Aliases for XIAP Gene
Aliases for XIAP Gene
- X-Linked Inhibitor Of Apoptosis 2 3 5
- X-Linked Inhibitor Of Apoptosis, E3 Ubiquitin Protein Ligase 2 3
- Baculoviral IAP Repeat-Containing Protein 4 3 4
- RING-Type E3 Ubiquitin Transferase XIAP 3 4
- Inhibitor Of Apoptosis Protein 3 3 4
- IAP-Like Protein 3 4
- X-Linked IAP 3 4
- HIAP-3 3 4
- BIRC4 3 4
- IAP-3 3 4
- HIAP3 3 4
- API3 3 4
External Ids for XIAP Gene
- HGNC: 592
- Entrez Gene: 331
- Ensembl: ENSG00000101966
- OMIM: 300079
- UniProtKB: P98170
Previous HGNC Symbols for XIAP Gene
- API3
- BIRC4
Previous GeneCards Identifiers for XIAP Gene
- GC0XP122823
- GC0XP122993
- GC0XP112378
Summaries for XIAP Gene
-
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
GeneCards Summary for XIAP Gene
XIAP (X-Linked Inhibitor Of Apoptosis) is a Protein Coding gene. Diseases associated with XIAP include Lymphoproliferative Syndrome, X-Linked, 2 and Lymphoproliferative Syndrome, X-Linked, 1. Among its related pathways are Apoptosis and survival Caspase cascade and Development ERBB-family signaling. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is BIRC3.
UniProtKB/Swiss-Prot for XIAP Gene
-
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.
-
The inhibitor of apoptosis (IAP) family of proteins are major regulators of apoptosis through interaction with components of the apoptotic signaling cascades. Discovered in baculovirus, human homologs can be described as baculovirus IAP repeat containing (BIRC) proteins.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XIAP Gene
Genomics for XIAP Gene
Regulatory Elements for XIAP Gene
Enhancers for XIAP Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG123779 | 1.2 | ENCODE dbSUPER | 13 | -78.6 | -78607 | 4.2 | PKNOX1 FOXA2 ZFP64 DMAP1 ZNF48 FOS ZNF202 REST PPARG ZNF623 | LOC101928402 THOC2 ENSG00000199705 XIAP XIAP-AS1 RNU6-122P LOC100422369 FERP1 CHCHD2P1 RNU7-69P |
| GH0XG123858 | 1.1 | ENCODE | 12.7 | +0.7 | 658 | 3.8 | PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 SP3 ZHX2 | XIAP XIAP-AS1 |
| GH0XG123906 | 0.5 | ENCODE | 22.8 | +47.0 | 47022 | 0.8 | ZNF263 FOS NR3C1 ZBTB40 ZKSCAN1 | XIAP ENSG00000199705 LOC100422369 XIAP-AS1 RNU6-122P STAG2 |
| GH0XG123846 | 1.2 | Ensembl ENCODE | 9.1 | -12.8 | -12793 | 0.7 | ATF1 GLIS2 ELK1 FOS CAVIN1 NCOA1 TSHZ1 REST SMARCA4 GLIS1 | XIAP GC0XM123858 ENSG00000199705 RN7SL190P |
| GH0XG123877 | 0.8 | Ensembl ENCODE | 9.9 | +18.8 | 18779 | 1.6 | ZNF202 PRDM6 NR2F1 IKZF1 CEBPB ZBTB33 SPI1 | XIAP RNU6-122P LOC100422369 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around XIAP on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the XIAP gene promoter:
Regulatory Element Products
Genomic Location for XIAP Gene
- Chromosome:
- X
- Start:
- 123,859,724 bp from pter
- End:
- 123,913,979 bp from pter
- Size:
- 54,256 bases
- Orientation:
- Plus strand
Genomic View for XIAP Gene
Genes around XIAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq25 by Ensembl
- Xq25 by Entrez Gene
- Xq25 by HGNC
XIAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XIAP Gene
Proteins for XIAP Gene
-
Protein details for XIAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P98170-XIAP_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase XIAP
- Protein Accession:
- P98170
- D3DTF2
- Q9NQ14
Protein attributes for XIAP Gene
- Size:
- 497 amino acids
- Molecular mass:
- 56685 Da
- Quaternary structure:
-
- Monomer, and homodimer. Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with TAB1/MAP3K7IP1 and AIFM1. Interaction with SMAC hinders binding of TAB1/MAP3K7IP1 and AIFM1. Interacts with TCF25 and COMMD1. Interacts with SEPT4 isoform 6, but not with other SEPT4 isoforms. Interacts with RIP1, RIP2, RIP3, RIP4, CCS and USP19. Interacts (via BIR 2 domain and BIR 3 domain) with HAX1 (via C-terminus) and this interaction blocks ubiquitination of XIAP/BIRC4. Interacts with the monomeric form of BIRC5/survivin. Interacts with TLE3 and TCF7L2/TCF4.
Protein Expression for XIAP Gene
Post-translational modifications for XIAP Gene
- Autoubiquitinated and degraded by the proteasome in apoptotic cells.
- Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal degradation.
- S-Nitrosylation down-regulates its E3 ubiquitin-protein ligase activity.
- Ubiquitination at isoforms=10, isoforms=31, Lys116, posLast=168168, Lys208, Lys322, and isoforms=328
- Modification sites at PhosphoSitePlus
Other Protein References for XIAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for XIAP
- R&D Systems Antibodies for XIAP (XIAP)
- Cell Signaling Technology (CST) Antibodies for XIAP (XIAP)
-
Custom Antibody ServicesOriGene Antibodies for XIAP
- Novus Biologicals Antibodies for XIAP
-
Cloud-Clone Corp. Antibodies for XIAP
- Invitrogen Antibodies for XIAP
- antibodies-online Antibodies for XIAP: See all 170
- GeneTex XIAP antibody for XIAP
-
Custom Antibody ServicesProSci Antibodies for XIAP
-
Santa Cruz Biotechnology (SCBT) Antibodies for XIAP
Protein Products
- R&D Systems Proteins and Enzymes for XIAP
-
OriGene Purified Proteins for XIAP
- Search Origene for MassSpec and Protein Over-expression Lysates for XIAP
- Origene Custom Protein Services for XIAP
- Sino Biological Recombinant Proteins for XIAP
- Browse Sino Biological Cell Lysates
-
Cloud-Clone Corp. Proteins for XIAP
- antibodies-online Proteins for XIAP: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for XIAP
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, Activity Assays, and other biochemical assays for XIAP (XIAP)
- Enzo Life Sciences assays for XIAP
- antibodies-online Kits for XIAP: See all 17
No data available for DME Specific Peptides for XIAP Gene
Domains & Families for XIAP Gene
Gene Families for XIAP Gene
Protein Domains for XIAP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for XIAP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P98170UniProtKB/Swiss-Prot:
XIAP_HUMAN :- The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit CASP3 and CASP7, while the third BIR is involved in CASP9 inhibition. The interactions with DIABLO/SMAC and PRSS25 are mediated by the second and third BIR domains.
- Belongs to the IAP family.
- Domain:
-
- The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit CASP3 and CASP7, while the third BIR is involved in CASP9 inhibition. The interactions with DIABLO/SMAC and PRSS25 are mediated by the second and third BIR domains.
- Family:
-
- Belongs to the IAP family.
Function for XIAP Gene
Molecular function for XIAP Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.
Enzyme Numbers (IUBMB) for XIAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 19473982 |
| GO:0004869 | cysteine-type endopeptidase inhibitor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 11257230 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for XIAP Gene
- MGI mutant phenotypes for XIAP:
-
inferred from 3 alleles
- mortality/aging
- cellular phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for XIAP:
-
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased cell death HMECs cells
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Decreased influenza A virus infection
- Increased cilium length after serum starvation
- Increased cilium length
- Decreased HIV-1 infection
- Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for XIAP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XIAP gene
- Search ViGene Biosciences for XIAP
CRISPR Products
-
OriGene CRISPR knockouts for XIAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for XIAP
- GenScript: Design CRISPR guide RNA sequences for XIAP
miRNA for XIAP Gene
- miRTarBase miRNAs that target XIAP
-
- hsa-mir-34a-3p (MIRT006260)
- hsa-mir-200b-3p (MIRT006671)
- hsa-mir-200c-3p (MIRT006672)
- hsa-mir-429 (MIRT006675)
- hsa-mir-181a-5p (MIRT006950)
- hsa-mir-181b-5p (MIRT006951)
- hsa-mir-215-5p (MIRT024546)
- hsa-mir-192-5p (MIRT026131)
- hsa-mir-101-3p (MIRT027269)
- hsa-mir-96-5p (MIRT027901)
- hsa-mir-125b-5p (MIRT045901)
- hsa-mir-106a-5p (MIRT048312)
- hsa-mir-17-5p (MIRT050938)
- hsa-let-7e-5p (MIRT051500)
- hsa-mir-24-3p (MIRT053061)
- hsa-mir-4782-3p (MIRT054447)
- hsa-mir-7-5p (MIRT108696)
- hsa-mir-302a-5p (MIRT108706)
- hsa-mir-940 (MIRT108708)
- hsa-mir-3164 (MIRT108711)
- hsa-mir-3609 (MIRT108712)
- hsa-mir-548ah-5p (MIRT108713)
- hsa-mir-6808-5p (MIRT108715)
- hsa-mir-6820-3p (MIRT108716)
- hsa-mir-6893-5p (MIRT108717)
- hsa-mir-7844-5p (MIRT108718)
- hsa-mir-20a-5p (MIRT108719)
- hsa-mir-93-5p (MIRT108720)
- hsa-mir-106b-5p (MIRT108722)
- hsa-mir-20b-5p (MIRT108724)
- hsa-mir-526b-3p (MIRT108726)
- hsa-mir-519d-3p (MIRT108727)
- hsa-mir-616-3p (MIRT108729)
- hsa-mir-3606-5p (MIRT108730)
- hsa-mir-3668 (MIRT108731)
- hsa-mir-4517 (MIRT108732)
- hsa-mir-4796-3p (MIRT108733)
- hsa-mir-548at-5p (MIRT108734)
- hsa-mir-5583-3p (MIRT108735)
- hsa-mir-5696 (MIRT108737)
- hsa-mir-6073 (MIRT108738)
- hsa-mir-7852-3p (MIRT108739)
- hsa-mir-541-5p (MIRT124959)
- hsa-mir-3159 (MIRT124960)
- hsa-mir-30c-2-3p (MIRT124963)
- hsa-mir-30b-3p (MIRT124964)
- hsa-mir-30c-1-3p (MIRT124965)
- hsa-mir-3689a-3p (MIRT124968)
- hsa-mir-3689b-3p (MIRT124969)
- hsa-mir-3689c (MIRT124970)
- hsa-mir-2392 (MIRT124971)
- hsa-mir-6779-5p (MIRT124976)
- hsa-mir-6780a-5p (MIRT124977)
- hsa-mir-6788-5p (MIRT124978)
- hsa-mir-1273h-5p (MIRT124982)
- hsa-mir-33a-5p (MIRT124983)
- hsa-mir-33b-5p (MIRT124989)
- hsa-mir-34c-3p (MIRT175543)
- hsa-mir-421 (MIRT175554)
- hsa-mir-548k (MIRT175560)
- hsa-mir-1258 (MIRT175561)
- hsa-mir-3124-3p (MIRT175564)
- hsa-mir-4670-3p (MIRT175571)
- hsa-mir-4803 (MIRT175577)
- hsa-mir-548av-5p (MIRT175579)
- hsa-mir-8054 (MIRT175589)
- hsa-mir-150-3p (MIRT229203)
- hsa-mir-5579-5p (MIRT229205)
- hsa-mir-5692a (MIRT229216)
- hsa-mir-124-5p (MIRT365873)
- hsa-mir-935 (MIRT365875)
- hsa-mir-6732-3p (MIRT365890)
- hsa-mir-6507-5p (MIRT365905)
- hsa-mir-4289 (MIRT409529)
- hsa-mir-130a-3p (MIRT438510)
- hsa-mir-412-3p (MIRT439280)
- ebv-mir-bart10-3p (MIRT439282)
- hsa-mir-584-5p (MIRT491910)
- hsa-mir-889-3p (MIRT491911)
- hsa-mir-4729 (MIRT491912)
- hsa-mir-142-3p (MIRT491913)
- hsa-mir-6513-5p (MIRT520103)
- hsa-mir-887-5p (MIRT520104)
- hsa-mir-3913-5p (MIRT520105)
- hsa-mir-3122 (MIRT520106)
- hsa-mir-450a-1-3p (MIRT520107)
- hsa-mir-7977 (MIRT520108)
- hsa-mir-8085 (MIRT520109)
- hsa-mir-6731-5p (MIRT520110)
- hsa-mir-6878-5p (MIRT520111)
- hsa-mir-4770 (MIRT520112)
- hsa-mir-6088 (MIRT520113)
- hsa-mir-143-3p (MIRT520114)
- hsa-mir-15b-3p (MIRT520115)
- hsa-mir-383-3p (MIRT520116)
- hsa-mir-6807-5p (MIRT520117)
- hsa-mir-7151-3p (MIRT520118)
- hsa-mir-5095 (MIRT520119)
- hsa-mir-29a-5p (MIRT520120)
- hsa-mir-1292-3p (MIRT520121)
- hsa-mir-4438 (MIRT520123)
- hsa-mir-3679-3p (MIRT533131)
- hsa-mir-2355-5p (MIRT533132)
- hsa-mir-7159-5p (MIRT533133)
- hsa-mir-4272 (MIRT533134)
- hsa-mir-505-3p (MIRT533135)
- hsa-mir-4423-3p (MIRT542615)
- hsa-mir-449c-5p (MIRT542616)
- hsa-mir-34b-5p (MIRT542617)
- hsa-mir-2682-5p (MIRT542618)
- hsa-mir-6511a-5p (MIRT542619)
- hsa-mir-1910-3p (MIRT542620)
- hsa-mir-451b (MIRT542621)
- hsa-mir-4266 (MIRT552805)
- hsa-mir-4709-5p (MIRT552806)
- hsa-mir-6888-5p (MIRT552807)
- hsa-mir-548l (MIRT552808)
- hsa-mir-559 (MIRT552809)
- hsa-mir-548y (MIRT552810)
- hsa-mir-548w (MIRT552811)
- hsa-mir-548o-5p (MIRT552812)
- hsa-mir-548j-5p (MIRT552813)
- hsa-mir-548i (MIRT552814)
- hsa-mir-548h-5p (MIRT552815)
- hsa-mir-548d-5p (MIRT552816)
- hsa-mir-548c-5p (MIRT552817)
- hsa-mir-548bb-5p (MIRT552818)
- hsa-mir-548b-5p (MIRT552819)
- hsa-mir-548ay-5p (MIRT552820)
- hsa-mir-548au-5p (MIRT552821)
- hsa-mir-548as-5p (MIRT552822)
- hsa-mir-548ar-5p (MIRT552823)
- hsa-mir-548aq-5p (MIRT552824)
- hsa-mir-548ap-5p (MIRT552825)
- hsa-mir-548am-5p (MIRT552826)
- hsa-mir-548ak (MIRT552827)
- hsa-mir-548ae-5p (MIRT552828)
- hsa-mir-548ad-5p (MIRT552829)
- hsa-mir-548ab (MIRT552830)
- hsa-mir-548a-5p (MIRT552831)
- hsa-mir-466 (MIRT564956)
- hsa-mir-103a-2-5p (MIRT564957)
- hsa-mir-1322 (MIRT564958)
- hsa-mir-1272 (MIRT564959)
- hsa-mir-4643 (MIRT564960)
- hsa-mir-4789-3p (MIRT564961)
- hsa-mir-4264 (MIRT616150)
- hsa-mir-4797-3p (MIRT616151)
- hsa-mir-4302 (MIRT616152)
- hsa-mir-6733-3p (MIRT616153)
- hsa-mir-1305 (MIRT627268)
- hsa-mir-6749-3p (MIRT627269)
- hsa-mir-6792-3p (MIRT627270)
- hsa-mir-4691-5p (MIRT627271)
- hsa-mir-3189-3p (MIRT627272)
- hsa-mir-212-5p (MIRT627273)
- hsa-mir-660-3p (MIRT627274)
- hsa-mir-5193 (MIRT627275)
- hsa-mir-129-5p (MIRT638111)
- hsa-mir-3680-3p (MIRT638112)
- hsa-mir-557 (MIRT638113)
- hsa-mir-507 (MIRT638114)
- hsa-mir-450b-5p (MIRT638115)
- hsa-mir-3140-3p (MIRT638116)
- hsa-mir-153-5p (MIRT638117)
- hsa-mir-302f (MIRT638118)
- hsa-mir-744-3p (MIRT651459)
- hsa-mir-106a-3p (MIRT651460)
- hsa-mir-6501-5p (MIRT651461)
- hsa-mir-4430 (MIRT651462)
- hsa-mir-3652 (MIRT651463)
- hsa-mir-564 (MIRT651464)
- hsa-mir-122-5p (MIRT651465)
- hsa-mir-504-3p (MIRT651466)
- hsa-mir-3135b (MIRT651467)
- hsa-mir-183-5p (MIRT651468)
- hsa-mir-454-3p (MIRT651469)
- hsa-mir-3666 (MIRT651470)
- hsa-mir-4295 (MIRT651471)
- hsa-mir-301b-3p (MIRT651472)
- hsa-mir-301a-3p (MIRT651473)
- hsa-mir-130b-3p (MIRT651474)
- hsa-mir-5197-5p (MIRT651475)
- hsa-mir-6739-3p (MIRT665367)
- hsa-mir-375 (MIRT665368)
- hsa-mir-4677-5p (MIRT665369)
- hsa-mir-4273 (MIRT665370)
- hsa-mir-7156-5p (MIRT665371)
- hsa-mir-4762-5p (MIRT665372)
- hsa-mir-34b-3p (MIRT671727)
- hsa-mir-6821-5p (MIRT676860)
- hsa-mir-4284 (MIRT676861)
- hsa-mir-640 (MIRT678367)
- hsa-mir-378a-5p (MIRT678368)
- hsa-mir-1193 (MIRT678369)
- hsa-mir-6821-3p (MIRT678370)
- hsa-mir-6790-3p (MIRT678371)
- hsa-mir-4662a-5p (MIRT679181)
- hsa-mir-1976 (MIRT679182)
- hsa-mir-3653-5p (MIRT679183)
- hsa-mir-6747-3p (MIRT679184)
- hsa-mir-575 (MIRT679185)
- hsa-mir-4676-5p (MIRT679186)
- hsa-mir-6858-3p (MIRT679187)
- hsa-mir-6848-3p (MIRT680487)
- hsa-mir-6843-3p (MIRT680488)
- hsa-mir-150-5p (MIRT680489)
- hsa-mir-186-3p (MIRT680490)
- hsa-mir-6736-5p (MIRT682888)
- hsa-mir-4701-3p (MIRT682889)
- hsa-mir-1262 (MIRT682890)
- hsa-mir-6720-5p (MIRT682891)
- hsa-mir-6512-3p (MIRT682892)
- hsa-mir-6509-3p (MIRT682893)
- hsa-mir-661 (MIRT682894)
- hsa-mir-6776-5p (MIRT682895)
- hsa-mir-4793-3p (MIRT682896)
- hsa-mir-766-3p (MIRT682897)
- hsa-mir-6742-3p (MIRT682898)
- hsa-mir-6849-3p (MIRT682899)
- hsa-mir-1273g-3p (MIRT682900)
- hsa-mir-181a-2-3p (MIRT682901)
- hsa-mir-483-3p (MIRT682902)
- hsa-mir-508-5p (MIRT682903)
- hsa-mir-6818-3p (MIRT697604)
- hsa-mir-4684-5p (MIRT697605)
- hsa-mir-593-3p (MIRT697606)
- hsa-mir-6895-3p (MIRT697607)
- hsa-mir-5699-3p (MIRT697608)
- hsa-mir-4421 (MIRT697609)
- hsa-mir-10b-5p (MIRT697610)
- hsa-mir-10a-5p (MIRT697611)
- hsa-mir-19b-3p (MIRT726093)
- hsa-mir-19a-3p (MIRT726094)
miRNA Products
- Search ViGene Biosciences for XIAP
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for XIAP
- Browse OriGene Inhibitory RNA Products For XIAP
-
ViGene Biosciences ready-to-package AAV shRNAs for XIAP gene
Clone Products
- Sino Biological Human cDNA Clone for XIAP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for XIAP
Cell Line Products
-
Horizon Cell Lines for XIAP
-
ViGene Biosciences adenoviral particle packaged cDNA for XIAP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XIAP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XIAP gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for XIAP Gene
Localization for XIAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for XIAP Gene
- Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| plasma membrane | 2 |
| endoplasmic reticulum | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 22304967 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,TAS | 15665297 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for XIAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis Modulation and Signaling |
.41
|
.33
|
| 2 | TNF signaling (REACTOME) |
.86
|
|
| 3 | Dimerization of procaspase-8 | ||
| 4 | Activation of caspases through apoptosome-mediated cleavage | ||
| 5 | Apoptosis and survival Caspase cascade | ||
Pathways by source for XIAP Gene
5 Sino Biological pathways for XIAP Gene
1 GeneTex pathway for XIAP Gene
1 Cell Signaling Technology pathway for XIAP Gene
8 BioSystems pathways for XIAP Gene
18 Reactome pathways for XIAP Gene
1 PharmGKB pathway for XIAP Gene
11 KEGG pathways for XIAP Gene
10 GeneGo (Thomson Reuters) pathways for XIAP Gene
2 R&D Systems pathways for XIAP Gene
5 Qiagen pathways for XIAP Gene
Interacting Proteins for XIAP Gene
Selected Interacting proteins:
ENSP00000347858
P98170-XIAP_HUMAN
for XIAP Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for XIAP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEP | 18049476 |
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
Drugs & Compounds for XIAP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Mitomycin | Approved | Pharma | Inhibits DNA synthesis,antibiotic and antitumor agent | 0 | ||
| 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide | Experimental | Pharma | Target | 0 | ||
| N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE | Experimental | Pharma | Target | 0 | ||
| GDC-0152 | Pharma | IAP antagonist,potent amd samll-molecule | 0 | |||
| LCL161 | Pharma | Antagonist | Antagonist of IAPs inhibitor, Inhibitor of apoptosis proteins (IAPS) antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| AZD 5582 dihydrochloride |
|
|
|
(3) Tocris Compounds for XIAP Gene
| Compound | Action | Cas Number |
|---|---|---|
| AZD 5582 dihydrochloride | Dimeric Smac mimetic; potent IAP inhibitor | |
| Embelin | Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor | 550-24-3 |
| UC 112 | IAP and XIAP inhibitor; antitumor | 383392-66-3 |
(10) ApexBio Compounds for XIAP Gene
| Compound | Action | Cas Number |
|---|---|---|
| AT-406 (SM-406) | 1071992-99-8 | |
| Birinapant (TL32711) | Potent XIAP/cIAP1 antagonist | 1260251-31-7 |
| BV6 | 1001600-56-1 | |
| Embelin | XIAP inhibitor,cell-permeable | 550-24-3 |
| GDC-0152 | IAP antagonist,potent amd samll-molecule | 873652-48-3 |
| LCL161 | Antagonist of IAPs inhibitor | 1005342-46-0 |
| Matrine | Alkaloid found in Sophora plant | 519-02-8 |
| Mitomycin C | Inhibits DNA synthesis,antibiotic and antitumor agent | 1950-07-7 |
| SM-164 | Anticancer agent | 957135-43-2 |
| UC 112 | IAP inhibitor | 383392-66-3 |
Transcripts for XIAP Gene
mRNA/cDNA for XIAP Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (204) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XIAP Gene
CRISPR Products
-
OriGene CRISPR knockouts for XIAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for XIAP
- GenScript: Design CRISPR guide RNA sequences for XIAP
miRNA Products
- Search ViGene Biosciences for XIAP
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for XIAP
- Browse OriGene Inhibitory RNA Products For XIAP
-
ViGene Biosciences ready-to-package AAV shRNAs for XIAP gene
Clone Products
- Sino Biological Human cDNA Clone for XIAP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for XIAP
Flow Cytometry Products
Expression for XIAP Gene
This gene is overexpressed in Peripheral blood mononuclear cells (16.7) and Pancreas (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XIAP Gene
NURSA nuclear receptor signaling pathways regulating expression of XIAP Gene:
XIAPSOURCE GeneReport for Unigene cluster for XIAP Gene:
Hs.356076mRNA Expression by UniProt/SwissProt for XIAP Gene:
P98170-XIAP_HUMAN
Tissue specificity:
Ubiquitous, except peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for XIAP Gene
- Nervous system(4.6)
- Heart(4.5)
- Blood(2.5)
- Intestine(2.4)
- Liver(2.4)
- Lung(2.4)
- Muscle(2.2)
- Spleen(2.2)
- Kidney(2.1)
- Bone marrow(2)
- Pancreas(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for XIAP Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- lymphatic
- nervous
- respiratory
Organs:
Head and neck:
- brain
- ear
- head
- meninges
- mouth
- neck
- pharynx
Thorax:
- heart
Abdomen:
- duodenum
- intestine
- liver
- pancreas
- small intestine
- spleen
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- lymph node
- red blood cell
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for XIAP
-
OriGene qPCR primer pairs and template standards for XIAP
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for XIAP Gene
Orthologs for XIAP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | XIAP 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | XIAP 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | XIAP 34 |
|
||
| BIRC4 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Xiap 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Xiap 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | XIAP 34 |
|
||
| IAP3 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | xiap 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | xiap 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4242 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012677 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Iap2 35 |
|
ManyToMany | |
| th 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany |
- Species where no ortholog for XIAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for XIAP Gene
(4) SIMAP similar genes for XIAP Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for XIAP Gene
Variants for XIAP Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs104894764 | Pathogenic | 123,886,014(+) | AAGTT(G/T)AAAAC | intron-variant, reference, stop-gained | |
| rs387907301 | Pathogenic | 123,886,270(+) | TTGTT(A/G)TGGTG | intron-variant, reference, missense | |
| rs1057515750 | Likely benign | 123,908,360(+) | AATTA(-/ATTA)GTAAG | nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs1057515756 | Likely benign | 123,912,215(+) | ACTGA(-/AAA)GAAAA | nc-transcript-variant, utr-variant-3-prime | |
| rs1057515761 | Likely benign | 123,913,753(+) | ACTGA(-/CTGA)TCTAA | nc-transcript-variant, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758890 | CNV | gain | 17122850 |
| esv3574512 | CNV | loss | 25503493 |
| esv3574513 | CNV | loss | 25503493 |
| esv3577236 | CNV | gain | 25503493 |
| nsv507991 | OTHER | sequence alteration | 20534489 |
Residual Variation Intolerance Score:
69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.43;
77.26% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for XIAP Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XIAP Gene
Disorders for XIAP Gene
(18) MalaCards diseases for XIAP Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoproliferative syndrome, x-linked, 2 |
|
|
| lymphoproliferative syndrome, x-linked, 1 |
|
|
| lymphoproliferative syndrome |
|
|
| dysgammaglobulinemia |
|
|
| malignant pleural mesothelioma |
|
Search XIAP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
XIAP_HUMAN- Lymphoproliferative syndrome, X-linked, 2 (XLP2) [MIM:300635]: A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma. {ECO:0000269 PubMed:17080092}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for XIAP
No data available for Genatlas for XIAP Gene
Publications for XIAP Gene
- Molecular interaction between HAX-1 and XIAP inhibits apoptosis. (PMID: 20171186) Kang Y.J. … Park S.G. (Biochem. Biophys. Res. Commun. 2010) 3 4 22 64
- cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. (PMID: 15665297) Samuel T. … Reed J.C. (Cancer Res. 2005) 3 4 22 64
- Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. (PMID: 12121969) MacFarlane M. … Cohen G.M. (J. Biol. Chem. 2002) 3 4 22 64
- Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. (PMID: 11447297) Suzuki Y. … Takahashi R. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 22 64
- Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PMID: 8552191) Liston P. … Korneluk R.G. (Nature 1996) 2 3 4 64
Products for XIAP Gene
- R&D Systems Antibodies for XIAP (XIAP)
- R&D Systems Proteins and Enzymes for XIAP
- R&D Systems Activity Assays, ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for XIAP (XIAP)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for XIAP
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for XIAP
- Search Origene for MassSpec and Protein Over-expression Lysates for XIAP
- Origene Custom Protein Services for XIAP
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for XIAP
- Browse OriGene Inhibitory RNA Products For XIAP
- OriGene qPCR primer pairs and template standards for XIAP
- OriGene qPCR primer pairs for XIAP
- OriGene CRISPR knockouts for XIAP
- OriGene ORF clones in human for XIAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For XIAP
- GenScript: Next-day shipping cDNA ORF clone for XIAP in any vector
- GenScript Custom Purified and Recombinant Proteins Services for XIAP
- GenScript Custom Assay Services for XIAP
- GenScript Custom overexpressing Cell Line Services for XIAP
- GenScript: Design CRISPR guide RNA sequences for XIAP
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for XIAP
- Cell Signaling Technology (CST) Antibodies for XIAP (XIAP)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for XIAP
- Sino Biological Recombinant Proteins for XIAP
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Browse Enzo Life Sciences for proteins
- Enzo Life Sciences assays for XIAP
- Enzo Life Sciences drugs & compounds for XIAP
- Search Enzo Life Sciences for proteins, assays, substrates, inhibitors & antibodies
- Novus Biologicals Antibodies for XIAP
- Novus Biologicals proteins and lysates for XIAP
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for XIAP
- Cloud-Clone Corp. Proteins for XIAP
- Invitrogen Antibodies for XIAP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for XIAP
- Addgene plasmids for XIAP
- antibodies-online Antibodies for XIAP: See all 170
- antibodies-online Kits for XIAP: See all 17
- antibodies-online Proteins for XIAP: See all 10
- Search antibodies-online for peptides
- GeneTex XIAP antibody for XIAP
- Search GeneTex for Proteins for XIAP
- ViGene Biosciences adenoviral particle packaged cDNA for XIAP gene
- ViGene Biosciences lentiviral particle packaged cDNA for XIAP gene
- ViGene Biosciences ready-to-package AAV shRNAs for XIAP gene
- Search ViGene Biosciences for XIAP
- Santa Cruz Biotechnology (SCBT) Antibodies for XIAP
- Search Santa Cruz Biotechnology (SCBT) for XIAP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for XIAP
- Custom Antibody ServicesProSci Antibodies for XIAP
- Search for XIAP Proteins at ProSci
- Horizon Cell Lines for XIAP
- Cyagen custom Knockout/knockin (KOKI) mouse models for XIAP
- VectorBuilder custom plasmid, inducible vectors for XIAP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XIAP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for XIAP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer