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HSPA9 Gene(Protein Coding)

Heat Shock Protein Family A (Hsp70) Member 9

GCID:
GC05M138554
GIFtS:
68
Genes Participants
UDN Logo

Aliases for HSPA9 Gene

Aliases for HSPA9 Gene

  • Heat Shock Protein Family A (Hsp70) Member 9 2 3 5
  • Heat Shock 70kDa Protein 9 (Mortalin) 2 3
  • 75 KDa Glucose-Regulated Protein 3 4
  • Peptide-Binding Protein 74 3 4
  • Mortalin2 2 3
  • HSPA9B 3 4
  • GRP-75 3 4
  • GRP75 3 4
  • PBP74 3 4
  • MOT 3 4
  • Epididymis Secretory Sperm Binding Protein Li 124m 3
  • Heat Shock 70kDa Protein 9B (Mortalin-2) 2
  • Catecholamine-Regulated Protein 40 3
  • Heat Shock 70 KDa Protein 9 4
  • Heat Shock 70kD Protein 9B 3
  • Mortalin, Perinuclear 3
  • P66-Mortalin 3
  • HEL-S-124m 3
  • Mortalin-2 3
  • Mortalin 4
  • Mt-HSP70 4
  • MTHSP75 3
  • SIDBA4 3
  • CRP40 3
  • EVPLS 3
  • MOT2 3
  • SAAN 3
  • CSA 3

External Ids for HSPA9 Gene

Previous HGNC Symbols for HSPA9 Gene

  • HSPA9B

Previous GeneCards Identifiers for HSPA9 Gene

  • GC05M137920
  • GC05M137923
  • GC05M133080
  • GC05M137890

Summaries for HSPA9 Gene

Entrez Gene Summary for HSPA9 Gene

  • This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

GeneCards Summary for HSPA9 Gene

HSPA9 (Heat Shock Protein Family A (Hsp70) Member 9) is a Protein Coding gene. Diseases associated with HSPA9 include Autosomal Dominant Sideroblastic Anemia and Autosomal Recessive Sideroblastic Anemia. Among its related pathways are Cellular response to heat stress and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA9 Gene

  • Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.

Gene Wiki entry for HSPA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA9 Gene

Genomics for HSPA9 Gene

Products:

  1. Regulatory Element

Regulatory Elements for HSPA9 Gene

Enhancers for HSPA9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPA9 on UCSC Golden Path with GeneCards custom track

Promoters for HSPA9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPA9 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HSPA9 gene promoter:

Genomic Location for HSPA9 Gene

Chromosome:
5
Start:
138,554,882 bp from pter
End:
138,575,629 bp from pter
Size:
20,748 bases
Orientation:
Minus strand

Genomic View for HSPA9 Gene

Genes around HSPA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HSPA9 Gene

Proteins for HSPA9 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HSPA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38646-GRP75_HUMAN
    Recommended name:
    Stress-70 protein, mitochondrial
    Protein Accession:
    P38646
    Secondary Accessions:
    • B2RCM1
    • P30036
    • P31932
    • Q1HB43
    • Q53H23
    • Q6GU03
    • Q9BWB7
    • Q9UC56

    Protein attributes for HSPA9 Gene

    Size:
    679 amino acids
    Molecular mass:
    73680 Da
    Quaternary structure:
    • Interacts with FXN. Interacts with HSCB. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with DNLZ, the interaction is required to prevent self-aggregation. Interacts with TESPA1.

    Three dimensional structures from OCA and Proteopedia for HSPA9 Gene

neXtProt entry for HSPA9 Gene

Proteomics data for HSPA9 Gene at MOPED

Protein Expression for HSPA9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HSPA9 Gene

  • Ubiquitination at Lys 121 and Lys 646
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HSPA9 (HSPA9B)
  • Cloud-Clone Corp. Antibodies for HSPA9

No data available for DME Specific Peptides for HSPA9 Gene

Domains & Families for HSPA9 Gene

Gene Families for HSPA9 Gene

HGNC:

Protein Domains for HSPA9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HSPA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P38646

UniProtKB/Swiss-Prot:

GRP75_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA9: view

Function for HSPA9 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HSPA9 Gene

UniProtKB/Swiss-Prot Function:
Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.

Gene Ontology (GO) - Molecular Function for HSPA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017134 fibroblast growth factor binding IEA --
GO:0051082 unfolded protein binding IEA,TAS 16130169
genes like me logo Genes that share ontologies with HSPA9: view

Phenotypes for HSPA9 Gene

MGI mutant phenotypes for HSPA9:
inferred from 1 alleles
GenomeRNAi human phenotypes for HSPA9:
genes like me logo Genes that share phenotypes with HSPA9: view

Animal Model Products

miRNA for HSPA9 Gene

miRTarBase miRNAs that target HSPA9

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA9 Gene

Localization for HSPA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA9 Gene

Mitochondrion. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA9 Gene COMPARTMENTS Subcellular localization image for HSPA9 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 4
cytosol 3
endoplasmic reticulum 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HSPA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 7684501
GO:0005925 focal adhesion IDA 21423176
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HSPA9: view

Pathways & Interactions for HSPA9 Gene

genes like me logo Genes that share pathways with HSPA9: view

SIGNOR curated interactions for HSPA9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HSPA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071347 cellular response to interleukin-1 IEA --
genes like me logo Genes that share ontologies with HSPA9: view

Drugs & Compounds for HSPA9 Gene

Products:

  1. Drug

(4) Drugs for HSPA9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for HSPA9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPA9: view

Transcripts for HSPA9 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HSPA9 Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(1018) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA9 Gene

Heat shock 70kDa protein 9 (mortalin):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^
SP1: - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - - - - - - -
SP7:
SP8:
SP9: - - - -

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - -

Relevant External Links for HSPA9 Gene

GeneLoc Exon Structure for
HSPA9
ECgene alternative splicing isoforms for
HSPA9

Expression for HSPA9 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for HSPA9 Gene

mRNA expression in normal human tissues for HSPA9 Gene
mRNA expression by BioGPS for HSPA9 GenemRNA expression by GTEx for HSPA9 Gene

Protein differential expression in normal tissues from HIPED for HSPA9 Gene

This gene is overexpressed in Nasal epithelium (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA9 Gene



SOURCE GeneReport for Unigene cluster for HSPA9 Gene Hs.184233

genes like me logo Genes that share expression patterns with HSPA9: view

Protein tissue co-expression partners for HSPA9 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPA9 Gene

Orthologs for HSPA9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia HSPA9 35
  • 92.69 (n)
  • 98.53 (a)
HSPA9 36
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia HSPA9 35
  • 92.73 (n)
  • 98.82 (a)
HSPA9 36
  • 99 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Hspa9 35
  • 90.28 (n)
  • 98.38 (a)
Hspa9 16
Hspa9 36
  • 98 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia HSPA9 35
  • 99.85 (n)
  • 99.85 (a)
HSPA9 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Hspa9 35
  • 90.62 (n)
  • 98.38 (a)
oppossum
(Monodelphis domestica)
 Mammalia HSPA9 36
  • 96 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HSPA9 35
  • 81.25 (n)
  • 94.13 (a)
HSPA9 36
  • 92 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia HSPA9 36
  • 90 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia hspa9 35
  • 78.16 (n)
  • 91.5 (a)
Str.4363 35
African clawed frog
(Xenopus laevis)
 Amphibia hspa9b-prov 35
zebrafish
(Danio rerio)
 Actinopterygii hspa9 35
  • 76.85 (n)
  • 89.51 (a)
hspa9b 35
hspa9 36
  • 86 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.697 35
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP010876 35
  • 67.88 (n)
  • 80.88 (a)
fruit fly
(Drosophila melanogaster)
 Insecta Hsc70-5 35
  • 68.23 (n)
  • 78.47 (a)
Hsc70-5 36
  • 74 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea hsp-6 35
  • 66.77 (n)
  • 76.92 (a)
hsp-6 36
  • 75 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AFR352C 35
  • 62.24 (n)
  • 68.12 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E22309g 35
  • 63.6 (n)
  • 67.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SSC1 35
  • 62.85 (n)
  • 66.4 (a)
SSA2 36
  • 50 (a)
 OneToMany
SSQ1 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons mtHsc70-1 35
  • 63.49 (n)
  • 64.13 (a)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.7686 35
rice
(Oryza sativa)
 Liliopsida Os09g0491772 35
  • 62.13 (n)
  • 63.54 (a)
corn
(Zea mays)
 Liliopsida Zm.700 35
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.4684 35
bread mold
(Neurospora crassa)
 Ascomycetes NCU08693 35
  • 61.61 (n)
  • 68.23 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes ssc1 35
  • 60.24 (n)
  • 63.48 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 47 (a)
 ManyToMany
Species with no ortholog for HSPA9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA9 Gene

ENSEMBL:
Gene Tree for HSPA9 (if available)
TreeFam:
Gene Tree for HSPA9 (if available)

Paralogs for HSPA9 Gene

Paralogs for HSPA9 Gene

(15) SIMAP similar genes for HSPA9 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for HSPA9 Gene

genes like me logo Genes that share paralogs with HSPA9: view

Variants for HSPA9 Gene

Sequence variations from dbSNP and Humsavar for HSPA9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_046482 -
VAR_046483 -
VAR_049622 -
VAR_049623 -

Variation tolerance for HSPA9 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA9 Gene

Human Gene Mutation Database (HGMD)
HSPA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSPA9 Gene

Disorders for HSPA9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HSPA9 Gene - From: ClinVar, Orphanet, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
autosomal dominant sideroblastic anemia
autosomal recessive sideroblastic anemia
  • congenital sideroblastic anemia
parkinson disease, late-onset
  • parkinson disease
- elite association - COSMIC cancer census association via MalaCards
Search HSPA9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPA9

Genetic Association Database (GAD)
HSPA9
Human Genome Epidemiology (HuGE) Navigator
HSPA9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA9
genes like me logo Genes that share disorders with HSPA9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA9 Gene

Publications for HSPA9 Gene

  1. Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. (PMID: 7684501) Domanico S.Z. … Pierce S.K. (Mol. Cell. Biol. 1993) 2 3 4 67
  2. Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity. (PMID: 19739077) Pilzer D. … Fishelson Z. (Int. J. Cancer 2010) 3 23
  3. Kinetic and structural characterization of human mortalin. (PMID: 20152901) Luo W.I. … Cowan J.A. (Protein Expr. Purif. 2010) 3 23
  4. Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions. (PMID: 20153329) Iosefson O. … Azem A. (FEBS Lett. 2010) 3 23
  5. Cloning, characterization, and functional studies of a human 40-kDa catecholamine-regulated protein: implications in central nervous system disorders. (PMID: 19280369) Gabriele J. … Mishra R.K. (Cell Stress Chaperones 2009) 3 23

Products for HSPA9 Gene

Sources for HSPA9 Gene

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