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Aliases for HOXD1 Gene

Aliases for HOXD1 Gene

  • Homeobox D1 2 3
  • HOX4G 3 4 6
  • Homeobox Protein Hox-GG 3 4
  • Homeo Box D1 2 3
  • HOX4 3 4
  • Homeobox Protein Hox-D1 3
  • Homeo Box 4G 3
  • Hox-4.7 3

External Ids for HOXD1 Gene

Previous Symbols for HOXD1 Gene

  • HOX4
  • HOX4G

Summaries for HOXD1 Gene

Entrez Gene Summary for HOXD1 Gene

  • This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXD1 Gene

HOXD1 (Homeobox D1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EVX1.

UniProtKB/Swiss-Prot for HOXD1 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures

Gene Wiki entry for HOXD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXD1 Gene

Genomics for HOXD1 Gene

Genomic Location for HOXD1 Gene

Start:
176,188,579 bp from pter
End:
176,190,907 bp from pter
Size:
2,329 bases
Orientation:
Plus strand

Genomic View for HOXD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXD1 Gene

Regulatory Elements for HOXD1 Gene

Proteins for HOXD1 Gene

  • Protein details for HOXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZZ0-HXD1_HUMAN
    Recommended name:
    Homeobox protein Hox-D1
    Protein Accession:
    Q9GZZ0
    Secondary Accessions:
    • B2RAB4

    Protein attributes for HOXD1 Gene

    Size:
    328 amino acids
    Molecular mass:
    34093 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXD1 Gene

Proteomics data for HOXD1 Gene at MOPED

Post-translational modifications for HOXD1 Gene

No Post-translational modifications

Other Protein References for HOXD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXD1 Gene

Domains for HOXD1 Gene

Gene Families for HOXD1 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for HOXD1 Gene

UniProtKB/Swiss-Prot:

HXD1_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q9GZZ0
Family:
  • Belongs to the Antp homeobox family. Labial subfamily.:
    • Q9GZZ0
genes like me logo Genes that share domains with HOXD1: view

Function for HOXD1 Gene

Molecular function for HOXD1 Gene

GENATLAS Biochemistry: homeo box D1(4G),homologous to mouse Hox-4.9,Drosophila lab
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures

Gene Ontology (GO) - Molecular Function for HOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXD1: view
genes like me logo Genes that share phenotypes with HOXD1: view

Animal Models for HOXD1 Gene

MGI Knock Outs for HOXD1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HOXD1 Gene

Localization for HOXD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXD1 Gene COMPARTMENTS Subcellular localization image for HOXD1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXD1: view

Pathways for HOXD1 Gene

SuperPathways for HOXD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0019233 sensory perception of pain IEA --
GO:0030182 neuron differentiation IEA --
GO:0048706 embryonic skeletal system development IEA --
genes like me logo Genes that share ontologies with HOXD1: view

No data available for Pathways by source for HOXD1 Gene

Transcripts for HOXD1 Gene

mRNA/cDNA for HOXD1 Gene

Unigene Clusters for HOXD1 Gene

Homeobox D1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2: -

Relevant External Links for HOXD1 Gene

GeneLoc Exon Structure for
HOXD1
ECgene alternative splicing isoforms for
HOXD1

Expression for HOXD1 Gene

mRNA expression in normal human tissues for HOXD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXD1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (10.8), Brain - Substantia nigra (5.4), and Kidney - Cortex (4.2).

SOURCE GeneReport for Unigene cluster for HOXD1 Gene Hs.83465

genes like me logo Genes that share expressions with HOXD1: view

Orthologs for HOXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXD1 36
  • 97.87 (n)
  • 97.26 (a)
HOXD1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXD1 36
  • 85.71 (n)
  • 83.23 (a)
HOXD1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXD1 36
  • 82.11 (n)
  • 77.52 (a)
HOXD1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxd1 36
  • 81.95 (n)
  • 83.38 (a)
Hoxd1 16
Hoxd1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXD1 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 63 (a)
OneToMany
-- 37
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hoxd1 36
  • 82.56 (n)
  • 83.69 (a)
lizard
(Anolis carolinensis)
Reptilia HOXD1 37
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxd1 36
  • 59.59 (n)
  • 56.12 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxc1a 37
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lab 37
  • 15 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ceh-13 37
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
OneToOne
Species with no ortholog for HOXD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HOXD1 Gene

ENSEMBL:
Gene Tree for HOXD1 (if available)
TreeFam:
Gene Tree for HOXD1 (if available)

Paralogs for HOXD1 Gene

Selected SIMAP similar genes for HOXD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXD1: view

Variants for HOXD1 Gene

Sequence variations from dbSNP and Humsavar for HOXD1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs55790665 -- 176,191,150(+) AGTAG(C/G)TGGGA downstream-variant-500B
rs112605255 -- 176,191,023(+) ATAAC(-/T)TTTTT downstream-variant-500B
rs138830306 -- 176,191,203(+) TTTTT(A/G)GTAGA downstream-variant-500B
rs141839800 -- 176,191,292(+) TGCTA(G/T)AATTA downstream-variant-500B
rs144649132 -- 176,191,331(+) AACTT(C/T)TAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HOXD1 Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV Gain 20364138
nsv875438 CNV Loss 21882294

Relevant External Links for HOXD1 Gene

HapMap Linkage Disequilibrium report
HOXD1

Disorders for HOXD1 Gene

(1) University of Copenhagen DISEASES for HOXD1 Gene

Relevant External Links for HOXD1

Genetic Association Database (GAD)
HOXD1
Human Genome Epidemiology (HuGE) Navigator
HOXD1
genes like me logo Genes that share disorders with HOXD1: view

No data available for UniProtKB/Swiss-Prot for HOXD1 Gene

Publications for HOXD1 Gene

  1. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  2. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  3. Isolation and characterization of the human homeobox gene HOX D1. (PMID: 11455954) Appukuttan B. … Stout J.T. (Mol. Biol. Rep. 2000) 3 4
  4. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PMID: 20852632) Goode E.L. … Pharoah P.D. (Nat. Genet. 2010) 3 49
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 49

Products for HOXD1 Gene

Sources for HOXD1 Gene

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