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Aliases for PRMT1 Gene

Aliases for PRMT1 Gene

  • Protein Arginine Methyltransferase 1 2 3
  • HRMT1L2 3 4 6
  • IR1B4 3 4 6
  • HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 2 2 3
  • Histone-Arginine N-Methyltransferase PRMT1 3 4
  • Interferon Receptor 1-Bound Protein 4 3 4
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase 1-Like 2 3
  • HMT1 HnRNP Methyltransferase-Like 2 (S. Cerevisiae) 2
  • Protein Arginine N-Methyltransferase 1 3
  • EC 2.1.1.125 4
  • EC 2.1.1.77 63
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • HCP1 3
  • ANM1 3
  • HMT2 4

External Ids for PRMT1 Gene

Previous HGNC Symbols for PRMT1 Gene

  • HRMT1L2

Previous GeneCards Identifiers for PRMT1 Gene

  • GC19P054873
  • GC19P050181
  • GC19P046557

Summaries for PRMT1 Gene

Entrez Gene Summary for PRMT1 Gene

  • This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

GeneCards Summary for PRMT1 Gene

PRMT1 (Protein Arginine Methyltransferase 1) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include identical protein binding and histone methyltransferase activity. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot for PRMT1 Gene

  • Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.

Gene Wiki entry for PRMT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT1 Gene

Genomics for PRMT1 Gene

Regulatory Elements for PRMT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRMT1 Gene

Start:
49,675,786 bp from pter
End:
49,689,029 bp from pter
Size:
13,244 bases
Orientation:
Plus strand

Genomic View for PRMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT1 Gene

Proteins for PRMT1 Gene

  • Protein details for PRMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99873-ANM1_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 1
    Protein Accession:
    Q99873
    Secondary Accessions:
    • B4E3C3
    • G5E9B6
    • Q15529
    • Q2VP93
    • Q6LEU5
    • Q8WUW5
    • Q99872
    • Q99874
    • Q9NZ04
    • Q9NZ05
    • Q9NZ06

    Protein attributes for PRMT1 Gene

    Size:
    361 amino acids
    Molecular mass:
    41516 Da
    Quaternary structure:
    • Homodimer and heterodimer with PRMT8. Individual homodimers can associate to form a homohexamer. Interacts with BTG1, BTG2, NFATC2IP and IFNAR1 (By similarity). Interacts with and methylates CHTOP, thereby enabling the interaction of CHTOP with the 5FMC complex (By similarity). Interacts with ILF3 and SUPT5H. Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1 transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress.

    Alternative splice isoforms for PRMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT1 Gene

Proteomics data for PRMT1 Gene at MOPED

Post-translational modifications for PRMT1 Gene

  • Ubiquitination at Lys103, Lys124, Lys173, Lys223, Lys233, Lys266, Lys303, and Lys332
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRMT1 (PRMT1)

Domains for PRMT1 Gene

Gene Families for PRMT1 Gene

HGNC:
  • PRMT :Protein arginine methyltransferases
IUPHAR :

Protein Domains for PRMT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99873

UniProtKB/Swiss-Prot:

ANM1_HUMAN :
  • Q99873
Domain:
  • Contains 1 SAM-dependent MTase PRMT-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with PRMT1: view

Function for PRMT1 Gene

Molecular function for PRMT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1 uM for AdoMet {ECO:0000269 PubMed:19405910}; KM=4.2 uM for H4 {ECO:0000269 PubMed:19405910}; Vmax=1.2 nmol/min/mg enzyme toward AdoMet {ECO:0000269 PubMed:19405910}; Vmax=1.24 nmol/min/mg enzyme toward H4 {ECO:0000269 PubMed:19405910};
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
UniProtKB/Swiss-Prot EnzymeRegulation: By BTG1, BTG2 and ILF3
UniProtKB/Swiss-Prot Function: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.

Enzyme Numbers (IUBMB) for PRMT1 Gene

Gene Ontology (GO) - Molecular Function for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10749851
GO:0008168 methyltransferase activity TAS 9545638
GO:0008170 N-methyltransferase activity IMP 19124016
GO:0008276 protein methyltransferase activity --
GO:0008469 histone-arginine N-methyltransferase activity --
genes like me logo Genes that share ontologies with PRMT1: view
genes like me logo Genes that share phenotypes with PRMT1: view

Animal Models for PRMT1 Gene

MGI Knock Outs for PRMT1:

Animal Model Products

CRISPR Products

miRNA for PRMT1 Gene

miRTarBase miRNAs that target PRMT1

No data available for Transcription Factor Targeting and HOMER Transcription for PRMT1 Gene

Localization for PRMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT1 Gene

Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRMT1 Gene COMPARTMENTS Subcellular localization image for PRMT1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10749851
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 9029147
GO:0005829 cytosol IBA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with PRMT1: view

Pathways for PRMT1 Gene

genes like me logo Genes that share pathways with PRMT1: view

Pathways by source for PRMT1 Gene

1 KEGG pathway for PRMT1 Gene
1 GeneGo (Thomson Reuters) pathway for PRMT1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development --
GO:0006325 chromatin organization TAS --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006479 protein methylation TAS 9545638
GO:0007166 cell surface receptor signaling pathway TAS 9029147
genes like me logo Genes that share ontologies with PRMT1: view

Compounds for PRMT1 Gene

(1) Drugbank Compounds for PRMT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-Adenosyl-L-Homocysteine
979-92-0 target

(10) Novoseek inferred chemical compound relationships for PRMT1 Gene

Compound -log(P) Hits PubMed IDs
arginine 87.4 127
adma 70.3 3
s-adenosylmethionine 66.5 2
s-adenosylhomocysteine 61.5 2
lysine 47.1 2
genes like me logo Genes that share compounds with PRMT1: view

Transcripts for PRMT1 Gene

Unigene Clusters for PRMT1 Gene

Protein arginine methyltransferase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRMT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: -
SP13: - - - -
SP14: - - - - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - -
SP20: - - -
SP21:
SP22:

ExUns: 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for PRMT1 Gene

GeneLoc Exon Structure for
PRMT1
ECgene alternative splicing isoforms for
PRMT1

Expression for PRMT1 Gene

mRNA expression in normal human tissues for PRMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRMT1 Gene

SOURCE GeneReport for Unigene cluster for PRMT1 Gene Hs.20521

mRNA Expression by UniProt/SwissProt for PRMT1 Gene

Q99873-ANM1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with PRMT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRMT1 Gene

Orthologs for PRMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRMT1 35
  • 95 (n)
  • 100 (a)
PRMT1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT1 35
  • 93.62 (n)
  • 100 (a)
PRMT1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt1 35
  • 92.36 (n)
  • 99.73 (a)
Prmt1 16
Prmt1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRMT1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Prmt1 35
  • 90.75 (n)
  • 99.72 (a)
lizard
(Anolis carolinensis)
Reptilia PRMT1 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23295 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt1 35
  • 78.56 (n)
  • 96.2 (a)
Str.4974 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2791 35
zebrafish
(Danio rerio)
Actinopterygii prmt1 35
  • 78.43 (n)
  • 89.8 (a)
prmt1 36
  • 90 (a)
OneToOne
zgc66201 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003462 35
  • 73.96 (n)
  • 74.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Art1 35
  • 68.95 (n)
  • 66.3 (a)
Art1 36
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea prmt-1 35
  • 67.37 (n)
  • 68.18 (a)
prmt-1 36
  • 66 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR190W 35
  • 59.5 (n)
  • 52.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 35
  • 55.05 (n)
  • 51.29 (a)
HMT1 36
  • 47 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07117g 35
  • 54.79 (n)
  • 52.61 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PRMT1A 35
  • 58.84 (n)
  • 58.54 (a)
rice
(Oryza sativa)
Liliopsida Os09g0359800 35
  • 59.16 (n)
  • 58.77 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07459 35
  • 64.41 (n)
  • 59.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rmt1 35
  • 55.87 (n)
  • 59.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2169 36
  • 70 (a)
OneToMany
Species with no ortholog for PRMT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRMT1 Gene

ENSEMBL:
Gene Tree for PRMT1 (if available)
TreeFam:
Gene Tree for PRMT1 (if available)

Paralogs for PRMT1 Gene

Paralogs for PRMT1 Gene

Pseudogenes.org Pseudogenes for PRMT1 Gene

genes like me logo Genes that share paralogs with PRMT1: view

Variants for PRMT1 Gene

Sequence variations from dbSNP and Humsavar for PRMT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs975484 -- 49,677,009(+) CGCTT(C/G)TTGCA upstream-variant-2KB
rs1135349 -- 49,685,457(+) gtgag(C/T)tgtga intron-variant, utr-variant-3-prime
rs2569634 -- 49,683,688(-) ttttt(G/T)gagac intron-variant
rs2738830 -- 49,677,677(+) CCGGG(A/G)ATGGG intron-variant
rs2738831 -- 49,677,679(+) GGGAA(G/T)GGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRMT1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897
dgv3972n71 CNV Loss 21882294
nsv912269 CNV Loss 21882294
nsv817854 CNV Gain 17921354
nsv470150 CNV Gain 18288195
esv24796 CNV Loss 19812545
nsv7308 OTHER Inversion 18451855

Relevant External Links for PRMT1 Gene

HapMap Linkage Disequilibrium report
PRMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT1 Gene

Disorders for PRMT1 Gene

(5) Novoseek inferred disease relationships for PRMT1 Gene

Disease -log(P) Hits PubMed IDs
ewings sarcoma 50.1 1
hepatitis c chronic 13.6 1
hepatitis c 9.64 2
breast cancer 9.01 5
cancer 6.56 4

Relevant External Links for PRMT1

Genetic Association Database (GAD)
PRMT1
Human Genome Epidemiology (HuGE) Navigator
PRMT1
genes like me logo Genes that share disorders with PRMT1: view

No data available for UniProtKB/Swiss-Prot for PRMT1 Gene

Publications for PRMT1 Gene

  1. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PMID: 9545638) Scott H.S. … Henry M.F. (Genomics 1998) 2 3 4 23
  2. Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. (PMID: 11387442) Wang H. … Zhang Y. (Science 2001) 3 4 23
  3. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. (PMID: 11448779) Strahl B.D. … Allis C.D. (Curr. Biol. 2001) 3 4 23
  4. Genomic organization, physical mapping, and expression analysis of the human protein arginine methyltransferase 1 gene. (PMID: 11097842) Scorilas A. … Diamandis E.P. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  5. Regulation of estrogen rapid signaling through arginine methylation by PRMT1. (PMID: 18657504) Le Romancer M. … Corbo L. (Mol. Cell 2008) 3 4 23

Products for PRMT1 Gene

Sources for PRMT1 Gene

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