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Aliases for HOXC11 Gene

Aliases for HOXC11 Gene

  • Homeobox C11 2 3 5
  • Homeobox Protein Hox-3H 3 4
  • Homeo Box C11 2 3
  • HOX3H 3 4

External Ids for HOXC11 Gene

Previous HGNC Symbols for HOXC11 Gene

  • HOX3H

Previous GeneCards Identifiers for HOXC11 Gene

  • GC12M054415
  • GC12P054479
  • GC12P054083
  • GC12P052653
  • GC12P054366
  • GC12P051405

Summaries for HOXC11 Gene

Entrez Gene Summary for HOXC11 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC11 Gene

HOXC11 (Homeobox C11) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXC11 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Gene Wiki entry for HOXC11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC11 Gene

Genomics for HOXC11 Gene

Regulatory Elements for HOXC11 Gene

Promoters for HOXC11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HOXC11 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXC11 Gene

Chromosome:
12
Start:
53,973,126 bp from pter
End:
53,977,643 bp from pter
Size:
4,518 bases
Orientation:
Plus strand

Genomic View for HOXC11 Gene

Genes around HOXC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC11 Gene

Proteins for HOXC11 Gene

  • Protein details for HOXC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43248-HXC11_HUMAN
    Recommended name:
    Homeobox protein Hox-C11
    Protein Accession:
    O43248
    Secondary Accessions:
    • A8K7D1
    • Q96DH2

    Protein attributes for HOXC11 Gene

    Size:
    304 amino acids
    Molecular mass:
    33748 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXC11 Gene

Proteomics data for HOXC11 Gene at MOPED

Post-translational modifications for HOXC11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC11 Gene

Domains & Families for HOXC11 Gene

Gene Families for HOXC11 Gene

Protein Domains for HOXC11 Gene

Suggested Antigen Peptide Sequences for HOXC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43248

UniProtKB/Swiss-Prot:

HXC11_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXC11: view

Function for HOXC11 Gene

Molecular function for HOXC11 Gene

GENATLAS Biochemistry:
homeo box C11(3H),homologous to mouse Hox-3.7,involved in mouse posterior limb patterning expressed in posterior limb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.
genes like me logo Genes that share phenotypes with HOXC11: view

Animal Models for HOXC11 Gene

MGI Knock Outs for HOXC11:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC11 Gene

Localization for HOXC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXC11 Gene COMPARTMENTS Subcellular localization image for HOXC11 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for HOXC11 Gene

Pathways & Interactions for HOXC11 Gene

SuperPathways for HOXC11 Gene

No Data Available

SIGNOR curated interactions for HOXC11 Gene

Activates:

Gene Ontology (GO) - Biological Process for HOXC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001759 organ induction IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 9582375
genes like me logo Genes that share ontologies with HOXC11: view

No data available for Pathways by source for HOXC11 Gene

Drugs & Compounds for HOXC11 Gene

No Compound Related Data Available

Transcripts for HOXC11 Gene

mRNA/cDNA for HOXC11 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXC11 Gene

Homeobox C11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC11 Gene

No ASD Table

Relevant External Links for HOXC11 Gene

GeneLoc Exon Structure for
HOXC11
ECgene alternative splicing isoforms for
HOXC11

Expression for HOXC11 Gene

mRNA expression in normal human tissues for HOXC11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC11 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x9.8), Artery - Tibial (x9.1), and Skin - Not Sun Exposed (Suprapubic) (x6.1).

SOURCE GeneReport for Unigene cluster for HOXC11 Gene Hs.127562

genes like me logo Genes that share expression patterns with HOXC11: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HOXC11 Gene

Orthologs for HOXC11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXC11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXC11 35
  • 95.94 (n)
  • 98.03 (a)
HOXC11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXC11 35
  • 93.64 (n)
  • 94.08 (a)
HOXC11 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxc11 35
  • 93.64 (n)
  • 97.7 (a)
Hoxc11 16
Hoxc11 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXC11 35
  • 99.45 (n)
  • 99.67 (a)
HOXC11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911859 35
  • 93.75 (n)
  • 97.7 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC11 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXC11 35
  • 74.25 (n)
  • 77.26 (a)
HOXC11 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXC11 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487406 35
  • 72.67 (n)
  • 75.33 (a)
Str.11603 35
zebrafish
(Danio rerio)
Actinopterygii hoxc11a 35
  • 68.22 (n)
  • 67.67 (a)
hoxc11a 36
  • 67 (a)
OneToMany
hoxc11b 36
  • 65 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
OneToMany
Species with no ortholog for HOXC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC11 Gene

ENSEMBL:
Gene Tree for HOXC11 (if available)
TreeFam:
Gene Tree for HOXC11 (if available)

Paralogs for HOXC11 Gene

(2) SIMAP similar genes for HOXC11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXC11: view

Variants for HOXC11 Gene

Sequence variations from dbSNP and Humsavar for HOXC11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_031850 -
VAR_034002 -

Structural Variations from Database of Genomic Variants (DGV) for HOXC11 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914

Variation tolerance for HOXC11 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXC11 Gene

HapMap Linkage Disequilibrium report
HOXC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC11 Gene

Disorders for HOXC11 Gene

Relevant External Links for HOXC11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXC11

No disorders were found for HOXC11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC11 Gene

Publications for HOXC11 Gene

  1. The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription. (PMID: 9582375) Mitchelmore C.E. … Noren O. (J. Biol. Chem. 1998) 3 4 23 67
  2. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  4. Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis. (PMID: 25476856) Liu Y.J. … Lin Z.M. (Tumour Biol. 2015) 3
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3

Products for HOXC11 Gene

Sources for HOXC11 Gene

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