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Aliases for HOXB8 Gene

Aliases for HOXB8 Gene

  • Homeobox B8 2 3 5
  • Homeobox Protein Hox-2.4 3 4
  • Homeobox Protein Hox-2D 3 4
  • Homeo Box B8 2 3
  • HOX2D 3 4
  • Homeo Box 2D 3
  • Hox-2.4 3
  • HOX2 3

External Ids for HOXB8 Gene

Previous HGNC Symbols for HOXB8 Gene

  • HOX2
  • HOX2D

Previous GeneCards Identifiers for HOXB8 Gene

  • GC17M046401
  • GC17M049170
  • GC17M047030
  • GC17M047164
  • GC17M044044
  • GC17M046688
  • GC17M042058

Summaries for HOXB8 Gene

Entrez Gene Summary for HOXB8 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB8 Gene

HOXB8 (Homeobox B8) is a Protein Coding gene. Diseases associated with HOXB8 include trichotillomania. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXB8 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB8 Gene

Genomics for HOXB8 Gene

Regulatory Elements for HOXB8 Gene

Genomic Location for HOXB8 Gene

Chromosome:
17
Start:
48,611,377 bp from pter
End:
48,615,112 bp from pter
Size:
3,736 bases
Orientation:
Minus strand

Genomic View for HOXB8 Gene

Genes around HOXB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB8 Gene

Proteins for HOXB8 Gene

  • Protein details for HOXB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17481-HXB8_HUMAN
    Recommended name:
    Homeobox protein Hox-B8
    Protein Accession:
    P17481
    Secondary Accessions:
    • Q9H1I2

    Protein attributes for HOXB8 Gene

    Size:
    243 amino acids
    Molecular mass:
    27574 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB8 Gene

Proteomics data for HOXB8 Gene at MOPED

Post-translational modifications for HOXB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXB8 Gene

Domains & Families for HOXB8 Gene

Gene Families for HOXB8 Gene

Suggested Antigen Peptide Sequences for HOXB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17481

UniProtKB/Swiss-Prot:

HXB8_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB8: view

Function for HOXB8 Gene

Molecular function for HOXB8 Gene

GENATLAS Biochemistry:
homeo box B8(2D),homologous to mouse Hox-2.4,Drosophila Antp,Ubx,abd-A,involved in the establishment of anteroposterior polarity of the anterior mouse limb,controlled by SHH through a negative feedback loop
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
genes like me logo Genes that share phenotypes with HOXB8: view

Animal Models for HOXB8 Gene

MGI Knock Outs for HOXB8:

Animal Model Products

  • Taconic Biosciences Mouse Models for HOXB8

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB8 Gene

Localization for HOXB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB8 Gene COMPARTMENTS Subcellular localization image for HOXB8 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HOXB8 Gene

Pathways & Interactions for HOXB8 Gene

SuperPathways for HOXB8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007625 grooming behavior IEA --
GO:0008344 adult locomotory behavior IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXB8: view

No data available for Pathways by source and SIGNOR curated interactions for HOXB8 Gene

Drugs & Compounds for HOXB8 Gene

No Compound Related Data Available

Transcripts for HOXB8 Gene

mRNA/cDNA for HOXB8 Gene

Unigene Clusters for HOXB8 Gene

Homeobox B8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB8 Gene

No ASD Table

Relevant External Links for HOXB8 Gene

GeneLoc Exon Structure for
HOXB8
ECgene alternative splicing isoforms for
HOXB8

Expression for HOXB8 Gene

mRNA expression in normal human tissues for HOXB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB8 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x24.4), Kidney - Cortex (x8.2), and Cervix - Endocervix (x4.8).

Protein differential expression in normal tissues from HIPED for HOXB8 Gene

This gene is overexpressed in Colon muscle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB8 Gene



SOURCE GeneReport for Unigene cluster for HOXB8 Gene Hs.514292

genes like me logo Genes that share expression patterns with HOXB8: view

Protein tissue co-expression partners for HOXB8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HOXB8 Gene

Orthologs for HOXB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100337349 35
  • 96.71 (n)
  • 99.3 (a)
dog
(Canis familiaris)
Mammalia HOXB8 35
  • 97.39 (n)
  • 99.59 (a)
HOXB8 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb8 35
  • 95.2 (n)
  • 98.35 (a)
Hoxb8 16
Hoxb8 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxb8 35
  • 95.47 (n)
  • 98.35 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB8 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB8 35
  • 83.82 (n)
  • 91.7 (a)
lizard
(Anolis carolinensis)
Reptilia HOXB8 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb8 35
  • 80.28 (n)
  • 86.67 (a)
Str.10287 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
hoxb8a 35
  • 73.06 (n)
  • 79.58 (a)
hoxb8a 36
  • 78 (a)
OneToMany
hoxb8b 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta abd-A 36
  • 15 (a)
ManyToMany
Ubx 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lin-39 36
  • 27 (a)
ManyToMany
mab-5 36
  • 31 (a)
ManyToMany
Species with no ortholog for HOXB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HOXB8 Gene

ENSEMBL:
Gene Tree for HOXB8 (if available)
TreeFam:
Gene Tree for HOXB8 (if available)

Paralogs for HOXB8 Gene

genes like me logo Genes that share paralogs with HOXB8: view

Variants for HOXB8 Gene

Sequence variations from dbSNP and Humsavar for HOXB8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2303484 -- 48,614,447(+) TAGCC(A/G)TAGAA reference, synonymous-codon
rs7406355 -- 48,614,061(+) GCAGG(A/G)TGAGG intron-variant
rs7406365 -- 48,614,225(+) CTGCC(A/C)GGCCT intron-variant
rs11267100 -- 48,614,229(+) AGGCC(-/CCCTGCCCGGCC)TTGGG intron-variant
rs56292972 -- 48,613,681(+) GGCGG(A/C)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOXB8 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990
esv2676919 CNV Deletion 23128226

Variation tolerance for HOXB8 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXB8 Gene

HapMap Linkage Disequilibrium report
HOXB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB8 Gene

Disorders for HOXB8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HOXB8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trichotillomania
  • hair-pulling syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HOXB8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOXB8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXB8
genes like me logo Genes that share disorders with HOXB8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB8 Gene

Publications for HOXB8 Gene

  1. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4 67
  2. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  4. FMRP regulates miR196a-mediated repression of HOXB8 via interaction with the AGO2 MID domain. (PMID: 24727796) Li Y. … Zhang C.Y. (Mol Biosyst 2014) 3
  5. Identification of HOXB8 and KLK11 expression levels as potential biomarkers to predict the effects of FOLFOX4 chemotherapy. (PMID: 23647300) Li S. … Pan J. (Future Oncol 2013) 3

Products for HOXB8 Gene

Sources for HOXB8 Gene

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