External Ids for HSF2 Gene
The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for HSF2 Gene
HSF2 (Heat Shock Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Proteolysis Putative SUMO-1 pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is HSF1.
UniProtKB/Swiss-Prot for HSF2 Gene
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked