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Aliases for HSF2 Gene

Aliases for HSF2 Gene

  • Heat Shock Transcription Factor 2 2 3 4 5
  • HSTF 2 4
  • HSTF2 4
  • HSF 2 4

External Ids for HSF2 Gene

Previous GeneCards Identifiers for HSF2 Gene

  • GC06P122491
  • GC06P122678
  • GC06P122702
  • GC06P122703
  • GC06P122762
  • GC06P120297

Summaries for HSF2 Gene

Entrez Gene Summary for HSF2 Gene

  • The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for HSF2 Gene

HSF2 (Heat Shock Transcription Factor 2) is a Protein Coding gene. Diseases associated with HSF2 include Acute Erythroid Leukemia. Among its related pathways are Proteolysis Putative SUMO-1 pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HSF1.

UniProtKB/Swiss-Prot for HSF2 Gene

  • DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Wiki entry for HSF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF2 Gene

Genomics for HSF2 Gene

Regulatory Elements for HSF2 Gene

Enhancers for HSF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G122470 1.4 ENCODE dbSUPER 18 +71.8 71840 2.8 PKNOX1 FOXA2 MLX ARNT SIN3A ARID4B DMAP1 ZNF2 YY1 SLC30A9 HSF2 PKIB SERINC1 ENSG00000275339
GH06G122398 1 ENCODE 19.7 +0.2 179 2.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 GATA2 ZNF207 FOS HSF2 PKIB ENSG00000279453
GH06G122408 0.7 ENCODE 19.5 +9.6 9561 1.7 ELF3 CTCF ZNF654 MAFG TRIM22 REST DPF2 RAD21 JUND ZNF316 HSF2 ENSG00000279453
GH06G122455 0.7 dbSUPER 18.1 +60.9 60915 9.9 SOX13 KLF1 PLRG1 KAT2B CTBP1 ZNF316 POLR2A MAFK RFX1 MAFG HSF2 PKIB ENSG00000275339 SERINC1
GH06G122451 0.6 dbSUPER 18.1 +53.4 53397 2.2 CTCF TEAD4 HLF DPF2 ZBTB40 HIC1 CTBP1 GATA3 CUX1 HSF2 ENSG00000275339 ENSG00000279453
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSF2 on UCSC Golden Path with GeneCards custom track

Promoters for HSF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000202056 454 2001 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF207 FOS ZNF263 SP3 SP5

Genomic Location for HSF2 Gene

Chromosome:
6
Start:
122,399,546 bp from pter
End:
122,433,119 bp from pter
Size:
33,574 bases
Orientation:
Plus strand

Genomic View for HSF2 Gene

Genes around HSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF2 Gene

Proteins for HSF2 Gene

  • Protein details for HSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03933-HSF2_HUMAN
    Recommended name:
    Heat shock factor protein 2
    Protein Accession:
    Q03933
    Secondary Accessions:
    • B4DGJ4
    • Q0VAH9
    • Q2M1K4
    • Q9H445

    Protein attributes for HSF2 Gene

    Size:
    536 amino acids
    Molecular mass:
    60348 Da
    Quaternary structure:
    • DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.

    Three dimensional structures from OCA and Proteopedia for HSF2 Gene

    Alternative splice isoforms for HSF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF2 Gene

Post-translational modifications for HSF2 Gene

  • Ubiquitination at isoforms=251
  • Modification sites at PhosphoSitePlus

Other Protein References for HSF2 Gene

No data available for DME Specific Peptides for HSF2 Gene

Domains & Families for HSF2 Gene

Suggested Antigen Peptide Sequences for HSF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q03933

UniProtKB/Swiss-Prot:

HSF2_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF2: view

No data available for Gene Families for HSF2 Gene

Function for HSF2 Gene

Molecular function for HSF2 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Ontology (GO) - Molecular Function for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 10561509
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 10561509
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 10561509
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with HSF2: view
genes like me logo Genes that share phenotypes with HSF2: view

Animal Models for HSF2 Gene

MGI Knock Outs for HSF2:

Animal Model Products

CRISPR Products

Transcription Factor Targets for HSF2 Gene

Selected GeneGlobe predicted Target genes for HSF2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for HSF2 Gene

Localization for HSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSF2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSF2: view

Pathways & Interactions for HSF2 Gene

genes like me logo Genes that share pathways with HSF2: view

Pathways by source for HSF2 Gene

1 GeneGo (Thomson Reuters) pathway for HSF2 Gene

Gene Ontology (GO) - Biological Process for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 1871106
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with HSF2: view

No data available for SIGNOR curated interactions for HSF2 Gene

Drugs & Compounds for HSF2 Gene

(4) Drugs for HSF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for HSF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSF2: view

Transcripts for HSF2 Gene

Unigene Clusters for HSF2 Gene

Heat shock transcription factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - -
SP6:
SP7:

Relevant External Links for HSF2 Gene

GeneLoc Exon Structure for
HSF2
ECgene alternative splicing isoforms for
HSF2

Expression for HSF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSF2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for HSF2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSF2 Gene



Protein tissue co-expression partners for HSF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSF2 Gene:

HSF2

SOURCE GeneReport for Unigene cluster for HSF2 Gene:

Hs.158195

Evidence on tissue expression from TISSUES for HSF2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with HSF2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF2 Gene

Orthologs for HSF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSF2 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia HSF2 34 35
  • 95.7 (n)
cow
(Bos Taurus)
Mammalia HSF2 34 35
  • 95.13 (n)
rat
(Rattus norvegicus)
Mammalia Hsf2 34
  • 90.9 (n)
mouse
(Mus musculus)
Mammalia Hsf2 34 16 35
  • 90.57 (n)
oppossum
(Monodelphis domestica)
Mammalia HSF2 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF2 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSF2 34 35
  • 76.2 (n)
lizard
(Anolis carolinensis)
Reptilia HSF2 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsf2 34
  • 67.82 (n)
zebrafish
(Danio rerio)
Actinopterygii hsf2 34 35
  • 61.62 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7999 34
fruit fly
(Drosophila melanogaster)
Insecta Hsf 36 35
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea Y53C10A.12 36
  • 28 (a)
hsf-1 35
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 35
  • 14 (a)
OneToMany
SKN7 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for HSF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSF2 Gene

ENSEMBL:
Gene Tree for HSF2 (if available)
TreeFam:
Gene Tree for HSF2 (if available)

Paralogs for HSF2 Gene

Paralogs for HSF2 Gene

(2) SIMAP similar genes for HSF2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HSF2 Gene

genes like me logo Genes that share paralogs with HSF2: view

Variants for HSF2 Gene

Sequence variations from dbSNP and Humsavar for HSF2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs770437959 Uncertain significance 122,432,114(+) TGTTC(A/G)CCTGG reference, missense
rs1000001736 -- 122,401,317(+) GAAGG(A/C)TCAGT intron-variant
rs1000101898 -- 122,408,492(+) TGTGG(A/C)TCTTT intron-variant
rs1000228563 -- 122,426,992(+) CTTCT(C/T)CTTTC intron-variant
rs1000351585 -- 122,401,649(+) TAAGC(G/T)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF2 Gene

Variant ID Type Subtype PubMed ID
esv2759467 CNV loss 17122850
nsv1161448 CNV duplication 26073780

Variation tolerance for HSF2 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSF2 Gene

Human Gene Mutation Database (HGMD)
HSF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF2 Gene

Disorders for HSF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSF2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
acute erythroid leukemia
  • acute erythroleukemia
- elite association - COSMIC cancer census association via MalaCards
Search HSF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSF2

Genetic Association Database (GAD)
HSF2
Human Genome Epidemiology (HuGE) Navigator
HSF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSF2
genes like me logo Genes that share disorders with HSF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF2 Gene

Publications for HSF2 Gene

  1. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. (PMID: 1871106) Schuetz T.J. … Kingston R.E. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 22 64
  2. Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. (PMID: 8339932) Sheldon L. … Kingston R.E. (Genes Dev. 1993) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. PEST sequences mediate heat shock factor 2 turnover by interacting with the Cul3 subunit of the Cul3-RING ubiquitin ligase. (PMID: 19768582) Xing H. … Sarge K.D. (Cell Stress Chaperones 2010) 3 22 64
  5. Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2. (PMID: 19017645) Tateishi Y. … Shirakawa M. (J. Biol. Chem. 2009) 3 22 64

Products for HSF2 Gene

Sources for HSF2 Gene

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