Aliases for HPCAL1 Gene
Aliases for HPCAL1 Gene
External Ids for HPCAL1 Gene
- HGNC: 5145
- Entrez Gene: 3241
- Ensembl: ENSG00000115756
- OMIM: 600207
- UniProtKB: P37235
Previous GeneCards Identifiers for HPCAL1 Gene
- GC02P010228
- GC02P010494
- GC02P010464
- GC02P010443
Summaries for HPCAL1 Gene
-
The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for HPCAL1 Gene
HPCAL1 (Hippocalcin Like 1) is a Protein Coding gene. Among its related pathways are Visual Cycle in Retinal Rods. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is HPCA.
UniProtKB/Swiss-Prot for HPCAL1 Gene
-
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
Additional gene information for HPCAL1 Gene
- Monarch Initiative
- Search for HPCAL1 at DataMed
- Search for HPCAL1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPCAL1 Gene
Genomics for HPCAL1 Gene
GeneHancer (GH) Regulatory Elements for HPCAL1 Gene
- Top Transcription factor binding sites by QIAGEN in the HPCAL1 gene promoter:
Regulatory Element Products
Genomic Locations for HPCAL1 Gene
- chr2:10,302,889-10,427,617
- (GRCh38/hg38)
- Size:
- 124,729 bases
- Orientation:
- Plus strand
- chr2:10,443,015-10,567,743
- (GRCh37/hg19)
Genomic View for HPCAL1 Gene
- Cytogenetic band:
-
- 2p25.1 by Ensembl
- 2p25.1 by Entrez Gene
- 2p25.1 by HGNC


RefSeq DNA sequence for HPCAL1 Gene
Proteins for HPCAL1 Gene
-
Protein details for HPCAL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P37235-HPCL1_HUMAN
- Recommended name:
- Hippocalcin-like protein 1
- Protein Accession:
- P37235
- Q969S5
Protein attributes for HPCAL1 Gene
- Size:
- 193 amino acids
- Molecular mass:
- 22313 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Probably binds two or three calcium ions.
Protein Expression for HPCAL1 Gene
Post-translational modifications for HPCAL1 Gene
- Ubiquitination at posLast=77
Other Protein References for HPCAL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for HPCAL1
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- GeneTex HPCAL1 antibody for HPCAL1
Protein Products
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-
ProSci Proteins for HPCAL1
-
Abcam proteins for HPCAL1
Assay Products
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Cloud-Clone Corp. Assay Kits for HPCAL1
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-
Quality Products:
No data available for DME Specific Peptides for HPCAL1 Gene
Domains & Families for HPCAL1 Gene
Gene Families for HPCAL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for HPCAL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HPCAL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P37235- Family:
-
- Belongs to the recoverin family.
Function for HPCAL1 Gene
Molecular function for HPCAL1 Gene
- GENATLAS Biochemistry:
- calcium binding protein,hippocalcin-like,expressed in brain
- UniProtKB/Swiss-Prot Function:
- May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
Phenotypes From GWAS Catalog for HPCAL1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for HPCAL1 Gene
- GenomeRNAi human phenotypes for HPCAL1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
Animal Model Products
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-
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-
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miRNA for HPCAL1 Gene
- miRTarBase miRNAs that target HPCAL1
-
- hsa-mir-7-5p (MIRT025893)
- hsa-mir-3976 (MIRT487657)
- hsa-mir-8085 (MIRT487658)
- hsa-mir-6731-5p (MIRT487659)
- hsa-mir-4745-3p (MIRT487660)
- hsa-mir-1538 (MIRT487661)
- hsa-mir-873-5p (MIRT487662)
- hsa-mir-6746-5p (MIRT487663)
- hsa-mir-6784-5p (MIRT487664)
- hsa-mir-4532 (MIRT487665)
- hsa-mir-1247-3p (MIRT487666)
- hsa-mir-4747-3p (MIRT487667)
- hsa-mir-6165 (MIRT487668)
- hsa-mir-2278 (MIRT487669)
- hsa-mir-1249-5p (MIRT736436)
- hsa-mir-125a-3p (MIRT736628)
- hsa-mir-1321 (MIRT737334)
- hsa-mir-3197 (MIRT741100)
- hsa-mir-3934-5p (MIRT743101)
- hsa-mir-4419a (MIRT744181)
- hsa-mir-4510 (MIRT745620)
- hsa-mir-4739 (MIRT748052)
- hsa-mir-4756-5p (MIRT748424)
- hsa-mir-4779 (MIRT748735)
- hsa-mir-5587-5p (MIRT751008)
- hsa-mir-6127 (MIRT752095)
- hsa-mir-6129 (MIRT752167)
- hsa-mir-6130 (MIRT752256)
- hsa-mir-6133 (MIRT752360)
- hsa-mir-6797-5p (MIRT756196)
- hsa-mir-6801-5p (MIRT756372)
- hsa-mir-6880-5p (MIRT758305)
- hsa-mir-6894-5p (MIRT758772)
- hsa-mir-7154-3p (MIRT759221)
- hsa-mir-764 (MIRT759533)
- hsa-mir-765 (MIRT759561)
- hsa-mir-766-5p (MIRT759640)
- hsa-mir-7847-3p (MIRT759842)
miRNA Products
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- Yeast expression
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HPCAL1 Gene
Localization for HPCAL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HPCAL1 Gene
- Membrane; Lipid-anchor.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016020 | membrane | IEA | -- |
GO:0070062 | extracellular exosome | IDA,HDA | 23376485 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HPCAL1 Gene
Pathways & Interactions for HPCAL1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Visual Cycle in Retinal Rods |
Pathways by source for HPCAL1 Gene
1 Qiagen pathway for HPCAL1 Gene
Interacting Proteins for HPCAL1 Gene
No data available for SIGNOR curated interactions for HPCAL1 Gene
Drugs & Compounds for HPCAL1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
calcium | Approved | Nutra | 0 |
Transcripts for HPCAL1 Gene
mRNA/cDNA for HPCAL1 Gene
- (17) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (315) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HPCAL1
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HPCAL1
- GenScript: Design CRISPR guide RNA sequences for HPCAL1
miRNA Products
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Inhibitory RNA Products
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Clone Products
-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available HPCAL1 gene related products
- orf clones - Search results for available HPCAL1 gene related products
- Applied Biological Materials Clones for HPCAL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
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SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||
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SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP9: | - | - |
Expression for HPCAL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Eye (Sensory Organs)
- Cholinergic Amacrine Cells Inner Nuclear Layer
- Mature Rod Cells Outer Nuclear Layer
-
Neurons
- Cholinergic Amacrine Cells Inner Nuclear Layer
- Mature Rod Cells Outer Nuclear Layer
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for HPCAL1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HPCAL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HPCAL1 Gene:
HPCAL1SOURCE GeneReport for Unigene cluster for HPCAL1 Gene:
Hs.580427Evidence on tissue expression from TISSUES for HPCAL1 Gene
- Nervous system(4.7)
- Liver(4.2)
- Pancreas(4.2)
Primer Products
-
OriGene qPCR primer pairs for HPCAL1
-
OriGene qPCR primer pairs and template standards for HPCAL1
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No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HPCAL1 Gene
Orthologs for HPCAL1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | HPCAL1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | HPCAL1 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | HPCAL1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | HPCAL1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Hpcal1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Hpcal1 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | HPCAL1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | HPCAL1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | HPCAL1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | hpcal1 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | HPCAL1 34 |
|
OneToOne | |
zgc:63695 33 |
|
||||
zgc73126 33 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007247 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Nca 35 33 |
|
||
CG5744 35 |
|
|
|||
Frq 35 |
|
|
|||
CG7646 35 |
|
|
|||
worm (Caenorhabditis elegans) |
Secernentea | ncs-3 35 |
|
|
|
ncs-2 35 |
|
|
|||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for HPCAL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HPCAL1 Gene
Paralogs for HPCAL1 Gene
(24) SIMAP similar genes for HPCAL1 Gene using alignment to 5 proteins:
Variants for HPCAL1 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000024924 | -- | 10,419,555(+) | AGAG/AG | intron_variant | |
rs1000047474 | -- | 10,410,921(+) | C/G | intron_variant | |
rs1000048108 | -- | 10,338,826(+) | G/T | genic_upstream_transcript_variant, intron_variant | |
rs1000075751 | -- | 10,300,967(+) | C/T | upstream_transcript_variant | |
rs1000086534 | -- | 10,353,608(+) | C/T | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv587e201 | CNV | deletion | 23290073 |
dgv679e199 | CNV | deletion | 23128226 |
esv1007136 | CNV | insertion | 20482838 |
esv2719644 | CNV | deletion | 23290073 |
esv2719646 | CNV | deletion | 23290073 |
esv2719648 | CNV | deletion | 23290073 |
esv2719650 | CNV | deletion | 23290073 |
esv27364 | CNV | loss | 19812545 |
esv3395574 | CNV | duplication | 20981092 |
esv3446200 | CNV | insertion | 20981092 |
esv3589797 | CNV | loss | 21293372 |
esv3589798 | CNV | loss | 21293372 |
nsv1007185 | CNV | gain | 25217958 |
nsv1071973 | CNV | deletion | 25765185 |
nsv1077349 | CNV | duplication | 25765185 |
nsv2605 | CNV | insertion | 18451855 |
nsv508827 | CNV | insertion | 20534489 |
Additional Variant Information for HPCAL1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HPCAL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPCAL1 Gene
Disorders for HPCAL1 Gene
Additional Disease Information for HPCAL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for HPCAL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HPCAL1 Gene
Publications for HPCAL1 Gene
- Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population. (PMID: 15834280) Kamide K … Miyata T (Journal of hypertension 2005) 3 22 44 58
- Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene. (PMID: 8038222) Kobayashi M … Noguchi T (Biochimica et biophysica acta 1994) 2 3 4 58
- Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins. (PMID: 16703469) Jheng FF … Chang LS (The protein journal 2006) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner. (PMID: 14739275) Oikawa K … Tateno M (The Journal of biological chemistry 2004) 2 3 58
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 26 available HPCAL1 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Search results for 20 available HPCAL1 Proteins ranked by validation data
- Compare Top HPCAL1 Proteins
- GeneTex HPCAL1 antibody for HPCAL1
- Search GeneTex for Proteins for HPCAL1
- ViGene Biosciences adenoviral particle packaged cDNA for HPCAL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HPCAL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HPCAL1 gene
- Search ViGene Biosciences for HPCAL1
- Search for HPCAL1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for HPCAL1
- Horizon Cell Lines for HPCAL1
- genomics-online: cdna clones - Search results for available HPCAL1 gene related products
- orf clones - Search results for available HPCAL1 gene related products
- genomics-online: gRNA clones - Search results for available HPCAL1 gene related products
- genomics-online: primer clones - Search results for available HPCAL1 gene related products
- genomics-online: shRNA clones - Search results for available HPCAL1 gene related products
Sources for HPCAL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew