Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BIRC3 Gene

Aliases for BIRC3 Gene

  • Baculoviral IAP Repeat Containing 3 2 3
  • Inhibitor Of Apoptosis Protein 1 2 3 4
  • Apoptosis Inhibitor 2 2 3 4
  • API2 3 4 6
  • TNFR2-TRAF-Signaling Complex Protein 1 3 4
  • TNFR2-TRAF Signaling Complex Protein 2 3
  • Baculoviral IAP Repeat-Containing 3 2 3
  • Mammalian IAP Homolog C 2 3
  • RING Finger Protein 49 3 4
  • IAP Homolog C 3 4
  • C-IAP2 3 4
  • HIAP1 3 4
  • HAIP1 3 6
  • IAP-1 3 4
  • RNF49 3 4
  • MIHC 3 4
  • Baculoviral IAP Repeat-Containing Protein 3 3
  • EC 6.3.2.- 4
  • HIAP-1 4
  • CIAP2 3
  • MALT2 3
  • AIP1 3
  • IAP1 4

External Ids for BIRC3 Gene

Previous HGNC Symbols for BIRC3 Gene

  • API2

Previous GeneCards Identifiers for BIRC3 Gene

  • GC11P104381
  • GC11P103545
  • GC11P102222
  • GC11P101725
  • GC11P101693
  • GC11P098114
  • GC11P102188

Summaries for BIRC3 Gene

Entrez Gene Summary for BIRC3 Gene

  • This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for BIRC3 Gene

BIRC3 (Baculoviral IAP Repeat Containing 3) is a Protein Coding gene. Diseases associated with BIRC3 include malt lymphoma and chronic neutrophilic leukemia. Among its related pathways are Pathways in cancer and ERK Signaling. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is XIAP.

UniProtKB/Swiss-Prot for BIRC3 Gene

  • Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Gene Wiki entry for BIRC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BIRC3 Gene

Genomics for BIRC3 Gene

Regulatory Elements for BIRC3 Gene

Genomic Location for BIRC3 Gene

Start:
102,317,450 bp from pter
End:
102,339,403 bp from pter
Size:
21,954 bases
Orientation:
Plus strand

Genomic View for BIRC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BIRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BIRC3 Gene

Proteins for BIRC3 Gene

  • Protein details for BIRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13489-BIRC3_HUMAN
    Recommended name:
    Baculoviral IAP repeat-containing protein 3
    Protein Accession:
    Q13489
    Secondary Accessions:
    • Q16628
    • Q9HC27
    • Q9UP46

    Protein attributes for BIRC3 Gene

    Size:
    604 amino acids
    Molecular mass:
    68372 Da
    Quaternary structure:
    • Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interaction with TRAF2 is required for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.

    Three dimensional structures from OCA and Proteopedia for BIRC3 Gene

neXtProt entry for BIRC3 Gene

Proteomics data for BIRC3 Gene at MOPED

Post-translational modifications for BIRC3 Gene

  • Auto-ubiquitinated and degraded by the proteasome in apoptotic cells
  • Ubiquitination at Lys211
  • Modification sites at PhosphoSitePlus

Other Protein References for BIRC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for BIRC3 (cIAP-2/HIAP-1)
  • Cell Signaling Technology (CST) Antibodies for BIRC3 (cIAP2)

No data available for DME Specific Peptides for BIRC3 Gene

Domains for BIRC3 Gene

Gene Families for BIRC3 Gene

HGNC:
  • BIRC :Baculoviral IAP repeat containing
  • RNF :RING-type (C3HC4) zinc fingers

Suggested Antigen Peptide Sequences for BIRC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13489

UniProtKB/Swiss-Prot:

BIRC3_HUMAN :
  • Q13489
Domain:
  • Contains 1 CARD domain.
Family:
  • Belongs to the IAP family.
Similarity:
  • Contains 3 BIR repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with BIRC3: view

Function for BIRC3 Gene

Molecular function for BIRC3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination.
UniProtKB/Swiss-Prot Function: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Enzyme Numbers (IUBMB) for BIRC3 Gene

Gene Ontology (GO) - Molecular Function for BIRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 16395405
GO:0005515 protein binding IPI 11907583
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA --
genes like me logo Genes that share ontologies with BIRC3: view
genes like me logo Genes that share phenotypes with BIRC3: view

Animal Models for BIRC3 Gene

MGI Knock Outs for BIRC3:

Animal Model Products

CRISPR Products

miRNA for BIRC3 Gene

miRTarBase miRNAs that target BIRC3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BIRC3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for BIRC3 Gene

Localization for BIRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BIRC3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BIRC3 Gene COMPARTMENTS Subcellular localization image for BIRC3 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
extracellular 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BIRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15665297
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005876 NOT spindle microtubule IBA --
genes like me logo Genes that share ontologies with BIRC3: view

Pathways for BIRC3 Gene

genes like me logo Genes that share pathways with BIRC3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for BIRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006915 apoptotic process --
GO:0007166 cell surface receptor signaling pathway TAS 8548810
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with BIRC3: view

Compounds for BIRC3 Gene

(33) Novoseek inferred chemical compound relationships for BIRC3 Gene

Compound -log(P) Hits PubMed IDs
ciap2 95.4 46
ciap1 93.7 26
pdtc 49.7 3
curcumin 44.5 5
ly294002 43.8 2
genes like me logo Genes that share compounds with BIRC3: view

Transcripts for BIRC3 Gene

Unigene Clusters for BIRC3 Gene

Baculoviral IAP repeat containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BIRC3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BIRC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: -
SP3:
SP4:
SP5: -

Relevant External Links for BIRC3 Gene

GeneLoc Exon Structure for
BIRC3
ECgene alternative splicing isoforms for
BIRC3

Expression for BIRC3 Gene

mRNA expression in normal human tissues for BIRC3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BIRC3 Gene

SOURCE GeneReport for Unigene cluster for BIRC3 Gene Hs.127799

mRNA Expression by UniProt/SwissProt for BIRC3 Gene

Q13489-BIRC3_HUMAN
Tissue specificity: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes
genes like me logo Genes that share expressions with BIRC3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BIRC3 Gene

Orthologs for BIRC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BIRC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BIRC3 35
  • 99.12 (n)
  • 99.01 (a)
BIRC3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BIRC3 35
  • 88.69 (n)
  • 85.76 (a)
BIRC3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BIRC3 35
  • 76.43 (n)
  • 74.5 (a)
BIRC3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Birc3 35
  • 77.19 (n)
  • 74.25 (a)
Birc3 16
Birc3 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Birc3 35
  • 76.91 (n)
  • 74.25 (a)
chicken
(Gallus gallus)
Aves ITA 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii birc2 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Iap2 36
  • 32 (a)
ManyToMany
th 36
  • 24 (a)
ManyToMany
Iap2 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for BIRC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BIRC3 Gene

ENSEMBL:
Gene Tree for BIRC3 (if available)
TreeFam:
Gene Tree for BIRC3 (if available)

Paralogs for BIRC3 Gene

Paralogs for BIRC3 Gene

Selected SIMAP similar genes for BIRC3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for BIRC3 Gene

genes like me logo Genes that share paralogs with BIRC3: view

Variants for BIRC3 Gene

Sequence variations from dbSNP and Humsavar for BIRC3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3460 -- 102,337,659(+) TGAAT(C/G)ACATT utr-variant-3-prime
rs13711 -- 102,339,006(+) GAAAG(A/C)ATCCA utr-variant-3-prime
rs546019 -- 102,327,510(-) aggtg(A/C/T)atgcc intron-variant
rs693746 -- 102,322,718(-) CTGCA(A/G)ACTTC utr-variant-5-prime, intron-variant
rs1055078 -- 102,324,638(+) GGGGT(C/T)CCTGT synonymous-codon, reference

Relevant External Links for BIRC3 Gene

HapMap Linkage Disequilibrium report
BIRC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BIRC3 Gene

Disorders for BIRC3 Gene

UniProtKB/Swiss-Prot

BIRC3_HUMAN
  • Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

(1) University of Copenhagen DISEASES for BIRC3 Gene

(38) Novoseek inferred disease relationships for BIRC3 Gene

Disease -log(P) Hits PubMed IDs
malt lymphoma 75.1 15
necrosis 61.1 18
tumors 54.8 32
lymphoma b-cell 50.5 3
leukemia 44.2 3

Relevant External Links for BIRC3

Genetic Association Database (GAD)
BIRC3
Human Genome Epidemiology (HuGE) Navigator
BIRC3
genes like me logo Genes that share disorders with BIRC3: view

Publications for BIRC3 Gene

  1. Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. (PMID: 11066071) Baens M. … Marynen P. (Genes Chromosomes Cancer 2000) 3 4 23
  2. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. (PMID: 8548810) Rothe M. … Goeddel D.V. (Cell 1995) 2 3 4
  3. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. (PMID: 8552191) Liston P. … Korneluk R.G. (Nature 1996) 2 3 4
  4. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. (PMID: 8643514) Uren A.G. … Vaux D.L. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 48

Products for BIRC3 Gene

  • Addgene plasmids for BIRC3

Sources for BIRC3 Gene

Back to Top

Content