Aliases for HOXD8 Gene
Aliases for HOXD8 Gene
External Ids for HOXD8 Gene
- HGNC: 5139
- Entrez Gene: 3234
- Ensembl: ENSG00000175879
- OMIM: 142985
- UniProtKB: P13378
Previous HGNC Symbols for HOXD8 Gene
- HOX4
- HOX4E
Previous GeneCards Identifiers for HOXD8 Gene
- GC02P175047
- GC02P175655
- GC02P176958
- GC02P177197
- GC02P177195
- GC02P176819
- GC02P176702
- GC02P168871
- GC02P176994
Summaries for HOXD8 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
GeneCards Summary for HOXD8 Gene
HOXD8 (Homeobox D8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is HOXC8.
UniProtKB/Swiss-Prot for HOXD8 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD8 Gene
Genomics for HOXD8 Gene
GeneHancer (GH) Regulatory Elements for HOXD8 Gene
Regulatory Element Products
Genomic Locations for HOXD8 Gene
- chr2:176,129,694-176,132,695
- (GRCh38/hg38)
- Size:
- 3,002 bases
- Orientation:
- Plus strand
- chr2:176,994,422-176,997,423
- (GRCh37/hg19)
Genomic View for HOXD8 Gene
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC


RefSeq DNA sequence for HOXD8 Gene
Proteins for HOXD8 Gene
-
Protein details for HOXD8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13378-HXD8_HUMAN
- Recommended name:
- Homeobox protein Hox-D8
- Protein Accession:
- P13378
- F8WBG7
- Q5BL00
- Q8IXZ1
Protein attributes for HOXD8 Gene
- Size:
- 290 amino acids
- Molecular mass:
- 31911 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXD8 Gene
Post-translational modifications for HOXD8 Gene
Other Protein References for HOXD8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXD8
- Invitrogen Antibodies for HOXD8
- Search GeneTex for Antibodies for HOXD8
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXD8
Protein Products
-
OriGene Purified Proteins for HOXD8
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXD8
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- antibodies-online: Search results for 7 available HOXD8 Proteins ranked by validation data
- Compare Top HOXD8 Proteins
-
Quality Products:
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-
Abcam proteins for HOXD8
Assay Products
- antibodies-online: Search results for 2 available HOXD8 Elisa Kits ranked by validation data
- Compare Top HOXD8 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for HOXD8 Gene
Domains & Families for HOXD8 Gene
Gene Families for HOXD8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HOXD8 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXD8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P13378- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXD8 Gene
Molecular function for HOXD8 Gene
- GENATLAS Biochemistry:
- homeo box D8(4E),homologous to mouse Hox-4.3,Drosophila antp,Ubx,abd-A
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Phenotypes From GWAS Catalog for HOXD8 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 1756725 |
GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 1756725 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA binding transcription factor activity | IEA | -- |
GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXD8 Gene
- MGI mutant phenotypes for HOXD8:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXD8:
Animal Models for HOXD8 Gene
- MGI Knock Outs for HOXD8:
-
- Hoxd8 tm1Jdes
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
- Search ViGene Biosciences for HOXD8
CRISPR Products
-
OriGene CRISPR knockouts for HOXD8
- genomics-online: gRNA clones - Search results for 69 available HOXD8 gene related products
- Overview of 69 available HOXD8 gene related products
- Applied Biological Materials CRISPR for HOXD8
-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for HOXD8 Gene
- miRTarBase miRNAs that target HOXD8
miRNA Products
- Search ViGene Biosciences for HOXD8
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HOXD8
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- genomics-online: shRNA clones - Search results for 69 available HOXD8 gene related products
- Overview of 69 available HOXD8 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HOXD8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXD8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HOXD8
- Applied Biological Materials Clones for HOXD8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HOXD8
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXD8 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXD8 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXD8 Gene
Localization for HOXD8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXD8 Gene
- Nucleus.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | NAS | 2568311 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HOXD8 Gene
Pathways & Interactions for HOXD8 Gene
Interacting Proteins for HOXD8 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006366 | transcription by RNA polymerase II | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXD8 Gene
Transcripts for HOXD8 Gene
mRNA/cDNA for HOXD8 Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (36) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXD8
- genomics-online: gRNA clones - Search results for 69 available HOXD8 gene related products
- Overview of 69 available HOXD8 gene related products
- Applied Biological Materials CRISPR for HOXD8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXD8
- GenScript: Design CRISPR guide RNA sequences for HOXD8
miRNA Products
- Search ViGene Biosciences for HOXD8
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HOXD8
- Browse OriGene Inhibitory RNA Products For HOXD8
- genomics-online: shRNA clones - Search results for 69 available HOXD8 gene related products
- Overview of 69 available HOXD8 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXD8 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HOXD8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXD8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HOXD8
- Applied Biological Materials Clones for HOXD8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b |
---|---|---|---|---|---|
SP1: | |||||
SP2: |
Expression for HOXD8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Somite (Muscoskeletal System)
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
- Thoracic Mesenchymal Sclerotome
- Sacral Mesenchymal Sclerotome
- Lumbar Mesenchymal Sclerotome
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Vertebral Body
- Osteochondro Mesenchymal Cells Vertebrae
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Vertebral Body
- Osteochondro Mesenchymal Cells Vertebrae
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Tendon amp Ligament
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
- Head Mesenchyme (Muscoskeletal System)
- Kidney (Urinary System)
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HOXD8 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXD8 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXD8 Gene:
HOXD8SOURCE GeneReport for Unigene cluster for HOXD8 Gene:
Hs.301963Evidence on tissue expression from TISSUES for HOXD8 Gene
- Kidney(4.3)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for HOXD8
- genomics-online: primer clones - Search results for 69 available HOXD8 gene related products
- Overview of 69 available HOXD8 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXD8 Gene
Orthologs for HOXD8 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | HOXD8 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | HOXD8 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | HOXD8 33 |
|
||
mouse (Mus musculus) |
Mammalia | Hoxd8 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | HOXD8 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | HOXD8 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | HOXD8 33 34 |
|
||
tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxd8 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | MGC68588 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Ubx 34 |
|
ManyToMany | |
abd-A 34 |
|
ManyToMany | |||
worm (Caenorhabditis elegans) |
Secernentea | mab-5 34 |
|
ManyToMany | |
lin-39 34 |
|
ManyToMany |
- Species where no ortholog for HOXD8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for HOXD8 Gene
Paralogs for HOXD8 Gene
(24) SIMAP similar genes for HOXD8 Gene using alignment to 2 proteins:
Variants for HOXD8 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1001383013 | -- | 176,130,269(+) | G/C/T | 5_prime_UTR_variant, intron_variant | |
rs1001595837 | -- | 176,132,415(+) | C/A | 3_prime_UTR_variant | |
rs1002199988 | -- | 176,130,834(+) | G/A | 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant | |
rs1002420999 | -- | 176,129,922(+) | T/A/C | 5_prime_UTR_variant, intron_variant | |
rs1003391653 | -- | 176,132,997(+) | C/G/T | downstream_transcript_variant |
Additional Variant Information for HOXD8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXD8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXD8 Gene
Disorders for HOXD8 Gene
Additional Disease Information for HOXD8
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for HOXD8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXD8 Gene
Publications for HOXD8 Gene
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58
- Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester AR … Hecht JT (American journal of medical genetics. Part A 2009) 3 44 58
- Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K … Matsuo N (Teratology 2002) 3 4 58
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott MP (Cell 1992) 2 3 58
- Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine PJ … Shows TB (Genomics 1990) 2 3 58
Products for HOXD8 Gene
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- Invitrogen Antibodies for HOXD8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for HOXD8
- VectorBuilder custom plasmid, inducible vectors for HOXD8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXD8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HOXD8
- antibodies-online: Search results for 55 available HOXD8 Antibodies ranked by validation data
- Compare Top HOXD8 Antibodies
- antibodies-online: Search results for 2 available HOXD8 Elisa Kits ranked by validation data
- Compare Top HOXD8 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 7 available HOXD8 Proteins ranked by validation data
- Compare Top HOXD8 Proteins
- Quality Products:
- Search GeneTex for Antibodies for HOXD8
- Search GeneTex for Proteins for HOXD8
- ViGene Biosciences adenoviral particle packaged cDNA for HOXD8 gene
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- Search ViGene Biosciences for HOXD8
- Santa Cruz Biotechnology (SCBT) Antibodies for HOXD8
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- Horizon Cell Lines for HOXD8
- genomics-online: cdna clones - Search results for 69 available HOXD8 gene related products
- Overview of 69 available HOXD8 gene related products
- orf clones - Search results for 69 available HOXD8 gene related products
- Overview of 69 available HOXD8 gene related products
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- Overview of 69 available HOXD8 gene related products
- genomics-online: primer clones - Search results for 69 available HOXD8 gene related products
- Overview of 69 available HOXD8 gene related products
- genomics-online: shRNA clones - Search results for 69 available HOXD8 gene related products
- Overview of 69 available HOXD8 gene related products
Sources for HOXD8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
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