Aliases for HOXD11 Gene
External Ids for HOXD11 Gene
Previous HGNC Symbols for HOXD11 Gene
Previous GeneCards Identifiers for HOXD11 Gene
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD11 Gene
HOXD11 (Homeobox D11) is a Protein Coding gene. Diseases associated with HOXD11 include syndactyly, type v and brachydactyly-syndactyly syndrome. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.
UniProtKB/Swiss-Prot for HOXD11 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.