Aliases for HSPA5 Gene
- Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) 2 3
- GRP78 3 4 6
- Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78 3 4
- Immunoglobulin Heavy Chain-Binding Protein 3 4
- BIP 3 4
- Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD) 2
- Epididymis Secretory Sperm Binding Protein Li 89n 3
External Ids for HSPA5 Gene
Previous HGNC Symbols for HSPA5 Gene
Previous GeneCards Identifiers for HSPA5 Gene
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]
GeneCards Summary for HSPA5 Gene
HSPA5 (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa)) is a Protein Coding gene. Diseases associated with HSPA5 include borna disease and wolfram syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include calcium ion binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.
UniProtKB/Swiss-Prot for HSPA5 Gene
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.