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Aliases for HSF2 Gene

Aliases for HSF2 Gene

  • Heat Shock Transcription Factor 2 2 3 4
  • HSTF 2 4
  • HSTF2 4
  • HSF 2 4

External Ids for HSF2 Gene

Previous GeneCards Identifiers for HSF2 Gene

  • GC06P122491
  • GC06P122678
  • GC06P122702
  • GC06P122703
  • GC06P122762
  • GC06P120297

Summaries for HSF2 Gene

Entrez Gene Summary for HSF2 Gene

  • The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for HSF2 Gene

HSF2 (Heat Shock Transcription Factor 2) is a Protein Coding gene. Diseases associated with HSF2 include acute erythroid leukemia. Among its related pathways are Proteolysis Putative SUMO-1 pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HSF1.

UniProtKB/Swiss-Prot for HSF2 Gene

  • DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

Gene Wiki entry for HSF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF2 Gene

Genomics for HSF2 Gene

Regulatory Elements for HSF2 Gene

Genomic Location for HSF2 Gene

Chromosome:
6
Start:
122,399,546 bp from pter
End:
122,433,119 bp from pter
Size:
33,574 bases
Orientation:
Plus strand

Genomic View for HSF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF2 Gene

Proteins for HSF2 Gene

  • Protein details for HSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03933-HSF2_HUMAN
    Recommended name:
    Heat shock factor protein 2
    Protein Accession:
    Q03933
    Secondary Accessions:
    • B4DGJ4
    • Q0VAH9
    • Q2M1K4
    • Q9H445

    Protein attributes for HSF2 Gene

    Size:
    536 amino acids
    Molecular mass:
    60348 Da
    Quaternary structure:
    • DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer

    Alternative splice isoforms for HSF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF2 Gene

Proteomics data for HSF2 Gene at MOPED

Post-translational modifications for HSF2 Gene

  • Ubiquitination at Lys 51
  • Modification sites at PhosphoSitePlus

Other Protein References for HSF2 Gene

Antibody Products

No data available for DME Specific Peptides for HSF2 Gene

Domains & Families for HSF2 Gene

Suggested Antigen Peptide Sequences for HSF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q03933

UniProtKB/Swiss-Prot:

HSF2_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF2: view

No data available for Gene Families for HSF2 Gene

Function for HSF2 Gene

Molecular function for HSF2 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

Gene Ontology (GO) - Molecular Function for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 10561509
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 10561509
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 10561509
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 1871106
genes like me logo Genes that share ontologies with HSF2: view
genes like me logo Genes that share phenotypes with HSF2: view

Animal Models for HSF2 Gene

MGI Knock Outs for HSF2:

Animal Model Products

Transcription Factor Targets for HSF2 Gene

Selected GeneGlobe predicted Target genes for HSF2

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for HSF2 Gene

Localization for HSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSF2 Gene COMPARTMENTS Subcellular localization image for HSF2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSF2: view

Pathways & Interactions for HSF2 Gene

genes like me logo Genes that share pathways with HSF2: view

Pathways by source for HSF2 Gene

1 GeneGo (Thomson Reuters) pathway for HSF2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter TAS 1871106
GO:0007283 spermatogenesis IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 10561509
genes like me logo Genes that share ontologies with HSF2: view

No data available for SIGNOR curated interactions for HSF2 Gene

Drugs & Compounds for HSF2 Gene

(4) Drugs for HSF2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
estrogen Pharma 0
leucine Nutra 93
serine Nutra 420
threonine Nutra 16

(2) Additional Compounds for HSF2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adriamycin
MG 132
133407-82-6
genes like me logo Genes that share compounds with HSF2: view

Transcripts for HSF2 Gene

Unigene Clusters for HSF2 Gene

Heat shock transcription factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - -
SP6:
SP7:

Relevant External Links for HSF2 Gene

GeneLoc Exon Structure for
HSF2
ECgene alternative splicing isoforms for
HSF2

Expression for HSF2 Gene

mRNA expression in normal human tissues for HSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSF2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for HSF2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSF2 Gene



SOURCE GeneReport for Unigene cluster for HSF2 Gene Hs.158195

genes like me logo Genes that share expression patterns with HSF2: view

Protein tissue co-expression partners for HSF2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HSF2 Gene

Orthologs for HSF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSF2 35
  • 95.13 (n)
  • 98.31 (a)
HSF2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSF2 35
  • 95.7 (n)
  • 98.02 (a)
HSF2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsf2 35
  • 90.57 (n)
  • 94.57 (a)
Hsf2 16
Hsf2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSF2 35
  • 99.67 (n)
  • 99.8 (a)
HSF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsf2 35
  • 90.9 (n)
  • 94.93 (a)
oppossum
(Monodelphis domestica)
Mammalia HSF2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF2 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSF2 35
  • 76.2 (n)
  • 81.25 (a)
HSF2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsf2 35
  • 67.82 (n)
  • 67.69 (a)
zebrafish
(Danio rerio)
Actinopterygii hsf2 35
  • 61.62 (n)
  • 61.97 (a)
hsf2 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7999 35
fruit fly
(Drosophila melanogaster)
Insecta Hsf 37
  • 47 (a)
Hsf 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53C10A.12 37
  • 28 (a)
hsf-1 36
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 36
  • 14 (a)
OneToMany
SKN7 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for HSF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSF2 Gene

ENSEMBL:
Gene Tree for HSF2 (if available)
TreeFam:
Gene Tree for HSF2 (if available)

Paralogs for HSF2 Gene

Paralogs for HSF2 Gene

(2) SIMAP similar genes for HSF2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HSF2 Gene

genes like me logo Genes that share paralogs with HSF2: view

Variants for HSF2 Gene

Sequence variations from dbSNP and Humsavar for HSF2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs484552 -- 122,428,748(-) TATAT(A/T)TATTT intron-variant
rs487487 -- 122,422,357(+) CAGAG(C/T)AAAAT intron-variant
rs491171 -- 122,408,021(+) gacac(C/T)aacct intron-variant
rs492250 -- 122,421,808(+) TTGAA(A/G)TTTCT intron-variant
rs502071 -- 122,417,917(+) TAGTG(G/T)CTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF2 Gene

Variant ID Type Subtype PubMed ID
dgv2006e1 CNV Complex 17122850

Variation tolerance for HSF2 Gene

Residual Variation Intolerance Score: 13.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSF2 Gene

HapMap Linkage Disequilibrium report
HSF2
Human Gene Mutation Database (HGMD)
HSF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF2 Gene

Disorders for HSF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSF2 Gene - From: NovoSeek

Disorder Aliases PubMed IDs
acute erythroid leukemia
  • acute erythroleukemia
- elite association
Search HSF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSF2

Genetic Association Database (GAD)
HSF2
Human Genome Epidemiology (HuGE) Navigator
HSF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSF2
genes like me logo Genes that share disorders with HSF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF2 Gene

Publications for HSF2 Gene

  1. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. (PMID: 1871106) Schuetz T.J. … Kingston R.E. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 23 67
  2. Heat shock protein and heat shock factor expression in sperm: relation to oligozoospermia and varicocele. (PMID: 20096881) Ferlin A. … Foresta C. (J. Urol. 2010) 23 67
  3. PEST sequences mediate heat shock factor 2 turnover by interacting with the Cul3 subunit of the Cul3-RING ubiquitin ligase. (PMID: 19768582) Xing H. … Sarge K.D. (Cell Stress Chaperones 2010) 23 67
  4. Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1. (PMID: 20176657) Butcher N.J. … Minchin R.F. (Carcinogenesis 2010) 23 67
  5. Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2. (PMID: 19017645) Tateishi Y. … Shirakawa M. (J. Biol. Chem. 2009) 23 67

Products for HSF2 Gene

Sources for HSF2 Gene

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