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Aliases for HOXB4 Gene

Aliases for HOXB4 Gene

  • Homeobox B4 2 3
  • HOX2F 3 4 6
  • Homeobox Protein Hox-2.6 3 4
  • Homeobox Protein Hox-2F 3 4
  • Homeo Box B4 2 3
  • Homeobox Protein Hox-B4 3
  • Homeo Box 2F 3
  • HOX-2.6 3
  • HOX2 3

External Ids for HOXB4 Gene

Previous HGNC Symbols for HOXB4 Gene

  • HOX2
  • HOX2F

Previous GeneCards Identifiers for HOXB4 Gene

  • GC17M046364
  • GC17M049133
  • GC17M046995
  • GC17M047127
  • GC17M047128
  • GC17M044007
  • GC17M046652
  • GC17M042021

Summaries for HOXB4 Gene

Entrez Gene Summary for HOXB4 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB4 Gene

HOXB4 (Homeobox B4) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXB4 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB4 Gene

Genomics for HOXB4 Gene

Regulatory Elements for HOXB4 Gene

Genomic Location for HOXB4 Gene

Start:
48,575,507 bp from pter
End:
48,580,111 bp from pter
Size:
4,605 bases
Orientation:
Minus strand

Genomic View for HOXB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB4 Gene

Proteins for HOXB4 Gene

  • Protein details for HOXB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17483-HXB4_HUMAN
    Recommended name:
    Homeobox protein Hox-B4
    Protein Accession:
    P17483
    Secondary Accessions:
    • Q9NTA0

    Protein attributes for HOXB4 Gene

    Size:
    251 amino acids
    Molecular mass:
    27604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB4 Gene

Proteomics data for HOXB4 Gene at MOPED

Post-translational modifications for HOXB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXB4 Gene

Domains for HOXB4 Gene

Gene Families for HOXB4 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17483

UniProtKB/Swiss-Prot:

HXB4_HUMAN :
  • P17483
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family. Deformed subfamily.
genes like me logo Genes that share domains with HOXB4: view

Function for HOXB4 Gene

Molecular function for HOXB4 Gene

GENATLAS Biochemistry: homeo box B4(2F),homologous to mouse Hox-2.6,Drosophila Dfd
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

LifeMap Function Summary for HOXB4 Gene

HOXB4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for HOXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB4: view
genes like me logo Genes that share phenotypes with HOXB4: view

Animal Models for HOXB4 Gene

MGI Knock Outs for HOXB4:

miRNA for HOXB4 Gene

miRTarBase miRNAs that target HOXB4
Targeting motifs for HOXB4 Gene
HOMER Transcription Factor Regulatory Elements motif HOXB4
  • Consensus sequence: TGATTRATGGCY Submotif: canonical Cell Type: ES GeoId: GSE34014

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for HOXB4 Gene

Localization for HOXB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB4 Gene COMPARTMENTS Subcellular localization image for HOXB4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXB4: view

Pathways for HOXB4 Gene

SuperPathways for HOXB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0002011 morphogenesis of an epithelial sheet IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0008283 cell proliferation IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXB4: view

No data available for Pathways by source for HOXB4 Gene

Compounds for HOXB4 Gene

(2) Novoseek inferred chemical compound relationships for HOXB4 Gene

Compound -log(P) Hits PubMed IDs
retinoid 37.9 1
oligonucleotide 12.1 1
genes like me logo Genes that share compounds with HOXB4: view

Transcripts for HOXB4 Gene

mRNA/cDNA for HOXB4 Gene

(40) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXB4 Gene

Homeobox B4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB4 Gene

No ASD Table

Relevant External Links for HOXB4 Gene

GeneLoc Exon Structure for
HOXB4
ECgene alternative splicing isoforms for
HOXB4

Expression for HOXB4 Gene

mRNA expression in normal human tissues for HOXB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB4 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (4.8) and Colon - Sigmoid (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXB4 Gene

SOURCE GeneReport for Unigene cluster for HOXB4 Gene Hs.664706

genes like me logo Genes that share expressions with HOXB4: view

No data available for mRNA Expression by UniProt/SwissProt for HOXB4 Gene

Orthologs for HOXB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB4 35
  • 99.87 (n)
  • 99.6 (a)
HOXB4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXB4 35
  • 96.94 (n)
  • 97.82 (a)
HOXB4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXB4 35
  • 93.33 (n)
  • 93.81 (a)
HOXB4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb4 35
  • 95.32 (n)
  • 96.93 (a)
Hoxb4 16
Hoxb4 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXB4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB4 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxb4 35
  • 94.3 (n)
  • 96.05 (a)
chicken
(Gallus gallus)
Aves HOXB4 35
  • 74.5 (n)
  • 73.73 (a)
lizard
(Anolis carolinensis)
Reptilia HOXB4 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb4 35
  • 66.83 (n)
  • 65.37 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxb4a 35
  • 69.12 (n)
  • 69.91 (a)
hoxb4a 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dfd 36
  • 18 (a)
OneToMany
Dfd 37
  • 78 (a)
Scr 37
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for HOXB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB4 Gene

ENSEMBL:
Gene Tree for HOXB4 (if available)
TreeFam:
Gene Tree for HOXB4 (if available)

Paralogs for HOXB4 Gene

Selected SIMAP similar genes for HOXB4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXB4: view

Variants for HOXB4 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXB4 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990
esv1007307 CNV Deletion 20482838
nsv819832 CNV Gain 19587683

Relevant External Links for HOXB4 Gene

HapMap Linkage Disequilibrium report
HOXB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HOXB4 Gene

Disorders for HOXB4 Gene

(3) Novoseek inferred disease relationships for HOXB4 Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia 44.1 1
leukemia 32.8 4
cancer 0 1
genes like me logo Genes that share disorders with HOXB4: view

No data available for UniProtKB/Swiss-Prot for HOXB4 Gene

Publications for HOXB4 Gene

  1. Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2. (PMID: 11085749) Giannola D.M. … Emerson S.G. (J. Exp. Med. 2000) 3 4 23
  2. Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression. (PMID: 11250656) Pan Q. … Simpson R.U. (J. Endocrinol. 2001) 3 23
  3. HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation. (PMID: 11984874) KAPmA1ves L.G. … Largman C. (Dev. Dyn. 2002) 3 23
  4. Effects of HOXB4 overexpression on ex vivo expansion and immortalization of hematopoietic cells from different species. (PMID: 17510218) Zhang X.B. … Kiem H.P. (Stem Cells 2007) 3 23
  5. High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. (PMID: 12406897) Schiedlmeier B. … Ostertag W. (Blood 2003) 3 23

Products for HOXB4 Gene

  • Addgene plasmids for HOXB4

Sources for HOXB4 Gene

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