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Aliases for HOXB8 Gene

Aliases for HOXB8 Gene

  • Homeobox B8 2 3
  • HOX2D 3 4 6
  • Homeobox Protein Hox-2.4 3 4
  • Homeobox Protein Hox-2D 3 4
  • Homeo Box B8 2 3
  • Homeobox Protein Hox-B8 3
  • Homeo Box 2D 3
  • Hox-2.4 3
  • HOX2 3

External Ids for HOXB8 Gene

Previous Symbols for HOXB8 Gene

  • HOX2
  • HOX2D

Summaries for HOXB8 Gene

Entrez Gene Summary for HOXB8 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB8 Gene

HOXB8 (Homeobox B8) is a Protein Coding gene. Diseases associated with HOXB8 include colorectal cancer and trichotillomania. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXB8 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB8 Gene

Genomics for HOXB8 Gene

Genomic Location for HOXB8 Gene

Start:
48,611,377 bp from pter
End:
48,615,112 bp from pter
Size:
3,736 bases
Orientation:
Minus strand

Genomic View for HOXB8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB8 Gene

Regulatory Elements for HOXB8 Gene

Proteins for HOXB8 Gene

  • Protein details for HOXB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17481-HXB8_HUMAN
    Recommended name:
    Homeobox protein Hox-B8
    Protein Accession:
    P17481
    Secondary Accessions:
    • Q9H1I2

    Protein attributes for HOXB8 Gene

    Size:
    243 amino acids
    Molecular mass:
    27574 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB8 Gene

Proteomics data for HOXB8 Gene at MOPED

Post-translational modifications for HOXB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXB8 Gene

Domains for HOXB8 Gene

Gene Families for HOXB8 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

UniProtKB/Swiss-Prot:

HXB8_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • P17481
Family:
  • Belongs to the Antp homeobox family.:
    • P17481
genes like me logo Genes that share domains with HOXB8: view

Function for HOXB8 Gene

Molecular function for HOXB8 Gene

GENATLAS Biochemistry: homeo box B8(2D),homologous to mouse Hox-2.4,Drosophila Antp,Ubx,abd-A,involved in the establishment of anteroposterior polarity of the anterior mouse limb,controlled by SHH through a negative feedback loop
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB8: view
genes like me logo Genes that share phenotypes with HOXB8: view

Animal Models for HOXB8 Gene

MGI Knock Outs for HOXB8:

miRNA for HOXB8 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXB8 Gene

Localization for HOXB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB8 Gene COMPARTMENTS Subcellular localization image for HOXB8 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXB8: view

Pathways for HOXB8 Gene

SuperPathways for HOXB8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development --
GO:0007625 grooming behavior IEA --
GO:0008344 adult locomotory behavior IEA --
genes like me logo Genes that share ontologies with HOXB8: view

No data available for Pathways by source for HOXB8 Gene

Transcripts for HOXB8 Gene

mRNA/cDNA for HOXB8 Gene

Unigene Clusters for HOXB8 Gene

Homeobox B8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB8 Gene

No ASD Table

Relevant External Links for HOXB8 Gene

GeneLoc Exon Structure for
HOXB8
ECgene alternative splicing isoforms for
HOXB8

Expression for HOXB8 Gene

mRNA expression in normal human tissues for HOXB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB8 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (24.4), Kidney - Cortex (8.2), and Cervix - Endocervix (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HOXB8 Gene

SOURCE GeneReport for Unigene cluster for HOXB8 Gene Hs.514292

genes like me logo Genes that share expressions with HOXB8: view

Orthologs for HOXB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100337349 36
  • 96.71 (n)
  • 99.3 (a)
dog
(Canis familiaris)
Mammalia HOXB8 36
  • 97.39 (n)
  • 99.59 (a)
HOXB8 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb8 36
  • 95.2 (n)
  • 98.35 (a)
Hoxb8 16
Hoxb8 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB8 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxb8 36
  • 95.47 (n)
  • 98.35 (a)
chicken
(Gallus gallus)
Aves HOXB8 36
  • 83.82 (n)
  • 91.7 (a)
lizard
(Anolis carolinensis)
Reptilia HOXB8 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb8 36
  • 80.28 (n)
  • 86.67 (a)
Str.10287 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
hoxb8a 36
  • 73.06 (n)
  • 79.58 (a)
hoxb8a 37
  • 78 (a)
OneToMany
hoxb8b 37
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta abd-A 37
  • 15 (a)
ManyToMany
Ubx 37
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lin-39 37
  • 27 (a)
ManyToMany
mab-5 37
  • 31 (a)
ManyToMany
Species with no ortholog for HOXB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HOXB8 Gene

ENSEMBL:
Gene Tree for HOXB8 (if available)
TreeFam:
Gene Tree for HOXB8 (if available)

Paralogs for HOXB8 Gene

Selected SIMAP similar genes for HOXB8 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HOXB8: view

Variants for HOXB8 Gene

Sequence variations from dbSNP and Humsavar for HOXB8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2303484 -- 48,614,447(+) TAGCC(A/G)TAGAA reference, synonymous-codon
rs2326016 -- 48,617,053(+) AGAGA(C/G)AGAAA upstream-variant-2KB
rs3809778 -- 48,616,415(-) CCCTT(C/T)ATGCA upstream-variant-2KB
rs3809779 -- 48,616,129(-) AGGGA(C/T)CTTTT upstream-variant-2KB
rs3809780 -- 48,616,081(-) AGGAC(A/G)GAAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HOXB8 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990
esv2676919 CNV Deletion 23128226

Relevant External Links for HOXB8 Gene

HapMap Linkage Disequilibrium report
HOXB8

Disorders for HOXB8 Gene

(1) University of Copenhagen DISEASES for HOXB8 Gene

genes like me logo Genes that share disorders with HOXB8: view

No data available for UniProtKB/Swiss-Prot for HOXB8 Gene

Publications for HOXB8 Gene

  1. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  2. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  3. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PMID: 2570724) Giampaolo A. … Peschle C. (Differentiation 1989) 3 4
  4. Organization of human class I homeobox genes. (PMID: 2576652) Boncinelli E. … Simeone A. (Genome 1989) 3 4
  5. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4

Products for HOXB8 Gene

  • Addgene plasmids for HOXB8

Sources for HOXB8 Gene

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