Aliases for HOXD8 Gene
Aliases for HOXD8 Gene
External Ids for HOXD8 Gene
- HGNC: 5139
- Entrez Gene: 3234
- Ensembl: ENSG00000175879
- OMIM: 142985
- UniProtKB: P13378
Previous HGNC Symbols for HOXD8 Gene
- HOX4
- HOX4E
Previous GeneCards Identifiers for HOXD8 Gene
- GC02P175047
- GC02P175655
- GC02P176958
- GC02P177197
- GC02P177195
- GC02P176819
- GC02P176702
- GC02P168871
- GC02P176994
Summaries for HOXD8 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
GeneCards Summary for HOXD8 Gene
HOXD8 (Homeobox D8) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is HOXA7.
UniProtKB/Swiss-Prot for HOXD8 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD8 Gene
Genomics for HOXD8 Gene
Regulatory Elements for HOXD8 Gene
Enhancers for HOXD8 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around HOXD8 on UCSC Golden Path with GeneCards custom track
Promoters for HOXD8 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around HOXD8 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HOXD8 Gene
- Chromosome:
- 2
- Start:
- 176,129,694 bp from pter
- End:
- 176,132,695 bp from pter
- Size:
- 3,002 bases
- Orientation:
- Plus strand
Genomic View for HOXD8 Gene
Genes around HOXD8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
HOXD8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXD8 Gene
Proteins for HOXD8 Gene
-
Protein details for HOXD8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13378-HXD8_HUMAN
- Recommended name:
- Homeobox protein Hox-D8
- Protein Accession:
- P13378
- F8WBG7
- Q5BL00
- Q8IXZ1
Protein attributes for HOXD8 Gene
- Size:
- 290 amino acids
- Molecular mass:
- 31911 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXD8 Gene
Post-translational modifications for HOXD8 Gene
Other Protein References for HOXD8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXD8
- Abcam antibodies for HOXD8
- Invitrogen Antibodies for HOXD8
- antibodies-online Antibodies for HOXD8: See all 47
- GeneTex HOXD8 antibody for HOXD8
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXD8
Protein Products
-
OriGene Purified Proteins for HOXD8
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXD8
- Origene Custom Protein Services for HOXD8
- antibodies-online Proteins for HOXD8: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXD8
- Abcam proteins for HOXD8
Assay Products
- antibodies-online Kits for HOXD8: See all 2
No data available for DME Specific Peptides for HOXD8 Gene
Domains & Families for HOXD8 Gene
Gene Families for HOXD8 Gene
Protein Domains for HOXD8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXD8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P13378UniProtKB/Swiss-Prot:
HXD8_HUMAN :- Contains 1 homeobox DNA-binding domain.
- Belongs to the Antp homeobox family.
- Domain:
-
- Contains 1 homeobox DNA-binding domain.
- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXD8 Gene
Molecular function for HOXD8 Gene
- GENATLAS Biochemistry:
- homeo box D8(4E),homologous to mouse Hox-4.3,Drosophila antp,Ubx,abd-A
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXD8 Gene
- MGI mutant phenotypes for HOXD8:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXD8:
Animal Models for HOXD8 Gene
- MGI Knock Outs for HOXD8:
-
- Hoxd8 tm1Jdes
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
- Search ViGene Biosciences for HOXD8
CRISPR Products
-
OriGene CRISPR knockouts for HOXD8
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD8
- GenScript: Design CRISPR guide RNA sequences for HOXD8
miRNA for HOXD8 Gene
- miRTarBase miRNAs that target HOXD8
miRNA Products
- Search ViGene Biosciences for HOXD8
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for HOXD8
- Browse OriGene Inhibitory RNA Products For HOXD8
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
Clone Products
- OriGene clones in human for HOXD8
- OriGene ORF clones in human,mouse for HOXD8
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- Addgene plasmids for HOXD8
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXD8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXD8 Gene
Localization for HOXD8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXD8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
No data available for Gene Ontology (GO) - Cellular Components for HOXD8 Gene
Pathways & Interactions for HOXD8 Gene
More details on SuperPathways for HOXD8
No Data Available
Interacting Proteins for HOXD8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0048705 | skeletal system morphogenesis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXD8 Gene
Transcripts for HOXD8 Gene
mRNA/cDNA for HOXD8 Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (36) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXD8
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD8
- GenScript: Design CRISPR guide RNA sequences for HOXD8
miRNA Products
- Search ViGene Biosciences for HOXD8
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for HOXD8
- Browse OriGene Inhibitory RNA Products For HOXD8
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
Clone Products
- OriGene clones in human for HOXD8
- OriGene ORF clones in human,mouse for HOXD8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXD8
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: |
Expression for HOXD8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Somite (Muscoskeletal System)
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
- Thoracic Mesenchymal Sclerotome
- Sacral Mesenchymal Sclerotome
- Lumbar Mesenchymal Sclerotome
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Vertebral Body
- Osteochondro Mesenchymal Cells Vertebrae
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Vertebral Body
- Osteochondro Mesenchymal Cells Vertebrae
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Tendon amp Ligament
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
- Head Mesenchyme (Muscoskeletal System)
- Kidney (Urinary System)
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HOXD8 Gene
This gene is overexpressed in Kidney - Cortex (x8.0).
This gene is overexpressed in Testis (49.1), Fetal testis (11.2), and Platelet (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXD8 Gene
SOURCE GeneReport for Unigene cluster for HOXD8 Gene Hs.301963
Primer Products
-
OriGene qPCR primer pairs for HOXD8
No data available for mRNA Expression by UniProt/SwissProt for HOXD8 Gene
Orthologs for HOXD8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HOXD8 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXD8 35 |
|
||
| HOXD8 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Hoxd8 35 |
|
||
| Hoxd8 16 |
|
||||
| Hoxd8 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | HOXD8 35 |
|
||
| HOXD8 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | HOXD8 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXD8 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXD8 35 |
|
||
| HOXD8 36 |
|
OneToOne | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxd8 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68588 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | abd-A 36 |
|
ManyToMany | |
| Ubx 36 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | lin-39 36 |
|
ManyToMany | |
| mab-5 36 |
|
ManyToMany |
- Species with no ortholog for HOXD8:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for HOXD8 Gene
Paralogs for HOXD8 Gene
(24) SIMAP similar genes for HOXD8 Gene using alignment to 2 proteins:
Variants for HOXD8 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs112559843 | -- | 176,132,547(+) | CAGAC(A/G)TCGGT | utr-variant-3-prime | |
| rs36051423 | -- | 176,132,850(+) | AAAAA(-/A)GGCCG | downstream-variant-500B | |
| rs138242849 | -- | 176,131,779(+) | TTAAA(A/G)AAGTT | utr-variant-3-prime | |
| rs148663631 | -- | 176,132,626(+) | ACGCA(G/T)AAAAA | utr-variant-3-prime | |
| rs78045814 | -- | 176,133,161(+) | TAACA(C/T)TCCCG | downstream-variant-500B |
Residual Variation Intolerance Score:
72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.34;
63.20% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HOXD8 Gene
Disorders for HOXD8 Gene
Relevant External Links for HOXD8
No disorders were found for HOXD8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXD8 Gene
Publications for HOXD8 Gene
- Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 48 67
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
- Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
- A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3
Products for HOXD8 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse DNA Damage and Repair Kits
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HOXD8
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXD8
- Origene Custom Protein Services for HOXD8
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for HOXD8
- Browse OriGene Inhibitory RNA Products For HOXD8
- OriGene qPCR primer pairs for HOXD8
- OriGene CRISPR knockouts for HOXD8
- OriGene clones in human for HOXD8
- OriGene ORF clones in human,mouse for HOXD8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript Custom Purified and Recombinant Proteins Services for HOXD8
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- GenScript: Design CRISPR guide RNA sequences for HOXD8
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- Novus Biologicals Antibodies for HOXD8
- Novus Biologicals proteins and lysates for HOXD8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HOXD8
- Abcam proteins for HOXD8
- Search for Assays for HOXD8 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Addgene plasmids for HOXD8
- antibodies-online Antibodies for HOXD8: See all 47
- antibodies-online Kits for HOXD8: See all 2
- antibodies-online Proteins for HOXD8: See all 9
- Search antibodies-online for peptides
- GeneTex HOXD8 antibody for HOXD8
- Search GeneTex for Proteins for HOXD8
- ViGene Biosciences adenoviral particle packaged cDNA for HOXD8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HOXD8 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HOXD8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
- Search ViGene Biosciences for HOXD8
- Search ViGene Biosciences for HOXD8
- Santa Cruz Biotechnology (SCBT) Antibodies for HOXD8
- Search Santa Cruz Biotechnology (SCBT) for HOXD8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HOXD8
Sources for HOXD8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
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- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
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- (119) GeneReviews
- (120) GeneTex
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- (149) ENCODE
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- (151) Horizon