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Aliases for HPN Gene

Aliases for HPN Gene

  • Hepsin 2 3
  • Transmembrane Protease Serine 1 3 4
  • EC 4 63
  • TMPRSS1 3 4
  • Transmembrane Protease 2
  • EC 3.4.21 63
  • Serine 1 2

External Ids for HPN Gene

Previous GeneCards Identifiers for HPN Gene

  • GC19P036148
  • GC19P035980
  • GC19P040207
  • GC19P040223
  • GC19P035531
  • GC19P032039

Summaries for HPN Gene

Entrez Gene Summary for HPN Gene

  • This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for HPN Gene

HPN (Hepsin) is a Protein Coding gene. Diseases associated with HPN include prostate cancer. Among its related pathways are Viral carcinogenesis. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS7.

UniProtKB/Swiss-Prot for HPN Gene

  • Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2.

Gene Wiki entry for HPN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPN Gene

Genomics for HPN Gene

Regulatory Elements for HPN Gene

Genomic Location for HPN Gene

35,040,506 bp from pter
35,066,577 bp from pter
26,072 bases
Plus strand

Genomic View for HPN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPN Gene

Proteins for HPN Gene

  • Protein details for HPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease hepsin
    Protein Accession:
    Secondary Accessions:
    • B2RDS4

    Protein attributes for HPN Gene

    417 amino acids
    Molecular mass:
    45011 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HPN Gene

neXtProt entry for HPN Gene

Proteomics data for HPN Gene at MOPED

Selected DME Specific Peptides for HPN Gene

Post-translational modifications for HPN Gene

  • Glycosylation at Asn 112
  • Modification sites at PhosphoSitePlus

Other Protein References for HPN Gene

Domains & Families for HPN Gene

Gene Families for HPN Gene

Suggested Antigen Peptide Sequences for HPN Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with HPN: view

Function for HPN Gene

Molecular function for HPN Gene

GENATLAS Biochemistry:
hepsin,cell membrane associated serine protease,activating factor VII
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
UniProtKB/Swiss-Prot Function:
Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2.

Enzyme Numbers (IUBMB) for HPN Gene

Gene Ontology (GO) - Molecular Function for HPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IDA 16908524
GO:0005515 protein binding IPI 15614436
GO:0008233 peptidase activity IDA 16908524
GO:0008236 serine-type peptidase activity IDA 19911255
GO:0015269 calcium-activated potassium channel activity ISS --
genes like me logo Genes that share ontologies with HPN: view
genes like me logo Genes that share phenotypes with HPN: view

Animal Models for HPN Gene

MGI Knock Outs for HPN:

miRNA for HPN Gene

miRTarBase miRNAs that target HPN

No data available for Transcription Factor Targets and HOMER Transcription for HPN Gene

Localization for HPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPN Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for HPN Gene COMPARTMENTS Subcellular localization image for HPN gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 17918732
GO:0005886 plasma membrane IDA 8346233
GO:0005887 integral component of plasma membrane IDA 1885621
GO:0005911 cell-cell junction ISS --
GO:0009986 cell surface IDA 8346233
genes like me logo Genes that share ontologies with HPN: view

Pathways & Interactions for HPN Gene

SuperPathways for HPN Gene

Superpath Contained pathways
1 Viral carcinogenesis
genes like me logo Genes that share pathways with HPN: view

Pathways by source for HPN Gene

1 KEGG pathway for HPN Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 16908524
GO:0007605 sensory perception of sound --
GO:0008360 regulation of cell shape IMP 8346233
GO:0010628 positive regulation of gene expression ISS --
GO:0010693 negative regulation of alkaline phosphatase activity IEA --
genes like me logo Genes that share ontologies with HPN: view

No data available for SIGNOR curated interactions for HPN Gene

Drugs & Compounds for HPN Gene

(9) Drugs for HPN Gene - From: DrugBank, NovoSeek, ClinicalTrials, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coagulation factor VIIa Approved Pharma Target 0
6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Experimental Pharma Target 0
Benzylsulfinic Acid Experimental Pharma Target 0
CRA_1144 Experimental Pharma Target 0
Taurine Experimental Nutra Non-selective, endogenous glycine receptor partial agonist 21

(1) Additional Compounds for HPN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HPN: view

Transcripts for HPN Gene

Unigene Clusters for HPN Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - - - - - -
SP7: -

Relevant External Links for HPN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HPN Gene

mRNA expression in normal human tissues for HPN Gene

mRNA differential expression in normal tissues according to GTEx for HPN Gene

This gene is overexpressed in Liver (x28.3), Pancreas (x8.8), and Kidney - Cortex (x7.8).

Protein differential expression in normal tissues from HIPED for HPN Gene

This gene is overexpressed in Skin (36.5), Plasma (16.1), and Urine (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HPN Gene

SOURCE GeneReport for Unigene cluster for HPN Gene Hs.182385

mRNA Expression by UniProt/SwissProt for HPN Gene

Tissue specificity: Present in most tissues, with the highest level in liver
genes like me logo Genes that share expression patterns with HPN: view

Protein tissue co-expression partners for HPN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HPN Gene

Orthologs for HPN Gene

This gene was present in the common ancestor of animals.

Orthologs for HPN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HPN 35
  • 90.09 (n)
  • 93.53 (a)
HPN 36
  • 94 (a)
(Canis familiaris)
Mammalia HPN 35
  • 90.33 (n)
  • 94.72 (a)
HPN 36
  • 95 (a)
(Mus musculus)
Mammalia Hpn 35
  • 84.67 (n)
  • 88.86 (a)
Hpn 16
Hpn 36
  • 84 (a)
(Pan troglodytes)
Mammalia HPN 35
  • 99.84 (n)
  • 100 (a)
HPN 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hpn 35
  • 84.18 (n)
  • 88.86 (a)
(Monodelphis domestica)
Mammalia HPN 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia HPN 36
  • 12 (a)
(Gallus gallus)
Aves HPN 36
  • 34 (a)
(Anolis carolinensis)
Reptilia HPN 36
  • 68 (a)
(Danio rerio)
Actinopterygii LOC100536154 35
  • 59.04 (n)
  • 54.47 (a)
HPN (1 of 2) 36
  • 51 (a)
HPN (2 of 2) 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11192 37
  • 37 (a)
CG11824 37
  • 40 (a)
CG11836 37
  • 38 (a)
CG1299 37
  • 33 (a)
CG3355 37
  • 39 (a)
CG4386 37
  • 37 (a)
CG4613 37
  • 41 (a)
CG6041 37
  • 36 (a)
CG7829 37
  • 34 (a)
eegrTry 37
  • 37 (a)
mas 37
  • 38 (a)
Sb 37
  • 38 (a)
Tequila 37
  • 34 (a)
zgrTry 37
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004568 35
  • 48.54 (n)
  • 42.98 (a)
(Caenorhabditis elegans)
Secernentea C07G1.1 37
  • 36 (a)
Species with no ortholog for HPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HPN Gene

Gene Tree for HPN (if available)
Gene Tree for HPN (if available)

Paralogs for HPN Gene

genes like me logo Genes that share paralogs with HPN: view

Variants for HPN Gene

Sequence variations from dbSNP and Humsavar for HPN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2305749 -- 35,041,401(+) AAGGG(G/T)TCGCT intron-variant, upstream-variant-2KB
rs2305750 -- 35,041,410(+) CTGGG(C/T)GAGGG intron-variant, upstream-variant-2KB
rs7252069 -- 35,057,080(+) ttaac(C/G/T)gacag intron-variant
rs12985780 -- 35,058,189(+) ACATA(C/T)ATAtt intron-variant
rs34561074 -- 35,041,555(+) GCACA(-/C)CCTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HPN Gene

Variant ID Type Subtype PubMed ID
nsv911610 CNV Loss 21882294
dgv3848n71 CNV Loss 21882294
nsv911613 CNV Loss 21882294
esv2718489 CNV Deletion 23290073

Variation tolerance for HPN Gene

Residual Variation Intolerance Score: 39.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HPN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPN Gene

Disorders for HPN Gene

MalaCards: The human disease database

(1) MalaCards diseases for HPN Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association
Search HPN in MalaCards View complete list of genes associated with diseases

Relevant External Links for HPN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HPN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPN Gene

Publications for HPN Gene

  1. Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model. (PMID: 19938013) Nandana S. … Matusik R. (Prostate 2010) 23 67
  2. Association of hepsin gene variants with prostate cancer risk and prognosis. (PMID: 20166135) Holt S.K. … Stanford J.L. (Prostate 2010) 23 67
  3. Discovering disease-specific biomarker genes for cancer diagnosis and prognosis. (PMID: 20441232) Huang H.C. … Zhao Z. (Technol. Cancer Res. Treat. 2010) 23 67
  4. Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. (PMID: 19911255) Chen M. … Chai K.X. (Mol. Cell. Biochem. 2010) 23 67
  5. Local protease signaling contributes to neural tube closure in the mouse embryo. (PMID: 20152175) Camerer E. … Coughlin S.R. (Dev. Cell 2010) 23 67

Products for HPN Gene

Sources for HPN Gene

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