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Aliases for HOXC8 Gene

Aliases for HOXC8 Gene

  • Homeobox C8 2 3
  • HOX3A 3 4 6
  • Homeobox Protein Hox-3A 3 4
  • Homeo Box C8 2 3
  • Hox-3.1, Mouse, Homolog Of 3
  • Homeobox Protein Hox-C8 3
  • Homeo Box 3A 3
  • HOX3 3

External Ids for HOXC8 Gene

Previous Symbols for HOXC8 Gene

  • HOX3
  • HOX3A

Summaries for HOXC8 Gene

Entrez Gene Summary for HOXC8 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC8 Gene

HOXC8 (Homeobox C8) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXC8 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC8 Gene

Genomics for HOXC8 Gene

Genomic Location for HOXC8 Gene

Start:
54,009,106 bp from pter
End:
54,012,763 bp from pter
Size:
3,658 bases
Orientation:
Plus strand

Genomic View for HOXC8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC8 Gene

Regulatory Elements for HOXC8 Gene

Transcription factor binding sites by QIAGEN in the HOXC8 gene promoter:

Proteins for HOXC8 Gene

  • Protein details for HOXC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31273-HXC8_HUMAN
    Recommended name:
    Homeobox protein Hox-C8
    Protein Accession:
    P31273
    Secondary Accessions:
    • A8K4J4
    • O15221
    • O15362

    Protein attributes for HOXC8 Gene

    Size:
    242 amino acids
    Molecular mass:
    27755 Da
    Quaternary structure:
    • Interacts with SMAD1 and HOMEZ.

neXtProt entry for HOXC8 Gene

Proteomics data for HOXC8 Gene at MOPED

Post-translational modifications for HOXC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC8 Gene

Domains for HOXC8 Gene

Gene Families for HOXC8 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

UniProtKB/Swiss-Prot:

HXC8_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • P31273
Family:
  • Belongs to the Antp homeobox family.:
    • P31273
genes like me logo Genes that share domains with HOXC8: view

Function for HOXC8 Gene

Molecular function for HOXC8 Gene

GENATLAS Biochemistry: homeo box C8(3A),homologous to mouse Hox-3.1,involved in mouse anterior and posterior patterning and innervation of the limb
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC8: view
genes like me logo Genes that share phenotypes with HOXC8: view

Animal Models for HOXC8 Gene

MGI Knock Outs for HOXC8:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXC8 Gene

Localization for HOXC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXC8 Gene COMPARTMENTS Subcellular localization image for HOXC8 gene
Compartment Confidence
nucleus 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with HOXC8: view

Pathways for HOXC8 Gene

SuperPathways for HOXC8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0030182 neuron differentiation IEA --
GO:0048705 skeletal system morphogenesis IEA --
genes like me logo Genes that share ontologies with HOXC8: view

No data available for Pathways by source for HOXC8 Gene

Transcripts for HOXC8 Gene

mRNA/cDNA for HOXC8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXC8 Gene

Homeobox C8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC8 Gene

No ASD Table

Relevant External Links for HOXC8 Gene

GeneLoc Exon Structure for
HOXC8
ECgene alternative splicing isoforms for
HOXC8

Expression for HOXC8 Gene

mRNA expression in normal human tissues for HOXC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC8 Gene

This gene is overexpressed in Muscle - Skeletal (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXC8 Gene

SOURCE GeneReport for Unigene cluster for HOXC8 Gene Hs.664500

genes like me logo Genes that share expressions with HOXC8: view

Orthologs for HOXC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXC8 36
  • 99.59 (n)
  • 99.17 (a)
HOXC8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXC8 36
  • 97.38 (n)
  • 99.59 (a)
HOXC8 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC607625 36
  • 95.57 (n)
  • 97.25 (a)
mouse
(Mus musculus)
Mammalia Hoxc8 36
  • 95.59 (n)
  • 99.59 (a)
Hoxc8 16
Hoxc8 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC8 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxc8 36
  • 95.87 (n)
  • 99.59 (a)
chicken
(Gallus gallus)
Aves HOXC8 36
  • 82.72 (n)
  • 93.12 (a)
lizard
(Anolis carolinensis)
Reptilia HOXC8 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xhoxc8 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc8 36
  • 83.49 (n)
  • 92.66 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxc8a 36
hoxc8a 36
  • 75.12 (n)
  • 87.1 (a)
hoxc8a 37
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta abd-A 37
  • 14 (a)
ManyToMany
Ubx 37
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lin-39 37
  • 26 (a)
ManyToMany
mab-5 37
  • 33 (a)
ManyToMany
Species with no ortholog for HOXC8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HOXC8 Gene

ENSEMBL:
Gene Tree for HOXC8 (if available)
TreeFam:
Gene Tree for HOXC8 (if available)

Paralogs for HOXC8 Gene

Selected SIMAP similar genes for HOXC8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXC8: view

Variants for HOXC8 Gene

Sequence variations from dbSNP and Humsavar for HOXC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs737219 -- 54,009,133(-) GCAGG(G/T)GGGGG utr-variant-5-prime
rs737220 -- 54,009,133(-) CAGGT(G/T)GGGGG utr-variant-5-prime
rs2083837 -- 54,009,600(-) GCTCG(A/C)CTCTT reference, missense
rs4016776 -- 54,008,878(+) tctct(-/CTCT)CTCGC upstream-variant-2KB
rs4142680 -- 54,011,406(+) CCCCC(C/T)TTAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HOXC8 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914
nsv899101 CNV Loss 21882294
nsv899102 CNV Loss 21882294
esv2672088 CNV Deletion 23128226

Relevant External Links for HOXC8 Gene

HapMap Linkage Disequilibrium report
HOXC8

Disorders for HOXC8 Gene

No disorders were found for HOXC8 Gene.

No data available for UniProtKB/Swiss-Prot for HOXC8 Gene

Publications for HOXC8 Gene

  1. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. (PMID: 11139569) Wan M. … Cao X. (J. Biol. Chem. 2001) 3 23
  2. Organization of human class I homeobox genes. (PMID: 2576652) Boncinelli E. … Simeone A. (Genome 1989) 3 4
  3. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PMID: 9357979) Flagiello D. … Malfoy B. (FEBS Lett. 1997) 3 4
  4. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  5. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3

Products for HOXC8 Gene

  • Addgene plasmids for HOXC8

Sources for HOXC8 Gene

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