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Aliases for HOXB9 Gene

Aliases for HOXB9 Gene

  • Homeobox B9 2 3
  • HOX2E 3 4 6
  • Homeobox Protein Hox-2.5 3 4
  • Homeobox Protein Hox-2E 3 4
  • Homeo Box B9 2 3
  • Homeobox Protein Hox-B9 3
  • Homeo Box 2E 3
  • HOX-2.5 3
  • HOX2 3

External Ids for HOXB9 Gene

Previous HGNC Symbols for HOXB9 Gene

  • HOX2E
  • HOX2

Previous GeneCards Identifiers for HOXB9 Gene

  • GC17M046409
  • GC17M049179
  • GC17M047040
  • GC17M047173
  • GC17M044053
  • GC17M046694
  • GC17M042067

Summaries for HOXB9 Gene

Entrez Gene Summary for HOXB9 Gene

  • This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB9 Gene

HOXB9 (Homeobox B9) is a Protein Coding gene. Diseases associated with HOXB9 include lung cancer and prostate cancer. Among its related pathways are Cyclins and Cell Cycle Regulation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXB9 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB9 Gene

Genomics for HOXB9 Gene

Regulatory Elements for HOXB9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXB9 Gene

Start:
48,621,156 bp from pter
End:
48,626,473 bp from pter
Size:
5,318 bases
Orientation:
Minus strand

Genomic View for HOXB9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB9 Gene

Proteins for HOXB9 Gene

  • Protein details for HOXB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17482-HXB9_HUMAN
    Recommended name:
    Homeobox protein Hox-B9
    Protein Accession:
    P17482
    Secondary Accessions:
    • B2RDB7
    • Q9H1I1

    Protein attributes for HOXB9 Gene

    Size:
    250 amino acids
    Molecular mass:
    28059 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB9 Gene

Proteomics data for HOXB9 Gene at MOPED

Post-translational modifications for HOXB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXB9 Gene

Domains for HOXB9 Gene

Gene Families for HOXB9 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXB9 Gene

Graphical View of Domain Structure for InterPro Entry

P17482

UniProtKB/Swiss-Prot:

HXB9_HUMAN :
  • P17482
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXB9: view

Function for HOXB9 Gene

Molecular function for HOXB9 Gene

GENATLAS Biochemistry: homeo box B9(2E),homologous to mouse Hox-2.5,Drosophila abd-B
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 10617598
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB9: view
genes like me logo Genes that share phenotypes with HOXB9: view

Animal Models for HOXB9 Gene

MGI Knock Outs for HOXB9:

Animal Model Products

CRISPR Products

miRNA for HOXB9 Gene

miRTarBase miRNAs that target HOXB9

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXB9 Gene

Localization for HOXB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB9 Gene COMPARTMENTS Subcellular localization image for HOXB9 gene
Compartment Confidence
nucleus 5
mitochondrion 4

Gene Ontology (GO) - Cellular Components for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with HOXB9: view

Pathways for HOXB9 Gene

genes like me logo Genes that share pathways with HOXB9: view

Pathways by source for HOXB9 Gene

1 Qiagen pathway for HOXB9 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0030879 mammary gland development IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0048706 embryonic skeletal system development IEA --
genes like me logo Genes that share ontologies with HOXB9: view

Transcripts for HOXB9 Gene

mRNA/cDNA for HOXB9 Gene

(82) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXB9 Gene

Homeobox B9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXB9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB9 Gene

No ASD Table

Relevant External Links for HOXB9 Gene

GeneLoc Exon Structure for
HOXB9
ECgene alternative splicing isoforms for
HOXB9

Expression for HOXB9 Gene

mRNA expression in normal human tissues for HOXB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB9 Gene

This gene is overexpressed in Colon - Transverse (26.4), Kidney - Cortex (9.3), and Small Intestine - Terminal Ileum (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HOXB9 Gene

SOURCE GeneReport for Unigene cluster for HOXB9 Gene Hs.463350

genes like me logo Genes that share expressions with HOXB9: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HOXB9 Gene

Orthologs for HOXB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB9 35
  • 99.6 (n)
  • 99.6 (a)
HOXB9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXB9 35
  • 98.4 (n)
  • 99.6 (a)
HOXB9 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXB9 35
  • 98.4 (n)
  • 99.2 (a)
HOXB9 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb9 35
  • 95.87 (n)
  • 96.8 (a)
Hoxb9 16
Hoxb9 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXB9 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB9 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxb9 35
  • 95.47 (n)
  • 96.8 (a)
chicken
(Gallus gallus)
Aves HOXB9 35
  • 78.81 (n)
  • 82.52 (a)
HOXB9 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXB9 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb9 35
  • 74.04 (n)
  • 74.59 (a)
MGC75797 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5766 35
zebrafish
(Danio rerio)
Actinopterygii hoxb9a 35
  • 70.45 (n)
  • 73.68 (a)
hoxb9a 36
  • 71 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for HOXB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB9 Gene

ENSEMBL:
Gene Tree for HOXB9 (if available)
TreeFam:
Gene Tree for HOXB9 (if available)

Paralogs for HOXB9 Gene

Selected SIMAP similar genes for HOXB9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXB9: view

Variants for HOXB9 Gene

Sequence variations from dbSNP and Humsavar for HOXB9 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8844 -- 48,621,348(-) TTGTC(A/G)GTGGC utr-variant-3-prime
rs2303485 -- 48,622,201(+) CCACC(A/G)GCTTG utr-variant-3-prime
rs2303486 -- 48,622,307(+) GCAAC(A/T)CCTCA utr-variant-3-prime
rs2303487 -- 48,627,174(+) TCCAA(G/T)AATCC upstream-variant-2KB
rs2875819 -- 48,621,130(+) AGAGC(C/T)AACAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HOXB9 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990

Relevant External Links for HOXB9 Gene

HapMap Linkage Disequilibrium report
HOXB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB9 Gene

Disorders for HOXB9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HOXB9 Gene including...

Search for HOXB9 Gene in MalaCards »

Relevant External Links for HOXB9

Genetic Association Database (GAD)
HOXB9
Human Genome Epidemiology (HuGE) Navigator
HOXB9
genes like me logo Genes that share disorders with HOXB9: view

No data available for UniProtKB/Swiss-Prot for HOXB9 Gene

Publications for HOXB9 Gene

  1. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  2. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  3. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PMID: 2570724) Giampaolo A. … Peschle C. (Differentiation 1989) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HOXB9 Gene

  • Addgene plasmids for HOXB9

Sources for HOXB9 Gene

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