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Aliases for HPX Gene

Aliases for HPX Gene

  • Hemopexin 2 3
  • Beta-1B-Glycoprotein 3 4
  • HX 3

External Ids for HPX Gene

Previous GeneCards Identifiers for HPX Gene

  • GC11M007195
  • GC11M006912
  • GC11M006411
  • GC11M006416
  • GC11M006408
  • GC11M006112

Summaries for HPX Gene

Entrez Gene Summary for HPX Gene

  • This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

GeneCards Summary for HPX Gene

HPX (Hemopexin) is a Protein Coding gene. Diseases associated with HPX include blackwater fever and pediatric multiple sclerosis. Among its related pathways are Vesicle-mediated transport and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include heme transporter activity.

UniProtKB/Swiss-Prot for HPX Gene

  • Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation

Gene Wiki entry for HPX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPX Gene

Genomics for HPX Gene

Regulatory Elements for HPX Gene

Genomic Location for HPX Gene

Chromosome:
11
Start:
6,431,038 bp from pter
End:
6,442,617 bp from pter
Size:
11,580 bases
Orientation:
Minus strand

Genomic View for HPX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPX Gene

Proteins for HPX Gene

  • Protein details for HPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02790-HEMO_HUMAN
    Recommended name:
    Hemopexin
    Protein Accession:
    P02790
    Secondary Accessions:
    • B2R957

    Protein attributes for HPX Gene

    Size:
    462 amino acids
    Molecular mass:
    51676 Da
    Quaternary structure:
    • Interacts with HEV ORF3 protein. Interacts with FLVCR1.
    Miscellaneous:
    • The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).
    SequenceCaution:
    • Sequence=CAA26382.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HPX Gene

Proteomics data for HPX Gene at MOPED

Post-translational modifications for HPX Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylation in the 30-40 region is minor compared to glycosylation at Thr-24 and Thr-29.
  • Glycosylation at Thr 24, Thr 29, Asn 64, Asn 187, Asn 240, Asn 246, and Asn 453
  • Modification sites at PhosphoSitePlus

Other Protein References for HPX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HPX Gene

Domains & Families for HPX Gene

Protein Domains for HPX Gene

Suggested Antigen Peptide Sequences for HPX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02790

UniProtKB/Swiss-Prot:

HEMO_HUMAN :
  • Belongs to the hemopexin family.
  • Contains 8 hemopexin repeats.
Family:
  • Belongs to the hemopexin family.
Similarity:
  • Contains 8 hemopexin repeats.
genes like me logo Genes that share domains with HPX: view

No data available for Gene Families for HPX Gene

Function for HPX Gene

Molecular function for HPX Gene

GENATLAS Biochemistry:
hemopexin,beta 1 glycoprotein of blood serum
UniProtKB/Swiss-Prot Function:
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation

Gene Ontology (GO) - Molecular Function for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20610401
GO:0015232 heme transporter activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HPX: view
genes like me logo Genes that share phenotypes with HPX: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPX

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HPX Gene

Localization for HPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPX Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HPX Gene COMPARTMENTS Subcellular localization image for HPX gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19056867
GO:0071682 endocytic vesicle lumen TAS --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with HPX: view

Pathways & Interactions for HPX Gene

genes like me logo Genes that share pathways with HPX: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for HPX Gene

Gene Ontology (GO) - Biological Process for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA --
GO:0006879 cellular iron ion homeostasis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0015886 heme transport IEA --
genes like me logo Genes that share ontologies with HPX: view

No data available for SIGNOR curated interactions for HPX Gene

Drugs & Compounds for HPX Gene

(16) Drugs for HPX Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Heparin Approved, Investigational Pharma Antagonist 672,226
Hyaluronan Approved Pharma 328
Iron Approved Pharma 957
Prednisolone Approved Pharma Agonist 1033

(17) Additional Compounds for HPX Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Agarose
Apotransferrin
cyanide
  • Carbon nitride ion
  • Chuck Norrisium
  • Cyanide
  • Cyanide ion
  • Cyanide(1-) ion
57-12-5
Fe3+
  • Fe(III)
  • Ferric ion
  • Iron(3+)
7439-89-6
genes like me logo Genes that share compounds with HPX: view

Transcripts for HPX Gene

Unigene Clusters for HPX Gene

Hemopexin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPX Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8: -
SP9:

Relevant External Links for HPX Gene

GeneLoc Exon Structure for
HPX
ECgene alternative splicing isoforms for
HPX

Expression for HPX Gene

mRNA expression in normal human tissues for HPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPX Gene

This gene is overexpressed in Liver (x52.1).

Protein differential expression in normal tissues from HIPED for HPX Gene

This gene is overexpressed in Synovial fluid (21.2), Plasma (10.4), and Serum (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HPX Gene



SOURCE GeneReport for Unigene cluster for HPX Gene Hs.426485

mRNA Expression by UniProt/SwissProt for HPX Gene

P02790-HEMO_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expression patterns with HPX: view

Protein tissue co-expression partners for HPX Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for HPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HPX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HPX 35
  • 81.05 (n)
  • 73.67 (a)
HPX 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HPX 35
  • 85.95 (n)
  • 81.9 (a)
HPX 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hpx 35
  • 81.84 (n)
  • 75.49 (a)
Hpx 16
Hpx 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HPX 35
  • 99.71 (n)
  • 99.78 (a)
HPX 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hpx 35
  • 82.57 (n)
  • 77.02 (a)
oppossum
(Monodelphis domestica)
Mammalia HPX 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HPX 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves HPX 35
  • 57.66 (n)
  • 47.84 (a)
HPX 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HPX 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495728 35
  • 54.95 (n)
  • 44.74 (a)
zebrafish
(Danio rerio)
Actinopterygii hpx 35
  • 50.65 (n)
  • 38.59 (a)
hpx 36
  • 33 (a)
OneToMany
HPX (2 of 2) 36
  • 38 (a)
OneToMany
Species with no ortholog for HPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPX Gene

ENSEMBL:
Gene Tree for HPX (if available)
TreeFam:
Gene Tree for HPX (if available)

Paralogs for HPX Gene

No data available for Paralogs for HPX Gene

Variants for HPX Gene

Sequence variations from dbSNP and Humsavar for HPX Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12117 - 6,440,254(-) GGGAC(C/T)GGGAG reference, missense
rs1042547 -- 6,431,292(+) TGCTA(A/C)AGTGA reference, stop-gained, synonymous-codon
rs2035675 -- 6,441,858(+) tgacc(A/G)ccTTA upstream-variant-2KB
rs2291482 -- 6,437,023(-) CTCCC(A/C/G)CAATG intron-variant
rs2306895 -- 6,439,991(-) TGGGC(C/T)TGGCA intron-variant

Variation tolerance for HPX Gene

Residual Variation Intolerance Score: 78.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HPX Gene

HapMap Linkage Disequilibrium report
HPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HPX Gene

Disorders for HPX Gene

MalaCards: The human disease database

(5) MalaCards diseases for HPX Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
blackwater fever
  • black water fever
pediatric multiple sclerosis
  • ms pediatric
testicular yolk sac tumor
  • testicular yolk sac neoplasm
atransferrinemia
  • familial hypotransferrinemia
amelogenesis imperfecta
  • aortic valve insufficiency
- elite association
Search HPX in MalaCards View complete list of genes associated with diseases

Relevant External Links for HPX

Genetic Association Database (GAD)
HPX
Human Genome Epidemiology (HuGE) Navigator
HPX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HPX
genes like me logo Genes that share disorders with HPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPX Gene

Publications for HPX Gene

  1. Heme scavenging and the other facets of hemopexin. (PMID: 19650691) Tolosano E. … Fiorito V. (Antioxid. Redox Signal. 2010) 23 67
  2. Hemopexin: anti-inflammatory, pro-inflammatory, or both? (PMID: 20047881) Bakker W.W. … Faas M.M. (J. Leukoc. Biol. 2010) 23 67
  3. Molecular interactions of MMP-13 C-terminal domain with chondrocyte proteins. (PMID: 20073988) Zhang L. … Gibson G. (Connect. Tissue Res. 2010) 23 67
  4. Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain. (PMID: 20159608) Redondo-MuA+oz J. … GarcA-a-Pardo A. (Cancer Cell 2010) 23 67
  5. Diagnostic value of the hemopexin N-glycan profile in hepatocellular carcinoma patients. (PMID: 20348404) Debruyne E.N. … Delanghe J.R. (Clin. Chem. 2010) 23 67

Products for HPX Gene

Sources for HPX Gene

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