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Aliases for HRH1 Gene

Aliases for HRH1 Gene

  • Histamine Receptor H1 2 3 5
  • HH1R 3 4
  • H1R 3 4
  • Histamine Receptor, Subclass H1 3
  • HisH1 3
  • H1-R 3

External Ids for HRH1 Gene

Previous GeneCards Identifiers for HRH1 Gene

  • GC03P011223
  • GC03P011270
  • GC03P011271
  • GC03P011272

Summaries for HRH1 Gene

Entrez Gene Summary for HRH1 Gene

  • Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

GeneCards Summary for HRH1 Gene

HRH1 (Histamine Receptor H1) is a Protein Coding gene. Diseases associated with HRH1 include rhinitis and allergic rhinitis. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and histamine binding. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for HRH1 Gene

  • In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

Tocris Summary for HRH1 Gene

  • Histamine H1 receptors are Galphaq/11-protein-coupled receptors that mediate allergic responses. These receptors are expressed in a wide variety of tissues including the gastrointestinal tract, CNS, airway and vascular smooth muscle cells and endothelial cells.

Gene Wiki entry for HRH1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRH1 Gene

Genomics for HRH1 Gene

Regulatory Elements for HRH1 Gene

Promoters for HRH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HRH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HRH1 Gene

Chromosome:
3
Start:
11,137,093 bp from pter
End:
11,263,557 bp from pter
Size:
126,465 bases
Orientation:
Plus strand

Genomic View for HRH1 Gene

Genes around HRH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRH1 Gene

Proteins for HRH1 Gene

  • Protein details for HRH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35367-HRH1_HUMAN
    Recommended name:
    Histamine H1 receptor
    Protein Accession:
    P35367
    Secondary Accessions:
    • A8K047
    • Q6P9E5

    Protein attributes for HRH1 Gene

    Size:
    487 amino acids
    Molecular mass:
    55784 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HRH1 Gene

neXtProt entry for HRH1 Gene

Proteomics data for HRH1 Gene at MOPED

Post-translational modifications for HRH1 Gene

  • Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.
  • Glycosylation at Asn 5 and Asn 18
  • Modification sites at PhosphoSitePlus

Other Protein References for HRH1 Gene

Antibody Products

  • R&D Systems Antibodies for HRH1 (Histamine H1 R)

No data available for DME Specific Peptides for HRH1 Gene

Domains & Families for HRH1 Gene

Gene Families for HRH1 Gene

Protein Domains for HRH1 Gene

Suggested Antigen Peptide Sequences for HRH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35367

UniProtKB/Swiss-Prot:

HRH1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HRH1: view

Function for HRH1 Gene

Molecular function for HRH1 Gene

GENATLAS Biochemistry:
histamine H1 receptor,ubiquitous,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating contraction on smooth muscle in the gut and bronchs and decreasing blood pressure
UniProtKB/Swiss-Prot Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

Gene Ontology (GO) - Molecular Function for HRH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004969 histamine receptor activity ISS --
genes like me logo Genes that share ontologies with HRH1: view
genes like me logo Genes that share phenotypes with HRH1: view

Animal Models for HRH1 Gene

MGI Knock Outs for HRH1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HRH1 Gene

Localization for HRH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRH1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HRH1 Gene COMPARTMENTS Subcellular localization image for HRH1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for HRH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HRH1: view

Pathways & Interactions for HRH1 Gene

genes like me logo Genes that share pathways with HRH1: view

Interacting Proteins for HRH1 Gene

SIGNOR curated interactions for HRH1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HRH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10818238
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8280179
GO:0007613 memory IEA --
GO:0008542 visual learning IEA --
GO:0019229 regulation of vasoconstriction IBA --
genes like me logo Genes that share ontologies with HRH1: view

Drugs & Compounds for HRH1 Gene

(236) Drugs for HRH1 Gene - From: Novoseek, ApexBio, DGIdb, IUPHAR, DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphenhydramine Approved Pharma Antagonist, antagonist, Target 212
Cyproheptadine Approved Pharma Antagonist, antagonist, Target 15
Risperidone Approved, Investigational Pharma Antagonist, antagonist, Target SR-2A inhibitor 477
Astemizole Approved, Withdrawn Pharma Pore Blocker, antagonist, Target 0
Chlorpheniramine Approved Pharma antagonist, Target 59

(40) Additional Compounds for HRH1 Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(plusmn)-<i>cis</i>-H<sub>2</sub>-PAT
Antagonist
(plusmn)-<i>trans</i>-H<sub>2</sub>-PAT
Antagonist
Promazine 5-sulfoxide
2-Pyridylethylamine dihydrochloride
3343-39-3
Doxepin hydrochloride
1229-29-4
genes like me logo Genes that share compounds with HRH1: view

Drug Products

Transcripts for HRH1 Gene

Unigene Clusters for HRH1 Gene

Histamine receptor H1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HRH1 Gene

No ASD Table

Relevant External Links for HRH1 Gene

GeneLoc Exon Structure for
HRH1
ECgene alternative splicing isoforms for
HRH1

Expression for HRH1 Gene

mRNA expression in normal human tissues for HRH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HRH1 Gene

This gene is overexpressed in Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for HRH1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HRH1 Gene



SOURCE GeneReport for Unigene cluster for HRH1 Gene Hs.1570

genes like me logo Genes that share expression patterns with HRH1: view

Protein tissue co-expression partners for HRH1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HRH1 Gene

Orthologs for HRH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HRH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRH1 36
  • 99 (a)
OneToOne
HRH1 35
  • 99.18 (n)
  • 98.97 (a)
cow
(Bos Taurus)
Mammalia HRH1 36
  • 82 (a)
OneToOne
HRH1 35
  • 84.67 (n)
  • 82.55 (a)
dog
(Canis familiaris)
Mammalia HRH1 35
  • 86.65 (n)
  • 86.24 (a)
HRH1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hrh1 16
Hrh1 35
  • 80.73 (n)
  • 78.4 (a)
Hrh1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HRH1 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hrh1 35
  • 80.3 (n)
  • 79.34 (a)
chicken
(Gallus gallus)
Aves HRH1 35
  • 54.88 (n)
  • 51.93 (a)
HRH1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HRH1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495566 35
  • 64.62 (n)
  • 62.87 (a)
zebrafish
(Danio rerio)
Actinopterygii hrh1 36
  • 37 (a)
OneToOne
hrh1 35
  • 52.84 (n)
  • 46.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7918 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gar-1 36
  • 14 (a)
ManyToMany
gar-2 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
Species with no ortholog for HRH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRH1 Gene

ENSEMBL:
Gene Tree for HRH1 (if available)
TreeFam:
Gene Tree for HRH1 (if available)

Paralogs for HRH1 Gene

Paralogs for HRH1 Gene

(2) SIMAP similar genes for HRH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HRH1: view

Variants for HRH1 Gene

Sequence variations from dbSNP and Humsavar for HRH1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7651620 - 11,259,846(+) TGGTG(A/G)ATCTG reference, missense
VAR_035761 A colorectal cancer sample
rs2067466 - 11,259,094(+) AACAA(C/G)ACCAC reference, missense
rs168333 -- 11,185,774(+) GTGTC(A/G)TGTTG intron-variant
rs364743 -- 11,185,080(+) TATCA(C/T)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HRH1 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735
nsv876535 CNV Gain 21882294
esv2609663 CNV Insertion 19546169
esv273392 CNV Insertion 20981092
esv268134 CNV Insertion 20981092
esv2724908 CNV Deletion 23290073
esv2151338 CNV Deletion 18987734
esv2724909 CNV Deletion 23290073

Variation tolerance for HRH1 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HRH1 Gene

HapMap Linkage Disequilibrium report
HRH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRH1 Gene

Disorders for HRH1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for HRH1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rhinitis
  • runny nose
allergic rhinitis
  • atopic rhinitis
asthma
  • asthma, protection against
dermatitis
  • eczema
cholinergic urticaria
- elite association - COSMIC cancer census association via MalaCards
Search HRH1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HRH1

Genetic Association Database (GAD)
HRH1
Human Genome Epidemiology (HuGE) Navigator
HRH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HRH1
genes like me logo Genes that share disorders with HRH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRH1 Gene

Publications for HRH1 Gene

  1. Molecular cloning of the human histamine H1 receptor gene. (PMID: 8003029) Fukui K. … Ito S. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 67
  2. Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. (PMID: 19558341) Murota H. … Katayama I. (Expert Opin Pharmacother 2009) 23 25 26
  3. Desloratadine for chronic idiopathic urticaria: a review of clinical efficacy. (PMID: 17902729) DuBuske L. (Am J Clin Dermatol 2007) 23 25 26
  4. Histamine upregulates the expression of inducible nitric oxide synthase in human intimal smooth muscle cells via histamine H1 receptor and NF-kappaB signaling pathway. (PMID: 17478759) Tanimoto A. … Sasaguri Y. (Arterioscler. Thromb. Vasc. Biol. 2007) 23 25 26
  5. A dual antagonist for chemokine CCR3 receptor and histamine H1 receptor. (PMID: 17336292) Suzuki K. … Shimizu Y. (Eur. J. Pharmacol. 2007) 23 25 26

Products for HRH1 Gene

Sources for HRH1 Gene

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