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Aliases for HPCAL1 Gene

Aliases for HPCAL1 Gene

  • Hippocalcin-Like 1 2 3
  • Calcium-Binding Protein BDR-1 2 3 4
  • Visinin-Like Protein 3 2 3 4
  • VILIP-3 3 4
  • BDR1 3 4
  • HLP2 3 4
  • Hippocalcin-Like Protein 1 3

External Ids for HPCAL1 Gene

Previous GeneCards Identifiers for HPCAL1 Gene

  • GC02P010228
  • GC02P010494
  • GC02P010464
  • GC02P010443

Summaries for HPCAL1 Gene

Entrez Gene Summary for HPCAL1 Gene

  • The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for HPCAL1 Gene

HPCAL1 (Hippocalcin-Like 1) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for HPCAL1 Gene

  • May be involved in the calcium-dependent regulation of rhodopsin phosphorylation

Gene Wiki entry for HPCAL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPCAL1 Gene

Genomics for HPCAL1 Gene

Regulatory Elements for HPCAL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HPCAL1 Gene

10,302,889 bp from pter
10,427,617 bp from pter
124,729 bases
Plus strand

Genomic View for HPCAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPCAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPCAL1 Gene

Proteins for HPCAL1 Gene

  • Protein details for HPCAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hippocalcin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q969S5

    Protein attributes for HPCAL1 Gene

    193 amino acids
    Molecular mass:
    22313 Da
    Quaternary structure:
    No Data Available
    • Probably binds two or three calcium ions.

neXtProt entry for HPCAL1 Gene

Proteomics data for HPCAL1 Gene at MOPED

Post-translational modifications for HPCAL1 Gene

  • Ubiquitination at Lys7, Lys63, and Lys174
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for HPCAL1 Gene

Domains for HPCAL1 Gene

Gene Families for HPCAL1 Gene

  • EFHAND :EF-hand domain containing

Protein Domains for HPCAL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • P37235
  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with HPCAL1: view

Function for HPCAL1 Gene

Molecular function for HPCAL1 Gene

GENATLAS Biochemistry:
calcium binding protein,hippocalcin-like,expressed in brain
UniProtKB/Swiss-Prot Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation

Gene Ontology (GO) - Molecular Function for HPCAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with HPCAL1: view

Animal Model Products

miRNA for HPCAL1 Gene

miRTarBase miRNAs that target HPCAL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HPCAL1 Gene

Localization for HPCAL1 Gene

Subcellular locations from

Jensen Localization Image for HPCAL1 Gene COMPARTMENTS Subcellular localization image for HPCAL1 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for HPCAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HPCAL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HPCAL1 Gene

Pathways for HPCAL1 Gene

SuperPathways for HPCAL1 Gene

genes like me logo Genes that share pathways with HPCAL1: view

Pathways by source for HPCAL1 Gene

1 Qiagen pathway for HPCAL1 Gene

Gene Ontology (GO) - Biological Process for HPCAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with HPCAL1: view

Compounds for HPCAL1 Gene

(1) HMDB Compounds for HPCAL1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Novoseek inferred chemical compound relationships for HPCAL1 Gene

Compound -log(P) Hits PubMed IDs
calcium 23.2 4
genes like me logo Genes that share compounds with HPCAL1: view

Transcripts for HPCAL1 Gene

Unigene Clusters for HPCAL1 Gene

Hippocalcin-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPCAL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPCAL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP5: - - - - - -
SP6: - - - -
SP8: - - -
SP9: - -

Relevant External Links for HPCAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HPCAL1 Gene

mRNA expression in normal human tissues for HPCAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPCAL1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.0) and Brain - Cerebellum (4.4).

Protein differential expression in normal tissues for HPCAL1 Gene

This gene is overexpressed in Bone (21.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HPCAL1 Gene

SOURCE GeneReport for Unigene cluster for HPCAL1 Gene Hs.580427

genes like me logo Genes that share expressions with HPCAL1: view

Expression partners for HPCAL1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HPCAL1 Gene

Orthologs for HPCAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HPCAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HPCAL1 35
  • 93.78 (n)
  • 99.48 (a)
  • 99 (a)
(Canis familiaris)
Mammalia HPCAL1 35
  • 94.13 (n)
  • 99.48 (a)
  • 99 (a)
(Mus musculus)
Mammalia Hpcal1 35
  • 92.06 (n)
  • 98.45 (a)
Hpcal1 16
Hpcal1 36
  • 98 (a)
(Pan troglodytes)
Mammalia HPCAL1 35
  • 99.31 (n)
  • 99.48 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Hpcal1 35
  • 92.4 (n)
  • 98.45 (a)
(Monodelphis domestica)
Mammalia HPCAL1 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia HPCAL1 36
  • 90 (a)
(Gallus gallus)
Aves HPCAL1 35
  • 87.74 (n)
  • 98.45 (a)
  • 98 (a)
(Anolis carolinensis)
Reptilia HPCAL1 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hpcal1 35
  • 82.9 (n)
  • 97.41 (a)
(Danio rerio)
Actinopterygii zgc73126 35
zgc:63695 35
  • 83.42 (n)
  • 91.19 (a)
  • 91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5744 37
  • 59 (a)
CG7646 37
  • 47 (a)
Frq 37
  • 58 (a)
Nca 37
  • 89 (a)
Nca 35
  • 70.37 (n)
  • 89.42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007247 35
  • 76.72 (n)
  • 88.36 (a)
(Caenorhabditis elegans)
Secernentea ncs-2 37
  • 51 (a)
ncs-3 37
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 80 (a)
Species with no ortholog for HPCAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HPCAL1 Gene

Gene Tree for HPCAL1 (if available)
Gene Tree for HPCAL1 (if available)

Paralogs for HPCAL1 Gene

genes like me logo Genes that share paralogs with HPCAL1: view

Variants for HPCAL1 Gene

Sequence variations from dbSNP and Humsavar for HPCAL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs741262 -- 10,327,593(-) AGTTA(C/G/T)TTGAA intron-variant
rs867953 -- 10,372,891(+) GACTG(C/T)GGCCC intron-variant
rs867954 -- 10,373,094(+) GAGAG(C/T)GGCAG intron-variant
rs876614 -- 10,408,451(-) CTGGA(A/G)GCCTT intron-variant
rs876615 -- 10,408,407(-) CTGGA(C/G)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HPCAL1 Gene

Variant ID Type Subtype PubMed ID
nsv873639 CNV Loss 21882294
esv27364 CNV Loss 19812545
esv2719644 CNV Deletion 23290073
dgv628e201 CNV Deletion 23290073
esv2719646 CNV Deletion 23290073
esv2719648 CNV Deletion 23290073
esv2719650 CNV Deletion 23290073
nsv873641 CNV Loss 21882294
nsv873642 CNV Loss 21882294
nsv508827 CNV Insertion 20534489
nsv2605 CNV Insertion 18451855
dgv4051n71 CNV Loss 21882294
dgv4052n71 CNV Loss 21882294
esv1007136 CNV Insertion 20482838
dgv679e199 CNV Deletion 23128226

Relevant External Links for HPCAL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPCAL1 Gene

Disorders for HPCAL1 Gene

Relevant External Links for HPCAL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HPCAL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HPCAL1 Gene

Publications for HPCAL1 Gene

  1. Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population. (PMID: 15834280) Kamide K. … Miyata T. (J. Hypertens. 2005) 3 23 48
  2. Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene. (PMID: 8038222) Kobayashi M. … Noguchi T. (Biochim. Biophys. Acta 1994) 2 3 4
  3. Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins. (PMID: 16703469) Jheng F.F. … Chang L.S. (Protein J. 2006) 3 23
  4. The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association. (PMID: 10683417) Spilker C. … Braunewell K.H. (Neuroscience 2000) 3 23
  5. Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain. (PMID: 10851344) Bernstein H.G. … Braunewell K.H. (J. Neurocytol. 1999) 3 23

Products for HPCAL1 Gene

Sources for HPCAL1 Gene

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