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Aliases for SERPINA9 Gene

Aliases for SERPINA9 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 9 2 3
  • Centerin 3 4 6
  • GCET1 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 9 2 3
  • Germinal Center B-Cell-Expressed Transcript 1 Protein 3 4
  • SERPINA11 3 4
  • Serine Proteinase Inhibitor A11 3
  • SERPINA11b 3
  • Serpin A9 3

External Ids for SERPINA9 Gene

Previous GeneCards Identifiers for SERPINA9 Gene

  • GC00U991020
  • GC14M092920
  • GC14M093998
  • GC14M094929
  • GC14M075109

Summaries for SERPINA9 Gene

GeneCards Summary for SERPINA9 Gene

SERPINA9 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 9) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA10.

UniProtKB/Swiss-Prot for SERPINA9 Gene

  • Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

Gene Wiki entry for SERPINA9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA9 Gene

Genomics for SERPINA9 Gene

Regulatory Elements for SERPINA9 Gene

Genomic Location for SERPINA9 Gene

Start:
94,462,717 bp from pter
End:
94,479,689 bp from pter
Size:
16,973 bases
Orientation:
Minus strand

Genomic View for SERPINA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA9 Gene

Proteins for SERPINA9 Gene

  • Protein details for SERPINA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WD7-SPA9_HUMAN
    Recommended name:
    Serpin A9
    Protein Accession:
    Q86WD7
    Secondary Accessions:
    • B4DVH4
    • B9ZVX3
    • Q2T9J2
    • Q6UWP9
    • Q86WD4
    • Q86WD5
    • Q86WD6
    • Q86YP6
    • Q86YP7

    Protein attributes for SERPINA9 Gene

    Size:
    417 amino acids
    Molecular mass:
    46557 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO32345.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for SERPINA9 Gene

neXtProt entry for SERPINA9 Gene

Proteomics data for SERPINA9 Gene at MOPED

Post-translational modifications for SERPINA9 Gene

  • Glycosylation at Asn101 and Asn390
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SERPINA9 (Serpin A9/Centerin)

No data available for DME Specific Peptides for SERPINA9 Gene

Domains for SERPINA9 Gene

Gene Families for SERPINA9 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINA9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WD7

UniProtKB/Swiss-Prot:

SPA9_HUMAN :
  • Q86WD7
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA9: view

Function for SERPINA9 Gene

Molecular function for SERPINA9 Gene

UniProtKB/Swiss-Prot Function:
Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

Gene Ontology (GO) - Molecular Function for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IDA 15489334
genes like me logo Genes that share ontologies with SERPINA9: view

Phenotypes for SERPINA9 Gene

GenomeRNAi human phenotypes for SERPINA9:
genes like me logo Genes that share phenotypes with SERPINA9: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINA9 Gene

Localization for SERPINA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA9 Gene

Isoform 1: Secreted.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 7: Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA9 Gene COMPARTMENTS Subcellular localization image for SERPINA9 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SERPINA9: view

Pathways for SERPINA9 Gene

SuperPathways for SERPINA9 Gene

No Data Available

Interacting Proteins for SERPINA9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000337133%0d%0a9606.ENSP00000053867%0d%0a
Selected Interacting proteins: ENSP00000337133 for SERPINA9 Gene via STRING

Symbol External ID(s) Details
GRN

Gene Ontology (GO) - Biological Process for SERPINA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030162 regulation of proteolysis --
genes like me logo Genes that share ontologies with SERPINA9: view

No data available for Pathways by source for SERPINA9 Gene

Transcripts for SERPINA9 Gene

Unigene Clusters for SERPINA9 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for SERPINA9 Gene

GeneLoc Exon Structure for
SERPINA9
ECgene alternative splicing isoforms for
SERPINA9

Expression for SERPINA9 Gene

mRNA expression in normal human tissues for SERPINA9 Gene

mRNA differential expression in normal tissues according to GTEx for SERPINA9 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (18.0) and Skin - Sun Exposed (Lower leg) (17.8).

SOURCE GeneReport for Unigene cluster for SERPINA9 Gene Hs.317970

mRNA Expression by UniProt/SwissProt for SERPINA9 Gene

Q86WD7-SPA9_HUMAN
Tissue specificity: Highly expressed in normal germinal center (GC) B-cells and GC B-cell-derived malignancies.
genes like me logo Genes that share expressions with SERPINA9: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for SERPINA9 Gene

Orthologs for SERPINA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SERPINA9 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SERPINA9 35
  • 81.57 (n)
  • 72.84 (a)
SERPINA9 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpina9 35
  • 74.84 (n)
  • 66.75 (a)
Serpina9 16
Serpina9 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERPINA9 35
  • 97.93 (n)
  • 96.78 (a)
SERPINA9 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpina9 35
  • 76.87 (n)
  • 66.75 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:174259 35
  • 49.77 (n)
  • 39.12 (a)
Species with no ortholog for SERPINA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SERPINA9 Gene

ENSEMBL:
Gene Tree for SERPINA9 (if available)
TreeFam:
Gene Tree for SERPINA9 (if available)

Paralogs for SERPINA9 Gene

genes like me logo Genes that share paralogs with SERPINA9: view

Variants for SERPINA9 Gene

Sequence variations from dbSNP and Humsavar for SERPINA9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs743207 -- 94,470,101(-) GTCAA(C/T)CATGC intron-variant, utr-variant-5-prime
rs927255 -- 94,476,676(-) caact(A/G)gcctg upstream-variant-2KB
rs971912 -- 94,467,910(-) catgc(A/G)tccat intron-variant
rs1002520 -- 94,477,297(+) TACTC(A/T)CGGTT upstream-variant-2KB
rs1268868 -- 94,473,515(-) tgaga(A/C)agagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA9 Gene

Variant ID Type Subtype PubMed ID
nsv470662 CNV Gain 18288195
nsv832863 CNV Gain 17160897
nsv832864 CNV Loss 17160897
nsv510649 CNV Loss 20534489
nsv1407 CNV Insertion 18451855
dgv655e1 CNV Complex 17122850

Relevant External Links for SERPINA9 Gene

HapMap Linkage Disequilibrium report
SERPINA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA9 Gene

Disorders for SERPINA9 Gene

(1) University of Copenhagen DISEASES for SERPINA9 Gene

Relevant External Links for SERPINA9

Genetic Association Database (GAD)
SERPINA9
Human Genome Epidemiology (HuGE) Navigator
SERPINA9
genes like me logo Genes that share disorders with SERPINA9: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SERPINA9 Gene

Publications for SERPINA9 Gene

  1. Molecular characterization of centerin, a germinal centre cell serpin. (PMID: 17447896) Paterson M.A. … Coughlin P.B. (Biochem. J. 2007) 3 4 23
  2. Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas. (PMID: 17898315) Montes-Moreno S. … Piris M.A. (Blood 2008) 3 4 23
  3. Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas. (PMID: 18550480) Paterson M.A. … Coughlin P.B. (Am. J. Clin. Pathol. 2008) 3 4 23
  4. Identification of centerin: a novel human germinal center B cell-restricted serpin. (PMID: 11069088) Frazer J.K. … Pascual V. (Eur. J. Immunol. 2000) 3 23
  5. Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells. (PMID: 12819018) Pan Z. … Chan W.C. (Am. J. Pathol. 2003) 3 4

Products for SERPINA9 Gene

Sources for SERPINA9 Gene

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