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Aliases for HOXC8 Gene

Aliases for HOXC8 Gene

  • Homeobox C8 2 3 5
  • Homeobox Protein Hox-3A 3 4
  • Homeo Box C8 2 3
  • HOX3A 3 4
  • Hox-3.1, Mouse, Homolog Of 3
  • Homeo Box 3A 3
  • HOX3 3

External Ids for HOXC8 Gene

Previous HGNC Symbols for HOXC8 Gene

  • HOX3
  • HOX3A

Previous GeneCards Identifiers for HOXC8 Gene

  • GC12M054416
  • GC12P054515
  • GC12P054119
  • GC12P052689
  • GC12P054402
  • GC12P051440

Summaries for HOXC8 Gene

Entrez Gene Summary for HOXC8 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC8 Gene

HOXC8 (Homeobox C8) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXC8 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXC8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC8 Gene

Genomics for HOXC8 Gene

Regulatory Elements for HOXC8 Gene

Enhancers for HOXC8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HOXC8 on UCSC Golden Path with GeneCards custom track

Promoters for HOXC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HOXC8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HOXC8 gene promoter:

Genomic Location for HOXC8 Gene

54,009,106 bp from pter
54,012,763 bp from pter
3,658 bases
Plus strand

Genomic View for HOXC8 Gene

Genes around HOXC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC8 Gene

Proteins for HOXC8 Gene

  • Protein details for HOXC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Hox-C8
    Protein Accession:
    Secondary Accessions:
    • A8K4J4
    • O15221
    • O15362

    Protein attributes for HOXC8 Gene

    242 amino acids
    Molecular mass:
    27755 Da
    Quaternary structure:
    • Interacts with SMAD1 and HOMEZ.

neXtProt entry for HOXC8 Gene

Proteomics data for HOXC8 Gene at MOPED

Post-translational modifications for HOXC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC8 Gene

Domains & Families for HOXC8 Gene

Gene Families for HOXC8 Gene

Suggested Antigen Peptide Sequences for HOXC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXC8: view

Function for HOXC8 Gene

Molecular function for HOXC8 Gene

GENATLAS Biochemistry:
homeo box C8(3A),homologous to mouse Hox-3.1,involved in mouse anterior and posterior patterning and innervation of the limb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
genes like me logo Genes that share phenotypes with HOXC8: view

Animal Models for HOXC8 Gene

MGI Knock Outs for HOXC8:

Animal Model Products

miRNA for HOXC8 Gene

miRTarBase miRNAs that target HOXC8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC8 Gene

Localization for HOXC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC8 Gene

Subcellular locations from

Jensen Localization Image for HOXC8 Gene COMPARTMENTS Subcellular localization image for HOXC8 gene
Compartment Confidence
cytoskeleton 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HOXC8 Gene

Pathways & Interactions for HOXC8 Gene

SuperPathways for HOXC8 Gene

No Data Available

SIGNOR curated interactions for HOXC8 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0048705 skeletal system morphogenesis IEA --
genes like me logo Genes that share ontologies with HOXC8: view

No data available for Pathways by source for HOXC8 Gene

Drugs & Compounds for HOXC8 Gene

No Compound Related Data Available

Transcripts for HOXC8 Gene

mRNA/cDNA for HOXC8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXC8 Gene

Homeobox C8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC8 Gene

No ASD Table

Relevant External Links for HOXC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOXC8 Gene

mRNA expression in normal human tissues for HOXC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC8 Gene

This gene is overexpressed in Muscle - Skeletal (x7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXC8 Gene

SOURCE GeneReport for Unigene cluster for HOXC8 Gene Hs.664500

genes like me logo Genes that share expression patterns with HOXC8: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HOXC8 Gene

Orthologs for HOXC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HOXC8 35
  • 97.38 (n)
  • 99.59 (a)
HOXC8 36
  • 100 (a)
(Canis familiaris)
Mammalia LOC607625 35
  • 95.57 (n)
  • 97.25 (a)
(Mus musculus)
Mammalia Hoxc8 35
  • 95.59 (n)
  • 99.59 (a)
Hoxc8 16
Hoxc8 36
  • 100 (a)
(Pan troglodytes)
Mammalia HOXC8 35
  • 99.59 (n)
  • 99.17 (a)
HOXC8 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hoxc8 35
  • 95.87 (n)
  • 99.59 (a)
(Ornithorhynchus anatinus)
Mammalia HOXC8 36
  • 81 (a)
(Gallus gallus)
Aves HOXC8 35
  • 82.72 (n)
  • 93.12 (a)
(Anolis carolinensis)
Reptilia HOXC8 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc8 35
  • 83.49 (n)
  • 92.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia xhoxc8 35
(Danio rerio)
Actinopterygii hoxc8a 35
hoxc8a 35
  • 75.12 (n)
  • 87.1 (a)
hoxc8a 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta abd-A 36
  • 14 (a)
Ubx 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea lin-39 36
  • 26 (a)
mab-5 36
  • 33 (a)
Species with no ortholog for HOXC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HOXC8 Gene

Gene Tree for HOXC8 (if available)
Gene Tree for HOXC8 (if available)

Paralogs for HOXC8 Gene

(7) SIMAP similar genes for HOXC8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXC8: view

Variants for HOXC8 Gene

Sequence variations from dbSNP and Humsavar for HOXC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2083837 -- 54,009,600(-) GCTCG(A/C)CTCTT reference, missense
rs7299442 -- 54,007,547(+) CTGTG(A/G)GGTGG upstream-variant-2KB
rs12814340 -- 54,011,955(+) cccct(C/G)cccAG utr-variant-3-prime
rs12818104 -- 54,009,072(+) cgccg(A/C)cCGCG upstream-variant-2KB
rs12818817 -- 54,009,250(+) AGCCA(C/G)AGGGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HOXC8 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914
nsv899101 CNV Loss 21882294
nsv899102 CNV Loss 21882294
esv2672088 CNV Deletion 23128226

Variation tolerance for HOXC8 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HOXC8 Gene

Disorders for HOXC8 Gene

Relevant External Links for HOXC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HOXC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC8 Gene

Publications for HOXC8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. (PMID: 11139569) Wan M. … Cao X. (J. Biol. Chem. 2001) 3 23
  3. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  4. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  5. Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8. (PMID: 25745994) Jiang Y. … Tao Y. (Oncogene 2015) 3

Products for HOXC8 Gene

Sources for HOXC8 Gene