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Aliases for PRMT1 Gene

Aliases for PRMT1 Gene

  • Protein Arginine Methyltransferase 1 2 3 5
  • HMT1 (HnRNP Methyltransferase, S. Cerevisiae)-Like 2 2 3
  • Histone-Arginine N-Methyltransferase PRMT1 3 4
  • Interferon Receptor 1-Bound Protein 4 3 4
  • HRMT1L2 3 4
  • IR1B4 3 4
  • Heterogeneous Nuclear Ribonucleoprotein Methyltransferase 1-Like 2 3
  • HMT1 HnRNP Methyltransferase-Like 2 (S. Cerevisiae) 2
  • Protein Arginine N-Methyltransferase 1 3
  • EC 2.1.1.319 4
  • EC 2.1.1.77 56
  • EC 2.1.1 56
  • HCP1 3
  • ANM1 3
  • HMT2 4

External Ids for PRMT1 Gene

Previous HGNC Symbols for PRMT1 Gene

  • HRMT1L2

Previous GeneCards Identifiers for PRMT1 Gene

  • GC19P054873
  • GC19P050181
  • GC19P046557

Summaries for PRMT1 Gene

Entrez Gene Summary for PRMT1 Gene

  • This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

GeneCards Summary for PRMT1 Gene

PRMT1 (Protein Arginine Methyltransferase 1) is a Protein Coding gene. Diseases associated with PRMT1 include Ewing Sarcoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRMT8.

UniProtKB/Swiss-Prot for PRMT1 Gene

  • Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Tocris Summary for PRMT1 Gene

  • Protein arginine methyltransferases are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain cancers.

Gene Wiki entry for PRMT1 Gene

Additional gene information for PRMT1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRMT1 Gene

Genomics for PRMT1 Gene

GeneHancer (GH) Regulatory Elements for PRMT1 Gene

Promoters and enhancers for PRMT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I049675 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565.3 +2.5 2491 6.3 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 PRMT1 NUP62 POLD1 IRF3 PRR12 ENSG00000268047 SNORD35A PTOV1-AS2 ALDH16A1 SNORD35B
GH19I049812 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.2 +137.8 137790 2.8 FOXA2 PKNOX1 CLOCK SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 KLF13 FUZ PRMT1 PTOV1 ADM5 CPT1C TSKS AP2A1 PTOV1-AS2 PTOV1-AS1 PTH2
GH19I049865 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19 +192.4 192358 6.2 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A ZNF610 PNKP NUP62 POLD1 PRR12 PTOV1-AS2 SNRNP70 SNORD35A ENSG00000268047 SNORD35B AKT1S1
GH19I050649 Enhancer 1.2 Ensembl ENCODE 28.2 +974.1 974051 0.9 HDGF ATF1 ARNT YBX1 GLI4 ETS1 ZNF766 ARID2 ZNF416 ZNF143 POLD1 IRF3 NUP62 PRMT1 ENSG00000268047 SIGLEC17P BCL2L12 PTOV1 ENSG00000267808 CPT1C
GH19I048958 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 -711.8 -711757 10.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 FTL GC19P048966 GC19P048967 ENSG00000267898 NUP62 PTOV1-AS2 IRF3 PRR12 SNORD35A SNORD35B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRMT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRMT1 gene promoter:

Genomic Locations for PRMT1 Gene

Genomic Locations for PRMT1 Gene
chr19:49,675,786-49,689,029
(GRCh38/hg38)
Size:
13,244 bases
Orientation:
Plus strand
chr19:50,179,043-50,192,286
(GRCh37/hg19)

Genomic View for PRMT1 Gene

Genes around PRMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRMT1 Gene

Proteins for PRMT1 Gene

  • Protein details for PRMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99873-ANM1_HUMAN
    Recommended name:
    Protein arginine N-methyltransferase 1
    Protein Accession:
    Q99873
    Secondary Accessions:
    • B4E3C3
    • G5E9B6
    • Q15529
    • Q2VP93
    • Q6LEU5
    • Q8WUW5
    • Q99872
    • Q99874
    • Q9NZ04
    • Q9NZ05
    • Q9NZ06

    Protein attributes for PRMT1 Gene

    Size:
    361 amino acids
    Molecular mass:
    41516 Da
    Quaternary structure:
    • Homodimer (PubMed:16879614). Heterodimer with PRMT8. Individual homodimers can associate to form a homohexamer. Interacts with BTG1, BTG2, NFATC2IP and IFNAR1 (By similarity). Interacts with and methylates CHTOP, thereby enabling the interaction of CHTOP with the 5FMC complex (PubMed:25284789). Interacts with ILF3 and SUPT5H. Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1 transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress. Interacts with and probably methylates ATXN2L (PubMed:25748791). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789). Interacts with DHX9 (via RGG region) (PubMed:15084609). Interacts (via N-terminus) with HABP4 (PubMed:16879614).

    Alternative splice isoforms for PRMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRMT1 Gene

Selected DME Specific Peptides for PRMT1 Gene

Q99873:
  • HEEMLKD
  • LDFKGQLC
  • VTNACLIKEVDIYTVK
  • IISEWMGY
  • FPDRATLYV
  • GTGILCMFAA
  • VLDVGSG
  • DYYFDSY
  • LYVTAIED
  • GIHEEML
  • KVVLDVG

Post-translational modifications for PRMT1 Gene

  • Ubiquitination at Lys124, isoforms=2, 3, 4173, Lys223, Lys233, Lys266, Lys303, and Lys332

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRMT1 (PRMT1)
  • Abcam antibodies for PRMT1

Domains & Families for PRMT1 Gene

Gene Families for PRMT1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PRMT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99873

UniProtKB/Swiss-Prot:

ANM1_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.
genes like me logo Genes that share domains with PRMT1: view

Function for PRMT1 Gene

Molecular function for PRMT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1 uM for AdoMet {ECO:0000269 PubMed:19405910}; KM=4.2 uM for H4 {ECO:0000269 PubMed:19405910}; Vmax=1.2 nmol/min/mg enzyme toward AdoMet {ECO:0000269 PubMed:19405910}; Vmax=1.24 nmol/min/mg enzyme toward H4 {ECO:0000269 PubMed:19405910};
UniProtKB/Swiss-Prot CatalyticActivity:
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
UniProtKB/Swiss-Prot EnzymeRegulation:
By BTG1, BTG2 and ILF3.
UniProtKB/Swiss-Prot Function:
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Enzyme Numbers (IUBMB) for PRMT1 Gene

Phenotypes From GWAS Catalog for PRMT1 Gene

Gene Ontology (GO) - Molecular Function for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22681889
GO:0005515 protein binding IPI 8663146
GO:0008168 methyltransferase activity IEA,TAS 9545638
GO:0008170 N-methyltransferase activity IMP,TAS 19124016
GO:0008276 protein methyltransferase activity IEA,IMP 28040436
genes like me logo Genes that share ontologies with PRMT1: view
genes like me logo Genes that share phenotypes with PRMT1: view

Animal Models for PRMT1 Gene

MGI Knock Outs for PRMT1:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRMT1 Gene

Localization for PRMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRMT1 Gene

Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRMT1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10749851
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm TAS 9029147
GO:0005829 cytosol IBA --
GO:0034709 methylosome IDA 25284789
genes like me logo Genes that share ontologies with PRMT1: view

Pathways & Interactions for PRMT1 Gene

genes like me logo Genes that share pathways with PRMT1: view

Pathways by source for PRMT1 Gene

SIGNOR curated interactions for PRMT1 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PRMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006479 protein methylation IMP,IEA 28040436
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0007166 cell surface receptor signaling pathway TAS 9029147
GO:0008284 positive regulation of cell proliferation IMP 28040436
genes like me logo Genes that share ontologies with PRMT1: view

Drugs & Compounds for PRMT1 Gene

(12) Drugs for PRMT1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma Target 0
AMI-1 Pharma PRMT1 inhibitor 0
C 21 Pharma Protein arginine methyltransferase 1 (PRMT1) inhibitor 0
C7280948 Pharma Novel PRMT1 inhibitor 0
TC-E 5003 Pharma PRMT1 inhibitor, potent, Selective PRMT1 inhibitor 0

(4) Additional Compounds for PRMT1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0

(4) ApexBio Compounds for PRMT1 Gene

Compound Action Cas Number
AMI-1 PRMT1 inhibitor
C 21 Protein arginine methyltransferase 1 (PRMT1) inhibitor 1229236-78-5
C7280948 Novel PRMT1 inhibitor 587850-67-7
TC-E 5003 PRMT1 inhibitor, potent 17328-16-4
genes like me logo Genes that share compounds with PRMT1: view

Drug Products

Transcripts for PRMT1 Gene

Unigene Clusters for PRMT1 Gene

Protein arginine methyltransferase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRMT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: -
SP13: - - - -
SP14: - - - - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - - -
SP20: - - -
SP21:
SP22:

ExUns: 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for PRMT1 Gene

GeneLoc Exon Structure for
PRMT1
ECgene alternative splicing isoforms for
PRMT1

Expression for PRMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRMT1 Gene

This gene is overexpressed in Testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRMT1 Gene



Protein tissue co-expression partners for PRMT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRMT1 Gene:

PRMT1

SOURCE GeneReport for Unigene cluster for PRMT1 Gene:

Hs.20521

mRNA Expression by UniProt/SwissProt for PRMT1 Gene:

Q99873-ANM1_HUMAN
Tissue specificity: Widely expressed (PubMed:11097842). Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).

Evidence on tissue expression from TISSUES for PRMT1 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Skin(3.6)
  • Muscle(3.1)
  • Eye(2.7)
  • Heart(2.5)
  • Kidney(2.3)
  • Adrenal gland(2.2)
  • Blood(2.1)
  • Intestine(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with PRMT1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRMT1 Gene

Orthologs for PRMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRMT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRMT1 33 34
  • 95 (n)
oppossum
(Monodelphis domestica)
Mammalia PRMT1 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRMT1 33 34
  • 93.62 (n)
mouse
(Mus musculus)
Mammalia Prmt1 33 16 34
  • 92.36 (n)
rat
(Rattus norvegicus)
Mammalia Prmt1 33
  • 90.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 22 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia PRMT1 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prmt1 33
  • 78.56 (n)
Str.4974 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23295 33
zebrafish
(Danio rerio)
Actinopterygii prmt1 33 34
  • 78.43 (n)
zgc66201 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2791 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003462 33
  • 73.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Art1 33 34
  • 68.95 (n)
worm
(Caenorhabditis elegans)
Secernentea prmt-1 33 34
  • 67.37 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR190W 33
  • 59.5 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMT1 33 34
  • 55.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07117g 33
  • 54.79 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PRMT1A 33
  • 58.84 (n)
rice
(Oryza sativa)
Liliopsida Os09g0359800 33
  • 59.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2169 34
  • 70 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07459 33
  • 64.41 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rmt1 33
  • 55.87 (n)
Species where no ortholog for PRMT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRMT1 Gene

ENSEMBL:
Gene Tree for PRMT1 (if available)
TreeFam:
Gene Tree for PRMT1 (if available)

Paralogs for PRMT1 Gene

Paralogs for PRMT1 Gene

Pseudogenes.org Pseudogenes for PRMT1 Gene

genes like me logo Genes that share paralogs with PRMT1: view

Variants for PRMT1 Gene

Sequence variations from dbSNP and Humsavar for PRMT1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000096176 -- 49,683,508(+) G/A intron_variant
rs1000163817 -- 49,686,890(+) C/T intron_variant
rs1000196752 -- 49,687,133(+) C/T intron_variant
rs1000295101 -- 49,688,085(+) C/T intron_variant
rs1000491710 -- 49,683,722(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRMT1 Gene

Variant ID Type Subtype PubMed ID
esv24796 CNV loss 19812545
nsv1160655 CNV deletion 26073780
nsv469715 CNV gain+loss 16826518
nsv470150 CNV gain 18288195
nsv7308 OTHER inversion 18451855
nsv817854 CNV gain 17921354
nsv828578 CNV loss 20364138
nsv833864 CNV gain 17160897
nsv833865 CNV gain+loss 17160897
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for PRMT1 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRMT1 Gene

Disorders for PRMT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRMT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • es
- elite association - COSMIC cancer census association via MalaCards
Search PRMT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRMT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PRMT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRMT1 Gene

Publications for PRMT1 Gene

  1. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). (PMID: 9545638) Scott HS … Henry MF (Genomics 1998) 2 3 4 22 58
  2. PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. (PMID: 19124016) Jobert L … Tora L (Experimental cell research 2009) 3 4 22 58
  3. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. (PMID: 19405910) Lakowski TM … Frankel A (The Biochemical journal 2009) 3 4 22 58
  4. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman CA … Press MF (BMC cancer 2009) 3 22 44 58
  5. Regulation of estrogen rapid signaling through arginine methylation by PRMT1. (PMID: 18657504) Le Romancer M … Corbo L (Molecular cell 2008) 3 4 22 58

Products for PRMT1 Gene