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Aliases for HOXB5 Gene

Aliases for HOXB5 Gene

  • Homeobox B5 2 3 5
  • Homeobox Protein HHO.C10 3 4
  • Homeobox Protein Hox-2A 3 4
  • Homeobox Protein Hu-1 3 4
  • Homeo Box B5 2 3
  • HOX2A 3 4
  • Homeo Box 2A 3
  • HHO.C10 3
  • Hox2.1 3
  • HOX2 3
  • HU-1 3

External Ids for HOXB5 Gene

Previous HGNC Symbols for HOXB5 Gene

  • HOX2
  • HOX2A

Previous GeneCards Identifiers for HOXB5 Gene

  • GC17M046379
  • GC17M049149
  • GC17M047010
  • GC17M047143
  • GC17M044023
  • GC17M046668
  • GC17M042037

Summaries for HOXB5 Gene

Entrez Gene Summary for HOXB5 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB5 Gene

HOXB5 (Homeobox B5) is a Protein Coding gene. Diseases associated with HOXB5 include teratocarcinoma and hirschsprung disease 1. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXB5 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB5 Gene

Genomics for HOXB5 Gene

Regulatory Elements for HOXB5 Gene

Genomic Location for HOXB5 Gene

Chromosome:
17
Start:
48,591,257 bp from pter
End:
48,593,961 bp from pter
Size:
2,705 bases
Orientation:
Minus strand

Genomic View for HOXB5 Gene

Genes around HOXB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB5 Gene

Proteins for HOXB5 Gene

  • Protein details for HOXB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09067-HXB5_HUMAN
    Recommended name:
    Homeobox protein Hox-B5
    Protein Accession:
    P09067
    Secondary Accessions:
    • B2RC69
    • P09069
    • Q17RP4

    Protein attributes for HOXB5 Gene

    Size:
    269 amino acids
    Molecular mass:
    29434 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA52681.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HOXB5 Gene

Proteomics data for HOXB5 Gene at MOPED

Post-translational modifications for HOXB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXB5 Gene

Domains & Families for HOXB5 Gene

Gene Families for HOXB5 Gene

Suggested Antigen Peptide Sequences for HOXB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09067

UniProtKB/Swiss-Prot:

HXB5_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB5: view

Function for HOXB5 Gene

Molecular function for HOXB5 Gene

GENATLAS Biochemistry:
homeo box B5(2A),homologous to mouse Hox-2.1,Drosophila Scr,involved in the positioning of the mouse upper limb bud
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB5: view
genes like me logo Genes that share phenotypes with HOXB5: view

Animal Models for HOXB5 Gene

MGI Knock Outs for HOXB5:

Animal Model Products

miRNA for HOXB5 Gene

miRTarBase miRNAs that target HOXB5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB5 Gene

Localization for HOXB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB5 Gene COMPARTMENTS Subcellular localization image for HOXB5 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HOXB5 Gene

Pathways & Interactions for HOXB5 Gene

SuperPathways for HOXB5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045446 endothelial cell differentiation IEA --
GO:0048704 embryonic skeletal system morphogenesis IEA --
genes like me logo Genes that share ontologies with HOXB5: view

No data available for Pathways by source and SIGNOR curated interactions for HOXB5 Gene

Drugs & Compounds for HOXB5 Gene

No Compound Related Data Available

Transcripts for HOXB5 Gene

mRNA/cDNA for HOXB5 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(63) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXB5 Gene

Homeobox B5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB5 Gene

No ASD Table

Relevant External Links for HOXB5 Gene

GeneLoc Exon Structure for
HOXB5
ECgene alternative splicing isoforms for
HOXB5

Expression for HOXB5 Gene

mRNA expression in normal human tissues for HOXB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB5 Gene

This gene is overexpressed in Colon - Transverse (x9.1), Kidney - Cortex (x6.9), Brain - Spinal cord (cervical c-1) (x5.4), and Small Intestine - Terminal Ileum (x4.1).

Protein differential expression in normal tissues from HIPED for HOXB5 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB5 Gene



SOURCE GeneReport for Unigene cluster for HOXB5 Gene Hs.654456

mRNA Expression by UniProt/SwissProt for HOXB5 Gene

P09067-HXB5_HUMAN
Tissue specificity: Spinal cord.
genes like me logo Genes that share expression patterns with HOXB5: view

Protein tissue co-expression partners for HOXB5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for HOXB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB5 35
  • 99.88 (n)
  • 100 (a)
HOXB5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXB5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXB5 36
  • 100 (a)
OneToOne
HOXB5 35
  • 97.65 (n)
  • 99.63 (a)
mouse
(Mus musculus)
Mammalia Hoxb5 16
Hoxb5 36
  • 99 (a)
OneToOne
Hoxb5 35
  • 94.67 (n)
  • 98.88 (a)
oppossum
(Monodelphis domestica)
Mammalia HOXB5 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB5 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxb5 35
  • 94.8 (n)
  • 98.88 (a)
chicken
(Gallus gallus)
Aves HOXB5 36
  • 85 (a)
OneToOne
HOXB5 35
  • 77.27 (n)
  • 81.82 (a)
lizard
(Anolis carolinensis)
Reptilia HOXB5 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hoxb5-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb5 35
  • 74.38 (n)
  • 75.29 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxb5a 36
  • 75 (a)
OneToMany
hoxb5b 36
  • 70 (a)
OneToMany
hoxb5a 35
fruit fly
(Drosophila melanogaster)
Insecta Scr 37
  • 73 (a)
ftz 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for HOXB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB5 Gene

ENSEMBL:
Gene Tree for HOXB5 (if available)
TreeFam:
Gene Tree for HOXB5 (if available)

Paralogs for HOXB5 Gene

(10) SIMAP similar genes for HOXB5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXB5: view

Variants for HOXB5 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXB5 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990

Variation tolerance for HOXB5 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXB5 Gene

HapMap Linkage Disequilibrium report
HOXB5
Human Gene Mutation Database (HGMD)
HOXB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HOXB5 Gene

Disorders for HOXB5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HOXB5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
hirschsprung disease 1
  • hirschsprung's disease
- elite association - COSMIC cancer census association via MalaCards
Search HOXB5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOXB5

Genetic Association Database (GAD)
HOXB5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXB5
genes like me logo Genes that share disorders with HOXB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB5 Gene

Publications for HOXB5 Gene

  1. A genome-wide association meta-analysis identifies new childhood obesity loci. (PMID: 22484627) Bradfield J.P. … Grant S.F. (Nat. Genet. 2012) 3 48 67
  2. Expression of Hoxb-5 during human lung development and in congenital lung malformations. (PMID: 14632303) Volpe M.V. … Nielsen H.C. (Birth Defects Res. Part A Clin. Mol. Teratol. 2003) 3 23
  3. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  4. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HOXB5 Gene

Sources for HOXB5 Gene

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