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Aliases for HRAS Gene

Aliases for HRAS Gene

  • Harvey Rat Sarcoma Viral Oncogene Homolog 2 3
  • V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 3
  • Transforming Protein P21 3 4
  • C-H-RAS 3 4
  • P21ras 3 4
  • HRAS1 3 4
  • Ras Family Small GTP Binding Protein H-Ras 3
  • Harvey Rat Sarcoma Viral Oncoprotein 3
  • Transformation Gene: Oncogene HAMSV 3
  • GTP- And GDP-Binding Peptide B 3
  • C-Ras-Ki-2 Activated Oncogene 3
  • Ha-Ras1 Proto-Oncoprotein 3
  • C-Has/Bas P21 Protein 3
  • P19 H-RasIDX Protein 3
  • GTPase HRas 3
  • C-BAS/HAS 3
  • C-HA-RAS1 3
  • H-RASIDX 3
  • H-Ras-1 4
  • Ha-Ras 4
  • HAMSV 3
  • RASH1 3
  • CTLO 3

External Ids for HRAS Gene

Previous Symbols for HRAS Gene

  • HRAS1

Summaries for HRAS Gene

Entrez Gene Summary for HRAS Gene

  • This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HRAS Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with HRAS include costello syndrome and spitz nevus. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include GTP binding and protein C-terminus binding. An important paralog of this gene is MRAS.

UniProtKB/Swiss-Prot for HRAS Gene

  • Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Gene Wiki entry for HRAS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRAS Gene

Genomics for HRAS Gene

Genomic Location for HRAS Gene

Start:
532,242 bp from pter
End:
537,287 bp from pter
Size:
5,046 bases
Orientation:
Minus strand

Genomic View for HRAS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRAS Gene

Regulatory Elements for HRAS Gene

Proteins for HRAS Gene

  • Protein details for HRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01112-RASH_HUMAN
    Recommended name:
    GTPase HRas
    Protein Accession:
    P01112
    Secondary Accessions:
    • B5BUA0
    • Q14080
    • Q6FHV9
    • Q9BR65
    • Q9UCE2

    Protein attributes for HRAS Gene

    Size:
    189 amino acids
    Molecular mass:
    21298 Da
    Quaternary structure:
    • In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3. Interacts with HSPD1. Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity). Forms a signaling complex with RASGRP1 and DGKZ. Interacts with RASSF5. Interacts with PDE6D. Interacts with IKZF3. Interacts with GNB2L1. Interacts with PIK3CG; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity). Interacts with RAPGEF2.

    Three dimensional structures from OCA and Proteopedia for HRAS Gene

    Alternative splice isoforms for HRAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HRAS Gene

Proteomics data for HRAS Gene at MOPED

Post-translational modifications for HRAS Gene

  • Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
  • Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi
  • S-nitrosylated; critical for redox regulation. Important for stimulating guanine nucleotide exchange. No structural perturbation on nitrosylation
  • The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HRAS Gene

No data available for DME Specific Peptides for HRAS Gene

Domains for HRAS Gene

UniProtKB/Swiss-Prot:

RASH_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Ras family.:
    • P01112
genes like me logo Genes that share domains with HRAS: view

No data available for Gene Families for HRAS Gene

Function for HRAS Gene

Molecular function for HRAS Gene

GENATLAS Biochemistry: Harvey rat sarcoma viral (v-Ha-ras1) oncogene homolog
UniProtKB/Swiss-Prot EnzymeRegulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)
UniProtKB/Swiss-Prot Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Gene Ontology (GO) - Molecular Function for HRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0005515 protein binding IPI 10369681
GO:0005525 GTP binding IDA 14500341
GO:0008022 protein C-terminus binding IPI 9219684
GO:0015093 ferrous iron transmembrane transporter activity --
genes like me logo Genes that share ontologies with HRAS: view
genes like me logo Genes that share phenotypes with HRAS: view

Animal Models for HRAS Gene

MGI Knock Outs for HRAS:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HRAS Gene

Localization for HRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRAS Gene

Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250}.
Isoform 2: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with GNB2L1 to the perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HRAS Gene COMPARTMENTS Subcellular localization image for HRAS gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 4
cytoskeleton 3
endoplasmic reticulum 2
endosome 2
extracellular 2
mitochondrion 2
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 10842192
GO:0005794 Golgi apparatus IDA 14500341
genes like me logo Genes that share ontologies with HRAS: view

Pathways for HRAS Gene

SuperPathways for HRAS Gene

Superpath Contained pathways
1 Signaling by FGFR
2 IL-2 Pathway
3 Insulin receptor signalling cascade
4 SHC1 events in ERBB2 signaling
5 Translation Insulin regulation of translation
genes like me logo Genes that share pathways with HRAS: view

Gene Ontology (GO) - Biological Process for HRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001934 positive regulation of protein phosphorylation IDA 22065586
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006184 obsolete GTP catabolic process --
genes like me logo Genes that share ontologies with HRAS: view

Compounds for HRAS Gene

(3) HMDB Compounds for HRAS Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(90) Novoseek inferred chemical compound relationships for HRAS Gene

Compound -log(P) Hits PubMed IDs
gtp 72.5 89
dihydroperillic acid 66.3 1
tyrosine 65.7 117
phosphatidylinositol 60.9 24
gdp 60.7 21
genes like me logo Genes that share compounds with HRAS: view

Transcripts for HRAS Gene

Unigene Clusters for HRAS Gene

V-Ha-ras Harvey rat sarcoma viral oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HRAS Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1:
SP2: -
SP3:
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for HRAS Gene

GeneLoc Exon Structure for
HRAS
ECgene alternative splicing isoforms for
HRAS

Expression for HRAS Gene

mRNA expression in normal human tissues for HRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HRAS Gene

SOURCE GeneReport for Unigene cluster for HRAS Gene Hs.37003

mRNA Expression by UniProt/SwissProt for HRAS Gene

P01112-RASH_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with HRAS: view

Orthologs for HRAS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HRAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRAS 36
  • 98.77 (n)
  • 99.47 (a)
HRAS 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HRAS 36
  • 88.54 (n)
  • 95.77 (a)
HRAS 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HRAS 36
  • 89.77 (n)
  • 97.88 (a)
K-RAS 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hras 36
  • 87.65 (n)
  • 100 (a)
Hras 37
  • 100 (a)
OneToOne
Hras1 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 70 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hras 36
  • 88.36 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves HRAS 36
  • 83.42 (n)
  • 97.88 (a)
HRAS1 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HRAS 37
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hras 36
  • 81.31 (n)
  • 96.3 (a)
Str.6315 36
zebrafish
(Danio rerio)
Actinopterygii hrasa 37
  • 95 (a)
OneToMany
hrasb 37
  • 94 (a)
OneToMany
LOC100151000 36
  • 82.72 (n)
  • 94.71 (a)
wufa04e08 36
fruit fly
(Drosophila melanogaster)
Insecta Ras85D 37
  • 77 (a)
OneToMany
Ras85D 38
  • 86 (a)
worm
(Caenorhabditis elegans)
Secernentea let-60 37
  • 76 (a)
OneToMany
C08F8.7 38
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 37
  • 35 (a)
ManyToMany
RAS2 37
  • 34 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.25522 36
Species with no ortholog for HRAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRAS Gene

ENSEMBL:
Gene Tree for HRAS (if available)
TreeFam:
Gene Tree for HRAS (if available)

Paralogs for HRAS Gene

Paralogs for HRAS Gene

genes like me logo Genes that share paralogs with HRAS: view

Variants for HRAS Gene

Sequence variations from dbSNP and Humsavar for HRAS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12628 Benign 534,242(-) AACCA(C/T)TTTGT synonymous-codon, reference, nc-transcript-variant
rs3730376 -- 532,573(-) CCGCC(C/T)CTGCC utr-variant-3-prime, intron-variant
rs28933406 other, Follicular thyroid carcinoma samples 533,875(-) CCGGC(A/C)AGGAG missense, reference, nc-transcript-variant
rs34273378 -- 532,173(+) AGGCC(-/T)TGAGG downstream-variant-500B
rs34584741 -- 534,215(+) CCTCT(-/A)ATAGT reference, frameshift-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for HRAS Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv931n71 CNV Loss 21882294
nsv896532 CNV Gain 21882294
essv23843 CNV CNV 17122850
dgv933n71 CNV Loss 21882294
nsv467634 CNV Loss 19166990
nsv896544 CNV Loss 21882294
nsv896545 CNV Loss 21882294
dgv934n71 CNV Loss 21882294
nsv896548 CNV Loss 21882294

Relevant External Links for HRAS Gene

HapMap Linkage Disequilibrium report
HRAS
Human Gene Mutation Database (HGMD)
HRAS

Disorders for HRAS Gene

(5) OMIM Diseases for HRAS Gene (190020)

UniProtKB/Swiss-Prot

RASH_HUMAN
  • Costello syndrome (CSTLO) [MIM:218040]: A rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities. {ECO:0000269 PubMed:16170316, ECO:0000269 PubMed:16329078, ECO:0000269 PubMed:16443854, ECO:0000269 PubMed:17054105, ECO:0000269 PubMed:18039947, ECO:0000269 PubMed:18247425, ECO:0000269 PubMed:19995790}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Congenital myopathy with excess of muscle spindles (CMEMS) [MIM:218040]: Variant of Costello syndrome. {ECO:0000269 PubMed:17412879}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]: A rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. {ECO:0000269 PubMed:12727991}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=Mutations which change positions 12, 13 or 61 activate the potential of HRAS to transform cultured cells and are implicated in a variety of human tumors.
  • Bladder cancer (BLC) [MIM:109800]: A malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas that begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Schimmelpenning-Feuerstein-Mims syndrome (SFM) [MIM:163200]: A disease characterized by sebaceous nevi, often on the face, associated with variable ipsilateral abnormalities of the central nervous system, ocular anomalies, and skeletal defects. Many oral manifestations have been reported, not only including hypoplastic and malformed teeth, and mucosal papillomatosis, but also ankyloglossia, hemihyperplastic tongue, intraoral nevus, giant cell granuloma, ameloblastoma, bone cysts, follicular cysts, oligodontia, and odontodysplasia. Sebaceous nevi follow the lines of Blaschko and these can continue as linear intraoral lesions, as in mucosal papillomatosis. {ECO:0000269 PubMed:22683711}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(92) Novoseek inferred disease relationships for HRAS Gene

Disease -log(P) Hits PubMed IDs
cfc syndrome 89.1 12
noonan syndrome 85.1 32
microsatellite instability 67 10
colorectal cancer 61.2 63
tumors 60.2 150

Relevant External Links for HRAS

GeneTests
HRAS
GeneReviews
HRAS
Genetic Association Database (GAD)
HRAS
Human Genome Epidemiology (HuGE) Navigator
HRAS
Tumor Gene Database (TGDB):
HRAS
genes like me logo Genes that share disorders with HRAS: view

Publications for HRAS Gene

  1. Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility. (PMID: 16488657) Sathyan K.M. … Kannan S. (Oral Oncol. 2006) 3 23 49
  2. Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China. (PMID: 18783589) Zhang Y. … Chen K. (BMC Cancer 2008) 3 23 49
  3. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. (PMID: 19487299) Ricarte-Filho J.C. … Fagin J.A. (Cancer Res. 2009) 3 23 49
  4. Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients. (PMID: 20150643) Jin Y. … Toguchida J. (Anticancer Res. 2010) 3 23 49
  5. Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas. (PMID: 20012784) Sadow P.M. … NosAc V. (Endocr. Pathol. 2010) 3 23

Products for HRAS Gene

  • Addgene plasmids for HRAS

Sources for HRAS Gene

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