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Aliases for HSPA5 Gene

Aliases for HSPA5 Gene

  • Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) 2 3
  • GRP78 3 4 6
  • Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78 3 4
  • Immunoglobulin Heavy Chain-Binding Protein 3 4
  • BIP 3 4
  • Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD) 2
  • Epididymis Secretory Sperm Binding Protein Li 89n 3
  • 78 KDa Glucose-Regulated Protein 3
  • Heat Shock 70 KDa Protein 5 4
  • HEL-S-89n 3
  • GRP-78 4
  • MIF2 3

External Ids for HSPA5 Gene

Previous HGNC Symbols for HSPA5 Gene

  • GRP78

Previous GeneCards Identifiers for HSPA5 Gene

  • GC09M119111
  • GC09M119643
  • GC09M121450
  • GC09M123373
  • GC09M125076
  • GC09M127036
  • GC09M127997
  • GC09M097610

Summaries for HSPA5 Gene

Entrez Gene Summary for HSPA5 Gene

  • The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

GeneCards Summary for HSPA5 Gene

HSPA5 (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa)) is a Protein Coding gene. Diseases associated with HSPA5 include borna disease and wolfram syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include calcium ion binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA5 Gene

  • Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Gene Wiki entry for HSPA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA5 Gene

Genomics for HSPA5 Gene

Regulatory Elements for HSPA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPA5 Gene

Start:
125,234,848 bp from pter
End:
125,241,387 bp from pter
Size:
6,540 bases
Orientation:
Minus strand

Genomic View for HSPA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA5 Gene

Proteins for HSPA5 Gene

  • Protein details for HSPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11021-GRP78_HUMAN
    Recommended name:
    78 kDa glucose-regulated protein
    Protein Accession:
    P11021
    Secondary Accessions:
    • B0QZ61
    • Q2EF78
    • Q9NPF1
    • Q9UK02

    Protein attributes for HSPA5 Gene

    Size:
    654 amino acids
    Molecular mass:
    72333 Da
    Quaternary structure:
    • Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1, OS9, SEL1L and SYVN1. Interacts with DNAJC10 and MX1. Interacts with METTL23. Interacts with CEMIP; the interaction induces calcium leakage from the endoplamic reticulum and cell migration.

    Three dimensional structures from OCA and Proteopedia for HSPA5 Gene

neXtProt entry for HSPA5 Gene

Proteomics data for HSPA5 Gene at MOPED

Post-translational modifications for HSPA5 Gene

  • Ubiquitination at Lys96, Lys113, Lys118, Lys213, Lys268, Lys326, Lys370, Lys376, Lys523, Lys547, Lys573, and Lys601
  • Glycosylation at Thr69, Thr203, and Thr643
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HSPA5 (GRP78)

No data available for DME Specific Peptides for HSPA5 Gene

Domains for HSPA5 Gene

Gene Families for HSPA5 Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA5 Gene

Suggested Antigen Peptide Sequences for HSPA5 Gene

Graphical View of Domain Structure for InterPro Entry

P11021

UniProtKB/Swiss-Prot:

GRP78_HUMAN :
  • P11021
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA5: view

Function for HSPA5 Gene

Molecular function for HSPA5 Gene

GENATLAS Biochemistry: glucose regulated protein (78kDa),HSP70 homolog,in the endoplasmic reticulum,subunit of PPP1CC2
UniProtKB/Swiss-Prot Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Gene Ontology (GO) - Molecular Function for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 20477988
GO:0005509 calcium ion binding TAS 16130169
GO:0005515 protein binding IPI 11907036
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity ISS --
genes like me logo Genes that share ontologies with HSPA5: view
genes like me logo Genes that share phenotypes with HSPA5: view

Animal Models for HSPA5 Gene

MGI Knock Outs for HSPA5:

Animal Model Products

CRISPR Products

miRNA for HSPA5 Gene

miRTarBase miRNAs that target HSPA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HSPA5 Gene

Localization for HSPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA5 Gene

Endoplasmic reticulum lumen. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA5 Gene COMPARTMENTS Subcellular localization image for HSPA5 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 11943137
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum TAS 16130169
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with HSPA5: view

Pathways for HSPA5 Gene

genes like me logo Genes that share pathways with HSPA5: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0002576 platelet degranulation TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0006983 ER overload response IEA --
GO:0006987 activation of signaling protein activity involved in unfolded protein response IEA --
genes like me logo Genes that share ontologies with HSPA5: view

Compounds for HSPA5 Gene

(1) Drugbank Compounds for HSPA5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Antihemophilic Factor
  • AHF
target chaperone

(98) Novoseek inferred chemical compound relationships for HSPA5 Gene

Compound -log(P) Hits PubMed IDs
tunicamycin 87.1 50
trans-4,5-dihydroxy-1,2-dithiane 84.3 4
thapsigargin 77.5 47
11-deoxy-16,16-dimethyl-pge2 73.3 4
2-deoxyglucose 57.7 18

(1) PharmGKB related drug/compound annotations for HSPA5 Gene

Drug/compound Annotation
Platinum compounds CA
genes like me logo Genes that share compounds with HSPA5: view

Transcripts for HSPA5 Gene

mRNA/cDNA for HSPA5 Gene

(1367) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA5 Gene

Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa):
Representative Sequences:

CRISPR Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA5 Gene

No ASD Table

Relevant External Links for HSPA5 Gene

GeneLoc Exon Structure for
HSPA5
ECgene alternative splicing isoforms for
HSPA5

Expression for HSPA5 Gene

mRNA expression in normal human tissues for HSPA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA5 Gene

SOURCE GeneReport for Unigene cluster for HSPA5 Gene Hs.743241

genes like me logo Genes that share expressions with HSPA5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPA5 Gene

Orthologs for HSPA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA5 35
  • 99.69 (n)
  • 100 (a)
HSPA5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA5 35
  • 94.05 (n)
  • 99.22 (a)
dog
(Canis familiaris)
Mammalia HSPA5 35
  • 94.09 (n)
  • 99.24 (a)
HSPA5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa5 35
  • 92.35 (n)
  • 98.62 (a)
Hspa5 16
Hspa5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPA5 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA5 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa5 35
  • 91.03 (n)
  • 98.47 (a)
chicken
(Gallus gallus)
Aves HSPA5 35
  • 84.59 (n)
  • 97.64 (a)
HSPA5 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA5 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hspa5-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492570 35
  • 80.91 (n)
  • 96.06 (a)
Str.3462 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11216 35
zebrafish
(Danio rerio)
Actinopterygii Dr.26116 35
hspa5 35
  • 77.55 (n)
  • 93.53 (a)
hspa5 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004192 35
  • 71.81 (n)
  • 82.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-3 35
  • 73.49 (n)
  • 82.52 (a)
Hsc70-3 36
  • 80 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hsp-3 35
  • 71.02 (n)
  • 79.69 (a)
hsp-3 36
  • 77 (a)
OneToMany
hsp-4 36
  • 75 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR038W 35
  • 62.97 (n)
  • 65.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR2 35
  • 64.59 (n)
  • 68.8 (a)
KAR2 38
SSA2 36
  • 64 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09559g 35
  • 64.93 (n)
  • 69.96 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4801 35
soybean
(Glycine max)
eudicotyledons Gma.17631 35
thale cress
(Arabidopsis thaliana)
eudicotyledons BIP1 35
  • 64.91 (n)
  • 70.93 (a)
rice
(Oryza sativa)
Liliopsida Os02g0115900 35
  • 66.13 (n)
  • 71.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03982 35
  • 65.76 (n)
  • 69.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bip1 35
  • 66.83 (n)
  • 69.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for HSPA5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA5 Gene

ENSEMBL:
Gene Tree for HSPA5 (if available)
TreeFam:
Gene Tree for HSPA5 (if available)

Paralogs for HSPA5 Gene

Paralogs for HSPA5 Gene

Selected SIMAP similar genes for HSPA5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HSPA5 Gene

genes like me logo Genes that share paralogs with HSPA5: view

Variants for HSPA5 Gene

Sequence variations from dbSNP and Humsavar for HSPA5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7922 -- 125,236,454(-) CTAAG(C/T)GGCTG utr-variant-3-prime
rs8759 -- 125,236,372(-) AAAGC(A/G)GGTAA utr-variant-3-prime
rs12009 -- 125,235,024(-) CAATA(C/T)AGCCA utr-variant-3-prime
rs387491 -- 125,241,169(+) ACAGG(C/G)CGTAG utr-variant-5-prime
rs391957 -- 125,241,745(+) CTTTT(C/T)CTTCT upstream-variant-2KB

Relevant External Links for HSPA5 Gene

HapMap Linkage Disequilibrium report
HSPA5
Human Gene Mutation Database (HGMD)
HSPA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSPA5 Gene

Disorders for HSPA5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HSPA5 Gene including...

Search for HSPA5 Gene in MalaCards »

UniProtKB/Swiss-Prot

GRP78_HUMAN
  • Note=Autoantigen in rheumatoid arthritis. {ECO:0000269 PubMed:11160188}.

(54) Novoseek inferred disease relationships for HSPA5 Gene

Disease -log(P) Hits PubMed IDs
shock 63.6 54
hepatitis halothane 46.8 1
solid tumor 38.3 4
cancer 37.7 52
colon cancer 32.4 8

Relevant External Links for HSPA5

Genetic Association Database (GAD)
HSPA5
Human Genome Epidemiology (HuGE) Navigator
HSPA5
genes like me logo Genes that share disorders with HSPA5: view

Publications for HSPA5 Gene

  1. Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: risk and prognosis. (PMID: 19533686) Zhu X. … Kung H.F. (Int. J. Cancer 2009) 3 23 48
  2. Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis. (PMID: 19411306) Xu D. … Truog W.E. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 23
  3. GRP78 as a marker of pre-eclampsia: an exploratory study. (PMID: 19482905) LaverriA"re A. … Cohen M. (Mol. Hum. Reprod. 2009) 3 23
  4. Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma. (PMID: 19309398) Zhuang L. … Hersey P. (Histopathology 2009) 3 23
  5. Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma. (PMID: 19386345) Weinreb I. … Perez-Ordonez B. (Hum. Pathol. 2009) 3 23

Products for HSPA5 Gene

  • Addgene plasmids for HSPA5

Sources for HSPA5 Gene

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