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Aliases for HOXC5 Gene

Aliases for HOXC5 Gene

  • Homeobox C5 2 3
  • HOX3D 3 4 6
  • Homeobox Protein Hox-3D 3 4
  • Homeobox Protein CP11 3 4
  • Homeo Box C5 2 3
  • Homeobox Protein Hox-C5 3
  • CP11 3
  • HOX3 3

External Ids for HOXC5 Gene

Previous HGNC Symbols for HOXC5 Gene

  • HOX3D
  • HOX3

Previous GeneCards Identifiers for HOXC5 Gene

  • GC12M054391
  • GC12P054539
  • GC12P054129
  • GC12P052713
  • GC12P054411
  • GC12P054379
  • GC12P051449
  • GC12P054471

Summaries for HOXC5 Gene

Entrez Gene Summary for HOXC5 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC5 Gene

HOXC5 (Homeobox C5) is a Protein Coding gene. Diseases associated with HOXC5 include b-cell lymphomas. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXC5 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC5 Gene

Genomics for HOXC5 Gene

Regulatory Elements for HOXC5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXC5 Gene

Start:
54,016,852 bp from pter
End:
54,035,361 bp from pter
Size:
18,510 bases
Orientation:
Plus strand

Genomic View for HOXC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC5 Gene

Proteins for HOXC5 Gene

  • Protein details for HOXC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00444-HXC5_HUMAN
    Recommended name:
    Homeobox protein Hox-C5
    Protein Accession:
    Q00444
    Secondary Accessions:

    Protein attributes for HOXC5 Gene

    Size:
    222 amino acids
    Molecular mass:
    24976 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXC5 Gene

Proteomics data for HOXC5 Gene at MOPED

Post-translational modifications for HOXC5 Gene

  • Ubiquitination at Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for HOXC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC5 Gene

Domains for HOXC5 Gene

Gene Families for HOXC5 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00444

UniProtKB/Swiss-Prot:

HXC5_HUMAN :
  • Q00444
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXC5: view

Function for HOXC5 Gene

Molecular function for HOXC5 Gene

GENATLAS Biochemistry: homeo box C5(3D),homologous to mouse Hox-3.4,Drosophila antp,Ubx,abd-A ,expressed in first trimester trophoblast,involved in mouse anterior limb patterning, expressed in anterior limb
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC5: view

Phenotypes for HOXC5 Gene

MGI mutant phenotypes for HOXC5:
inferred from 1 alleles
GenomeRNAi human phenotypes for HOXC5:
genes like me logo Genes that share phenotypes with HOXC5: view

Animal Models for HOXC5 Gene

MGI Knock Outs for HOXC5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HOXC5 Gene

Localization for HOXC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXC5 Gene COMPARTMENTS Subcellular localization image for HOXC5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with HOXC5: view

Pathways for HOXC5 Gene

SuperPathways for HOXC5 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Homeobox (HOX) Genes in human,mouse,rat
    • Stem Cell Transcription Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for HOXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1346761
GO:0009952 anterior/posterior pattern specification IEA --
GO:0048706 embryonic skeletal system development IEA --
genes like me logo Genes that share ontologies with HOXC5: view

No data available for Pathways by source for HOXC5 Gene

Transcripts for HOXC5 Gene

mRNA/cDNA for HOXC5 Gene

(228) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXC5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HOXC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC5 Gene

No ASD Table

Relevant External Links for HOXC5 Gene

GeneLoc Exon Structure for
HOXC5
ECgene alternative splicing isoforms for
HOXC5

Expression for HOXC5 Gene

mRNA expression in normal human tissues for HOXC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC5 Gene

This gene is overexpressed in Fallopian Tube (6.5) and Ovary (4.2).
genes like me logo Genes that share expressions with HOXC5: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for HOXC5 Gene

Orthologs for HOXC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXC5 35
  • 97.11 (n)
  • 96.8 (a)
HOXC5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXC5 35
  • 98.5 (n)
  • 99.1 (a)
dog
(Canis familiaris)
Mammalia HOXC5 35
  • 97.45 (n)
  • 96.4 (a)
mouse
(Mus musculus)
Mammalia Hoxc5 35
  • 98.5 (n)
  • 99.55 (a)
Hoxc5 16
Hoxc5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxc5 35
  • 98.5 (n)
  • 99.55 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc5 35
  • 73.94 (n)
  • 73.64 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxc5a 35
  • 58.45 (n)
  • 57.99 (a)
hoxc5a 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ftz 36
  • 18 (a)
OneToMany
Scr 37
  • 75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for HOXC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC5 Gene

ENSEMBL:
Gene Tree for HOXC5 (if available)
TreeFam:
Gene Tree for HOXC5 (if available)

Paralogs for HOXC5 Gene

Selected SIMAP similar genes for HOXC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXC5: view

Variants for HOXC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXC5 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914
nsv899102 CNV Loss 21882294
esv2672088 CNV Deletion 23128226
nsv832418 CNV Loss 17160897

Relevant External Links for HOXC5 Gene

HapMap Linkage Disequilibrium report
HOXC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HOXC5 Gene

Disorders for HOXC5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HOXC5 Gene including...

Search for HOXC5 Gene in MalaCards »

(4) Novoseek inferred disease relationships for HOXC5 Gene

Disease -log(P) Hits PubMed IDs
lymphoma t-cell 54.4 4
lymphoma non-hodgkins 48.4 3
leukemia 35.6 5
lymphoma 24.7 6

Relevant External Links for HOXC5

Genetic Association Database (GAD)
HOXC5
Human Genome Epidemiology (HuGE) Navigator
HOXC5
genes like me logo Genes that share disorders with HOXC5: view

No data available for UniProtKB/Swiss-Prot for HOXC5 Gene

Publications for HOXC5 Gene

  1. The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins. (PMID: 1346761) Arcioni L. … Mavilio F. (EMBO J. 1992) 3 4 23
  2. Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease. (PMID: 16215934) Gong L.G. … Sun K.L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005) 3 23 48
  3. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  4. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  5. Organization of human class I homeobox genes. (PMID: 2576652) Boncinelli E. … Simeone A. (Genome 1989) 3 4

Products for HOXC5 Gene

Sources for HOXC5 Gene

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