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Aliases for HOXD10 Gene

Aliases for HOXD10 Gene

  • Homeobox D10 2 3
  • HOX4D 3 4 6
  • Homeobox Protein Hox-4E 3 4
  • Homeobox Protein Hox-4D 3 4
  • Homeo Box D10 2 3
  • HOX4E 3 4
  • Homeobox Protein Hox-D10 3
  • Homeo Box 4D 3
  • Hox-4.4 3
  • HOX4 3

External Ids for HOXD10 Gene

Previous Symbols for HOXD10 Gene

  • HOX4
  • HOX4D

Summaries for HOXD10 Gene

Entrez Gene Summary for HOXD10 Gene

  • This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXD10 Gene

HOXD10 (Homeobox D10) is a Protein Coding gene. Diseases associated with HOXD10 include vertical talus, congenital and congenital vertical talus, bilateral. Among its related pathways are Proteoglycans in cancer and MicroRNAs in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is HOXD11.

UniProtKB/Swiss-Prot for HOXD10 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXD10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD10 Gene

Genomics for HOXD10 Gene

Genomic Location for HOXD10 Gene

Start:
176,108,790 bp from pter
End:
176,119,942 bp from pter
Size:
11,153 bases
Orientation:
Plus strand

Genomic View for HOXD10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXD10 Gene

Regulatory Elements for HOXD10 Gene

Proteins for HOXD10 Gene

  • Protein details for HOXD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28358-HXD10_HUMAN
    Recommended name:
    Homeobox protein Hox-D10
    Protein Accession:
    P28358
    Secondary Accessions:
    • Q6NT10

    Protein attributes for HOXD10 Gene

    Size:
    340 amino acids
    Molecular mass:
    38411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXD10 Gene

Proteomics data for HOXD10 Gene at MOPED

Post-translational modifications for HOXD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXD10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXD10 Gene

Domains for HOXD10 Gene

Gene Families for HOXD10 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for HOXD10 Gene

UniProtKB/Swiss-Prot:

HXD10_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • P28358
Family:
  • Belongs to the Abd-B homeobox family.:
    • P28358
genes like me logo Genes that share domains with HOXD10: view

Function for HOXD10 Gene

Molecular function for HOXD10 Gene

GENATLAS Biochemistry: homeo box D10(4D),homologous to mouse Hox-4.5
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXD10: view
genes like me logo Genes that share phenotypes with HOXD10: view

Animal Models for HOXD10 Gene

MGI Knock Outs for HOXD10:

miRNA for HOXD10 Gene

miRTarBase miRNAs that target HOXD10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXD10 Gene

Localization for HOXD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXD10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXD10 Gene COMPARTMENTS Subcellular localization image for HOXD10 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXD10: view

Pathways for HOXD10 Gene

genes like me logo Genes that share pathways with HOXD10: view

Pathways by source for HOXD10 Gene

2 KEGG pathways for HOXD10 Gene

Gene Ontology (GO) - Biological Process for HOXD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development --
GO:0006351 transcription, DNA-templated IEA --
GO:0007338 single fertilization IEA --
GO:0007519 skeletal muscle tissue development IEA --
GO:0008344 adult locomotory behavior IEA --
genes like me logo Genes that share ontologies with HOXD10: view

Transcripts for HOXD10 Gene

mRNA/cDNA for HOXD10 Gene

Unigene Clusters for HOXD10 Gene

Homeobox D10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXD10 Gene

No ASD Table

Relevant External Links for HOXD10 Gene

GeneLoc Exon Structure for
HOXD10
ECgene alternative splicing isoforms for
HOXD10

Expression for HOXD10 Gene

mRNA expression in normal human tissues for HOXD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXD10 Gene

This gene is overexpressed in Uterus (13.3), Vagina (7.8), Colon - Sigmoid (6.9), Cervix - Ectocervix (5.5), Kidney - Cortex (4.9), and Prostate (4.8).

SOURCE GeneReport for Unigene cluster for HOXD10 Gene Hs.123070

mRNA Expression by UniProt/SwissProt for HOXD10 Gene

P28358-HXD10_HUMAN
Tissue specificity: Strongly expressed in the adult male and female urogenital tracts
genes like me logo Genes that share expressions with HOXD10: view

Orthologs for HOXD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXD10 36
  • 99.8 (n)
  • 99.71 (a)
HOXD10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXD10 36
  • 97.45 (n)
  • 99.41 (a)
HOXD10 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXD10 37
  • 83 (a)
OneToOne
HOXD11 36
  • 98.24 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Hoxd10 36
  • 97.16 (n)
  • 98.82 (a)
Hoxd10 16
Hoxd10 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXD10 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxd10 36
  • 97.45 (n)
  • 98.82 (a)
chicken
(Gallus gallus)
Aves HOXD10 36
  • 87.08 (n)
  • 92.31 (a)
HOXD10 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXD10 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68611 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxd10 36
  • 83.04 (n)
  • 86.09 (a)
Str.2493 36
zebrafish
(Danio rerio)
Actinopterygii hoxd10a 36
  • 70.9 (n)
  • 70.69 (a)
hoxd10a 37
  • 69 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 22 (a)
OneToMany
Species with no ortholog for HOXD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXD10 Gene

ENSEMBL:
Gene Tree for HOXD10 (if available)
TreeFam:
Gene Tree for HOXD10 (if available)

Paralogs for HOXD10 Gene

Selected SIMAP similar genes for HOXD10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXD10: view

Variants for HOXD10 Gene

Sequence variations from dbSNP and Humsavar for HOXD10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs818630 -- 176,115,295(-) TTTGA(A/C)AAGGC upstream-variant-2KB
rs2593777 -- 176,117,397(+) AAGCC(C/G)CAGCT synonymous-codon, reference
rs2593778 -- 176,117,398(+) AGCCG(C/G)AGCTC reference, missense
rs3731792 -- 176,118,858(+) AAAAC(A/C/G)AAAAC intron-variant
rs3731793 -- 176,118,877(+) aaaac(A/C)aaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOXD10 Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV Gain 20364138
nsv875437 CNV Loss 21882294
nsv875438 CNV Loss 21882294
nsv527187 CNV Loss 19592680
nsv517968 CNV Loss 19592680
dgv4368n71 CNV Loss 21882294
nsv875442 CNV Loss 21882294
nsv875446 CNV Loss 21882294

Relevant External Links for HOXD10 Gene

HapMap Linkage Disequilibrium report
HOXD10
Human Gene Mutation Database (HGMD)
HOXD10

Disorders for HOXD10 Gene

(1) OMIM Diseases for HOXD10 Gene (142984)

UniProtKB/Swiss-Prot

HXD10_HUMAN
  • Vertical talus, congenital (CVT) [MIM:192950]: A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence. {ECO:0000269 PubMed:15146389}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for HOXD10 Gene

(2) Novoseek inferred disease relationships for HOXD10 Gene

Disease -log(P) Hits PubMed IDs
vertical talus, congenital 94.9 1
charcot-marie-tooth disease 76 1

Relevant External Links for HOXD10

Genetic Association Database (GAD)
HOXD10
Human Genome Epidemiology (HuGE) Navigator
HOXD10
genes like me logo Genes that share disorders with HOXD10: view

Publications for HOXD10 Gene

  1. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (PMID: 1756725) Zappavigna V. … Duboule D. (EMBO J. 1991) 3 4 23
  2. A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease. (PMID: 15146389) Shrimpton A.E. … Hootnick D.R. (Am. J. Hum. Genet. 2004) 3 4 23
  3. Congenital vertical talus in four generations of the same family. (PMID: 15368082) Levinsohn E.M. … Hootnick D.R. (Skeletal Radiol. 2004) 3 23
  4. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. (PMID: 18922890) Reddy S.D. … Kumar R. (Cancer Res. 2008) 3 23
  5. Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. (PMID: 1351871) Redline R.W. … Collins T. (Genomics 1992) 3 4

Products for HOXD10 Gene

Sources for HOXD10 Gene

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