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Aliases for HOXB7 Gene

Aliases for HOXB7 Gene

  • Homeobox B7 2 3
  • HOX2C 3 4 6
  • Homeobox Protein HHO.C1 3 4
  • Homeobox Protein Hox-2C 3 4
  • Homeo Box B7 2 3
  • Homeobox Protein Hox-B7 3
  • Homeo Box C1 Protein 3
  • Homeo Box 2C 3
  • Hox-2.3 3
  • HHO.C1 3
  • HOX2 3

External Ids for HOXB7 Gene

Previous HGNC Symbols for HOXB7 Gene

  • HOX2
  • HOX2C

Previous GeneCards Identifiers for HOXB7 Gene

  • GC17M046395
  • GC17M049165
  • GC17M047026
  • GC17M047159
  • GC17M044039
  • GC17M046684
  • GC17M042053

Summaries for HOXB7 Gene

Entrez Gene Summary for HOXB7 Gene

  • This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB7 Gene

HOXB7 (Homeobox B7) is a Protein Coding gene. Diseases associated with HOXB7 include cytomegalovirus infection and melanoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXB7 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB7 Gene

Genomics for HOXB7 Gene

Regulatory Elements for HOXB7 Gene

Transcription factor binding sites by QIAGEN in the HOXB7 gene promoter:

Genomic Location for HOXB7 Gene

48,607,227 bp from pter
48,633,572 bp from pter
26,346 bases
Minus strand

Genomic View for HOXB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB7 Gene

Proteins for HOXB7 Gene

  • Protein details for HOXB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Hox-B7
    Protein Accession:
    Secondary Accessions:
    • A8K3N8
    • Q15957
    • Q53FN3
    • Q96BQ6

    Protein attributes for HOXB7 Gene

    217 amino acids
    Molecular mass:
    24015 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB7 Gene

Proteomics data for HOXB7 Gene at MOPED

Post-translational modifications for HOXB7 Gene

  • Ubiquitination at Lys191 and Lys193
  • Modification sites at PhosphoSitePlus

Other Protein References for HOXB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXB7 Gene

Domains for HOXB7 Gene

Gene Families for HOXB7 Gene

  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXB7 Gene

Graphical View of Domain Structure for InterPro Entry



  • P09629
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB7: view

Function for HOXB7 Gene

Molecular function for HOXB7 Gene

GENATLAS Biochemistry: homeo box B7(2C),homologous to mouse Hox-2.3,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 1678287
GO:0005515 protein binding IPI 17308091
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB7: view

Phenotypes for HOXB7 Gene

genes like me logo Genes that share phenotypes with HOXB7: view

Animal Models for HOXB7 Gene

MGI Knock Outs for HOXB7:

miRNA for HOXB7 Gene

miRTarBase miRNAs that target HOXB7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXB7 Gene

Localization for HOXB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB7 Gene

Subcellular locations from

Jensen Localization Image for HOXB7 Gene COMPARTMENTS Subcellular localization image for HOXB7 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for HOXB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 1678287
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HOXB7: view

Pathways for HOXB7 Gene

SuperPathways for HOXB7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1678287
GO:0007275 multicellular organismal development NAS 2885844
GO:0009952 anterior/posterior pattern specification IEA --
GO:0030099 myeloid cell differentiation IEA --
genes like me logo Genes that share ontologies with HOXB7: view

No data available for Pathways by source for HOXB7 Gene

Compounds for HOXB7 Gene

(1) Novoseek inferred chemical compound relationships for HOXB7 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 32.2 6
genes like me logo Genes that share compounds with HOXB7: view

Transcripts for HOXB7 Gene

mRNA/cDNA for HOXB7 Gene

Unigene Clusters for HOXB7 Gene

Homeobox B7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB7 Gene

No ASD Table

Relevant External Links for HOXB7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOXB7 Gene

mRNA expression in normal human tissues for HOXB7 Gene

mRNA differential expression in normal tissues according to GTEx for HOXB7 Gene

This gene is overexpressed in Colon - Transverse (10.4), Kidney - Cortex (5.1), and Small Intestine - Terminal Ileum (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXB7 Gene

SOURCE GeneReport for Unigene cluster for HOXB7 Gene Hs.436181

genes like me logo Genes that share expressions with HOXB7: view

No data available for mRNA Expression by UniProt/SwissProt for HOXB7 Gene

Orthologs for HOXB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HOXB7 35
  • 99.54 (n)
  • 99.08 (a)
HOXB7 36
  • 99 (a)
(Bos Taurus)
Mammalia HOXB7 35
  • 96.47 (n)
  • 98.08 (a)
HOXB7 36
  • 95 (a)
(Canis familiaris)
Mammalia HOXB7 35
  • 95.69 (n)
  • 96.65 (a)
HOXB7 36
  • 96 (a)
(Mus musculus)
Mammalia Hoxb7 35
  • 93.59 (n)
  • 93.75 (a)
Hoxb7 16
Hoxb7 36
  • 94 (a)
(Monodelphis domestica)
Mammalia HOXB7 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia HOXB7 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Hoxb7 35
  • 92.79 (n)
  • 93.27 (a)
(Gallus gallus)
Aves HOXB-7 36
  • 75 (a)
HOXB7 35
  • 76.65 (n)
  • 76.81 (a)
(Anolis carolinensis)
Reptilia HOXB7 36
  • 74 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1210 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494663 35
  • 74.6 (n)
  • 71.36 (a)
(Danio rerio)
Actinopterygii hoxb7a 35
  • 65.7 (n)
  • 61.35 (a)
hoxb7a 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Antp 36
  • 23 (a)
Antp 37
  • 82 (a)
Species with no ortholog for HOXB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB7 Gene

Gene Tree for HOXB7 (if available)
Gene Tree for HOXB7 (if available)

Paralogs for HOXB7 Gene

Selected SIMAP similar genes for HOXB7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXB7: view

Variants for HOXB7 Gene

Sequence variations from dbSNP and Humsavar for HOXB7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs15689 -- 48,607,567(-) AAGGA(C/T)ATTAT utr-variant-3-prime
rs734492 -- 48,608,927(+) GCCCA(C/G)TCCCC intron-variant
rs890430 -- 48,609,208(+) TGAAG(C/G)GTAGA intron-variant
rs890431 -- 48,609,478(+) ACCAT(C/T)GCTGG intron-variant
rs1042216 -- 48,607,979(-) CGCAC(A/G)CGCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HOXB7 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990
esv2676919 CNV Deletion 23128226

Relevant External Links for HOXB7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB7 Gene

Disorders for HOXB7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HOXB7 Gene including...

Search for HOXB7 Gene in MalaCards »

(8) Novoseek inferred disease relationships for HOXB7 Gene

Disease -log(P) Hits PubMed IDs
cmv infection 33.4 1
glioblastoma 32.3 3
breast carcinoma 22.2 1
breast cancer 13.9 3
melanoma 6.68 4

Relevant External Links for HOXB7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HOXB7: view

No data available for UniProtKB/Swiss-Prot for HOXB7 Gene

Publications for HOXB7 Gene

  1. HOXB7 constitutively activates basic fibroblast growth factor in melanomas. (PMID: 8756643) CarAc A. … Colombo M.P. (Mol. Cell. Biol. 1996) 3 23
  2. HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development. (PMID: 9457903) Stelnicki E.J. … Largman C. (J. Invest. Dermatol. 1998) 3 23
  3. Transduction of the SkBr3 breast carcinoma cell line with the HOXB7 gene induces bFGF expression, increases cell proliferation and reduces growth factor dependence. (PMID: 9681827) CarAc A. … Colombo M.P. (Oncogene 1998) 3 23
  4. Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation. (PMID: 10208421) CarA" A. … Peschle C. (Oncogene 1999) 3 23
  5. CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein. (PMID: 10435624) Chariot A. … Bours V. (Oncogene 1999) 3 23

Products for HOXB7 Gene

Sources for HOXB7 Gene

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