17P071634

Summaries for BIRC5 Gene

Entrez Gene Summary for BIRC5 Gene

  • This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for BIRC5 Gene

BIRC5 (Baculoviral IAP Repeat Containing 5) is a Protein Coding gene. Diseases associated with BIRC5 include serous cystadenocarcinoma and ovarian serous cystadenocarcinoma. Among its related pathways are Pathways in cancer and GPCR Pathway. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for BIRC5 Gene

  • Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Gene Wiki entry for BIRC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC5 Gene

Genomics for BIRC5 Gene

Regulatory Elements for BIRC5 Gene

Transcription factor binding sites by QIAGEN in the BIRC5 gene promoter:

Genomic Location for BIRC5 Gene

Start:
78,214,186 bp from pter
End:
78,225,636 bp from pter
Size:
11,451 bases
Orientation:
Plus strand

Genomic View for BIRC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BIRC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC5 Gene

Proteins for BIRC5 Gene

  • Protein details for BIRC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15392-BIRC5_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 5
    Protein Accession:
    O15392
    Secondary Accessions:
    • A2SUH6
    • B2R4R1
    • Q2I3N8
    • Q4VGX0
    • Q53F61
    • Q5MGC6
    • Q6FHL2
    • Q75SP2
    • Q9P2W8

    Protein attributes for BIRC5 Gene

    Size:
    142 amino acids
    Molecular mass:
    16389 Da
    Quaternary structure:
    • Monomer or homodimer. Exists as a homodimer in the apo state and as a monomer in the CPC-bound state. The monomer protects cells against apoptosis more efficiently than the dimer. Only the dimeric form is capable of enhancing tubulin stability in cells. When phosphorylated, interacts with LAMTOR5/HBXIP; the resulting complex binds pro-CASP9, as well as active CASP9, but much less efficiently. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with JTB. Interacts with CDCA8 and INCENP; interaction is direct. Interacts with EVI5. Interacts with GTP-bound RAN in both the S and M phases of the cell cycle. Interacts with USP9X. Interacts with tubulin. Interacts with BIRC2/c-IAP1. The acetylated form at Lys-129 interacts with STAT3. The monomeric form deacetylated at Lys-129 interacts with XPO1/CRM1. The monomeric form interacts with XIAP/BIRC4. Both the dimeric and monomeric form can interact with DIABLO/SMAC. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for BIRC5 Gene

    Alternative splice isoforms for BIRC5 Gene

neXtProt entry for BIRC5 Gene

Proteomics data for BIRC5 Gene at MOPED

Post-translational modifications for BIRC5 Gene

  • Acetylation at Lys-129 by CBP results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.
  • In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes (PubMed:14610074). Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities (PubMed:21252625). Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity (PubMed:24866247).
  • Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.
  • Ubiquitination at Lys23
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BIRC5 Gene

Domains for BIRC5 Gene

Gene Families for BIRC5 Gene

HGNC:
  • BIRC :Baculoviral IAP repeat containing

Protein Domains for BIRC5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15392

UniProtKB/Swiss-Prot:

BIRC5_HUMAN :
  • O15392
Domain:
  • The BIR repeat is necessary and sufficient for LAMTOR5 binding
Family:
  • Belongs to the IAP family.
Similarity:
  • Contains 1 BIR repeat.
genes like me logo Genes that share domains with BIRC5: view

Function for BIRC5 Gene

Molecular function for BIRC5 Gene

UniProtKB/Swiss-Prot Function: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.
UniProtKB/Swiss-Prot Induction: Up-regulated by COMP.

Gene Ontology (GO) - Molecular Function for BIRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0004869 cysteine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 11024045
GO:0008017 microtubule binding TAS 21536684
GO:0008270 zinc ion binding NAS 10949039
genes like me logo Genes that share ontologies with BIRC5: view
genes like me logo Genes that share phenotypes with BIRC5: view

Animal Models for BIRC5 Gene

MGI Knock Outs for BIRC5:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BIRC5 Gene

Localization for BIRC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC5 Gene

Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC5 Gene COMPARTMENTS Subcellular localization image for BIRC5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
mitochondrion 3
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BIRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 16322459
GO:0000775 chromosome, centromeric region IDA 11084331
GO:0000777 condensed chromosome kinetochore IDA 15665297
GO:0005634 nucleus IDA 15665297
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with BIRC5: view

Pathways for BIRC5 Gene

genes like me logo Genes that share pathways with BIRC5: view

Gene Ontology (GO) - Biological Process for BIRC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 9859993
GO:0000226 microtubule cytoskeleton organization --
GO:0000278 mitotic cell cycle TAS --
GO:0000910 cytokinesis IMP 12805209
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BIRC5: view

Compounds for BIRC5 Gene

(160) Novoseek inferred chemical compound relationships for BIRC5 Gene

Compound -log(P) Hits PubMed IDs
naphtho(1,2-b)furan-4,5-dione 73.5 3
ciap2 71.7 10
paclitaxel 64 100
suberoylanilide hydroxamic acid 63.6 11
deguelin 63.3 15
genes like me logo Genes that share compounds with BIRC5: view

Transcripts for BIRC5 Gene

Unigene Clusters for BIRC5 Gene

Baculoviral IAP repeat containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5:
SP6: -

Relevant External Links for BIRC5 Gene

GeneLoc Exon Structure for
BIRC5
ECgene alternative splicing isoforms for
BIRC5

Expression for BIRC5 Gene

mRNA expression in normal human tissues for BIRC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BIRC5 Gene

This gene is overexpressed in Testis (14.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BIRC5 Gene

SOURCE GeneReport for Unigene cluster for BIRC5 Gene Hs.744872

mRNA Expression by UniProt/SwissProt for BIRC5 Gene

O15392-BIRC5_HUMAN
Tissue specificity: Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.
genes like me logo Genes that share expressions with BIRC5: view

Orthologs for BIRC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIRC5 35
  • 98.84 (n)
  • 98.26 (a)
BIRC5 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BIRC5 35
  • 90.14 (n)
  • 90.14 (a)
BIRC5 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIRC5 35
  • 90.14 (n)
  • 90.85 (a)
BIRC5 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Birc5 35
  • 82.62 (n)
  • 83.57 (a)
Birc5 16
Birc5 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BIRC5 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BIRC5 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Birc5 35
  • 81.32 (n)
  • 82.98 (a)
chicken
(Gallus gallus)
Aves BIRC5 35
  • 65.69 (n)
  • 60.58 (a)
BIRC5 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BIRC5 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia birc5.2 35
  • 64.2 (n)
  • 57.78 (a)
Str.8111 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1470 35
zebrafish
(Danio rerio)
Actinopterygii birc5a 35
  • 58.01 (n)
  • 54.33 (a)
birc5a 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Det 36
  • 31 (a)
OneToOne
Species with no ortholog for BIRC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIRC5 Gene

ENSEMBL:
Gene Tree for BIRC5 (if available)
TreeFam:
Gene Tree for BIRC5 (if available)

Paralogs for BIRC5 Gene

genes like me logo Genes that share paralogs with BIRC5: view

No data available for Paralogs for BIRC5 Gene

Variants for BIRC5 Gene

Sequence variations from dbSNP and Humsavar for BIRC5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1042489 -- 78,224,125(+) GTCCC(C/T)GGCTC utr-variant-3-prime, nc-transcript-variant
rs1042541 -- 78,225,289(+) TGGCT(A/G)CCAGC utr-variant-3-prime, nc-transcript-variant
rs1042542 -- 78,225,347(+) CTAAG(C/T)GCAAC utr-variant-3-prime, nc-transcript-variant
rs2071214 - 78,223,510(+) CTGCG(A/G)AGAAA synonymous-codon, reference, missense, nc-transcript-variant
rs2239680 -- 78,223,702(+) TGCTC(C/T)TGTTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for BIRC5 Gene

Variant ID Type Subtype PubMed ID
dgv3278n71 CNV Loss 21882294
nsv524306 CNV Gain 19592680
nsv908876 CNV Gain 21882294

Relevant External Links for BIRC5 Gene

HapMap Linkage Disequilibrium report
BIRC5
Human Gene Mutation Database (HGMD)
BIRC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BIRC5 Gene

Disorders for BIRC5 Gene

(90) Novoseek inferred disease relationships for BIRC5 Gene

Disease -log(P) Hits PubMed IDs
cancer 78.7 258
tumors 77.9 314
bladder cancer 63.5 114
nsclc 59.7 151
hepatocellular carcinoma 58.4 76

Relevant External Links for BIRC5

Genetic Association Database (GAD)
BIRC5
Human Genome Epidemiology (HuGE) Navigator
BIRC5
genes like me logo Genes that share disorders with BIRC5: view

No data available for UniProtKB/Swiss-Prot for BIRC5 Gene

Publications for BIRC5 Gene

  1. Survivin-deltaEx3 and survivin-2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. (PMID: 10626797) Mahotka C. … Gerharz C.D. (Cancer Res. 1999) 3 4 23
  2. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. (PMID: 9256286) Ambrosini G. … Altieri D.C. (Nat. Med. 1997) 3 4 23
  3. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. (PMID: 14610074) Wheatley S.P. … Earnshaw W.C. (J. Biol. Chem. 2004) 3 4 23
  4. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (PMID: 15665297) Samuel T. … Reed J.C. (Cancer Res. 2005) 3 4 23
  5. Molecular cloning and bioinformatics analysis of a novel spliced variant of survivin from human breast cancer cells. (PMID: 16329164) Zheng W. … Yang S. (DNA Seq. 2005) 3 4 23

Products for BIRC5 Gene

Sources for BIRC5 Gene

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