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Aliases for HOXC8 Gene

Aliases for HOXC8 Gene

  • Homeobox C8 2 3
  • Homeobox Protein Hox-3A 3 4
  • Homeo Box C8 2 3
  • HOX3A 3 4
  • Hox-3.1, Mouse, Homolog Of 3
  • Homeo Box 3A 3
  • HOX3 3

External Ids for HOXC8 Gene

Previous HGNC Symbols for HOXC8 Gene

  • HOX3
  • HOX3A

Previous GeneCards Identifiers for HOXC8 Gene

  • GC12M054416
  • GC12P054515
  • GC12P054119
  • GC12P052689
  • GC12P054402
  • GC12P051440

Summaries for HOXC8 Gene

Entrez Gene Summary for HOXC8 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC8 Gene

HOXC8 (Homeobox C8) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXC8 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC8 Gene

Genomics for HOXC8 Gene

Regulatory Elements for HOXC8 Gene

Transcription factor binding sites by QIAGEN in the HOXC8 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXC8 Gene

Chromosome:
12
Start:
54,009,106 bp from pter
End:
54,012,763 bp from pter
Size:
3,658 bases
Orientation:
Plus strand

Genomic View for HOXC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC8 Gene

Proteins for HOXC8 Gene

  • Protein details for HOXC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31273-HXC8_HUMAN
    Recommended name:
    Homeobox protein Hox-C8
    Protein Accession:
    P31273
    Secondary Accessions:
    • A8K4J4
    • O15221
    • O15362

    Protein attributes for HOXC8 Gene

    Size:
    242 amino acids
    Molecular mass:
    27755 Da
    Quaternary structure:
    • Interacts with SMAD1 and HOMEZ.

neXtProt entry for HOXC8 Gene

Proteomics data for HOXC8 Gene at MOPED

Post-translational modifications for HOXC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXC8 Gene

Domains & Families for HOXC8 Gene

Gene Families for HOXC8 Gene

Suggested Antigen Peptide Sequences for HOXC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31273

UniProtKB/Swiss-Prot:

HXC8_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXC8: view

Function for HOXC8 Gene

Molecular function for HOXC8 Gene

GENATLAS Biochemistry:
homeo box C8(3A),homologous to mouse Hox-3.1,involved in mouse anterior and posterior patterning and innervation of the limb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC8: view
genes like me logo Genes that share phenotypes with HOXC8: view

Animal Models for HOXC8 Gene

MGI Knock Outs for HOXC8:

Animal Model Products

miRNA for HOXC8 Gene

miRTarBase miRNAs that target HOXC8

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXC8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HOXC8 Gene

Localization for HOXC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXC8 Gene COMPARTMENTS Subcellular localization image for HOXC8 gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with HOXC8: view

Pathways & Interactions for HOXC8 Gene

SuperPathways for HOXC8 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for HOXC8 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0030182 neuron differentiation IEA --
genes like me logo Genes that share ontologies with HOXC8: view

No data available for Pathways by source for HOXC8 Gene

Drugs & Compounds for HOXC8 Gene

No Compound Related Data Available

Transcripts for HOXC8 Gene

mRNA/cDNA for HOXC8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXC8 Gene

Homeobox C8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXC8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC8 Gene

No ASD Table

Relevant External Links for HOXC8 Gene

GeneLoc Exon Structure for
HOXC8
ECgene alternative splicing isoforms for
HOXC8

Expression for HOXC8 Gene

mRNA expression in normal human tissues for HOXC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC8 Gene

This gene is overexpressed in Muscle - Skeletal (x7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXC8 Gene



SOURCE GeneReport for Unigene cluster for HOXC8 Gene Hs.664500

genes like me logo Genes that share expression patterns with HOXC8: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HOXC8 Gene

Orthologs for HOXC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXC8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXC8 35
  • 97.38 (n)
  • 99.59 (a)
HOXC8 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC607625 35
  • 95.57 (n)
  • 97.25 (a)
mouse
(Mus musculus)
Mammalia Hoxc8 35
  • 95.59 (n)
  • 99.59 (a)
Hoxc8 16
Hoxc8 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXC8 35
  • 99.59 (n)
  • 99.17 (a)
HOXC8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxc8 35
  • 95.87 (n)
  • 99.59 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC8 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXC8 35
  • 82.72 (n)
  • 93.12 (a)
lizard
(Anolis carolinensis)
Reptilia HOXC8 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc8 35
  • 83.49 (n)
  • 92.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia xhoxc8 35
zebrafish
(Danio rerio)
Actinopterygii hoxc8a 35
hoxc8a 35
  • 75.12 (n)
  • 87.1 (a)
hoxc8a 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta abd-A 36
  • 14 (a)
ManyToMany
Ubx 36
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lin-39 36
  • 26 (a)
ManyToMany
mab-5 36
  • 33 (a)
ManyToMany
Species with no ortholog for HOXC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HOXC8 Gene

ENSEMBL:
Gene Tree for HOXC8 (if available)
TreeFam:
Gene Tree for HOXC8 (if available)

Paralogs for HOXC8 Gene

(7) SIMAP similar genes for HOXC8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXC8: view

Variants for HOXC8 Gene

Sequence variations from dbSNP and Humsavar for HOXC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs737219 -- 54,009,133(-) GCAGG(G/T)GGGGG utr-variant-5-prime
rs737220 -- 54,009,133(-) CAGGT(G/T)GGGGG utr-variant-5-prime
rs2083837 -- 54,009,600(-) GCTCG(A/C)CTCTT reference, missense
rs4016776 -- 54,008,878(+) tctct(-/CTCT)CTCGC upstream-variant-2KB
rs4142680 -- 54,011,406(+) CCCCC(C/T)TTAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HOXC8 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914
nsv899101 CNV Loss 21882294
nsv899102 CNV Loss 21882294
esv2672088 CNV Deletion 23128226

Variation tolerance for HOXC8 Gene

Residual Variation Intolerance Score: 49.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXC8 Gene

HapMap Linkage Disequilibrium report
HOXC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC8 Gene

Disorders for HOXC8 Gene

Relevant External Links for HOXC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXC8
genes like me logo Genes that share disorders with HOXC8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC8 Gene

Publications for HOXC8 Gene

  1. Xwnt8 directly initiates expression of labial Hox genes. (PMID: 19623617) In der Rieden P.M. … Durston A.J. (Dev. Dyn. 2010) 23 67
  2. In vitro osteoblast differentiation is negatively regulated by Hoxc8. (PMID: 19214787) Zheng Y.J. … Kim M.H. (Appl. Biochem. Biotechnol. 2010) 23 67
  3. Membrane transducing activity of recombinant Hoxc8 protein and its possible application as a gene delivery vector. (PMID: 18446053) Kim E.S. … Kim M.H. (Exp. Mol. Med. 2008) 23 67
  4. Smads oppose Hox transcriptional activities. (PMID: 16405960) Li X. … Cao X. (Exp. Cell Res. 2006) 23 67
  5. Exploring the potential of complex formation between a mutant DNA and the wild type protein counterpart: a MM and MD simulation approach. (PMID: 16406716) Roy S. … Sen S. (J. Mol. Graph. Model. 2006) 23 67

Products for HOXC8 Gene

Sources for HOXC8 Gene

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