Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HOXB7 Gene

Aliases for HOXB7 Gene

  • Homeobox B7 2 3 5
  • Homeobox Protein HHO.C1 3 4
  • Homeobox Protein Hox-2C 3 4
  • Homeo Box B7 2 3
  • HOX2C 3 4
  • Homeo Box C1 Protein 3
  • Homeo Box 2C 3
  • Hox-2.3 3
  • HHO.C1 3
  • HOX2 3

External Ids for HOXB7 Gene

Previous HGNC Symbols for HOXB7 Gene

  • HOX2
  • HOX2C

Previous GeneCards Identifiers for HOXB7 Gene

  • GC17M046395
  • GC17M049165
  • GC17M047026
  • GC17M047159
  • GC17M044039
  • GC17M046684
  • GC17M042053

Summaries for HOXB7 Gene

Entrez Gene Summary for HOXB7 Gene

  • This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB7 Gene

HOXB7 (Homeobox B7) is a Protein Coding gene. Diseases associated with HOXB7 include ovarian endodermal sinus tumor and ovarian primitive germ cell tumor. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXB7 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB7 Gene

Genomics for HOXB7 Gene

Regulatory Elements for HOXB7 Gene

Transcription factor binding sites by QIAGEN in the HOXB7 gene promoter:

Genomic Location for HOXB7 Gene

Chromosome:
17
Start:
48,607,227 bp from pter
End:
48,633,572 bp from pter
Size:
26,346 bases
Orientation:
Minus strand

Genomic View for HOXB7 Gene

Genes around HOXB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB7 Gene

Proteins for HOXB7 Gene

  • Protein details for HOXB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09629-HXB7_HUMAN
    Recommended name:
    Homeobox protein Hox-B7
    Protein Accession:
    P09629
    Secondary Accessions:
    • A8K3N8
    • Q15957
    • Q53FN3
    • Q96BQ6

    Protein attributes for HOXB7 Gene

    Size:
    217 amino acids
    Molecular mass:
    24015 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB7 Gene

Proteomics data for HOXB7 Gene at MOPED

Post-translational modifications for HOXB7 Gene

  • Ubiquitination at Lys 191 and Lys 193
  • Modification sites at PhosphoSitePlus

Other Protein References for HOXB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXB7 Gene

Domains & Families for HOXB7 Gene

Gene Families for HOXB7 Gene

Suggested Antigen Peptide Sequences for HOXB7 Gene

Graphical View of Domain Structure for InterPro Entry

P09629

UniProtKB/Swiss-Prot:

HXB7_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB7: view

Function for HOXB7 Gene

Molecular function for HOXB7 Gene

GENATLAS Biochemistry:
homeo box B7(2C),homologous to mouse Hox-2.3,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17308091
genes like me logo Genes that share ontologies with HOXB7: view
genes like me logo Genes that share phenotypes with HOXB7: view

Animal Models for HOXB7 Gene

MGI Knock Outs for HOXB7:

Animal Model Products

miRNA for HOXB7 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB7 Gene

Localization for HOXB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB7 Gene COMPARTMENTS Subcellular localization image for HOXB7 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HOXB7: view

Pathways & Interactions for HOXB7 Gene

SuperPathways for HOXB7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 1678287
GO:0009952 anterior/posterior pattern specification IEA --
GO:0048704 embryonic skeletal system morphogenesis IEA --
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA --
genes like me logo Genes that share ontologies with HOXB7: view

No data available for Pathways by source and SIGNOR curated interactions for HOXB7 Gene

Drugs & Compounds for HOXB7 Gene

(1) Additional Compounds for HOXB7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HOXB7: view

Transcripts for HOXB7 Gene

mRNA/cDNA for HOXB7 Gene

Unigene Clusters for HOXB7 Gene

Homeobox B7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB7 Gene

No ASD Table

Relevant External Links for HOXB7 Gene

GeneLoc Exon Structure for
HOXB7
ECgene alternative splicing isoforms for
HOXB7

Expression for HOXB7 Gene

mRNA expression in normal human tissues for HOXB7 Gene

mRNA differential expression in normal tissues according to GTEx for HOXB7 Gene

This gene is overexpressed in Colon - Transverse (x10.4), Kidney - Cortex (x5.1), and Small Intestine - Terminal Ileum (x4.8).

Protein differential expression in normal tissues from HIPED for HOXB7 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXB7 Gene



SOURCE GeneReport for Unigene cluster for HOXB7 Gene Hs.436181

genes like me logo Genes that share expression patterns with HOXB7: view

Protein tissue co-expression partners for HOXB7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HOXB7 Gene

Orthologs for HOXB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB7 35
  • 99.54 (n)
  • 99.08 (a)
HOXB7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXB7 36
  • 95 (a)
OneToOne
HOXB7 35
  • 96.47 (n)
  • 98.08 (a)
dog
(Canis familiaris)
Mammalia HOXB7 35
  • 95.69 (n)
  • 96.65 (a)
HOXB7 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb7 16
Hoxb7 35
  • 93.59 (n)
  • 93.75 (a)
Hoxb7 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXB7 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB7 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxb7 35
  • 92.79 (n)
  • 93.27 (a)
chicken
(Gallus gallus)
Aves HOXB-7 36
  • 75 (a)
OneToOne
HOXB7 35
  • 76.65 (n)
  • 76.81 (a)
lizard
(Anolis carolinensis)
Reptilia HOXB7 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1210 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494663 35
  • 74.6 (n)
  • 71.36 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxb7a 36
  • 57 (a)
OneToOne
hoxb7a 35
  • 65.7 (n)
  • 61.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Antp 37
  • 82 (a)
Antp 36
  • 23 (a)
OneToMany
Species with no ortholog for HOXB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB7 Gene

ENSEMBL:
Gene Tree for HOXB7 (if available)
TreeFam:
Gene Tree for HOXB7 (if available)

Paralogs for HOXB7 Gene

(18) SIMAP similar genes for HOXB7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXB7: view

Variants for HOXB7 Gene

Sequence variations from dbSNP and Humsavar for HOXB7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs7406910 - 48,610,894(+) TAAAG(C/T)ATTCG reference, missense
rs1126558 -- 48,610,533(-) CCCCT(C/G)GATGC reference, missense
rs3786138 -- 48,609,262(-) ATCAG(C/T)ACCTC intron-variant
rs7224295 -- 48,609,193(+) CTGGG(C/T)GGTGG intron-variant
rs8076815 -- 48,610,236(+) AAAGC(C/T)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOXB7 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990
esv2676919 CNV Deletion 23128226

Variation tolerance for HOXB7 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.38; 71.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXB7 Gene

HapMap Linkage Disequilibrium report
HOXB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB7 Gene

Disorders for HOXB7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HOXB7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian endodermal sinus tumor
  • endodermal sinus tumor of ovary
ovarian primitive germ cell tumor
- elite association - COSMIC cancer census association via MalaCards
Search HOXB7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOXB7

Genetic Association Database (GAD)
HOXB7
Human Genome Epidemiology (HuGE) Navigator
HOXB7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXB7
genes like me logo Genes that share disorders with HOXB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB7 Gene

Publications for HOXB7 Gene

  1. Correlation between genetic variations in Hox clusters and Hirschsprung's disease. (PMID: 17274802) Garcia-BarcelA^ M.M. … Tam P.K. (Ann. Hum. Genet. 2007) 3 48 67
  2. Differential expression of HOXB7 gene in multiple myeloma and extramedullary multiple myeloma patients. (PMID: 19878270) Novak E.M. … Bydlowski S.P. (Eur. J. Haematol. 2010) 3 23
  3. Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. (PMID: 19956843) De Souza Setubal Destro M.F. … Coletta R.D. (Int. J. Oncol. 2010) 3 23
  4. A role for the HOXB7 homeodomain protein in DNA repair. (PMID: 17308091) Rubin E. … Sukumar S. (Cancer Res. 2007) 3 23
  5. Inhibition of 13-cis retinoic acid-induced gene expression of homeobox B7 by thalidomide. (PMID: 17514648) MilanoviA8 D. … Herskind C. (Int. J. Cancer 2007) 3 23

Products for HOXB7 Gene

Sources for HOXB7 Gene

Back to Top

Content