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Aliases for HOXC11 Gene

Aliases for HOXC11 Gene

  • Homeobox C11 2 3 5
  • Homeobox Protein Hox-3H 3 4
  • Homeo Box C11 2 3
  • HOX3H 3 4
  • Homeobox Protein Hox-C11 3

External Ids for HOXC11 Gene

Previous HGNC Symbols for HOXC11 Gene

  • HOX3H

Previous GeneCards Identifiers for HOXC11 Gene

  • GC12M054415
  • GC12P054479
  • GC12P054083
  • GC12P052653
  • GC12P054366
  • GC12P051405

Summaries for HOXC11 Gene

Entrez Gene Summary for HOXC11 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC11 Gene

HOXC11 (Homeobox C11) is a Protein Coding gene. Diseases associated with HOXC11 include Childhood Type Dermatomyositis. Among its related pathways are Mesodermal Commitment Pathway. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is HOXA11.

UniProtKB/Swiss-Prot for HOXC11 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Gene Wiki entry for HOXC11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC11 Gene

Genomics for HOXC11 Gene

Regulatory Elements for HOXC11 Gene

Enhancers for HOXC11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G053971 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +17.1 17117 36.8 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 ZNF740 MAP3K12 ENSG00000258344 LOC100652999 HOXC8 HOXC5 SP1 HOTAIR CBX5 HOXC4
GH12G054195 1.5 FANTOM5 Ensembl ENCODE 10.6 +223.6 223550 3.1 HDGF PKNOX1 KLF17 ZNF121 GLIS2 ZNF366 SMARCC2 FOS KLF7 KDM4B MAP3K12 HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 MIR196A2 MIR615 HOXC4 HOXC5
GH12G054191 1.2 Ensembl ENCODE 10.6 +218.6 218612 0.9 ATF1 WRNIP1 ARID4B SIN3A ZNF2 ZNF143 KLF7 DEK SP3 YY2 HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 MIR615 HOXC4 HOXC5 MAP3K12 LOC102724030
GH12G054130 1.2 ENCODE dbSUPER 10.3 +161.6 161638 8.3 FOXA2 ZSCAN4 KLF17 FEZF1 RAD21 RARA ZNF121 MIXL1 DEK EGR2 FLJ12825 TARBP2 SMUG1 MIR615 HOXC4 HOXC5 HOXC6 ENSG00000260470 HOXC8 HOXC-AS1
GH12G054079 1.1 ENCODE 10.4 +108.2 108163 4.6 HDGF PKNOX1 CREB3L1 ARNT FEZF1 ZNF2 YY1 CBX5 REST KAT8 FLJ12825 CBX5 MIR615 HOXC4 HOXC5 HOXC6 MAP3K12 HOXC8 HOXC-AS1 HOXC-AS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOXC11 on UCSC Golden Path with GeneCards custom track

Promoters for HOXC11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052266 974 1001 AGO1 SIN3A FEZF1 GLIS2 DEK SP3 CAVIN1 REST SMARCB1 ZNF592

Genomic Location for HOXC11 Gene

Chromosome:
12
Start:
53,973,126 bp from pter
End:
53,977,643 bp from pter
Size:
4,518 bases
Orientation:
Plus strand

Genomic View for HOXC11 Gene

Genes around HOXC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC11 Gene

Proteins for HOXC11 Gene

  • Protein details for HOXC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43248-HXC11_HUMAN
    Recommended name:
    Homeobox protein Hox-C11
    Protein Accession:
    O43248
    Secondary Accessions:
    • A8K7D1
    • Q96DH2

    Protein attributes for HOXC11 Gene

    Size:
    304 amino acids
    Molecular mass:
    33748 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXC11 Gene

Post-translational modifications for HOXC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC11 Gene

Domains & Families for HOXC11 Gene

Gene Families for HOXC11 Gene

Protein Domains for HOXC11 Gene

Suggested Antigen Peptide Sequences for HOXC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43248

UniProtKB/Swiss-Prot:

HXC11_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXC11: view

Function for HOXC11 Gene

Molecular function for HOXC11 Gene

GENATLAS Biochemistry:
homeo box C11(3H),homologous to mouse Hox-3.7,involved in mouse posterior limb patterning expressed in posterior limb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Gene Ontology (GO) - Molecular Function for HOXC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9582375
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 9582375
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC11: view
genes like me logo Genes that share phenotypes with HOXC11: view

Animal Models for HOXC11 Gene

MGI Knock Outs for HOXC11:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC11 Gene

Localization for HOXC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXC11 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for HOXC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with HOXC11: view

Pathways & Interactions for HOXC11 Gene

SuperPathways for HOXC11 Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with HOXC11: view

Pathways by source for HOXC11 Gene

1 BioSystems pathway for HOXC11 Gene

SIGNOR curated interactions for HOXC11 Gene

Activates:

Gene Ontology (GO) - Biological Process for HOXC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001656 metanephros development IEA --
GO:0001759 organ induction IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HOXC11: view

Transcripts for HOXC11 Gene

mRNA/cDNA for HOXC11 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXC11 Gene

Homeobox C11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC11 Gene

No ASD Table

Relevant External Links for HOXC11 Gene

GeneLoc Exon Structure for
HOXC11
ECgene alternative splicing isoforms for
HOXC11

Expression for HOXC11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXC11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC11 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x9.8), Artery - Tibial (x9.1), and Skin - Not Sun Exposed (Suprapubic) (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of HOXC11 Gene:

HOXC11

SOURCE GeneReport for Unigene cluster for HOXC11 Gene:

Hs.127562
genes like me logo Genes that share expression patterns with HOXC11: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC11 Gene

Orthologs for HOXC11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXC11 34 35
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia HOXC11 34 35
  • 95.94 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911859 34
  • 93.75 (n)
dog
(Canis familiaris)
Mammalia HOXC11 34 35
  • 93.64 (n)
mouse
(Mus musculus)
Mammalia Hoxc11 34 16 35
  • 93.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC11 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXC11 34 35
  • 74.25 (n)
lizard
(Anolis carolinensis)
Reptilia HOXC11 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487406 34
  • 72.67 (n)
Str.11603 34
zebrafish
(Danio rerio)
Actinopterygii hoxc11a 34 35
  • 68.22 (n)
hoxc11b 35
  • 65 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 11 (a)
OneToMany
Species where no ortholog for HOXC11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC11 Gene

ENSEMBL:
Gene Tree for HOXC11 (if available)
TreeFam:
Gene Tree for HOXC11 (if available)

Paralogs for HOXC11 Gene

(2) SIMAP similar genes for HOXC11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXC11: view

Variants for HOXC11 Gene

Sequence variations from dbSNP and Humsavar for HOXC11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12427129 --
rs34652380 --

Structural Variations from Database of Genomic Variants (DGV) for HOXC11 Gene

Variant ID Type Subtype PubMed ID
esv2759900 CNV gain+loss 17122850
nsv428282 CNV gain 18775914
nsv826379 CNV gain 20364138

Variation tolerance for HOXC11 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXC11 Gene

Human Gene Mutation Database (HGMD)
HOXC11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC11 Gene

Disorders for HOXC11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HOXC11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
childhood type dermatomyositis
  • childhood dermatomyositis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HOXC11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXC11
genes like me logo Genes that share disorders with HOXC11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXC11 Gene

Publications for HOXC11 Gene

  1. The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription. (PMID: 9582375) Mitchelmore C.E. … Noren O. (J. Biol. Chem. 1998) 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4 64
  4. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
  5. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3 64

Products for HOXC11 Gene

Sources for HOXC11 Gene

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