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Aliases for HPN Gene

Aliases for HPN Gene

  • Hepsin 2 3 5
  • Transmembrane Protease Serine 1 3 4
  • EC 3.4.21.106 4 63
  • TMPRSS1 3 4
  • Testicular Tissue Protein Li 85 3
  • Transmembrane Protease 2
  • EC 3.4.21 63
  • Serine 1 2

External Ids for HPN Gene

Previous GeneCards Identifiers for HPN Gene

  • GC19P036148
  • GC19P035980
  • GC19P040207
  • GC19P040223
  • GC19P035531
  • GC19P032039

Summaries for HPN Gene

Entrez Gene Summary for HPN Gene

  • This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for HPN Gene

HPN (Hepsin) is a Protein Coding gene. Diseases associated with HPN include Prostate Cancer and Male Reproductive Organ Cancer. Among its related pathways are Viral carcinogenesis and Signaling by MST1. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS11A.

UniProtKB/Swiss-Prot for HPN Gene

  • Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).

Gene Wiki entry for HPN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPN Gene

Genomics for HPN Gene

Regulatory Elements for HPN Gene

Enhancers for HPN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HPN on UCSC Golden Path with GeneCards custom track

Promoters for HPN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HPN on UCSC Golden Path with GeneCards custom track

Genomic Location for HPN Gene

Chromosome:
19
Start:
35,040,506 bp from pter
End:
35,066,577 bp from pter
Size:
26,072 bases
Orientation:
Plus strand

Genomic View for HPN Gene

Genes around HPN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPN Gene

Proteins for HPN Gene

  • Protein details for HPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05981-HEPS_HUMAN
    Recommended name:
    Serine protease hepsin
    Protein Accession:
    P05981
    Secondary Accessions:
    • B2RDS4

    Protein attributes for HPN Gene

    Size:
    417 amino acids
    Molecular mass:
    45011 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HPN Gene

neXtProt entry for HPN Gene

Proteomics data for HPN Gene at MOPED

Selected DME Specific Peptides for HPN Gene

Post-translational modifications for HPN Gene

  • Glycosylation at Asn 112
  • Modification sites at PhosphoSitePlus

Other Protein References for HPN Gene

Antibody Products

Domains & Families for HPN Gene

Gene Families for HPN Gene

Suggested Antigen Peptide Sequences for HPN Gene

Graphical View of Domain Structure for InterPro Entry

P05981

UniProtKB/Swiss-Prot:

HEPS_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
  • Contains 1 SRCR domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with HPN: view

Function for HPN Gene

Molecular function for HPN Gene

GENATLAS Biochemistry:
hepsin,cell membrane associated serine protease,activating factor VII
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys.
UniProtKB/Swiss-Prot Function:
Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).

Enzyme Numbers (IUBMB) for HPN Gene

genes like me logo Genes that share phenotypes with HPN: view

Animal Models for HPN Gene

MGI Knock Outs for HPN:

Animal Model Products

miRNA for HPN Gene

miRTarBase miRNAs that target HPN

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HPN Gene

Localization for HPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPN Gene

Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HPN Gene COMPARTMENTS Subcellular localization image for HPN gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0043025 neuronal cell body ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HPN: view

Pathways & Interactions for HPN Gene

genes like me logo Genes that share pathways with HPN: view

Pathways by source for HPN Gene

2 Reactome pathways for HPN Gene
1 KEGG pathway for HPN Gene

Gene Ontology (GO) - Biological Process for HPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008360 regulation of cell shape IMP 8346233
GO:0010628 positive regulation of gene expression ISS --
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 19843851
GO:0034769 basement membrane disassembly IDA 16908524
GO:0043066 negative regulation of apoptotic process IDA 15614436
genes like me logo Genes that share ontologies with HPN: view

No data available for SIGNOR curated interactions for HPN Gene

Drugs & Compounds for HPN Gene

(9) Drugs for HPN Gene - From: DrugBank, ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coagulation factor VIIa Approved Pharma Target 0
6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Experimental Pharma Target 0
Benzylsulfinic Acid Experimental Pharma Target 0
CRA_1144 Experimental Pharma Target 0
Taurine Experimental Nutra Non-selective, endogenous glycine receptor partial agonist 26

(1) Additional Compounds for HPN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HPN: view

Transcripts for HPN Gene

Unigene Clusters for HPN Gene

Hepsin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HPN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - - - - - -
SP7: -
SP8:

Relevant External Links for HPN Gene

GeneLoc Exon Structure for
HPN
ECgene alternative splicing isoforms for
HPN

Expression for HPN Gene

mRNA expression in normal human tissues for HPN Gene

mRNA differential expression in normal tissues according to GTEx for HPN Gene

This gene is overexpressed in Liver (x28.3), Pancreas (x8.8), and Kidney - Cortex (x7.8).

Protein differential expression in normal tissues from HIPED for HPN Gene

This gene is overexpressed in Skin (36.5), Plasma (16.1), and Urine (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HPN Gene



SOURCE GeneReport for Unigene cluster for HPN Gene Hs.182385

mRNA Expression by UniProt/SwissProt for HPN Gene

P05981-HEPS_HUMAN
Tissue specificity: Detected in liver and kidney.
genes like me logo Genes that share expression patterns with HPN: view

Protein tissue co-expression partners for HPN Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HPN Gene

Orthologs for HPN Gene

This gene was present in the common ancestor of animals.

Orthologs for HPN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HPN 35
  • 90.09 (n)
  • 93.53 (a)
HPN 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HPN 35
  • 90.33 (n)
  • 94.72 (a)
HPN 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hpn 35
  • 84.67 (n)
  • 88.86 (a)
Hpn 16
Hpn 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HPN 35
  • 99.84 (n)
  • 100 (a)
HPN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hpn 35
  • 84.18 (n)
  • 88.86 (a)
oppossum
(Monodelphis domestica)
Mammalia HPN 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HPN 36
  • 12 (a)
OneToOne
chicken
(Gallus gallus)
Aves HPN 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HPN 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100536154 35
  • 59.04 (n)
  • 54.47 (a)
HPN (1 of 2) 36
  • 51 (a)
OneToMany
HPN (2 of 2) 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11192 37
  • 37 (a)
CG11824 37
  • 40 (a)
CG11836 37
  • 38 (a)
CG1299 37
  • 33 (a)
CG3355 37
  • 39 (a)
CG4386 37
  • 37 (a)
CG4613 37
  • 41 (a)
CG6041 37
  • 36 (a)
CG7829 37
  • 34 (a)
eegrTry 37
  • 37 (a)
mas 37
  • 38 (a)
Sb 37
  • 38 (a)
Tequila 37
  • 34 (a)
zgrTry 37
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004568 35
  • 48.54 (n)
  • 42.98 (a)
worm
(Caenorhabditis elegans)
Secernentea C07G1.1 37
  • 36 (a)
Species with no ortholog for HPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HPN Gene

ENSEMBL:
Gene Tree for HPN (if available)
TreeFam:
Gene Tree for HPN (if available)

Paralogs for HPN Gene

genes like me logo Genes that share paralogs with HPN: view

Variants for HPN Gene

Sequence variations from dbSNP and Humsavar for HPN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12985780 -- 35,058,189(+) ACATA(C/T)ATAtt intron-variant
rs68093093 -- 35,042,005(+) ACGTC(C/T)CCCCA intron-variant, utr-variant-5-prime
rs71167506 -- 35,058,510(+) TAATA(-/ATA)TATTA intron-variant
rs72550255 -- 35,041,037(+) TGGGC(C/T)GCGCC intron-variant, upstream-variant-2KB
rs72550256 -- 35,041,038(+) GGGCC(A/G)CGCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HPN Gene

Variant ID Type Subtype PubMed ID
nsv911610 CNV Loss 21882294
dgv3848n71 CNV Loss 21882294
nsv911613 CNV Loss 21882294
esv2718489 CNV Deletion 23290073

Variation tolerance for HPN Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HPN Gene

Disorders for HPN Gene

MalaCards: The human disease database

(2) MalaCards diseases for HPN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
male reproductive organ cancer
  • male genital cancer
- elite association - COSMIC cancer census association via MalaCards
Search HPN in MalaCards View complete list of genes associated with diseases

Relevant External Links for HPN

Genetic Association Database (GAD)
HPN
Human Genome Epidemiology (HuGE) Navigator
HPN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HPN
genes like me logo Genes that share disorders with HPN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPN Gene

Publications for HPN Gene

  1. A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells. (PMID: 2835076) Leytus S.P. … Davie E.W. (Biochemistry 1988) 2 3 4 67
  2. Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor. (PMID: 19911255) Chen M. … Chai K.X. (Mol. Cell. Biochem. 2010) 3 23
  3. Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA. (PMID: 20015050) Owen K.A. … Ellis V. (Biochem. J. 2010) 3 23
  4. Association of hepsin gene variants with prostate cancer risk and prognosis. (PMID: 20166135) Holt S.K. … Stanford J.L. (Prostate 2010) 3 23
  5. Detection of early prostate cancer using a hepsin-targeted imaging agent. (PMID: 18381435) Kelly K.A. … Weissleder R. (Cancer Res. 2008) 3 23

Products for HPN Gene

Sources for HPN Gene

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