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Aliases for PRMT1 Gene

Aliases for PRMT1 Gene

  • Protein Arginine Methyltransferase 1 2 3 5
  • HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 2 2 3
  • Histone-Arginine N-Methyltransferase PRMT1 3 4
  • Interferon Receptor 1-Bound Protein 4 3 4
  • HRMT1L2 3 4
  • IR1B4 3 4
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase 1-Like 2 3
  • HMT1 HnRNP Methyltransferase-Like 2 (S. Cerevisiae) 2
  • EC 2.1.1.319 4
  • EC 2.1.1.77 63
  • EC 2.1.1 63
  • HCP1 3
  • ANM1 3
  • HMT2 4

External Ids for PRMT1 Gene

Previous HGNC Symbols for PRMT1 Gene

  • HRMT1L2

Previous GeneCards Identifiers for PRMT1 Gene

  • GC19P054873
  • GC19P050181
  • GC19P046557

Summaries for PRMT1 Gene

Entrez Gene Summary for PRMT1 Gene

  • This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

GeneCards Summary for PRMT1 Gene

PRMT1 (Protein Arginine Methyltransferase 1) is a Protein Coding gene. Diseases associated with PRMT1 include allergic encephalomyelitis and ewing sarcoma. Among its related pathways are Gene Expression and Tryptophan metabolism. GO annotations related to this gene include poly(A) RNA binding and methyltransferase activity. An important paralog of this gene is PRMT6.

UniProtKB/Swiss-Prot for PRMT1 Gene

  • Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Tocris Summary for PRMT1 Gene

Gene Wiki entry for PRMT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT1 Gene

Genomics for PRMT1 Gene

Regulatory Elements for PRMT1 Gene

Promoters for PRMT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRMT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRMT1 Gene

Chromosome:
19
Start:
49,675,786 bp from pter
End:
49,689,029 bp from pter
Size:
13,244 bases
Orientation:
Plus strand

Genomic View for PRMT1 Gene

Genes around PRMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT1 Gene

Proteins for PRMT1 Gene

  • Protein details for PRMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99873-ANM1_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 1
    Protein Accession:
    Q99873
    Secondary Accessions:
    • B4E3C3
    • G5E9B6
    • Q15529
    • Q2VP93
    • Q6LEU5
    • Q8WUW5
    • Q99872
    • Q99874
    • Q9NZ04
    • Q9NZ05
    • Q9NZ06

    Protein attributes for PRMT1 Gene

    Size:
    361 amino acids
    Molecular mass:
    41516 Da
    Quaternary structure:
    • Homodimer and heterodimer with PRMT8. Individual homodimers can associate to form a homohexamer. Interacts with BTG1, BTG2, NFATC2IP and IFNAR1 (By similarity). Interacts with and methylates CHTOP, thereby enabling the interaction of CHTOP with the 5FMC complex (PubMed:25284789). Interacts with ILF3 and SUPT5H. Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1 transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress. Interacts with and probably methylates ATXN2L (PubMed:25748791). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789).

    Alternative splice isoforms for PRMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT1 Gene

Proteomics data for PRMT1 Gene at MOPED

Post-translational modifications for PRMT1 Gene

  • Ubiquitination at Lys 124, Lys 173, Lys 223, Lys 233, Lys 266, Lys 303, and Lys 332
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRMT1 (PRMT1)

Domains & Families for PRMT1 Gene

Gene Families for PRMT1 Gene

Protein Domains for PRMT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99873

UniProtKB/Swiss-Prot:

ANM1_HUMAN :
  • Contains 1 SAM-dependent MTase PRMT-type domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Domain:
  • Contains 1 SAM-dependent MTase PRMT-type domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with PRMT1: view

Function for PRMT1 Gene

Molecular function for PRMT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1 uM for AdoMet {ECO:0000269 PubMed:19405910}; KM=4.2 uM for H4 {ECO:0000269 PubMed:19405910}; Vmax=1.2 nmol/min/mg enzyme toward AdoMet {ECO:0000269 PubMed:19405910}; Vmax=1.24 nmol/min/mg enzyme toward H4 {ECO:0000269 PubMed:19405910};
UniProtKB/Swiss-Prot CatalyticActivity:
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
UniProtKB/Swiss-Prot EnzymeRegulation:
By BTG1, BTG2 and ILF3.
UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Enzyme Numbers (IUBMB) for PRMT1 Gene

Gene Ontology (GO) - Molecular Function for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 8663146
GO:0008168 methyltransferase activity IEA,TAS 9545638
GO:0016274 protein-arginine N-methyltransferase activity IEA,TAS --
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IEA,IMP 25284789
GO:0042802 identical protein binding IPI 16169070
genes like me logo Genes that share ontologies with PRMT1: view
genes like me logo Genes that share phenotypes with PRMT1: view

Animal Models for PRMT1 Gene

MGI Knock Outs for PRMT1:

Animal Model Products

miRNA for PRMT1 Gene

miRTarBase miRNAs that target PRMT1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT1 Gene

Localization for PRMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT1 Gene

Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRMT1 Gene COMPARTMENTS Subcellular localization image for PRMT1 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PRMT1 Gene

Pathways & Interactions for PRMT1 Gene

genes like me logo Genes that share pathways with PRMT1: view

SIGNOR curated interactions for PRMT1 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA,IMP 25284789
GO:0035246 peptidyl-arginine N-methylation IDA,TAS --
GO:0045648 positive regulation of erythrocyte differentiation IMP 23483889
genes like me logo Genes that share ontologies with PRMT1: view

Drugs & Compounds for PRMT1 Gene

(10) Drugs for PRMT1 Gene - From: DGIdb, Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma Target 0
AMI-1 Pharma 0
C21 Pharma 0
RM65 Pharma 0

(3) Additional Compounds for PRMT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRMT1: view

Transcripts for PRMT1 Gene

Unigene Clusters for PRMT1 Gene

Protein arginine methyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: -
SP13: - - - -
SP14: - - - - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - -
SP20: - - -
SP21:
SP22:

ExUns: 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for PRMT1 Gene

GeneLoc Exon Structure for
PRMT1
ECgene alternative splicing isoforms for
PRMT1

Expression for PRMT1 Gene

mRNA expression in normal human tissues for PRMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRMT1 Gene

This gene is overexpressed in Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRMT1 Gene



SOURCE GeneReport for Unigene cluster for PRMT1 Gene Hs.20521

mRNA Expression by UniProt/SwissProt for PRMT1 Gene

Q99873-ANM1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PRMT1: view

Protein tissue co-expression partners for PRMT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRMT1 Gene

Orthologs for PRMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRMT1 36
  • 78 (a)
OneToOne
PRMT1 35
  • 95 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia PRMT1 35
  • 93.62 (n)
  • 100 (a)
PRMT1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prmt1 36
  • 100 (a)
OneToOne
Prmt1 16
Prmt1 35
  • 92.36 (n)
  • 99.73 (a)
oppossum
(Monodelphis domestica)
Mammalia PRMT1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Prmt1 35
  • 90.75 (n)
  • 99.72 (a)
lizard
(Anolis carolinensis)
Reptilia PRMT1 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23295 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt1 35
  • 78.56 (n)
  • 96.2 (a)
Str.4974 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2791 35
zebrafish
(Danio rerio)
Actinopterygii prmt1 35
  • 78.43 (n)
  • 89.8 (a)
zgc66201 35
prmt1 36
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003462 35
  • 73.96 (n)
  • 74.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Art1 36
  • 63 (a)
OneToMany
Art1 35
  • 68.95 (n)
  • 66.3 (a)
worm
(Caenorhabditis elegans)
Secernentea prmt-1 36
  • 66 (a)
OneToMany
prmt-1 35
  • 67.37 (n)
  • 68.18 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR190W 35
  • 59.5 (n)
  • 52.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 36
  • 47 (a)
OneToMany
HMT1 35
  • 55.05 (n)
  • 51.29 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07117g 35
  • 54.79 (n)
  • 52.61 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PRMT1A 35
  • 58.84 (n)
  • 58.54 (a)
rice
(Oryza sativa)
Liliopsida Os09g0359800 35
  • 59.16 (n)
  • 58.77 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07459 35
  • 64.41 (n)
  • 59.68 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rmt1 35
  • 55.87 (n)
  • 59.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2169 36
  • 70 (a)
OneToMany
Species with no ortholog for PRMT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRMT1 Gene

ENSEMBL:
Gene Tree for PRMT1 (if available)
TreeFam:
Gene Tree for PRMT1 (if available)

Paralogs for PRMT1 Gene

Paralogs for PRMT1 Gene

Pseudogenes.org Pseudogenes for PRMT1 Gene

genes like me logo Genes that share paralogs with PRMT1: view

Variants for PRMT1 Gene

Sequence variations from dbSNP and Humsavar for PRMT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_037501 -
rs11673683 - 49,684,016(+) ACTGC(C/T)TCTTC nc-transcript-variant, reference, missense
rs1135349 -- 49,685,457(+) gtgag(C/T)tgtga intron-variant, utr-variant-3-prime
rs3816047 -- 49,683,854(-) GGCTA(C/G)AGCCT intron-variant
rs8111346 -- 49,677,603(+) GTGGG(G/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRMT1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897
dgv3972n71 CNV Loss 21882294
nsv912269 CNV Loss 21882294
nsv817854 CNV Gain 17921354
nsv470150 CNV Gain 18288195
esv24796 CNV Loss 19812545
nsv7308 OTHER Inversion 18451855

Variation tolerance for PRMT1 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRMT1 Gene

HapMap Linkage Disequilibrium report
PRMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT1 Gene

Disorders for PRMT1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRMT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic encephalomyelitis
  • experimental autoimmune encephalomyelitis
ewing sarcoma
  • neuroepithelioma
amyotrophic lateral sclerosis type 6
  • amyotrophic lateral sclerosis 6, with or without frontotemporal dementia
- elite association - COSMIC cancer census association via MalaCards
Search PRMT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRMT1

Genetic Association Database (GAD)
PRMT1
Human Genome Epidemiology (HuGE) Navigator
PRMT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRMT1
genes like me logo Genes that share disorders with PRMT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRMT1 Gene

Publications for PRMT1 Gene

  1. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PMID: 9545638) Scott H.S. … Henry M.F. (Genomics 1998) 2 3 4 23 67
  2. PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. (PMID: 19124016) Jobert L. … Tora L. (Exp. Cell Res. 2009) 3 23
  3. Type I Arginine Methyltransferases PRMT1 and PRMT-3 Act Distributively. (PMID: 19158082) KAPlbel K. … Wahle E. (J. Biol. Chem. 2009) 3 23
  4. The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation. (PMID: 19643181) Nicholson T.B. … Richard S. (Pharmacol. Res. 2009) 3 23
  5. Physical and functional interactions between hnRNP K and PRMT family proteins. (PMID: 19101556) Chan J.Y. … Huang S.M. (FEBS Lett. 2009) 3 23

Products for PRMT1 Gene

Sources for PRMT1 Gene

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