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Aliases for HSF2 Gene

Aliases for HSF2 Gene

  • Heat Shock Transcription Factor 2 2 3 4
  • HSTF 2 4
  • HSTF2 4
  • HSF 2 4

External Ids for HSF2 Gene

Previous GeneCards Identifiers for HSF2 Gene

  • GC06P122491
  • GC06P122678
  • GC06P122702
  • GC06P122703
  • GC06P122762
  • GC06P120297

Summaries for HSF2 Gene

Entrez Gene Summary for HSF2 Gene

  • The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for HSF2 Gene

HSF2 (Heat Shock Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Proteolysis Putative SUMO-1 pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is HSF1.

UniProtKB/Swiss-Prot for HSF2 Gene

  • DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

Gene Wiki entry for HSF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF2 Gene

Genomics for HSF2 Gene

Regulatory Elements for HSF2 Gene

Genomic Location for HSF2 Gene

Start:
122,399,546 bp from pter
End:
122,433,119 bp from pter
Size:
33,574 bases
Orientation:
Plus strand

Genomic View for HSF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF2 Gene

Proteins for HSF2 Gene

  • Protein details for HSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03933-HSF2_HUMAN
    Recommended name:
    Heat shock factor protein 2
    Protein Accession:
    Q03933
    Secondary Accessions:
    • B4DGJ4
    • Q0VAH9
    • Q2M1K4
    • Q9H445

    Protein attributes for HSF2 Gene

    Size:
    536 amino acids
    Molecular mass:
    60348 Da
    Quaternary structure:
    • DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer

    Alternative splice isoforms for HSF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF2 Gene

Proteomics data for HSF2 Gene at MOPED

Post-translational modifications for HSF2 Gene

  • Ubiquitination at Lys51 and Lys54
  • Modification sites at PhosphoSitePlus

Other Protein References for HSF2 Gene

Antibody Products

No data available for DME Specific Peptides for HSF2 Gene

Domains for HSF2 Gene

Suggested Antigen Peptide Sequences for HSF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q03933

UniProtKB/Swiss-Prot:

HSF2_HUMAN :
  • Q03933
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF2: view

No data available for Gene Families for HSF2 Gene

Function for HSF2 Gene

Molecular function for HSF2 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

Gene Ontology (GO) - Molecular Function for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 10561509
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 10561509
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 10561509
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 1871106
genes like me logo Genes that share ontologies with HSF2: view
genes like me logo Genes that share phenotypes with HSF2: view

Animal Models for HSF2 Gene

MGI Knock Outs for HSF2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HSF2 Gene

Localization for HSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSF2 Gene COMPARTMENTS Subcellular localization image for HSF2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSF2: view

Pathways for HSF2 Gene

genes like me logo Genes that share pathways with HSF2: view

Pathways by source for HSF2 Gene

1 GeneGo (Thomson Reuters) pathway for HSF2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter TAS 1871106
GO:0006950 response to stress --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with HSF2: view

Compounds for HSF2 Gene

(6) Novoseek inferred chemical compound relationships for HSF2 Gene

Compound -log(P) Hits PubMed IDs
mg 132 59.7 3
leucine 24.7 2
adriamycin 16.4 1
threonine 1.25 1
estrogen 0 3
genes like me logo Genes that share compounds with HSF2: view

Transcripts for HSF2 Gene

Unigene Clusters for HSF2 Gene

Heat shock transcription factor 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - -
SP6:
SP7:

Relevant External Links for HSF2 Gene

GeneLoc Exon Structure for
HSF2
ECgene alternative splicing isoforms for
HSF2

Expression for HSF2 Gene

mRNA expression in normal human tissues for HSF2 Gene

mRNA differential expression in normal tissues according to GTEx for HSF2 Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

Protein differential expression in normal tissues for HSF2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSF2 Gene

SOURCE GeneReport for Unigene cluster for HSF2 Gene Hs.158195

genes like me logo Genes that share expressions with HSF2: view

Expression partners for HSF2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HSF2 Gene

Orthologs for HSF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSF2 35
  • 95.13 (n)
  • 98.31 (a)
HSF2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSF2 35
  • 95.7 (n)
  • 98.02 (a)
HSF2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsf2 35
  • 90.57 (n)
  • 94.57 (a)
Hsf2 16
Hsf2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSF2 35
  • 99.67 (n)
  • 99.8 (a)
HSF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsf2 35
  • 90.9 (n)
  • 94.93 (a)
oppossum
(Monodelphis domestica)
Mammalia HSF2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF2 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSF2 35
  • 76.2 (n)
  • 81.25 (a)
HSF2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsf2 35
  • 67.82 (n)
  • 67.69 (a)
zebrafish
(Danio rerio)
Actinopterygii hsf2 35
  • 61.62 (n)
  • 61.97 (a)
hsf2 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7999 35
fruit fly
(Drosophila melanogaster)
Insecta Hsf 37
  • 47 (a)
Hsf 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53C10A.12 37
  • 28 (a)
hsf-1 36
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 36
  • 14 (a)
OneToMany
SKN7 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for HSF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSF2 Gene

ENSEMBL:
Gene Tree for HSF2 (if available)
TreeFam:
Gene Tree for HSF2 (if available)

Paralogs for HSF2 Gene

Paralogs for HSF2 Gene

Selected SIMAP similar genes for HSF2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HSF2 Gene

genes like me logo Genes that share paralogs with HSF2: view

Variants for HSF2 Gene

Sequence variations from dbSNP and Humsavar for HSF2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs484552 -- 122,428,748(-) TATAT(A/T)TATTT intron-variant
rs487487 -- 122,422,357(+) CAGAG(C/T)AAAAT intron-variant
rs491171 -- 122,408,021(+) gacac(C/T)aacct intron-variant
rs492250 -- 122,421,808(+) TTGAA(A/G)TTTCT intron-variant
rs502071 -- 122,417,917(+) TAGTG(G/T)CTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF2 Gene

Variant ID Type Subtype PubMed ID
dgv2006e1 CNV Complex 17122850

Relevant External Links for HSF2 Gene

HapMap Linkage Disequilibrium report
HSF2
Human Gene Mutation Database (HGMD)
HSF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF2 Gene

Disorders for HSF2 Gene

(4) Novoseek inferred disease relationships for HSF2 Gene

Disease -log(P) Hits PubMed IDs
shock 78.6 70
erythroleukemia 71.6 10
neurodegenerative diseases 10.3 1
breast cancer 0 1

Relevant External Links for HSF2

Genetic Association Database (GAD)
HSF2
Human Genome Epidemiology (HuGE) Navigator
HSF2
genes like me logo Genes that share disorders with HSF2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HSF2 Gene

Publications for HSF2 Gene

  1. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. (PMID: 1871106) Schuetz T.J. … Kingston R.E. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. (PMID: 8339932) Sheldon L. … Kingston R.E. (Genes Dev. 1993) 3 4 23
  3. Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development. (PMID: 9118008) Walsh D. … Nagata K. (Cell. Mol. Life Sci. 1997) 3 23
  4. The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62. (PMID: 9367915) Yoshima T. … Yanagi H. (Biochem. Biophys. Res. Commun. 1997) 3 23
  5. Novel testis-specific protein that interacts with heat shock factor 2. (PMID: 9651507) Yoshima T. … Yanagi H. (Gene 1998) 3 23

Products for HSF2 Gene

Sources for HSF2 Gene

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