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Aliases for HOXB9 Gene

Aliases for HOXB9 Gene

  • Homeobox B9 2 3 5
  • Homeobox Protein Hox-2.5 3 4
  • Homeobox Protein Hox-2E 3 4
  • Homeo Box B9 2 3
  • HOX2E 3 4
  • Homeobox Protein Hox-B9 3
  • Homeo Box 2E 3
  • HOX-2.5 3
  • HOX2 3

External Ids for HOXB9 Gene

Previous HGNC Symbols for HOXB9 Gene

  • HOX2E
  • HOX2

Previous GeneCards Identifiers for HOXB9 Gene

  • GC17M046409
  • GC17M049179
  • GC17M047040
  • GC17M047173
  • GC17M044053
  • GC17M046694
  • GC17M042067

Summaries for HOXB9 Gene

Entrez Gene Summary for HOXB9 Gene

  • This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB9 Gene

HOXB9 (Homeobox B9) is a Protein Coding gene. Among its related pathways are Cyclins and Cell Cycle Regulation. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXA9.

UniProtKB/Swiss-Prot for HOXB9 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB9 Gene

Genomics for HOXB9 Gene

Regulatory Elements for HOXB9 Gene

Enhancers for HOXB9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G048538 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 14.7 +53.3 53308 68.8 CREB3L1 AGO1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D ZNF610 HOXB2 SKAP1 HOXB9 HOXB3 ENSG00000264701 HOXB-AS1 HOXB-AS3 SUMO2P17 HOXB-AS4 HOXB1
GH17G048293 2.1 Ensembl ENCODE 9.6 +331.6 331576 2.8 ZBTB40 ZNF766 SCRT2 RELB FOS IKZF2 CREM ZNF362 ELF4 JUNB SKAP1 MIR1203 HOXB9 HOXB-AS4 CBX1 SNX11 CDK5RAP3 PRR15L EGID-105371807 ENSG00000266222
GH17G048238 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +384.3 384311 7.2 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF766 FOS JUNB TBX21 ZNF592 SNX11 COPZ2 CDK5RAP3 ITGB3 RNU6-1152P SKAP1 MIR1203 EGID-105371807 ENSG00000266601 CBX1
GH17G048623 1.7 FANTOM5 ENCODE dbSUPER 10.3 -0.2 -178 6.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A FEZF1 ZNF766 CBX5 SP3 ENSG00000264701 HOXB9 PRAC2 PRAC1 HOXB13 LOC105371811 HOXB2 HOXB8 HOXB5 HOXB6
GH17G048011 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9 +613.0 613042 4.3 HDGF PKNOX1 ARNT SIN3A ZNF2 ZBTB7B ZNF143 ZNF207 ZNF548 ZNF263 PRR15L SCRN2 COPZ2 CDK5RAP3 SKAP1 MRPL45P2 CBX1 SUMO2P17 MIR152 RPS2P47
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOXB9 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXB9 Gene

Chromosome:
17
Start:
48,615,128 bp from pter
End:
48,626,473 bp from pter
Size:
11,346 bases
Orientation:
Minus strand

Genomic View for HOXB9 Gene

Genes around HOXB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB9 Gene

Proteins for HOXB9 Gene

  • Protein details for HOXB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17482-HXB9_HUMAN
    Recommended name:
    Homeobox protein Hox-B9
    Protein Accession:
    P17482
    Secondary Accessions:
    • B2RDB7
    • Q9H1I1

    Protein attributes for HOXB9 Gene

    Size:
    250 amino acids
    Molecular mass:
    28059 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB9 Gene

Post-translational modifications for HOXB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXB9 Gene

Domains & Families for HOXB9 Gene

Gene Families for HOXB9 Gene

Suggested Antigen Peptide Sequences for HOXB9 Gene

Graphical View of Domain Structure for InterPro Entry

P17482

UniProtKB/Swiss-Prot:

HXB9_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXB9: view

Function for HOXB9 Gene

Molecular function for HOXB9 Gene

GENATLAS Biochemistry:
homeo box B9(2E),homologous to mouse Hox-2.5,Drosophila abd-B
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10617598
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB9: view
genes like me logo Genes that share phenotypes with HOXB9: view

Animal Models for HOXB9 Gene

MGI Knock Outs for HOXB9:

Animal Model Products

CRISPR Products

miRNA for HOXB9 Gene

miRTarBase miRNAs that target HOXB9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB9 Gene

Localization for HOXB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXB9 gene
Compartment Confidence
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with HOXB9: view

Pathways & Interactions for HOXB9 Gene

genes like me logo Genes that share pathways with HOXB9: view

Pathways by source for HOXB9 Gene

1 Qiagen pathway for HOXB9 Gene

Gene Ontology (GO) - Biological Process for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0030879 mammary gland development IEA --
genes like me logo Genes that share ontologies with HOXB9: view

No data available for SIGNOR curated interactions for HOXB9 Gene

Transcripts for HOXB9 Gene

mRNA/cDNA for HOXB9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(82) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXB9 Gene

Homeobox B9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB9 Gene

No ASD Table

Relevant External Links for HOXB9 Gene

GeneLoc Exon Structure for
HOXB9
ECgene alternative splicing isoforms for
HOXB9

Expression for HOXB9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB9 Gene

This gene is overexpressed in Colon - Transverse (x26.4), Kidney - Cortex (x9.3), and Small Intestine - Terminal Ileum (x7.2).

Protein differential expression in normal tissues from HIPED for HOXB9 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB9 Gene



Protein tissue co-expression partners for HOXB9 Gene

NURSA nuclear receptor signaling pathways regulating expression of HOXB9 Gene:

HOXB9

SOURCE GeneReport for Unigene cluster for HOXB9 Gene:

Hs.463350

Evidence on tissue expression from TISSUES for HOXB9 Gene

  • Muscle(4.2)
  • Intestine(3.1)
genes like me logo Genes that share expression patterns with HOXB9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB9 Gene

Orthologs for HOXB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB9 34 35
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia HOXB9 34 35
  • 98.4 (n)
dog
(Canis familiaris)
Mammalia HOXB9 34 35
  • 98.4 (n)
mouse
(Mus musculus)
Mammalia Hoxb9 34 16 35
  • 95.87 (n)
rat
(Rattus norvegicus)
Mammalia Hoxb9 34
  • 95.47 (n)
oppossum
(Monodelphis domestica)
Mammalia HOXB9 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB9 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB9 34 35
  • 78.81 (n)
lizard
(Anolis carolinensis)
Reptilia HOXB9 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb9 34
  • 74.04 (n)
MGC75797 34
zebrafish
(Danio rerio)
Actinopterygii hoxb9a 34 35
  • 70.45 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5766 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToMany
Species where no ortholog for HOXB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB9 Gene

ENSEMBL:
Gene Tree for HOXB9 (if available)
TreeFam:
Gene Tree for HOXB9 (if available)

Paralogs for HOXB9 Gene

(6) SIMAP similar genes for HOXB9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXB9: view

Variants for HOXB9 Gene

Sequence variations from dbSNP and Humsavar for HOXB9 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000123927 -- 48,621,676(+) AGAAG(C/T)CGACG utr-variant-3-prime, utr-variant-5-prime
rs1000541350 -- 48,620,758(+) GACAT(C/T)CTCAG downstream-variant-500B, utr-variant-5-prime
rs1000911501 -- 48,624,916(+) CCTCT(C/T)CCCGG intron-variant
rs1001040440 -- 48,624,047(+) CTGGA(C/G)GGGAG intron-variant, upstream-variant-2KB
rs1001216259 -- 48,623,526(+) GCTCT(A/T)GGAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HOXB9 Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv2758694 CNV gain 17122850
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897

Variation tolerance for HOXB9 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXB9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB9 Gene

Disorders for HOXB9 Gene

Relevant External Links for HOXB9

Genetic Association Database (GAD)
HOXB9
Human Genome Epidemiology (HuGE) Navigator
HOXB9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXB9

No disorders were found for HOXB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXB9 Gene

Publications for HOXB9 Gene

  1. Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population. (PMID: 19341834) Rouault K. … FAcrec C. (Osteoarthr. Cartil. 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4 64
  5. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64

Products for HOXB9 Gene

Sources for HOXB9 Gene

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