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Aliases for HOXD10 Gene

Aliases for HOXD10 Gene

  • Homeobox D10 2 3 5
  • Homeobox Protein Hox-4D 3 4
  • Homeobox Protein Hox-4E 3 4
  • Homeo Box D10 2 3
  • HOX4D 3 4
  • HOX4E 3 4
  • Homeo Box 4D 3
  • Hox-4.4 3
  • HOX4 3

External Ids for HOXD10 Gene

Previous HGNC Symbols for HOXD10 Gene

  • HOX4
  • HOX4D

Previous GeneCards Identifiers for HOXD10 Gene

  • GC02P175034
  • GC02P175642
  • GC02P176945
  • GC02P177184
  • GC02P176807
  • GC02P176689
  • GC02P168858
  • GC02P176973

Summaries for HOXD10 Gene

Entrez Gene Summary for HOXD10 Gene

  • This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXD10 Gene

HOXD10 (Homeobox D10) is a Protein Coding gene. Diseases associated with HOXD10 include vertical talus, congenital and congenital vertical talus, unilateral. Among its related pathways are MicroRNAs in cancer and Proteoglycans in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HOXD11.

UniProtKB/Swiss-Prot for HOXD10 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXD10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD10 Gene

Genomics for HOXD10 Gene

Regulatory Elements for HOXD10 Gene

Enhancers for HOXD10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HOXD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXD10 Gene

176,108,790 bp from pter
176,119,942 bp from pter
11,153 bases
Plus strand

Genomic View for HOXD10 Gene

Genes around HOXD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXD10 Gene

Proteins for HOXD10 Gene

  • Protein details for HOXD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Hox-D10
    Protein Accession:
    Secondary Accessions:
    • Q6NT10

    Protein attributes for HOXD10 Gene

    340 amino acids
    Molecular mass:
    38411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXD10 Gene

Proteomics data for HOXD10 Gene at MOPED

Post-translational modifications for HOXD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXD10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXD10 Gene

Domains & Families for HOXD10 Gene

Gene Families for HOXD10 Gene

Protein Domains for HOXD10 Gene

Suggested Antigen Peptide Sequences for HOXD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXD10: view

Function for HOXD10 Gene

Molecular function for HOXD10 Gene

GENATLAS Biochemistry:
homeo box D10(4D),homologous to mouse Hox-4.5
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with HOXD10: view
genes like me logo Genes that share phenotypes with HOXD10: view

Human Phenotype Ontology for HOXD10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HOXD10 Gene

MGI Knock Outs for HOXD10:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HOXD10 Gene

Localization for HOXD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXD10 Gene

Subcellular locations from

Jensen Localization Image for HOXD10 Gene COMPARTMENTS Subcellular localization image for HOXD10 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HOXD10 Gene

Pathways & Interactions for HOXD10 Gene

genes like me logo Genes that share pathways with HOXD10: view

Pathways by source for HOXD10 Gene

2 KEGG pathways for HOXD10 Gene

SIGNOR curated interactions for HOXD10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HOXD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007519 skeletal muscle tissue development IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0009954 proximal/distal pattern formation IEA --
genes like me logo Genes that share ontologies with HOXD10: view

Drugs & Compounds for HOXD10 Gene

No Compound Related Data Available

Transcripts for HOXD10 Gene

mRNA/cDNA for HOXD10 Gene

Unigene Clusters for HOXD10 Gene

Homeobox D10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXD10 Gene

No ASD Table

Relevant External Links for HOXD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOXD10 Gene

mRNA expression in normal human tissues for HOXD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXD10 Gene

This gene is overexpressed in Uterus (x13.3), Vagina (x7.8), Colon - Sigmoid (x6.9), Cervix - Ectocervix (x5.5), Kidney - Cortex (x4.9), and Prostate (x4.8).

SOURCE GeneReport for Unigene cluster for HOXD10 Gene Hs.123070

mRNA Expression by UniProt/SwissProt for HOXD10 Gene

Tissue specificity: Strongly expressed in the adult male and female urogenital tracts.
genes like me logo Genes that share expression patterns with HOXD10: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HOXD10 Gene

Orthologs for HOXD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HOXD10 35
  • 97.45 (n)
  • 99.41 (a)
HOXD10 36
  • 99 (a)
(Canis familiaris)
Mammalia HOXD11 35
  • 98.24 (n)
  • 100 (a)
HOXD10 36
  • 83 (a)
(Mus musculus)
Mammalia Hoxd10 35
  • 97.16 (n)
  • 98.82 (a)
Hoxd10 16
Hoxd10 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hoxd10 35
  • 97.45 (n)
  • 98.82 (a)
(Monodelphis domestica)
Mammalia HOXD10 36
  • 93 (a)
(Pan troglodytes)
Mammalia HOXD10 35
  • 99.8 (n)
  • 99.71 (a)
HOXD10 36
  • 100 (a)
(Gallus gallus)
Aves HOXD10 35
  • 87.08 (n)
  • 92.31 (a)
HOXD10 36
  • 92 (a)
(Anolis carolinensis)
Reptilia HOXD10 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxd10 35
  • 83.04 (n)
  • 86.09 (a)
Str.2493 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68611 35
(Danio rerio)
Actinopterygii hoxd10a 35
  • 70.9 (n)
  • 70.69 (a)
hoxd10a 36
  • 69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for HOXD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXD10 Gene

Gene Tree for HOXD10 (if available)
Gene Tree for HOXD10 (if available)

Paralogs for HOXD10 Gene

(2) SIMAP similar genes for HOXD10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXD10: view

Variants for HOXD10 Gene

Sequence variations from dbSNP and Humsavar for HOXD10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_022582 Vertical talus, congenital (CVT)
rs818630 -- 176,115,295(-) TTTGA(A/C)AAGGC upstream-variant-2KB
rs3731792 -- 176,118,858(+) AAAAC(A/C/G)AAAAC intron-variant
rs3731793 -- 176,118,877(+) aaaac(A/C)aaaac intron-variant
rs6147035 -- 176,119,465(+) ATATA(-/TATATA/TATATATATATATATA/TATATATATATATATATA)AAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HOXD10 Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV Gain 20364138
nsv875437 CNV Loss 21882294
nsv875438 CNV Loss 21882294
nsv527187 CNV Loss 19592680
nsv517968 CNV Loss 19592680
dgv4368n71 CNV Loss 21882294
nsv875442 CNV Loss 21882294
nsv875446 CNV Loss 21882294

Variation tolerance for HOXD10 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXD10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD10 Gene

Disorders for HOXD10 Gene

MalaCards: The human disease database

(8) MalaCards diseases for HOXD10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vertical talus, congenital
  • charcot-marie-tooth disease, foot deformity of
congenital vertical talus, unilateral
congenital vertical talus, bilateral
syndactyly, type v
  • syndactyly type 5
  • syndactyly type 2
- elite association - COSMIC cancer census association via MalaCards


  • Vertical talus, congenital (CVT) [MIM:192950]: A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence. {ECO:0000269 PubMed:15146389}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HOXD10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HOXD10: view

No data available for Genatlas for HOXD10 Gene

Publications for HOXD10 Gene

  1. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. (PMID: 1756725) Zappavigna V. … Duboule D. (EMBO J. 1991) 3 4 23 67
  2. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. (PMID: 18922890) Reddy S.D. … Kumar R. (Cancer Res. 2008) 3 23
  3. A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease. (PMID: 15146389) Shrimpton A.E. … Hootnick D.R. (Am. J. Hum. Genet. 2004) 3 23
  4. Congenital vertical talus in four generations of the same family. (PMID: 15368082) Levinsohn E.M. … Hootnick D.R. (Skeletal Radiol. 2004) 3 23
  5. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3

Products for HOXD10 Gene

Sources for HOXD10 Gene