Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HOXC11 Gene

Aliases for HOXC11 Gene

  • Homeobox C11 2 3
  • Homeobox Protein Hox-3H 3 4
  • Homeo Box C11 2 3
  • HOX3H 3 4
  • Homeobox Protein Hox-C11 3

External Ids for HOXC11 Gene

Previous HGNC Symbols for HOXC11 Gene

  • HOX3H

Previous GeneCards Identifiers for HOXC11 Gene

  • GC12M054415
  • GC12P054479
  • GC12P054083
  • GC12P052653
  • GC12P054366
  • GC12P051405

Summaries for HOXC11 Gene

Entrez Gene Summary for HOXC11 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC11 Gene

HOXC11 (Homeobox C11) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXC11 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene

Gene Wiki entry for HOXC11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC11 Gene

Genomics for HOXC11 Gene

Regulatory Elements for HOXC11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXC11 Gene

Start:
53,973,126 bp from pter
End:
53,977,643 bp from pter
Size:
4,518 bases
Orientation:
Plus strand

Genomic View for HOXC11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC11 Gene

Proteins for HOXC11 Gene

  • Protein details for HOXC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43248-HXC11_HUMAN
    Recommended name:
    Homeobox protein Hox-C11
    Protein Accession:
    O43248
    Secondary Accessions:
    • A8K7D1
    • Q96DH2

    Protein attributes for HOXC11 Gene

    Size:
    304 amino acids
    Molecular mass:
    33748 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXC11 Gene

Proteomics data for HOXC11 Gene at MOPED

Post-translational modifications for HOXC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXC11 Gene

Domains for HOXC11 Gene

Gene Families for HOXC11 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for HOXC11 Gene

Suggested Antigen Peptide Sequences for HOXC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43248

UniProtKB/Swiss-Prot:

HXC11_HUMAN :
  • O43248
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXC11: view

Function for HOXC11 Gene

Molecular function for HOXC11 Gene

GENATLAS Biochemistry:
homeo box C11(3H),homologous to mouse Hox-3.7,involved in mouse posterior limb patterning expressed in posterior limb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene

Gene Ontology (GO) - Molecular Function for HOXC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9582375
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 9582375
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with HOXC11: view
genes like me logo Genes that share phenotypes with HOXC11: view

Animal Models for HOXC11 Gene

MGI Knock Outs for HOXC11:

Animal Model Products

miRNA for HOXC11 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXC11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXC11 Gene

Localization for HOXC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXC11 Gene COMPARTMENTS Subcellular localization image for HOXC11 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for HOXC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HOXC11: view

Pathways for HOXC11 Gene

SuperPathways for HOXC11 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HOXC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development --
GO:0001656 metanephros development IEA --
GO:0001759 organ induction IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007492 endoderm development TAS 9582375
genes like me logo Genes that share ontologies with HOXC11: view

No data available for Pathways by source for HOXC11 Gene

Transcripts for HOXC11 Gene

mRNA/cDNA for HOXC11 Gene

(4) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXC11 Gene

Homeobox C11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXC11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC11 Gene

No ASD Table

Relevant External Links for HOXC11 Gene

GeneLoc Exon Structure for
HOXC11
ECgene alternative splicing isoforms for
HOXC11

Expression for HOXC11 Gene

mRNA expression in normal human tissues for HOXC11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC11 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (9.8), Artery - Tibial (9.1), and Skin - Not Sun Exposed (Suprapubic) (6.1).

SOURCE GeneReport for Unigene cluster for HOXC11 Gene Hs.127562

genes like me logo Genes that share expressions with HOXC11: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for HOXC11 Gene

Orthologs for HOXC11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXC11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXC11 35
  • 95.94 (n)
  • 98.03 (a)
HOXC11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXC11 35
  • 93.64 (n)
  • 94.08 (a)
HOXC11 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxc11 35
  • 93.64 (n)
  • 97.7 (a)
Hoxc11 16
Hoxc11 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXC11 35
  • 99.45 (n)
  • 99.67 (a)
HOXC11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911859 35
  • 93.75 (n)
  • 97.7 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC11 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXC11 35
  • 74.25 (n)
  • 77.26 (a)
HOXC11 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXC11 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487406 35
  • 72.67 (n)
  • 75.33 (a)
Str.11603 35
zebrafish
(Danio rerio)
Actinopterygii hoxc11a 35
  • 68.22 (n)
  • 67.67 (a)
hoxc11a 36
  • 67 (a)
OneToMany
hoxc11b 36
  • 65 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
OneToMany
Species with no ortholog for HOXC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC11 Gene

ENSEMBL:
Gene Tree for HOXC11 (if available)
TreeFam:
Gene Tree for HOXC11 (if available)

Paralogs for HOXC11 Gene

Selected SIMAP similar genes for HOXC11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXC11: view

Variants for HOXC11 Gene

Sequence variations from dbSNP and Humsavar for HOXC11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_031850 -
VAR_034002 -

Structural Variations from Database of Genomic Variants (DGV) for HOXC11 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914

Relevant External Links for HOXC11 Gene

HapMap Linkage Disequilibrium report
HOXC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC11 Gene

Disorders for HOXC11 Gene

No disorders were found for HOXC11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HOXC11 Gene

Publications for HOXC11 Gene

  1. The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription. (PMID: 9582375) Mitchelmore C.E. … Noren O. (J. Biol. Chem. 1998) 3 4 23
  2. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  4. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HOXC11 Gene

Sources for HOXC11 Gene

Back to Top

Content